Product "Levodopa": imiyalelo ukusetyenziswa, inkcazo, ukwakheka, analogs kunye nohlolo

Yintoni na ichiza 'Levodopa "? Imiyalelo yokusebenzisa, ixabiso, ukubuyekeza ichiza kuya kuxoxwa phambili umganyana. Uza kufunda oko kumiselwe kulo iyeza, ukuba wayenazo na abasabela ezingalunganga kunye Izimo, apho fomu iyafumaneka ukuba ukuthengisa, nto leyo ifakiwe kumafa yawo, njalo-njalo.

Ekwakhiweni, imilo, inkcazo

Ukuba ngawaphi amacandelo iqulathe ichiza "Levodopa"? Imiyalelo yokusebenzisa ibonisa ukuba eyona nto ebonakalayo ichiza levodopa. Ekuthengisweni oku ngohlobo amacwecwe setyhula spigot umbala omhlophe, zahlanganiswa kwiibhokisi cell nentaba nekhadibhodi, ngokulandelelana kwazo.

Umgaqo ekusebenzeni medicament

iziyobisi "Levodopa" Zisebenza njani? Imiyalelo yokusebenzisa, ncomo baxele ukuba olu dibaniso arhente antiparkinsonian. Ijolise ukuphelisa ngqongqo, hypokinesia, lafa, uluchwe kunye dysphagia.

Emzimbeni, esebenza icandelo iyeza atshintshelwe dopamine (CNS), ngaloo ndlela ababumba ukunqongophala kwe element.

Dopamine okwenzeka zomzimba peripheral, ubonisa akukho imiphumo anti-Parkinson of levodopa. Oku kungenxa yokuba akukho ukungena kwinkqubo luvo kwaye yintoni unobangela enkulu ngayo ebuhlungu ichiza.

Ukunciphisa idosi enye into esebenzayo emzimbeni womntu othile wabelwa medicament zidityaniswe kunye inhibitors peripheral dopa-decarboxylase. Le ndlela inceda ukwehlisa ziziphumo ebezingalindelekanga emva kokuthatha iipilisi.

Pharmacokinetics

ako njani amayeza kakhulu 'Levodopa "? Imiyalelo isicelo ithi emva kokuba ichiza emzimbeni kubhaliwe kakhulu ezabalazela ngokukhawuleza ukusuka emathunjini.

Kukufakwa into esebenzayo yi malunga ne-20-30%. Kule nomphumela enyangayo yabonwa emva malunga 3 h.

ekudleni (kuquka ukutya okuthile) ichaphazela ngqo kukufakwa ichiza.

Ichiza umzimba, ngaloo ndlela kusenziwa metabolites eziliqela. Kukhuthaza le into esebenzayo kwenzeka ngokusebenzisa nezintso, yaye emathunjini.

Ubungqina obubonakalayo buxela

Kuphantsi kwaziphi iimeko izigulane emiselweyo ichiza "Levodopa"? Imiyalelo yokusebenzisa ngokwezi okukhomba zilandelayo:

• syndrome postencephalitic zengqondo okubangela izifo cerebrovascular okanye ukunxila okanye ityhefu;
• syndrome Parkinson kaThixo, kananjalo, nto leyo kwabangelwa kukusetyenziswa kweziyobisi antipsychotic;
• isifo Parkinson kaThixo.

Izimo

Nokuba kukho Izimo kwi "L-dopa 'iziyobisi? Imiyalelo yokusebenzisa ingxelo ukuba olu nyango Akuvunyelwe ukuba kwezi meko zilandelayo:

• hypersensitivity ukuba amacandelo;
• kudityaniswe Mao inhibitor;
• ngethuba lokukhulelwa ngexesha lwebele-ekondleni umntwana;
• izigulane ngaphantsi kweminyaka eli-18.

Ngononophelo olukhulu ichiza ingabhekiswa abaqeshwe:

• emphysema;
• phambi isifo semiphunga, isifo sentliziyo, inkqubo isibindi ezidalwe nezitsha;
• isifuba inyumoniya;
• izenzo ngengqondo;
• wolusu (kuquka imbali);
• engile-ukuvalwa glaucoma;
• ukuxhuzula phindo (yombono);
• open-angle neglaucoma, leyo kwenzeka ngendlela ezingapheliyo;
• wezintso kwaye isibindi ukungaphumeleli;
• iposi engabalulekanga (imbali), ngokunjalo iindlela yeentlobo ezahlukeneyo arrhythmias;
• isilonda duodenal isisu;
• CNS ezabonakala engcinezelo;
• nokuphazamiseka intliziyo isingqisho.

Ichiza "L-dopa": imiyalelo yokusebenzisa

Inkcazelo ichiza sele uchazwe apha ngasentla. Njengoko kumele kube njalo?

Ngokutsho imiyalelo, ichiza sithathwa ngomlomo. Idosi ichanekile ngokuthe linyuke ukusuka kwi lincinane ukuya kwelona (ngokuxhomekeke isigulane ngamnye).

Baqala unyango kunye ne nedosi ye-0.25-1 g Esi sixa yahlulwe ziinxalenye ezintathu. Idosi ichanekile yaba yintsimi 0,125-0,75 g Ngaba oko ngamaxesha ezilinganayo ixesha (umz, iintsuku ezintathu), ugxininise impendulo isigulana ngamnye, phezulu ukuya mzuzu xa isiphumo elilelona iya ndazigcina nothomalaliso.

Ithamo liphezulu ngosuku mayingagqithi grams ezisibhozo.

Amayeza kuyo nayiphi na imeko, musa khansela kabukhali. Misa balithathe ngcembe.

ukusabela ezingalunganga

Ngaba iziphumo ebezingalindelekanga ichiza 'Levodopa "? Imiyalelo Sebenzisa ithi kwimeko yokwamkela kwayo kuloo mntu unakho ukusabela ezithile ekunzima ezichaphazela ukusebenza kwazo zonke iinkqubo ze umzimba:

• nemithambo yegazi: iyangongoza intliziyo, arrhythmia, ukuphazamiseka xi, reactions intolerance, syncope, njalo-njalo.
• wokugaya: sorhudo, ukugabha, ukuqunjelwa, ukudla, ukuqhina, utshintsho incasa, umlomo owomileyo, wopha iphecana zesisu.

Kufuneka kuqatshelwe ukuba ngaphandle reactions icala ezichaphazela ukusebenza hematopoiesis, wokuchama, yokuphefumla, kunye neenkqubo luvo. Amaninzi kakhulu izigulane abafumana eli chiza negazi kwenzeka, utshintsho parameters elebhu kunye neziphumo engathandekiyo apha esikhumbeni.

Amatyala libanda (iimpawu, unyango)

Ekusebenziseni ngeedosi eziphezulu wabonisa ukwandiswa ebalulekileyo yeziphumo ebezingalindelekanga. iimeko zifuna unyango ngohlobo lavage, esweni yomguli imeko jikelele kunye nokusebenza kwentliziyo. Ukuba kuyimfuneko, enze unyango antiarrhythmic.

imithi

ukwamkelwa okanye batolike ingqwalasela yokulungiselela "ditilina" beta-agonists, kunye nezenzi zenzelwe inhalation zomzimba, lwandisa amathuba arrhythmias zentliziyo.

Bioavailability "Levodopa" uyakwazi ukunciphisa yokunciphisa tricyclic.

Ukudityaniswa ichiza with "thioxanthenes," "Diazepam" antipsychotic "Phenytoin" m-holinoblokatorami "clonidine", "Difenilbutilpiperidinom" "Papaverine", "Clozapine", "phenothiazine" "pyridoxine" yaye "reserpine" ngokufuthi lunciphisa ifuthe layo antiparkinsonian.

imixube Lithium ukwandisa amathuba kukuvela dyskinesias kunye nemibono, yaye "methyldopa" medicament kwandisa ngayo icala.

Indibaniso inhibitors Mao kunye "Levodopa" kukhokelela ejikeleza kakuhle. Kulo mba, lo lokuphumla phakathi amathamo ezi amayeza kufuneka kwiintsuku ezili-14.

ukuncipha ko- uxinzelelo yabonakala indibanisela amayeza kwaye kwaqwalaselwa "tubocurarine".

Drug "metoclopramide" ukwanda bioavailability "Levodopa" nokukhawulezisa yokulahla esiswini. Oku kuchaphazela ngokungalunganga khosi yesi sifo.

iingcebiso ezithile zokusetyenziswa kweziyobisi

Into ekufuneka uyazi phambi kokuthatha iipilisi 'Levodopa "? Imiyalelo zokusetyenziswa (ixabiso ngezantsi) ilumkisa malunga isoyikiso empilweni ngu kurhoxiswe ngokukhawuleza i medicament.

Kwiimeko apho akunakwenzeka ukuba baphephe kunciphiso idosi okanye ukurhoxiswa amayeza zifuna esweni rhoqo imeko yesigulane.

Phambi ichiza ayikhuthazwa ukuba ukudla zizityebi leeprothini, kuba lunciphisa absorbability ukwimo esebenzayo.

Uthomalaliso ifuna esweni okokoko ezahlukeneyo iinkqubo, amalungu, kunye iparameters negazi.

Price kunye analogue

I-analogue ikufutshane ukulungiselela "L-dopa" ithetha ezifana njenge "levodopa benserazide" yaye "Levodopa Carbidopa". Imiyalelo yokusebenzisa ingxelo ukuba la machiza kufuneka Yayibubungqina ezifanayo, iziphumo ebezingalindelekanga, indlela amanyathelo kunye Izimo. Umahluko phakathi kwezi mali yi ukwakhiwa kwawo.

Ezinjalo izinto ezisebenzayo ezifana carbidopa kunye benserazide ukunciphisa imveliso dopamine e izihlunu peripheral, ngaleyo ndlela kwande isixa levodopa nghena CNS.

Ngenxa yoko, oko ngokukhuselekileyo makuqatshelwe ukuba imigaqo "Levodopa Carbidopa" yaye "benserazide levodopa" (imiyalelo ukusetyenziswa kwezi ndlela nazo okulungiswe ekupakishweni) ishenxisa ezongezelelweyo yokwamkela inhibitors peripheral dopa-decarboxylase.

Ezinye ngoontanga, ngoko ke yokugqibela kuquka loo mithi "Isik Meath", "Tremonorm", "Dopar 275", "Tidomet", "Duellin ',' Sinemet ',' Zimoks", "Sindopa", "Isik" "Lac". Kufuneka atyumbe ugqirha kuphela.

Ixabiso 'Levodopa "ichiza kakhulu eliphezulu. Ezikhemisti, unako ukuthenga le amayeza ngaphakathi 1500-1850 engange.

Reviews imithi

Unyango nasiphi na isifo kufuneka kwenziwa kuphela injongo ugqirha onamava. Kwaye Parkinson xa kungekho ngaphandle.

Izigulane abathatha ichiza "Levodopa" ngokokubona kwayo kuphela, kwaye akuyi kuba nemiphumo emihle nezinyangayo. Kaninzi le ncomo medicament ubukho beHIV. Abasebenzisi baxele ukuba nkqu ukusetyenziswa elide amayeza ukuphuculwa langutana ndilugcinile kakuhle.

Ukuba iyeza sithathwa phantsi ingqalelo yi-mali, nto leyo ibhalwe yobungcali anamava ulandela ikhondo esi sifo, inkqubo yonyango siphantse sibe yimpumelelo. Oku kungenxa yokuba ichiza esebenzayo kufuneka ezibanjiswe umthamo engqongqo, leyo ixhomekeke kwisigulana, iimpawu zesi sifo kunye nezinye izinto.

Izigulane asiyithobeli ngqo kwirejimeni yonyango, ndikuxelile ukuba ichiza "Levodopa" iphumelela kakhulu ekususeni iingxaki zempilo.

Enyanisweni, abaninzi ukhalaze malunga neendleko eziphezulu amayeza. Nangona kunjalo, iingcali zithi ukuba ixabiso eli chiza sifanelekile ngokupheleleyo.