Phosphatase awana - i marker enzyme

Ukuziqhelisa, oonoklinikhi badla ngokujongana kokunyuka ngequbuliso kumsebenzi phosphatase obrak. Ngokusebenzisa kweekhithi multi-test ukulungiselela izifundo kwemichiza ukuba unalo ithuba ukulawula umsebenzi enzyme. Ngokutsho kwinqanaba lomsebenzi enzyme wathi uyakwazi ukubona izifo yenkqubo hepatobiliary kunye ijwabu ithambo.

phosphatase awana - enzayimi fanele ukuba udidi hydrolases, ohlaba iqela phosphate evela biopolymers ezahlukeneyo (iiproteni, nucleic, sezakhi). Lo msebenzi ephezulu enzyme yanikwa ingqalelo kwimeko obrak. I-enzyme ibekwe iiseli ezinxulumene inwebu plasma karhulumente, ngoko libhekisela enzayim inwebu-ebembophile. phosphatase awana (ALP) ubunjwe isozymes ezahlukeneyo ibekwa epithelium zhelchnovyvodnyh nemibhobho inwebu plasmatic of hepatocytes kunye luvo, ithambo, emathunjini, ngumkhaya, zezintso.

Ukumisela Umsebenzi of isoenzymes ngokusebenzisa electrophoresis. Noko ke, ALP isozymes musa zinamalungu Okukodwa ecacileyo, kunye neendlela electrophoretic kunzima kakhulu. Ngoko ke, ukuba lula uphando usebenzisa indlela esekelwe phezu isoenzymes ezahlukeneyo uvakalelo ukufudumeza. Isisu phosphatase awana iphathelele iqhekeza thermostable kunye isozymes kwesibindi kunye ithambo - a thermolabile. Eyona nokubanda nokushisa na phosphatase ithambo.

phosphatase serum awana ngumxube ngethambo zesibindi isoenzymes. Ukukhululwa enzyme ukusuka igazi izicwili ezahlukeneyo kuxhomekeke kurhulumente komzimba kunye nobudala ephilayo (ukukhulelwa, parturition, zisanyisa ngamandla). Umsebenzi aphezulu phosphatase obrak egazini labantu abatsha kungenxa ukusebenza kakhulu osteoblasts e esiqwini ithambo, ezo zibangelwa iinkqubo ukukhula elikhutheleyo eziphilayo. Ngeli xesha, umsebenzi enzyme kwandisa igazi ngenxa isoenzyme ithambo. Kwisiqingatha sesibini ukukhulelwa kunye zokubeleka ngokubonakalayo ukwandisa nokutshatyalaliswa ngumkhaya kubangela ukunyuka uyondelelwano lwee- isoenzyme placental.

Ukwandisa lwee- phosphatase obrak egazini kudla ibhaliswe ngezifo wesibindi ithambo. umonakalo Parenchymal kwesibindi ebangela ukunyuka okungephi kumsebenzi enzyme serum igazi, njengoko phosphatase ialakalin ezinxulumene ingaphandle iseli. In lwezonyango hepatology isibindi isoenzyme kubonisa ukuba lokufunyaniswa cholestasis. Oku kungenxa yokwanda Yindibanisela iiseli ibile duct AP enzyme bodwa ukungathobeli in inyongo. Hyperenzymemia eliphezulu ingakumbi ngexesha kuphuhliso inkqubo pathologic kunye inyongo stasis kwi zesibindi bile duct. Ngoko ke umsebenzi enzymatic of phosphatase obrak kwi serum igazi inyuswe phindene kalishumi. Ukuba umonakalo intrahepatic umsebenzi transcriptase biliary landa igazi 2-3 kuphela amaxesha. awana phosphatase norm for abadala ukuya kwiminyaka-31 zenza 39,0-92,0 IU / L emva kweminyaka 31 - 39,0-117,0 IU / L. Izinga awana phosphatase kubantwana abangaphantsi kweminyaka eli-10 - 106,0-213,0 IU / L ukuya kwiminyaka-3 - 71,0-213,0 IU / l, kwaye ezisanda kuzalwa - 35,0-106,0 IU / L.

Xa ngezifo ithambo, kukho ukuba lwakukhula umsebenzi osteoclasts, ngexesha kuphuhliso yamathambo, osteodistorofii, hyperparathyroidism egazini kwandisa umsebenzi ialakalin bone phosphatase. Kulo mzekelo, umsebenzi iyonke ialakalin phosphatase egazini banda izihlandlo 3-10. Moshilongo yokuqala yamathambo kunye osteodystrophy na ukunyuka ethile kumsebenzi phosphatase kwi kulwelo synovia. Ukunyuka kumsebenzi phosphatase obrak kulwelo cerebrospinal luphawu ngokoyiswa inwebu neuronal, apho yenzelwe.