Le esigcwele of Langerhans zepancreas. Antibodies iiseli nemisele ka Langerhans

esigcwele ngamnye Langerhans yenza kakhulu, kubaluleke kakhulu ukuba lonke eziphilayo. qhaza Its - kukulawula okuqulethwe carbohydrate egazini.

History of izovela

Le esigcwele of Langerhans wachazwa kuqala ngo-1869. Discoverer of ngokuseka ebalulekileyo ibekwe kwi injeke (ikakhulu nomsila inxalenye yayo), wayengumfundi oselula Rudolfa Virhova - Paul Langerhans. Yaba nguye lowo ahlolwe phantsi Sisihloko ngemicroscope leeseli, leyo nasekumeni lwabo morphological yohlukile kwezinye izihlunu pancreatic.

kamva Kuye kwafunyaniswa ukuba Langerhans nemisele umsebenzi ezidalwe olwenziwa. Le owenziwa yi P. Ulezko-Stroganov. Ngowe-1889 waba okokuqala unxibelelwano phakathi ekubulaleni nemisele ka Langerhans kunye nophuhliso seswekile.

Yintoni kuba esigcwele ka Langerhans?

Okwangoku, esi sakhiwo sele efunde kakuhle ngokwaneleyo. Ngoku kakuhle ukuba lokhu uye ezahlukeneyo. Okwangoku, siyazi abo zilandelayo:

• cells alpha;
• iiseli beta;
• iiseli olwandle;
• pp-iiseli;
• iiseli epsilon.

Kungenxa ngeyantlukwano kwiiseli zabo esigcwele enze yonke imisebenzi eyabelwe kubo.

Alpha-iiseli

Olu hlobo yi malunga ne-15-20% of esigcwele ekhoyo. Eyona njongo iphambili yale alpha-iiseli na imveliso glucagon. Le hormone sele indalo lipid kwaye insulin ochasene ngokungaqhelekanga. Xa wakhululwayo, glucagon ngqo wesibindi, apho ukuqhagamshelana receptors ezithile, uMthetho imveliso iswekile yi glycogen iyafa.

iiseli Beta

Nemisele of Langerhans na iintlobo zezona common kakhulu. Bona akhawunti malunga 65-80% yabo bebonke. Ngoku kufunyaniswe ukuba umsebenzi wabo iphambili ukuphuhlisa enye hormone ibalulekileyo - insulin. Le nto i ochasene le glucagon. Lukhuthaza ukusebenza glycogen ukubunjwa nokuyigcina esibindini kunye nezihlunu. Ngenxa yale nkqubo isixa ukuhla kwe glucose egazini.

iiseli Delta

Nemisele of Langerhans zepancreas yolu hlobo azenzeki rhoqo. Zi-% 2-10 nje kuphela yabo bebonke. Ngoku iimpawu zazo ezisebenzayo baziwa kakuhle. Kuye kwafunyaniswa ukuba ezi seli nokulungelelanisa somatostatin. Umsebenzi osisiqu eziphilayo esebenzayo kukuba ukucinezela kokuveliswa somatotropin, somatotropin kunye hormone thyrotropin-lokukhululwa. Oko kukuthi, yenza ngqo kwi ngxenye kunye cipande yebhinqa.

PP-iiseli

esigcwele ngamnye Langerhans lohlobo ababandakanyekayo lokufundiswa polypeptide pancreatic. De kube sekupheleni umsebenzi yayo ayenziwanga efunda. Okwangoku, yena wothulelw iimpawu abathintela imveliso juice pancreatic. Ukongeza, isiphumo yayo inceda ukuyekelela umsipha egudileyo lwesinye inyongo. Kwiminyaka yakutshanje behlolisisa kakhulu ngokubonakalayo ukuxhomekeka ye inqanaba imveliso ukwimo ukusuka ukuyilwa yamathumba amabi. Isiphumo bafumanisa ukuba luphuhliso yabo yandiswe inqanaba polypeptide pancreatic. Ngoko ke le into eziphilayo esebenzayo zingathathwa njengommakishi omhle yamathumba amabi, zepancreas.

iiseli Epsilon

Ezi nemisele ze Langerhans zezona rhoqo. Of lubalo olupheleleyo ngaphantsi kwe-1%. Umsebenzi omkhulu iiseli ezinjalo kukuvelisa ihomoni okuthiwa ghrelin. Le izinto esebenzayo kukho inani elikhulu imisebenzi, kodwa kufundwa kakhulu ifuthe layo qondisa kwi onombilini.

Malunga nemisele zokugula of Langerhans

Hlula ezi sezakhiwo ezibalulekileyo okukuchaphazela umzimba neziphumo kakhulu emibi. Kwimeko apho avelisa antibodies nemisele ka Langerhans, inani lokugqibela ngokwamanqanaba lifinyele. Hlula ngaphezu kwe-90% ye-iiseli unciphisa ukuveliswa insulin ukuya kwinqanaba eliphantsi kakhulu. Isiphumo uphuhliso izifo ezinobungozi ezifana ezifana neswekile. Antibodies esigcwele iiseli akholisa ukubakho izigulane eselula.

Umonakalo omkhulu inani leeseli nabakwaziyo gormonprodutsiiruyuschih unobangela ukudumba injeke - pancreatitis.

Indlela ukugcina iiseli esigcwele?

Kuya kufuneka ukuba uthathe unonophelo zepancreas lonke liphela. Okokuqala kuyimfuneko ukushiya ukuzinkcinkca iziselo ezinxilisayo. Isibakala sokuba banayo na injeke lonke ukutya nefuthe kakhulu elibi. Kwimeko ukusetyenziswa kotywala elide ebantwini kwenzeka kwaye iqhubela pancreatitis, ekugqibeleni kunokukhokelela iiseli shoka esigcwele omkhulu.

Ngaphandle zotywala kungalinxeba ngokwaneleyo injeke unalo isixa esikhulu ukutya zizityebi amafutha ezilwanyana. Kulo mzekelo, le meko iya mandundu kwimeko phambi kokuba isigulane umthendeleko ixesha elide Akadla nto.

Kwimeko ukuba inyama pancreatic sele inkqubo esinganyangekiyo ukudumba, kunyanzelekile ukuba adibane ingcali - ugqirha okanye gastroenterologist. Ulwazi amakhono oogqirha amisele ikhondo eyiyo unyango, leyo kakhulu isantya uphuhliso utshintsho zophendlo lwezifo. Emva koku iya kubanjwa injeke ultrasound nyaka ngamnye, nto leyo yenzelwa basenze kunye namanye amalungu ka kwisisu. Ukongeza, kuyimfuneko ukuba sithathe uhlalutyo zengqo- igazi kwisiqulatho yayo amylase.

Ukuze ubone kuqala pancreatitis ezingapheliyo, ukongeza elebhu zomculo izifundo, ziya kunceda ikliniki. Uphawu iphambili yale sifo imbonakalo iintlungu ikota yesangqa ephezulu ekhohlo. Ngapha koko, oku uyaxhalaba mlinganiswa zoster kwaye kwenzeka rhoqo emva kokuba izixa ezikhulu ukutya zizityebi amafutha ezilwanyana. Ukongeza, isigulana emva kwesidlo ukuze sibe nenkxalabo malunga imvakalelo rhoqo ubunzima esiswini. Zonke ezi mpawu balishiye ngokukhawuleza ngokwaneleyo okanye anciphise namandla aso kwi izigulane abafumana amayeza equlethe pancreatin. Phakathi kwabo, amachiza athandwa kakhulu got "Creon", "Mezim" yaye "Pancreatin". Ukuba unayo nayiphi na ukudumba kwi injeke inyama ngcono kwaye inkunkuma konke konke zokusela utywala. Inyaniso kukuba nkqu imali encinci zingangunobangela inkqubo sifo, ngaloo ndlela igcina kakhulu umzimba.