Ukususela oko kunceda "UDenise" (tablets)? Imiyalelo yokusebenzisa, analogs

Ngaba uyazi ukuba yintoni eyenza "UDenise" (tablets)? Ukuba ulwazi abanalo, ngoko siya uwusondeza izinto kweli nqaku.

imveliso Packaging nokubunjwa kwayo

Isibakala into eyenza "UDenise" (tablets), sichaza ngezantsi. Le nto esebenzayo kule ichiza nimesulide. Kwakhona isakhiwo, oko kuquka amacandelo afana microcrystalline kwincindi, aspartame, calcium phosphate, colloidal lesilicon dioxide, umbona starch, nemagnesium stearate, isodiyam carboxymethyl starch, talc kunye yi incasa.

Xa ukuthengiswa medicament uthathwa amacwecwe namadyungudyungu 10, zipakishwe kwiibhokisi kwikhadibhodi.

Umgaqo yesenzo ichiza

Ngaphambi kokuba siphendule lo mbuzo oko kwenza "UDenise" (tablets), kufuneka usixelele isebenza njani na ichiza.

Ngokutsho imiyalelo, oko NSAIDs ukuba emane abangaphangeliyo Cox-2, oko kukuthi i-enzayimi ababandakanyekayo Yindibanisela prostaglandins - njengabalamli iintlungu, nangokurhala kunye nokudumba. iipropati koko anti-ukudumba, ingqalelo ichiza imiboniso iintlungu kunye nesenzo antipyretic.

Asinako ukuba ichiza abangaphangeliyo i (ingathityazwa) ukubunjwa prostaglandin E2 kwi enyukela kwinkqubo iindlela nociceptive kunye nommandla ukudumba, ngokunjalo ngeendlela Uhanjiso neemvakalelo (iintlungu) apha emqolo.

Ukulungiselela "naiz" analogs ezidweliswe ngezantsi, kunciphisa uyondelelwano lwee- prostaglandin H2 (siphila ixesha elifutshane), ukusuka apho, phantsi kwempembelelo prostaglandin isomerase, kukho prostaglandin E2. Ukunciphisa uyondelelwano lwee- umkhondo yokugqibela yokuncipha kwenani iqondo ukusebenza receptor-lohlobo ER (prostanoid), nto leyo obubonakaliswa neziphumo ukudumba kunye iintlungu.

Kufuneka kuqatshelwe ukuba ubukhulu minor ichiza ichaphazela ingqalelo Cox-1. Phantsi kweemeko komzimba, ukuba ngenkankulu kuthintela prostaglandin E2 kwi CD. Oku kunciphisa inani iziganeko iziyobisi ezibi.

Eyona engundoqo iimpawu ichiza (NSAID)

Ukulungiselela "naiz" nako ukuze kuthintelwe zegazi udibaniso. Oku kwenzeka ngokuthi ziyibuyisela umva le Yindibanisela thromboxane A2 kunye endoperoxides. Ukongeza, ukuba ofihla inkqubo release histamine, yaye kunciphisa ngesidanga bronchoconstriction, leyo okubangelwa sesichengeni acetaldehyde kunye histamine.

Iingcali ziye zabonisa ukuba nimesulide elungileyo abangaphangeliyo ukuba Yindibanisela urokinase kunye IL-6, nokuthintela ukutshatyalaliswa intlala. Ngaphezu koko, oko abangaphangeliyo ukuba Yindibanisela metalloproteases, nokuthintela ukutshatyalaliswa collagen kunye proteoglycans.

Ngokutsho imiyalelo, ngokunciphisa umsebenzi myeloperoxidase ethathelwa ingqalelo iziyobisi ebonisa izinto antioxidant kwaye abangaphangeliyo ukuyilwa imveliso (ezinetyhefu) ukubola O _2. It esinxibelelana receptors glucocorticoid kwaye isebenze kubo, into leyo eyenza igalelo inyathelo anti-ukudumba.

Le kinetics ka iziyobisi

Emva iintlungu ngomlomo "UDenise" ifunxwe ukusuka emathunjini. ekudleni kunciphisa umyinge kukufakwa ichiza, kodwa kuchaphazela kwalo.

umthamo wegazi Incopho ye nimesulide afunyenwe emva kweeyure 2.6. kunxulumano lwayo iproteni efikelela 95%.

Eli chiza ungena kuzo zonke izicwili nobufazi. Ngaphezu koko, efunyanwa kulo nangokurhala asidi medium focal kunye fluid synovia.

nethe Nimesulide esibindini. Bawo-ubomi ziiyure ezi-5. Yena uboniswa nezintso, kwakunye kunye inyongo.

Ubungqina obubonakalayo buxela ukuba iilozenji

Ukususela oko kunceda "UDenise" (tablets)? Kwezi mali ezimiselweyo:

• sciatica, isifo samathambo, sciatica;
• lumbago, osteoarthritis, syndrome articular, isifo samathambo kunye sifo exacerbation;
• samathambo psoriatic, arthralgia, ankylosing spondylitis;
• kwamalunga of imvelaphi ezahlukeneyo, osteochondrosis kunye radicular syndrome;
• ukudumba nemisipha, myalgia, imvelaphi samathambo kunye samathambo, bursitis, ukudumba imisipha;

• syndromes buhlungu imvelaphi ezahlukeneyo (kuqukwa nokwenzakala, postoperative, bamazinyo, algodismenoree, intloko ebuhlungu);
• inflammations kwenkqubo musculoskeletal kunye inyama ithambile.

Kufuneka kuqatshelwe ukuba kakuhle ukuba "UDenise" lobushushu. Eli chiza isetyenziswa ngumkhuhlane imvelaphi ezahlukeneyo, kuquka izifo ukudumba kunye esosulelayo.

Izimo NSAIDs

Drug "UDenise" aluvumelekanga ukuqesha ukukhulelwa. Kwakhona, oku kufuneka ingasetyenziswa:

• "Aspirin triad";
• ilunga nangokujaduka sisilonda le iphecana zesisu (in exacerbation);
• lwebele;
• ukopha evela iphecana zesisu;
• umsebenzi isibindi othile;
• kubantwana ukuya kwiminyaka emibini;
• insufficiency sezintso yayinzima;
• giperuvstvitelnosti.

Ngononophelo olulodwa le arhente esimiselweyo uhlobo isifo seswekile sinwenwa, lwegazi kunye insufficiency intliziyo.

Indlela ukuthatha "UDenise"?

Kujongwa amayeza ngendlela iipilisi emiselweyo ngaphakathi kuphela. izigulane abadala kucetyiswa ukuba uthathe 100 mg kabini ngemini. Idosi iphezulu ichiza ngosuku ngu 400 mg.

Ngokuphathelele amacwecwe esasazekayo, ke, phambi kokuba enze iyeza enjalo, kufuneka ngaphambili iqhawulwa ml-5 zamanzi eziqhelekileyo (1 dessert icephe). Wadla kufuneka isixhobo ekupheleni isidlo okanye emva kwesidlo.

Abantwana ngeziyobisi emacwecweni engamiswanga. Kubo, kukho olunye uhlobo ichiza - imisiwe. Kucetyiswa ukuba le kweminyaka emibini.

icala izenzakalo

Ukulungiselela "naiz", lo umthamo leyo thaca ngasentla baxabane ezingafunekiyo ezifana:

• heartburn, kohlobo, isicaphucaphu, ianemia, ukugabha;
• agranulocytosis, iintlungu esiswini, ianemia, isifo sorhudo, leukopenia;
• ilunga nangokujaduka sisilonda ye phecana zesisu, intloko ebuhlungu, ukwanda transaminases isibindi;
• mothuko anaphylactic, isiyezi, irhashalala;
• isongezo ukopha xesha, bronchospasm, hematuria, ukugcinwa fluid.

amacala libanda

Ziziphi iimpawu kwenzeka xa efumana inani elikhulu "UDenise" tablets? Esithathwa iyeza kufuneka imiselwe igqirha khona. Kwimeko yokufakwa ngengozi beziyobisi (kukuninzi), isigulane lisenokuba ezi mpawu zilandelayo: unditsho, ukwanda koxinzelelo lwegazi, kwinwebu iphecana zesisu, umsebenzi kidney kakuhle, ukusilela isibindi, kunye nokudandatheka sokuphefumla.

Ukuze ukususa States wahlamba isisu nomonde, amalahle iyasebenza yaye nonyango nomqondiso.

imithi

Kunye ngaxeshanye ukulungiselela preroralnom lolwamkelo esikolweni "naiz" womchamo 'digoxin' "phenytoin", iiarhente umfutho kunye arhente lithium, kwakunye nezinye NSAID, cyclosporine, anticoagulants, methotrexate, amayeza hypoglycemic (ngomlomo), isigulane nga ha kombisa imithi (ukusuka kwesi le arhente kukhuphisana iyabophelela kunye neeproteni).

Drug "UDenise": analogs kunye nohlaziyo

Faka isixhobo kunokuthathwa amayeza afana "nimulid", "phezu", "Arcoxia", "Mesulid", "meloxicam", "Nimesil", "Movalis" "nimesulide" "Denebola", "Niemiec".

Uninzi nokubuyekezwa nkonzo kuqulunqo sikho HIV. Ngokutsho kwabo, akubikho ngokukhawuleza "UDenise" iintlungu, ichiza isetyenziswe ngempumelelo kakhulu arhente anti-ukudumba. Nangona ezinye izigulane zithi eli chiza ethile enkulu. Kudla kakhulu kubangela ngayo kwicala ezifana iingxaki nesiyezi, ubuthathaka kunye nenkqubo yokucola. Kulo mzekelo, oogqirha bacebisa ukutshintshwa iziyobisi efanayo.