PTH landa - njengoko kuboniswa uhlalutyo?

hormone Parathyroid (ebizwa hormone parathyroid, parathyrin) - hormone yi amadlala parathyroid zomzimba (parathyroid), apho ibekwe kwicala anterolateral entanyeni. Bona ngaphaya nobubovu lengqula, nto leyo ngokusondeleyo kufutshane kumphezulu ngasemva kwayo kwaye amazantsi yesabelo zayo zombini. hormone Parathyroid ngokwendalo yemizimba yethu imbaxa iproteni iziyobisi - polypeptide acid acid yezabelo.

Owona msebenzi walo ukuba bathathe inxaxheba yaye ummiselo calcium phosphorus yokucolwa emzimbeni. Umxholo ikhalsiyam egazini kunye secretion incindi yedlala parathyroid zixhomekeke ngqo omnye komnye. Hormone kungandisa xi icalcium ngokwenza izihlunu bone, wezintso kwaye isiqwenga zesisu. Le parathyrin bone kwandisa logoff dutywa inxalenye izimbiwa ngokuvuselela kuyondelelaniswe enqanda ezithile ukuba banoxanduva yokuwa bone. Bone inyama ufakwa phantsi kwempembelelo PTH resorption kunye calcium ion ibekwe egazini. Bekunye paratgormot calcium Exchange kunceda ekulawuleni umgangatho phosphate emzimbeni. Ukunciphisa ngobunzulu inkqubo yokuqala eziphilayo, oko icacisa indlela yesibini. Ngaphezu koko, lo hormone ebandakanyekileyo ekuphuculeni Yindibanisela calcitriol ethunjini, ukunceda calcium reabsorption. hormone Parathyroid ethatha inxaxheba ngqo ekumiseleni imisebenzi yabo bonke enzayim calcium-abaxhomekeke katalirizuemye abasabela ngayo. Phantsi sakhe eqalwa inkqubo coagulation igazi.

Ukuba PTH uya eziphakamileyo, ngoko kwasekwa kwezifo ezinzima ezidalwe ezinxulumene ngengqibelelo ithambo ukungathobeli - hyperparathyroidism, kwamathambo. Isiphumo onjalo siphene komzimba kakhulu izinciphiso calcium kwegazi, nto leyo ekhokelela ukuba nokwanda excitability neuromuscular. Comorbidities kulo mzekelo unako ukukhonza isiqulatho eliphezulu kwealkali emzimbeni kunye nophuhliso ukusilela kwezintso. Ngokunciphisa isiqulatho icalcium lens emehlweni abanale kwenzeka.

Amanqanaba hormone kwamadlala parathyroid egazini ixhomekeke isingqisho lomzimba. Inqanaba carcinoma icwangcisiwe malunga-8 kusasa, ngoxa kwiiyure 14-16 yosuku, xa umntu e kwincopho umsebenzi, hormone parathyroid ukwanda. test igazi ikhutshwa phandle inani parathyrin immunohemilyuminestsentsii. Kufuneka benze isisu engenanto, kunye usuku okanye iintsuku ezimbini phambi kokuba isampulu yegazi kuphelisa inani utywala kunye umthambo enzima iiyure eziliqela phambi kokuba inkqubo, musa ukutshaya.

Ekuhlaziyeni hormone parathyroid kumiselwe kuphela xa isigulane kurhanelwa ubukho izifo ezifana hyper- kunye gipokaltsimiya, urolithiasis kunye neurofibromatosis. Kwakhona ezibonisa uhlalutyo njongo kungabandakanya: kwamathambo psevdoperelomy amathambo elide, nayiphi na ukusebenza komzimba utshintsha ithambo osteosclerosis okanye imizimba vertebral orhanelwa ezidalwe ezininzi uhlobo neoplasia 1 kunye nohlobo 2 (AMADODA 1.2). On izinga parathormone ukuba umntu omdala igqalwa 9,5-75 nanziya / ml. Oku kusebenza kuzo zombini amadoda kunye namakhosikazi aselekhulile okuzala. Ukuba ibonise ukuba PTH sele eziphakamileyo, kukho zonke izizathu ukucinga ukuba isigulana okuqala, wesibini, hyperparathyroidism ephakamileyo, pseudohypoparathyreosis okanye Zollinger-Ellison syndrome.

Phantsi odibeneyo hyperparathyroidism ephambili hyperplasia le ingaba parathyroid, umhlaza inwebu wesinye ezidalwe neoplasia iintlobo ezimbini. Co. hyperparathyroidism zasesekondari ziquka insufficiency ezondeleyo kwezintso, hypervitaminosis D, sisilonda sikabhobhosi, yamathambo, isifo Crohn kaThixo. Ukuba PTH uya eziphakamileyo, ngoko uhlalutyo idla kwenziwa kubanjiswene ne kwinkcazelo kwinqanaba ikhalsiyam egazini kwaye kwixesha elizayo Uthelekiso izikhombisi ababini uze uchonge izixhomekeki.