Hypothalamic hormone ukukhulula

emzimbeni yokukhupha na neurohormone zabantu ukuba kuhlelwe nucleus hypothalamic. Bona anqanda (statins) okanye ivuselele (liberiny) imveliso iihomoni utshixelo yebhinqa. Oyenza isebenze kwamadlala yonyango, kwaye kukho ummiselo nokukhululwa hormone. Iinxalenye aphezulu kwenkqubo luvo kunye nenkqubo yonyango ezinento ngenxa iihomoni lokukhululwa.

umsebenzi hypothalamic

Enye yeendima ezibalulekileyo kwinkqubo yonyango unoxanduva lokuyila ka emzimbeni - le ngxenye. Iveliswe yi izinto ngxenye ezi iihomoni inxaxheba kwiinkqubo pathways komzimba.

Kule ngxenye kukho iiseli zemithambo ukuqinisekisa ukuveliswa kwezinto eziyimfuneko umzimba kufuneka ukuba imisebenzi yesiqhelo. Ezi seli zibizwa ngokuba neurosecretory. umsebenzi wabo - ukufumana la mandla akho lo iindawo ezahlukeneyo e-nervous system. izinto bodwa kwenzeka ngokusebenzisa aksovazalnye leesynapse.

Iveliswe iihomoni ngokukhupha hypothalamic, okanye njengoko ibizwa ngokwahlukileyo, statins kunye liberiny, zibalulekile eqhelekileyo yokusebenza ingqondo yebhinqa. Ngokwemvelo yemizimba yethu, ukuba peptides. Ngenxa inhliziyo imichiza nemithambo na kuyondelelaniswe zabo, uthuthwa egazini yi inkqubo hypothalamic-yebhinqa yebhinqa.

ngezigaba hormone

Cinga hormone ukukhululeka kakhulu ezaziwayo-kakuhle:

• Ziyibuyisela umva le secretion of umsebenzi yebhinqa - yinto somatostatin melanostatin, prolaktostatine.
• Ivuselela - sithetha melanoliberine, prolaktoliberine, folliberine, lyuliberine, somatoliberin, hormone thyrotropin-nikhulula, hormone gonadotropin-ukukhululwa corticotropin.

Ezi izinto, okanye mandithi ezinye zazo, kube kalukhuni eziveliswa ngamanye amaqumrhu, hayi kuphela ngxenye (umz, pancreas).

Statins kunye liberiny

Ukusebenza ingqondo yebhinqa ixhomekeke ngqo phezu kwabo. nabo babe negalelo ekusebenzeni kwamadlala ezidalwe peripheral:

• ndlala;
• amaqanda emantombazaneni;
• amasende kumadoda.

Statins kunye liberiny apho elaziwa zezi:

• dopamine;
• GnRH (lyuliberin, folliberin);
• melonostatin;
• somatostatin;
• tireoliberin.

Le secretion of luteinizing ihomoni kunye hormone follicle-oluvuselela le yebhinqa GnRH anikezele.

Ngomhla umsebenzi androgen ngabantu nabo kuchaphazela GnRH, negalelo ekwandeni komsebenzi sperm kunye neqondo yobuntu.

Kunye nabafazi neurohormone linoxanduva sexesheni, isixa hormone kuyahlukana kunye sigaba somjikelo ngayo.

Imveliso Ukunqongophala yokukhulula iihomoni kubangela ubudlolo kwakunye induku.

Iimpawu hormone

hormone Corticotropin onoxanduva ukukhathazeka, eveliswe ngxenye. Le yenye ebalulekileyo into yokukhupha, ukwenza ngokudibene hormone yebhinqa kunye neziphumo zawo phezu adrenal. Abantu kunye nokungabikho kwale hormone badla ubunzima wegazi, kunye insufficiency adrenal.

GnRH - hormone kuphucula ukwenziwa gonadotropins - naye imveliso ngxenye. Libizwa ngokuba hormone gonadotropin-lokukhululwa.

Kwindlela eqhelekileyo yokusebenza amalungu okuzala akakwazi ukwenza ngaphandle GnRH. Yiyo le hormone inoxanduva ngokwemvelo ukuba sexesheni kwabasetyhini. Kukuthatha kwakhe ukwenzeka inkqubo nokwanda kunye nokukhululwa eqandeni. Le hormone inoxanduva yobuntu (drive sex). Xa kukho imveliso zaneleyo hormone yi le ngxenye ngayo amabhinqa ukuphuhlisa ubudlolo. Yintoni enye ukukhulula hormone?

somatoliberin

Kakhulu kukhululwa ngokukhawuleza kwi esakhula. osemqoka yalo esentloko kukuba inkqubo kuqheleke ukukhula omzimba kunye neenkqubo zomzimba. Ukususela imveliso yayo ixhomekeke uphuhliso ngokupheleleyo kwaye ukuyilwa umntwana. Imveliso Ukunqongophala hormone ukusuka ngxenye inokukhokelela dwarfism (dwarfism).

Prolaktoliberin

kwenzeka uphuhliso wakhe isebenza ngexesha yokumitha lonke ixesha ukutya unina womntwana. Lo mba akhululwe normalizes ukwenziwa prolactin, ukwakha imibhobho kwamadlala mammary.

Prolaktostatin

Prolaktostatin libhekisela subclass of statins eziveliswa ngxenye, linoxanduva inhibition of prolactin.

Ngu prolaktostatinam ziquka:

· Dopamine;

· Somatostatin;

· Melanostatin.

isenzo zazo eziphambili lujoliswe abathintela hormone utshixelo lwe yebhinqa kunye ngxenye.

Melanotropin-sokukhululwa hormone

Kwinkqubo-bala lintsundu kombala kunye nokwahlukana kweeseli kuchaphazela melanoliberin. Kwakhona enza iziqalelo ze DWP yebhinqa.

Iimpembelelo ukuziphatha neurophysiological. Isetyenziswa kokususa unyango ithi edakumbisayo kunye parkinsonism.

Thyrotropin-ukukhupha hormone (TRH)

Hormone thyrotropin-nokukhutshwa ngxenye siyasebenza thyroliberine. Ukhuthaza ukuveliswa hormone le yebhinqa thyritropic sobuKristu.

Ubukhulu encinane iphembelela inkqubo prolactin. Thyroliberine kwandisa lwee- thyroxine egazini.

CNS kunempembelelo enkulu phezu iinkqubo zemveliso hormone. Kuba imveliso neurohormones zinoxanduva inkqubo yolawulo cell neurosecretory.

imisebenzi esisiseko liberinov

Le hypothalamic ukukhulula iihomoni. Yenza imisebenzi yolawulo. GnRH bunjani ukusebenza kwenkqubo okuzala kwabasetyhini kunye namadoda.

Abanoxanduva kwenziwe incindi yedlala follicle-iyahuthaza, kwaye ingachaphazela ukusebenza amatyhalarha kunye zamaqanda.

Icandelo ezifana lyuliberin, iguqulela Ozahlulayo ukusebenza ngomhla ovulation, ukwakha amathuba ukukhulelwa Palsy.

Abasetyhini abanandaba ubomi olusondeleyo, kwaye lyuliberin folliberin ziveliswe ngobuninzi ayonelanga.

Kukho izizathu ukukhupha enxulumene isabelo umndilili le ngxenye, kodwa eziwafaka kumaqela iiseli yebhinqa yebhinqa cipande kwaye awufunyaniswanga zisafundwa.

Agonists ukukhupha hormone: iziyobisi

Njengoko sele sibonile, aba amadlala eziveliswa ngxenye. Xa ayinqwenelayo ukuba ukuvuselela amaqanda, umzekelo phambi inkqubo-IVF, kusetyenziswa agonists okanye corticotropin ukukhupha analogs hormone. Oko kukuthi, banayo emzimbeni isiphumo esifanayo hormone yayo.

Kodwa ke amathuba reactions ezibi yinxalenye yomzimba ababhinqileyo. Oku kwenzeka ngenxa kumanqanaba estrogen asezantsi. Iziphumo ziqhelekileyo zibandakanya:

• intloko ebuhlungu;
• ukubila ngokugqithiseleyo;
• komzimba;
• nokoma zangasese;
• zokulwa nale ngxaki;
• kukudakumba.

Iziyobisi zisetyenziswa ngolu hlobo lulandelayo:

• "Diferelin" i decapeptide analogu ngumntu hormone zendalo lokukhululwa.
• "Dekapeptil" njengenxalenye triptorelin, analogue lokwenziwa of GnRH. Kwisiqingatha ubomi elide. zisetyenziswa ukuze amadlozi ngesirinji.
• "Lyukrin idepho" - leuprorelin. It has anti-estrogen, isiphumo anti-androgenic, ayiphilise endometriosis, enama-oxhomekeke yamathumba - umhlaza endlaleni, fibroids zesibeleko. "Lyukrin idepho" kunciphisa uyondelelwano lwee- testosterone ngabantu, estradiol kwabasetyhini, ukongeza, abangaphangeliyo yebhinqa incretia FSH, LH.
• Isiphumo ichiza ngcembe ulibuyele secretion nokomzimba hormone.
• 'Zoladex' - analogu zokwenziwa of yincindi-wokuba hormone yendalo (LH). Kudla asetyenziswe ku-IVF. Kunciphisa uyondelelwano lwee- estradiol egazini, oku kwenzeka ngenxa kwezithandani of LH secretion of cipande yebhinqa.
  

Siye saxubusha amalungiselelo agonists ikhuphe hormone.

abamelene

Ekubeni xa benikwa ukukhupha hormone agonists ukunyuka kakhulu estradiol Inokwenzeka ukukhululwa ngokukhawuleza of luteinizing hormone. Oku kukhokelela ovulation phambi kwexesha kunye nokonakaliswa amaqanda. Ukuze uphephe oku, le abamelene ikhuphe ukusetyenziswa hormone. Ngenxa yokuba izenzo zabo sishukumisa ingqondo yebhinqa kwakhona. Ovarian hyperstimulation syndrome akuthethi ukuzibonakalisa, kodwa kunjalo edla ngokwenzeka ngenxa yokusetyenziswa elide GnRH agonists. Ngaba elawulwa zingaphelanga iintsuku ezintlanu ukusuka ekuqaleni nesicelo follicle oluvuselela hormone.

Kuthomalaliso kuphumelela, bonke-injongo amalungiselelo kufuneka ube yincutshe kuphela.