"Dopamine": umyalelo manual, ncomo, iinkcazelo, analogs

Amayeza ukusebenza "Dopamine" kweziyobisi ngenxa yelo yalo izinto adrenergic wayicola ukwanda jikelele ngethoni, ukukhuthaza kwezihlunu ezesifuba imithambo yegazi, ukusebenza iinkqubo ezikhoyo kule nkqubo luvo. Ngokufanayo, umzimba basabela ngendlela dopamine ihomoni zendalo, apho ukufaka phantsi kweemeko eziqhelekileyo kweeseli zengqondo. Ukusebenzisa le sixhobo amayeza into isuke yimfuno yokulwa ngempumelelo iimpembelelo yokothuka ithi, izifo sentliziyo (arrhythmia kubandakanywa), ityhefu ukutya kunye nokudakumba.

Ukutya uze kinetics

Ngokutsho imiyalelo ukusetyenziswa, "Dopamine", kuxhomekeka idosi, inokuba arhente causative ibeta adrenergic kunye uhlobo alpha, nemiphumo emihle hemodynamics systemic kwaye ngokomgangatho nokuphucula musculature umsebenzi kwemithambo yegazi kunye nezintso. Le into esebenzayo isasazwa ngokufanayo wonke umzimba, apho kukho inxalenye reactants uleyisayo umqobo segazi lobuchopho.

Isiphumo therapeutic lwenzeka kwisithuba imizuzu emihlanu emva kokuba ulawulo kweziyobisi kunye nokuqhubeka ukuba isimbuku malunga imizuzu elishumi. ukutya elandelayo, okwenzeka kwesibindi, nezintso eyase a plasma kwasekwa iikhompawundi engasebenziyo. Malunga nama-80% ye-dose idubule kwi nomchamo njengoko metabolites ngosuku lokuqala.

Xa umntu uyakhuthazwa ukuba asebenzise ichiza "Dopamine"?

Imiyalelo zokusetyenziswa ikhankanya uluhlu lwamatyala:

• usethubeni lokuba imvelaphi ezahlukeneyo (.. in t h umbuso okubangelwe ukusebenza zidluliselwe okanye usuleleko ityhefu, kunye disorder kwentliziyo);
• insufficiency yegazi (ifom oyingozi);
• ehlangeneyo okanye nehambisana ityhefu ukutya (iyeza yandisa diuresis, leyo kakuhle kuchaphazela umyinge we ityhefu);
• hypotension.

Ukusetyenziswa kunye umthamo "dopamine"

Iyeza ibhekisela iqela ekufumaneni amalungiselelo efakwa idriphu. ithamo ubalo senziwa uthatha yokothuka yokwenene imeko ingqalelo kunye hlengiso mandatory uxinzelelo lwegazi. Ukongeza, kuya kuthathelwa ingqalelo indlela lomguli ukuya ukumnika xa iyonke.

Kubalulekile ukuqonda ukuba idosi (mg) - hayi kwiimpawu kuphela uqikelelo. Isiphumo sokugqibela kuxhomekeke kwisantya ngayo ichiza iya kuqaliswa "Dopamine". Imiyalelo yokusebenzisa ngokwahlula phakathi kwezi meko:

• inzuzo wokuchama - ukusuka 100 ukuya 250 g / min;
• unyango kunye utyando udibaniso - ukusuka 300 ukuya kuma-700 g / min;
• nengxaki senhliziyo okanye olutshintshatshintshayo shoka yokubolisa ubhalo - ukusuka 750 ukuya 1500 mcg / min.

Ukuba ukusungulwa mali olungephi ye arrhythmia kwentliziyo sele ichongiwe ithamo solution kwanda. Izigulane KIDS iziyobisi zivuza ne ngamandla ka-4 ukuya 6 mg / kg / min. Udayalo siyahlengahlengiswa ngamnye, kusekelwe phezu kweemeko kangangoko basabela njani.

Ithamo ubuninzi dopamine kwisigulana efanayo inokuba nomahluko - isikhokelo ubeka injongo (excitation kidney kwezihlunu, imithambo yegazi, intliziyo, njl ...). Kodwa ukwandisa izinga lokuhanjiswa kweziyobisi ukuya kwinqanaba 30 mcg / kg / min okanye ngaphezulu akunconywa, njengoko oku ngokungalunganga kuchaphazela imeko yesigulane.

Izimo kwi "dopamine"

Kumatyeli xa ukusetyenziswa ichiza contraindicated, kwazisa bonke imiyalelo efanayo ukuze zisetyenziswe. "Dopamine", ingakumbi, alikwazi ukugunyazisa izigulane unesifo ngezifo oluntsonkothileyo esinobubovu lengqula okanye izifo ezingapheliyo echaphazela adrenal. Kakade ke, loo miqathango kumele kwaye isici kweekhomponenti zeziyobisi.

ezibangelwa Heart isingqisho xa yamafutha nomonde okanye okuqhubekayo - esinye ezimbini into embi kakhulu ukuba akwazi kuba sisiseko yobume waqiqa ngokuphathelele non-ukusetyenziswa isisombululo ukumnika zonyango. Ukongeza, ukuba ayinqweneleki ukubhenela sentlalo drippers "dopamine", ukuba omabini la iSifo zilandelayo:

• hyperthyroidism;
• diabetes;
• pheochromocytoma.

Musa ukuvumela ulawulo ngaxeshanye beziyobisi kunye ngeendlela zomzimba, enziwe kwi Ngokwesiseko halogen (okanye izithako zawo). Sokuqeshwa ichiza kubafazi abakhulelweyo isigqibo ngugqirha khona.

iziphumo ezingalindelekanga: Iimpawu kunye nesimilo

Drug "Dopamine" (imiyalelo ukusetyenziswa ngqo njengoko kubonisiwe) sisixhobo ngemiba yezemfundo ukuba sesichengeni kwabantu. Ngaphezu koko, umgca phantsi kweemeko phakathi isiphumo Kwimeko eyingenelo, xa ukumnika kuphakamisa uphuhliso ziziphumo ebezingalindelekanga, zingcakacile kangangokuba into yokuba ukusetyenziswa kwemali kuba owalathwe lilungelo leZiko eliQinisekisa iingcali ezinamava kunye abaneziqu kakhulu.

Umzekelo, kwempumelelo ukukhuthaza inkqubo ukujika yegazi malunga ziintlekele ingongoma okanye ezintsonkothileyo (elibukelweyo nokuxhuma elibukhali uxinzelelo lwegazi, iintlungu nokoyika ngamandla ezahlukeneyo kummandla esifubeni, njalo njalo. P.). Phakathi kwezinye ziyabagulisa - inkantsi inyumoniya, isicaphucaphu, iintloko ezibuhlungu kakhulu, chaza yimincili, ukutshintsha ixhala elimsulwa, bamba umphefumlo.

Ngamanye amaxesha kukho necrosis ulusu amancinci, ukuthetha kwam ngeempumlo kunye ukopha esiswini. Ekubeni ukuchongwa libanda kakhulu yeziphumo ebezingalindelekanga ayikho nzima. Nangona kunjalo, lo obugqithisileyo sithembele Izinga eliphezulu (mg) ngezixa ezincinane uyakwazi ukuguqulela kwiinkqubo efihliweyo ekunzima ukuxilonga, iyenza nzima Nokwethisa iimpembelelo ezingalunganga ezinokwenzeka input efakwa "dopamine."

oyi

Indlela ethile abasabela imisela imiqathango eyongezelelweyo ukwenzela ukusetyenziswa "Dopamine" iziyobisi. Imiyalelo Sebenzisa ithi:

• isisombululo ngaphambi ulawulo nomntu ogulayo ohlala nematha, kuyimfuneko ukwenza utshintsho lwe hypovolemia ngenxa ulwelo igazi ziphene;
• izigulane kwiiveki kutshanje ezifunyenweyo rhoqo monoamine oxidase inhibitors, elawulwa hayi ngaphezulu kwe-10% ye idosi eqhelekileyo;
• nokubandakanywa kufuneka ikhatshwe ulawulo olusisinyanzelo izinga umyinge ukuchama kunye aveliswa ngamaxesha athile intliziyo; Kufuneka enze iliso uxinzelelo lwegazi (uxinzelelo abazinzileyo imithambo yegazi, kunye ukuhla imveliso umchamo - umqondiso kuloo idosi "dopamine" kufuneka incitshiswe);
• izigulane abangaphantsi kweminyaka eli-18 zibekwe ngokuzenzekelayo emngciphekweni, kuba eli qela yobudala alubanga izifundo ezinkulu-iscale indlela abasabela ngayo amalungu kunye neenkqubo kwi amacandelo ichiza;
• ngokwazisa isisombululo ibe emzimbeni njengoko imfuno kungenzeka ukuba afeze kumnombo igazi enkulu (ukunciphisa ingozi extravasation); Ukuba igazi ngaphandle imithambo yegazi inwebu kusekho imfuneko yokuba athathe amanyathelo akhawulezileyo nokungena;
• xa ukusola yokuqala kuphuhliso ischemia peripheral, ukusetyenziswa ichiza wayeka.

Intsebenziswano kunye namanye amachiza

Ngokusekelwe iimpawu lwesakhiwo eekhemikhali ichiza "Dopamine" (inkcazo yokulungiselela ezinikwe apha ngentla), kunokwenzeka ukuba ukugqiba ukuba afanelekile amayeza. Ngokukodwa, isisombululo modem kulwelo obrak (amalungu ukusivala), kwakunye intsimbi kunye neetyuwa, hydrochloride (lusicande vitamin yomoya B1 yokugqibela). Isiphumo iqinile of ukumnika damped ukuba ngaxeshanye kwi "dopamine" ngokuhamba konwaywa umdlalo mecamylamine (okanye izithako yayo).

Ingqanyaniswe ukusetyenziswa levodopa kweziyobisi phantse iqinisekisa kukuvela fibrillation okuqhubekayo. Kwelinye icala, ezi izinto esebenzayo ezifana ergometrine kunye ergotamine ingakhokelela ekuboleni, kwaye "dopamine" libanda kakhulu - nokuba abangele legazi intracranial.

Uthi ukuhambisana oluhle glycosides, esetyenziswa zentliziyo, kunye womchamo.

Popular analogue "dopamine"

amagama orhwebo iziyobisi, indlela esebenzayo ongqamana isakhiwo iziyobisi "Dopamine" (analogs zithiwe thaca ukuze ndiwabonakalise ngesidanga nokufumaneka kwabo inxaxheba kurhwebo lwasemakhaya):

• "Dopamine," ukuvelisa lizwe - Russia.
• "Dopamine-Admeda", eJamani.
• "Dopamine-Solvay 200», eJamani.
• "Dopamine-50 Solvay", eJamani.
• "Dopamine hydrochloride", Poland.
• "Dopmin", Finland.

"Dopamine": iimbono nezimvo

Ngenxa yobume ichiza ukuze uqhelane kunye iimbono ezigulane malunga ukusebenza kwayo phantse akunakwenzeka (izigulane bangenele inkqubo iimela, ukuba nematha, ingaba kwigumbi labagula kakhulu okanye ngqo phezu kwetafile yokusebenza). impikiswano Professional ezifanayo zenzeka kumaphepha kwiiforam oluqhutywa ikakhulu Iintlungu inkonzo abasebenzi "Emergency Uncedo lwezonyango".

"Dopamine", ncomo apho inkoliso yabo iza kuba Akukwazi ukuba umntu ngaphandle imfundo efanelekileyo - kwiziko lezempilo yindlela non-conservative samanyathelo: indlela ilawulwa yi ukuqaliswa kwedosi yokuqala ukuze kufikelelwe isiphumo efunekayo, oko kukuthi, yonke ubude bexesha lekhefu. Ngaphezu koko, lo gqirha ngokulungelanisa imeko-volume kunye nokuphuma izinga isisombululo ngokusebenzisa kumda wesangqa kwemali ukutshintsha iipropati yayo elapha.

dopamine ihomoni Natural kunye abamelene

igama sesikweni iyalila dopamine flight hormone. It is a ikhemikhali oluntsonkothileyo ukuba kuhlelwe yi iiseli zobuchopho kwaye inikezela eqhelekileyo (njengesiqhelo ekuqondeni babantu) ukusebenza onke amaqela kwezihlunu hayi kuphela. Nti, khululeka, ulungele naluphi na uvavanyo - yindlela lo mfanekiso ngamnye psychophysical, apho kwakukho ukukhululwa umzimba hormone. Xa ukuswela kweziyobisi efika "iziyolo lobunzima": indlela wabona mathidala looding ukwamkeleka okwenzekayo jikelele, intshukumo amanqina, iinkqubo yengqondo behlisa.

Maxa wambi kukho imfuneko receptors ngumntu ethintela ukuba aphendule flight hormone. Indima isithintelo gqithi zisebenze abamelene dopamine. Amayeza eli qela ayibandakanyi amathuba okufumana "ukwaneliseka wemvelo," oko kukuthi, enyanisweni, bungacinywa umsebenzi ngokwasengqondweni yesigulana. Ukusekwa isabelo abamelene kwale hormone onesizathu schizophrenia, unyango ngamachiza, migraine ezondeleyo, ukuphazamiseka esiswini.