Ubungqina obubonakalayo buxela ukuba Sebenzisa "Metformin": imfundo kunye nengxelo

"Metformin" kubalulekile ukuba abantu abanengxaki seswekile sinwenwa. "Metformin Richter" ezibonisa zokusetyenziswa leyo efanelekileyo izigulane ezininzi seswekile, inceda ukwehlisa amazinga eswekile yegazi, ngaloo ndlela nokugcina inqanaba efanelekileyo carbohydrate ukutya, ukuze ngokwenjenjalo kuphuculwe umgangatho wobomi, njengoko kuboniswa iimpendulo ezininzi ezintle izigulane.

Pharmacodynamics kunye Pharmacokinetics

"Metformin" imenza inkqubo gluconeogenesis esibindini kwaye iba sisithintelo ukuya emathunjini emzimbeni glucose. Ngenxa yoko kukho nokwandiswa peripheral glucose cleavage kwaye yandisa kwesibindi inyama uvakalelo insulin. Ezi nkqubo ezingahambi arhente ngayo gipoglemicheskimi aluchaphazeli imveliso zendalo iiseli beta zepancreas insulin, ngokungafaniyo kwezinye analogue iziyobisi "Metformin".

Ubungqina obubonakalayo buxela ukuba ubunzima amayeza ilahleko wabonakala ngenxa ukukwazi layo ukuzinzisa okanye kakhulu ukunciphisa ubunzima emzimbeni wakhe.

Emva kokuthatha "Metformin" ukusuka iphecana zesisu aqalile ukungena into esebenzayo kunye amanyathelo enempumelelo buqala kweziyobisi emva kweeyure 2-2.5. Eyona special kukuba oko kuthetha unlinkability phantse ngokupheleleyo kwiiproteni plasma.

"Metformin" uyakwazi inokuqokelelana nezintso nomhlehlo wesibindi, amathe nobubovu, iithishu eqatha. Ukuboniswa phantse ngokupheleleyo izintso emva kweeyure 9-12 emva nolawulo. Ukuba isigulana umsebenzi miseka iindlela sezintso bangaqokelela emzimbeni ixesha elide.

Iimpawu kunye Izimo

Ubungqina obubonakalayo buxela ukuba Sebenzisa "Metformin" ngolu hlobo lulandelayo:

• Diabetes uhlobo sinwenwa 2, edlula ngaphandle bayafuna ketoacidosis, nto leyo ibaluleke kakhulu seswekile ukuba utyebile.
• Kudibaniso insulin kuhlobo 2 seswekile, ukutyeba ngokugqithiseleyo, ndincumeze, kulandele ukuxhathisa insulin eziziisekondari.

Nangona ukusebenza eliphezulu ichiza, kukho Izimo nokusetyenziswa "Metformin":

• Ketoacidosis isekwimo seswekile predkomatoznoe okanye ukuba khokhoma.
• Ukungasebenzi le izintso.
• izifo Acute, ekhokelela yimbonakalo kidney kwekhono - usuleleko, emzimbeni kunye sorhudo kakhulu okanye ukugabha, ifiva, izifo isixokelelwano sokuphefumla, hypoxia.
• izifo Acute kunye ezondeleyo, ekhokelela inkangeleko esiqwini hypoxia - ukusilela kwentliziyo okanye nokuphefumla, iqhosha elibukhali engabalulekanga.
• Unenzondelelo ungenelelo ngotyando, emva koko uthomalaliso-insulin ezicwangcisiweyo.
• Isibindi kwekhono.
• Ityhefu ethanol Acute, butywala esinganyangekiyo.
• Ukukhulelwa.
• Ibele.
• Isici.

balawule

Izikali "Metformin" ixhomekeke ngokusekelwe kumxholo iswekile yegazi kwaye yabelwa ngugqirha isigulane ngamnye. Ngokuqhelekileyo ukuqala Ibanga idosi ukusuka 0.5 ukuya ku-1 g / ngosuku. (1-2 tablets), kwaye ke ngoko, kususelwa kwinqanaba iswekile emva kweentsuku 10-15 ukwamkelwa kunokwenzeka ekwandiseni inani balawule.

Ithamo yesondlo "Metformin" yi 1.5-2.0 g / ngosuku. (3-4 tablets), kunye idosi ubuninzi - 3.0 g / ngosuku. okanye tablets 6. Kuba izigulane ebudaleni idosi oluphambili ephezulu - hayi ngaphezulu kwe 1.0 g / ngosuku. (Tablets 2).

Ubungqina obubonakalayo buxela ukuba Sebenzisa 'Metformin "kunye namaxwebhu angqina ngaye ezigulane zibonisa ukuba ichiza kufuneka kuthathwe ngexesha izidlo okanye ngoko nangoko emva kwayo, amanzi plain okusela. Le idosi yemihla ngemihla Kucetyiswa ukuba bazohlule babe 2-3 amathamo imini yonke.

Izenzo e libanda

Libanda, ingakhokelela lactic acidosis, leyo esongela ukufa.

lactic acidosis luphawulwa mpawu zilandelayo:

• Isiyezi kunye isicaphucaphu nokugabha.
• Norhudo.
• Ukuhla elibukhali lobushushu emzimbeni.
• nokuphefumla rapid.
• ubuhlungu elibukhali izihlunu, isisu.
• Ukulahleka sezingqondweni kunye nokuqalisa isiqaqa.

Xa kwi onobulali ubuncinane iimpawu lactic acidosis kufuneka ngoko nangoko ezithatha ichiza "Metformin" athathe amanyathelo ukuya esibhedlele.

Lo msebenzi kakhulu ngempumelelo zonyango xa ihaemodialysis na lactic acidosis, kunye nokuphathwa kakuhle iimpawu ngamnye.

Unxibelelwano namanye amachiza

Le zibonisa "Metformin" iziyobisi zokusetyenziswa leyo ngaphandle ukusetyenziswa esihamba kunye beziyobisi kunye nezinye iziyobisi ayikwazi ingasetyenziswa kunye dinazolom ngenxa hyperglycemia isiphumo yokugqibela. Ukuba kuyimfuneko, dinazolom unyango kufuneka kwenziwe uhlengahlengiso ithamo "Metformin", nekufuneka ubambe ugqirha.

"Metformin" Reception kufuneka uyeke ngokupheleleyo naluphi na uhlengahlengiso balawule kunye nezo iziyobisi zilandelayo:

• "Chlorpromazine".
• Neuroleptics.
• izivimbela, hormone, womchamo thiazide kunye loop.
• "Epinephrine".
• "Cimetidine".

Kwakhona, xa eboniswe ukusetyenziswa "Metformin" kuyimfuneko ukulishiya ngokupheleleyo ukuthathwa utywala, kungenjalo, ebalawula abantu iimpendulo yezigulane, isiphumo therapeutic yehliswe kakhulu.

"Metformin": ingxelo xa kusetyenziswa ukunciphisa umzimba

omnye kuphela isiphumo enyangayo ayiphelelanga ubungaka- ukusebenzisa iziyobisi "Metformin". Iimpawu zibonisa ukuba ukusetyenziswa, kunye nohlaziyo ubungqina ubuchule ezifana:

• Ukunciphisa iswekile egazini.
• Ukunciphisa insulin yendalo, nto leyo ekhokelela ukuba unciphiso ukutya.
• Uvimba ukuyilwa amafutha ekudleni esibindini.
• Ukunciphisa izinga nokwenziwa wekhabohayidreyiti engena umzimba ngokutya.

Ukuze usebenzise i 'Metformin' ukuze ukunciphisa umzimba kucingwa ukuba umsebenzi wayo ophambili kukudala imeko apho kukho inkcitho yesibambiso ngamanqatha kunokuba kwezihlunu kwezihlunu. Ngenxa we nesiphumo nibe ekulahlekeni ubunzima bomzimba, ngokutsho eninzi ingxelo malunga yokulungiselela zombini izigulane kunye noogqirha, kufuneka ukudala iimeko zivuma:

• Ukulahla umgubo emnandi, kwakunye ukutya lula (noodles, okuziinkozo, iitapile ezicujiweyo).
• Ukunciphisa ukungenisa calories.
• Ezisebenzayo kunye umthambo rhoqo.

Xa usebenzisa i "Metformin" ekunciphiseni idosi kufuneka ushiye 500 mg / imini, kwaye ukufakwa kufuneka zinikwe phambi kwesidlo sasemini kunye adle. Izimvo isiguli yokulungiselela ibonisa impumelelo obaneleyo xa esasiphosa ngayo umzimba, kodwa ukusetyenziswa "Metformin" kanye ezi iinjongo akuvumelekanga ngaphandle kokubonisana gqirha kunye isazi.

imiphumela emibi

Nangona kubonakala ngokubanzi ukusetyenziswa, "metformin" kungabangela kunye nembonakalo ezinye iimpawu ezingentle iphecana zesisu, okubangelwa iziphumo ebezingalindelekanga ichiza:

• Ukugabha kunye isicaphucaphu.
• imnyama okanye ukungabikho kwalo.
• Flatulence, urhudo, iintlungu esiswini.

Lidla ezi mpawu ekuqaleni unyango kunye, ngokoluvo lwezigulane shwaka odwa.

ziphumo bezingalindelekanga kakhulu ngakumbi kwezinye iindlela:

• B12 ezisilelayo vitamin, kunye lactic acidosis.
• igazi Megaloblastic.
• Hypoglycemia.
• Ulusu irhashalala njenge uxabane.

imiyalelo ezikhethekileyo ukusetyenziswa, kwaye namaxwebhu angqina ngaye nomonde

Njengazo naziphi na ezinye chiza Izimo yayo nokubonakaliswa ukusetyenziswa, "Metformin" kufuna ingqalelo ngenyameko idosi kunye nexesha zifunyenwe.

Ngokukodwa, ngexesha ulwamkelo kufuneka basoko belwakhele umkhanya umsebenzi kidney, apho ubuncinane kabini ngonyaka, kwakunye ngokubonakala myalgia kufuneka limisele isiqulatho zincancise kwi-plasma. Ukongezelela, qho emva kweenyanga ezintandathu kufuneka esweni creatinine serum, ingakumbi ubudala izigulane.

Xa benikwa "Metformin" kunye sulfonylureas kubalulekile ukuba esweni rhoqo kwinqanaba glucose egazini.

Xa izifo kwenkqubo genitourinary, okanye izifo bronchopulmonary kufuneka ngoko nangoko ingxelo ngayo kugqirha wakho.

Ichiza alichaphazeli ukukwazi ukuqhuba imoto kwaye akuyiphazamisi emsebenzini ndlela.

Indibaniso "Metformin" kunye namanye amachiza hypoglycemic kungakhokelela kuphuhliso iimeko hypoglycemic, iphawulwa memory disorder, ezithintela ukulawula imoto kunye wenza kwezinye izinto ezinokuba yingozi kwaye zifuna ingqwalasela kunye indlela okukhulu.

Xa ixesha unyango akuvumelekanga ngokungqongqo ukusetyenziswa kotywala kunye neziyobisi ethanol.

Ngokutsho reviews beziyobisi "Metformin" nangona ezininzi oyikisayo icala provleniya kwenzeka ukuba nangoku inqabile kakhulu, okanye isidanga engaphantsi. Nokuba abathandi bathi mnandi ngakumbi, lo gama uthatha amayeza unako ukuthenga iqhekeza ikeyiki okanye ilekese, nangona kungeyonto ayenza rhoqo.

Kwakhona amanqaku ngokutsha patsintov seswekile kunye okuba ukwanda yokuba ukhulelwe ngoxa kunokwamkela "Metformin 'ukuba kunceda nje ukuphelisa esi sifo, kodwa kwakhona ukufumana ulonwabo emtshatweni.