ACE inhibitors - amachiza eyiyo zentliziyo lwangoku

Inhibitor okanye ACE angiotensin ukuguqula into ebizwa vasodilators esinamandla ezisetyenziswa zentliziyo yonyango wegazi. Isenzo eli qela iziyobisi kuyoluka ethintela adrenal hormone angiotensin II - pressor factor ephambili echaphazela ixabiso uxinzelelo lwegazi. ACE inhibitors zithintela yokuwa bradykinin, enokungena imeko ezityeni, yaye ngenxa yoko nokuphakama uxinzelelo lwegazi. La machiza kunceda ukwandisa amanqanaba igazi prostaglandins vasodilator ukunciphisa iimpawu sisifo sentliziyo esinganyangekiyo, ngokufuthi waphawula kwizigulane kunye lwegazi kubalulekile. Kwangaxeshanye, ACE inhibitors, ngokungafaniyo nezinye iziyobisi kuthoba uxinzelelo lwegazi kuba nafuthe glucose lipid ukutya, ukunciphisa izintso ziiprotein womchamo.

ACE inhibitor zisetyenziselwa iminyaka engaphezu kwama-40. Ingqalo eli qela iziyobisi ngo-1975 ukuba kuhlelwe captopril, wasebenzisa namhlanje. Kwiminyaka embalwa kamva wafumana enalapril kunye lisinopril. Baye indawo ngaphezu inhibitors ACE mihla isizukulwana esitsha.

Xa zentliziyo mihla ACE inhibitors zisetyenziswa amachiza ezingundoqo yonyango unesifo isifo, isifo sentliziyo kobuchopho, ukusilela intliziyo esinganyangekiyo.

ACE inhibitor yokuhlela

Kukho ukuhlelwa ezininzi inhibitors ACE, ezo zisekelwe ukususwa umendo kwi kweziyobisi kusuka emzimbeni, ngokuxhomekeke iqela kwemichiza kulo molecule kunxityelelwana ACE embindini amanyathelo msebenzi. Ulwahlulo uqhelekileyo yezenzo imithi.

Ngokutsho inyathelo amayeza of angiotensin ukuguqula inhibitors zonke izinto bohlulwa babe ngamaqela amathathu.

Iqela lokuqala captopril okanye hood, apho abangaphangeliyo ngqo, ngamanye abangaphangeliyo lo angiotensin I ukuguqula umsebenzi hormone kwisigaba esilandelayo - angiotensin II. Ukuze alondoloze captopril okanye kapoten uxinzelelo lwegazi eqhelekileyo athatyathiweyo izihlandlo ezithathu ukuya kwezine ngosuku.

Ukuze iqela lesibini kiso enalapril, ramipril, trandalopril, tsilazipril, fosinopril, quinapril kunye nezinye iziyobisi zitshintshele emzimbeni ibe iikhompawundi esebenzayo ezinempembelelo vasodilatory. La machiza ngokwaneleyo ukuba kanye kuphela ngemini.

Ekugqibeleni, iqela lesithathu ibandakanya lisinopril Zestril, prinivil, prestarium okanye perindopril. ACE inhibitor iqela lesithathu Kucetyiswa ukuba lizithathe kanye okanye kabini emini.

iziphumo ebezingalindelekanga ze-ACE inhibitor

Xa ufumana eli qela amachiza kufuneka bazazi kuphuhliso neziphumo ezibi kunokwenzeka. Kwezinye iimeko, ukuthatha ACE inhibitors zingavela ukhohlokhohlo owomileyo, kumanqanaba potassium egazini, isiyezi, irhashalala isikhumba negazi, angioedema. Ezi iingxaki ziye lupheliswe ngokupheleleyo emva zokurhoxa iziyobisi. ukukhohlela Dry livela ngomhla wesithathu-sesihlanu unyango. Ukubonakala kwaso kungenxa sokuzuza amaphaphu bradykinin. Ukhohlokhohlo liyalahleka ngokupheleleyo emva ukupheliswa inhibitor. Ezinye izigulane kunganciphisa ukutya kunye nokuphazanyiswa incasa ziqhele.

Omnye Izimo ezinkulu ukusetyenziswa ACE inhibitors kuba amabini sezintso umfula constriction. Kulo mzekelo, uxinzelelo lwegazi yaligqiba ngokuvusa umgangatho renin egazini apho la machiza akukho isiphumo.

inkathalelo eyodwa kufuneka banikwe inhibitors ACE ezondeleyo izifo wesibindi nezintso kuphuhliso iimpawu insufficiency hepatic kunye sezintso.