UNorma CRP in chemistry igazi

C-izidubuli protein (CRP okanye CRP ukusuka IsiNgesi C-izidubuli protein) ibhekisa iiproteni plasma yegazi. CRP kwi kuhlalutyo zengqo- igazi yeyona vakalelo, ukuba aphendule ngokukhawuleza ukwanda kwinqanaba yoxinaniso kwesigaba nokoyika nayiphi na inkqubo yokukrala ibakho emzimbeni.

Le yokusabela idlala indima olukhuselayo. Ukulungiselela iinjongo diagnostic, uhlalutyo CRP ngaxeshanye kunye nomlinganiselo ESR isetyenziswa njenge sisalathisi komtshiso oko.

C-izidubuli protein - oko kukuthi

Igama le protini ngenxa yokuba isakhono imvula (ukusuka kwisiLatini praecipitatio elithi, ngokoqobo lithetha Esiwa phantsi, okt ndibopha, imvula). Sibopha ukuya C-polysaccharide of pneumococci kwaye ikhusela umzimba ukususela ekusulelekeni.

CRP eshukumisa ekuveliseni iiseli zegazi ezimhlophe, nayo ibe ngumqobo kwezifo kunye nezinye. Kwakhona eli iproteni kuphucula umsebenzi esebenzayo T-lymphocyte ezichaphazela phagocytosis, agglutination kunye imvula abasabela ibakho emzimbeni.

Indima CRP emzimbeni

Yintoni indima yalo iiprothini umzimba? CRP imfutshane ukususa umzimba okunamafutha acid kunye lysophospholipids bioactive ukuba ziveliswa ngenxa yomonakalo imifinya iseli na ukudumba okanye izityalo ezithile necrosis.

Phosphatidylcholine - yeyona nto engundoqo zonke ingaphandle cell. Ngokuqhelekileyo, ukuba ibekwe kwi inwebu umaleko engaphakathi kwaye zabonwa kumphezulu wazo. Xa ukudumba kwenzeka nawuphi na umonakalo iseli kwaye kungoko imifinya zabo. Phosphatidylcholine yi umaleko zangaphandle ingaphandle cell. Ngaba iyileyo ngayo phosphatidylserine kunye fosfadiletanolaminom. Ezi phospholipids ke hydrolyzed baza basenza abalamli yomeleleyo emzimbeni kweenkqubo nemvelo.

Ngaloo ndlela negalelo hemolysis (intshabalalo) iiseli ezibomvu igazi kunokuba yingozi kwi inwebu iseli ngokwabo. Le nkqubo kuphakamisa ukuyilwa izilwa-buhlungu kunye nezinye awakwazi ukuba ekspoziruyutsya kwiseli komhlaba uze ube CRP ndibopha site kunye iseli ndizayo eyonakeleyo. Phambili ukusebenza kwawo macrophage, apho kamva lubamba iintsalela iiseli ezonakeleyo.

Ngoko ke, lo CRP kuhlalutyo zengqo- igazi sisalathisi umonakalo yebhovin kwindawo na nangokurhala, ukwenzakala kunye necrosis.

Izizathu CRP yokwanda

CRP yenziweyo iiseli isibindi kwaye glycoprotein. Uhlalutyo CRP - ntoni na? Phantsi yempembelelo yabalamli eziphilayo asebenzayo (kubo ikhankanywe apha ngasentla), kwaye phantsi haydrolisis of phospholipids, lukwakhuthaza imveliso CRP. umxholo wayo uqalisa avuke iiyure ezimbalwa. Iyeza imini emva ekuqaleni kwenkqubo pathologic CRP protein yokukrala okanye enye kwi sifundo ngamachiza igazi kunokuba ngentla phindene eqhelekileyo. Ingakumbi ichazwe ngokucacileyo kwezifo.

CRP ukwanda kunye notshintsho necrotic zomzimba oko kwenzeka ngexesha isifo sentliziyo, ukufa kwamalungu kunye nangezilonda ukubola. Iziphumo zophando lwakutshanje lwezonyango lubonisa ukuba ukwanda kwale iiprothini serum ekuso ngenxa yegazi kwemithambo yegazi. Kuye kwafunyaniswa ukuba utshintsho atherosclerotic nemithambo kwenzeka ukudumba iyathamba kwemithambo yegazi. Izinto nezinegalelo kolkutshintsho lwezidumbu, zezi zilandelayo:

• ukutshaya,
• ukutyeba
• seswekile.

Isiphumo CRP ukuba isifo sentliziyo

Nokuba ukwanda encinane CRP kuhlalutyo zengqo- igazi kunokubonisa umtshiso etsha iindonga imithambo yegazi yaye ngaloo ndlela kube ngumqondiso utshintsho atherosclerotic.

Yinto eyaziwayo ukuba ukwanda kumanqanaba asezantsi mninzi lipoprotein (LDL) ichaphazela ukuyilwa umonakalo atherosclerotic kwi lumina nemithambo. Kodwa ke uphando lwakutsha nje luye lwabonisa ukuba izigulane ezinomthamo ophakamileyo CRP egazini kunye eqhelekileyo amanqanaba LDL umngcipheko iziganeko sentliziyo iphezulu kakhulu kunaleyo abo CRP izikhombisi eziqhelekileyo, kunye nesiqulatho LDL zanda.

Kwizigulane kunye nesifo semithambo ngentliziyo (isifo), kwakunye izigulane abaye baba stroke, wahlaselwa yintliziyo okanye badlule inkqubo Agqitha stenosis kwemithambo yenhliziyo, CRP uhlalutyo entle (ngasentla eziqhelekileyo) luphawu abane kakuhle. Oku kubonisa indlela kokubetha nezolo okanye isifo sentliziyo, njl

Eziphilayo: CRP ngaphezu kwesiqhelo. Le nto ibonisa ukuba

Uhlalutyo CRP - ntoni kwaye yintoni abonisa ukwanda zesi salathisi? Okokuqala kufanele kuqatshelwe ukuba izinga isalathisi kwi igazi 0 ukuya kwi-0.5 mg / l. Ukunyusa izinga layo egazini zingachaphazela zombini iinkqubo zophendlo lwezifo kunye nokomzimba. Cinga kuqala, phantsi kwazo naziphi na iimeko zophendlo lwezifo kunokwandisa ixabiso CRP.

iinkqubo yezifo ukuba ukwandisa izinga CRP

Ngoko ke, eli xabiso yaligqiba kwezi meko zilandelayo:

• Emva iinkqubo zosulele ezosulelayo, ingakumbi ukuba babe imvelaphi yebhaktiriya.
• Ngexesha exacerbation kweenkqubo komzimba okanye esosulelayo-ukudumba, kuquka utshintsho atherosclerotic sisezindongeni imithambo yegazi.
• Xa nawuphi na umonakalo ingqibelelo izicwili (yesifo sentliziyo, utyando, kwentlungu, frostbite, ukutsha, njalo-njalo).
• Xa ekonakaleni yamathumba kwimeko iinkqubo umhlaza kunye ukubonakala metastases ezintsha.
• Xa uxinzelelo oluphezulu lwegazi.
• Xa ezimbi yonyango (ukutyeba, isifo seswekile, ngaphaya okanye ukungabikho hormone ngesondo, njl njl).
• Kwiimeko zokugxojwa protein ukutya.
• Xa utshintsho atherosclerotic kwimikhumbi.
• Abantu abahlukumeza icuba.

ithi bokuphila ezichaphazela CRP

Ukongeza kwezi meko lwezifo kuhlalutyo zengqo- of CRP kungachaphazela ezinye iimeko nokomzimba. Ngenxa yoko, izinga wayo kuvuka kunye amandla ebalulekileyo emzimbeni, ezifana:

• Iimbaleki ngexesha isiganeko okanye ukuxhathisa yoqeqesho.
• Xa abasetyhini ngexesha lokukhulelwa, ingakumbi xa kukho toxicosis.
• Xa efumana izicwangcisi hormone okanye ezinye iihomoni.
• Ukusela utywala okanye ngamanqatha kutya imini phambi kokuba igazi ukwenzela uhlalutyo.
• Ukubakho grafts okanye efakwe apha emzimbeni.

Kwezinye iimeko, CRP ngezantsi eqhelekileyo

Ukongeza, xi CRP kuhlalutyo zengqo- wegazi lingehla kancinane kwaye ube ngezantsi eqhelekileyo izigulane abafumana amayeza athile, ingakumbi xa isigulane kuthatha ixesha elide. Ezi amayeza ziquka:

• iihomoni Glucocorticoid.
• Nonsteroidal amachiza anti-ukudumba.
• Beta-blocker.

CRP: yamihla

ukufunda CRP - oko luphawu ethe kakhulu. Uhlalutyo CRP inokuba kwenziwa kusetyenziswa iindlela ezahlukeneyo. ubungqina bakhe zisenokwahluka ngandlel ngokuxhomekeke uvakalelo of wezenzi ezahlukeneyo. Ngoko ke, laboratory ngamnye evelisa uhlalutyo CRP, izinga eboniswe kunikezelo umphumo.

Ngenxa yoko, iilebhu ngamnye abonisa izinga ka-0 ukuya kwi-0.5 mg / l. Ke namanye, esebenzisa iindlela ezahlukeneyo, sibonile iziphumo ekhutshwe isifundo ukuba CRP izinga - 0 ukuya 0.3 mg / l. Ngoko ke, xa ufunda isiphumo kusoloko kufuneka sinikele ingqalelo nemimiselo ekhankanyiweyo.

Ukongeza, lwamanani ukuveza iziphumo kolu hlahlelo baye baba kutshanje. Ngaphambili, kwakusetyenziswa indlela yakudala, leyo iziphumo luqikelelo. Ibinzana ubuninzi yale hlalutyo ezikhutshwe iminqamlezo. Ngoko ke, lo mmiselo kubangelwa "embi" (-). Ukuba iziphumo ezidibanisayo ibhaqwe, lona ngokohlobo impendulo enjalo - "HIV" (+). Kwizibiyeli inani iminqamlezo ebhaliweyo ukusuka kwelinye ukuya kwisine.

ixabiso sokuxilonga CRP

Kubalulekile kunye neminye imiqondiso kunye neendlela ucwaningo DRR. Ngoko ke, lo iproteni uyiphendula kwii lokuqala sifo kulo emzimbeni, okanye kuphuhliso nezinye izinto ezimbi. Emva kweeyure nje ezimbalwa emva kokuba iposi engabalulekanga inqanaba lophuhliso zesi salathisi egazini iqalisa ukukhula. Kwaye bonke ubusuku, yena nako ukwandisa phindene kalishumi.

Uphononongo zesi salathisi ngokuhamba kwexesha yenza ugqirha ukuba bagwebe ukusebenza unyango ekhethiweyo. Ngenxa yoko, ngokunciphisa ngobunzulu inkqubo okanye ezinye izifo samathambo ziza kuncitshiswa yaye inqanaba CRP egazini.

Le analysis iqhubeka ixesha elide ukuba ulwazi kakhulu, kwakunye nokuphuhliswa kweendlela ezintsha sokuxilonga uphando akakwazi asuse nto.

Indlela ukufumana uvavanyo neeprothini C-izidubuli

Ukuze Kwathi olu hlalutyo, kufuneka uqeqesho olukhethekileyo. Kodwa khumbula ukuba zonke iimvavanyo igazi ethathwe kusasa ungatyanga ukuthatha. Emini, ezinye zalathisi zisenokwahluka ngandlel ', umzekelo, iswekile okanye iiseli ezimhlophe zegazi. Uhlalutyo Igazi idla elinikiweyo zidityaniswe. Kusenokuba iimvavanyo samathambo, kanye njengoko ziquka ukufunda CRP, okanye ICBC, apho ESR liphandisisiwe. Bonke bephela, kunye noviwo kunye imbali yezonyango zibalulekile uxilongo oluchanekileyo.

Igazi kwi CRP iyathathwa umthambo kwigumbi unyango eklinikhi okanye naliphi na elinye iziko lonyango.

Phambi naliphi na igazi kule sifundo ukufumana iziphumo ethembeke ngakumbi imigaqo embalwa ezilula kufuneka iqalwe:

1. Isidlo ngosuku olwandulela akufuneki ukuba kakhulu emva kwexesha kwaye unobubele.
2. Nangoko, phambi kokuba unikezelo igazi ukuba asifuneki sitye kutya kwaye kuyacetyiswa ukuba ukutshaya. Ukuvunyelwa ukuba basele amanzi.
3. Ngobusuku obandulela kufuneka uphephe nayiphi iziselo ezinxilisayo, iti ngamandla kakhulu nekofu.
4. A iiyure ezimbalwa phambi kokuba unikezelo kuhlalutyo kucetyiswa ukuba shushu ngokugqithisileyo umzimba, okanye ngolunye uhlobo, overcooling. Ngamanye amazwi, akunakwenzeka ukuya isampuli yegazi ngoko nangoko emva bath yokugquma, ne beach okanye kwezikhumba, okanye ongahambisaniyo emngxunyeni.
5. Phambi kokuba iKhabhinethi imizuzu kukhethwa eliqela ukuze uhlale ukhululeke.

Ziziphi izifo kuyinto CRP ukwanda

Ukuba uvavanyo igazi kwenziwa CRP, izinga kukuba ukuya ku 0.5 mg / l. Ukuba inqanaba le salathisi ngasentla, ngokungqinelana kunye nezinye iimpawu isigulane kufuneka orhanelwa ezi zifo zilandelayo:

• Izifo Systemic rheumatism (isifo samathambo, systemic lupus zomzimba, njalo njalo).
• usuleleko Acute amagciwane.
• izifo ezinzwaneni.
• Ukuphazamiseka ye phecana zesisu (gastritis sisilonda, isilonda esiswini okanye duodenum 12, sisilonda sikabhobhosi, njalo njalo).
• Lokubola yamathumba ingozi okanye metastases kwiinkqubo umhlaza.
• ezigula ezininzi.
• iposi engabalulekanga (ngosuku lwesibini emva CRP kuhlaselwa liphuma ekho de kube sekupheleni kwiiveki 3, izinga kwimeko angina eqhelekileyo).
• Endocarditis.
• amyloidosis Secondary.
• Tuberculosis.
• Meningitis.
• Neutropenia.
• nokudumba ezisanda kuzalwa.
• Iingxaki ezivela kotyando, ezifana peritonitis yophela postoperative.
• Kwimeko abohlukeneyo, ukwanda CRP ingabonisa ukwaliwa.

Ngoko ke, safumanisa yonke loo uphando, njengoko uhlahlelo CRP - ntoni na kwaye kwandiswe phantsi kweziphi iimeko kuyo. Uphando ezithile malunga CRP ukhonza elimakishayo, kwaye ikuvumela ukuqikelela iingxaki nesifo sentliziyo kunokwenzeka. Oku kwenza kube lula ukuba bafumane ixesha ukuthintela ukugxagxiseka isigulane ukuthintela iingxaki.

Indlela yokuphatha i CRP esinyusiweyo

Kufuneka kuqondwe ukuba ukunyuka kwamazinga CRP - yinto nje ukuba uphawu, kungekhona isifo. Yeyiphi kwezi ezimbi kunokwenzeka ibonisa kule nomphumela, ugqirha isigqibo. Ukuze wenze oku, umele ukuba bahlolisise ngenyameko yonke idatha yesaveyi ezifunyenweyo, uze uhlole isigulane ngocoselelo ukuqokelela imbali. Emva koku iya ngenqindi phantsi axilonge kuphela. Unyango eyabelwe akukho iimpawu ezithile kwaye kwafunyaniswa ukuba izifo ngokubanzi.