Motilium: imiyalelo

I-Motilium ikhiqizwa kwiipilisi ezijoliswe ekuhlaleni okanye ngendlela yokumiswa. Into esebenzayo yeziyobisi yi-domperidone, ebhekisela kwi- antiemetics yento eseleyo , esithintela i-dopamine receptors kwingqondo.

I-Motilium (umyalelo kule nto ibonisa) inezixhobo ze-antiemetic ngenxa yokuba i-domperidone inqanda ukuveliswa kwe-dopamine, njengenye i-neuroleptics. Nangona kunjalo, isicatshulwa esisebenzayo asixhamli kakuhle kwi -barrier-brain brain, emva kokulawulwa kwayo, phantse akukho miphumo echaphazelekayo. Kufuneka kuqatshelwe ukuba i-Motilium ivuselela i-pituitary gland, ngokukodwa, ukukhululwa kweprolactin.

Xa uphathwa nge-domperidone, ixesha lokutshatyalaliswa kwe-danthral kunye ne-duodenal landa, ukukhutshwa kwesisu kuya kukhawuleza, kwaye uxinzelelo lwe-sphincter ephantsi kwenkqubo yesondlo ekhuphuka kubantu abaphilileyo. Isilwanyana asichaphazeli umveliso wejusi yesisu.

Iimpawu ze-Pharmacokinetic

Emva kokuthatha isisu esingenalutho, iyeza elithi "Motilium" (umyalelo uthini oku) ngokukhawuleza ukuxhamla kwi-intestinal tract. Ingxininiso ephezulu yeziyobisi kwi-plasma yegazi ichazwe emva kwemizuzu engama-60.

I-Domperidone icetyiswa ukuba ithathwe ngaphambi kokutya, njengoko uphando lubonisile ukuba le nyeza ithathwe emva kokutya idityanisiwe ukusuka ezindongeni zamathumbu.

I-Motilium, imiqondiso yokusetyenziswa

Isilwayo simiselwe:

- kunye nesifo sokugaya, esihambelana nesisu sokuphuphuma kwesisu, ukuqhaqhaqhafaza, intlungu, ukubetha, ukunyanzelisa, ukucabisa, ukuhlanza, ukutshaya;

- kunye nesicathulo kunye nokuhlanza kwe-etiology esebenzayo, eyosuleleka emva kwe-radiotherapy, unyango lweziyobisi okanye ukuphulwa kokutya;

- ngokusicasula kunye nokuhlanza okubangelwa yi-dopamine izidakamizwa ze-agonist kwiimeko zokulawula kwabo kwisifo sika-Parkinson (uL-dopa, umzekelo, kunye ne-bromocriptine).

I-Motilium, imiyalelo yesilinganiso

Ngenkathazo yokugaya kwimizimba engapheliyo, abadala kunye nabantwana abafikelele kwiminyaka emihlanu banqunywe i-10 mg yesilwanyana. Phuza ngaphambi kokutya malunga nemizuzu engama-30. Ukuba kuyimfuneko, ugqirha unokucebisa ukusetyenziswa kwesi sibongo ngaphambi kokulala. Umlinganiselo osemgangathweni wamanzi oneminyaka engaphantsi kwe-12 ubudala (ukususela kwiminyaka emi-5) inikwe umlinganiselo we-2.4 mg we-domperidone nge-1 kg yesisindo somzimba womntwana, kodwa akufanele kudlule i-80 mg.

Ukuqwalasela ukungabikho komsebenzi, ugqirha unokuphinda kabini umthamo omnye we-Motilium kubantu abadala, kunye nabantwana abafikelele kwiminyaka eyi-12. Kodwa nangayiphi na imeko, awukwazi ukudlulela umthamo wemihla ngemihla - 80 mg.

I-Motilium (umyalelo ubonisa ngokucacileyo oku), eveliswe ngendlela yamacwecwe e-resorption, ejoliswe kuphela kubadala kunye nabantwana abanomzimba osisigxina esingama-35 kg. Kwizonyango, ukuxinwa kwemithi ye-Motilium® kufuneka kusetyenziswe.

Kwizigulane ezinokungazinzi, kunokucetyiswa ukwandisa ithuba phakathi kwamanani amabini eziyobisi. Ngokubhekiselele kwinto yokuba i-1% kuphela ye-domperidone idityanisiwe ingatshintshi kwizintso, akusisimfuneko ukulungelelanisa inani lezonyango esisinye sezigulane ezintso. Xa kuqeshwe ngokuphindaphindiweyo ugqirha kufuneka acinge ngogonyamelo lokungaphumeleli kwenkunkuma, kwiimeko ezizodwa ukunciphisa umthamo kunokufuneka.

Ukungqinelana kwisiza "Motilium"

Iyeza alinakuthathwa ngaphakathi:

- nge-mechanical obstestinal obstruction or perforation, xa kuyingozi ukuvuselela umsebenzi wemoto yesisu;

- ngesisu esiswini;

- kunye ne-prolactin-secreting- tumor of the pituitary (prolactinoma);

- kunye ne-ketoconazole yokwamkelwa kwangokufanayo;

- kubantwana abaneminyaka engaphantsi kweminyaka emihlanu ubudala, ifomu lethebhulethi lichazwe, "i-Motilium" inconywa njengokumiswa;

- kunye neempembelelo ezithintekayo kwelinye lala macandelo.

Ekubeni ubuninzi bonyango luxhomekeke kwisibindi, kuqiqweni ukunika i-domperidone kwizigulane ezingasebenzi ngokwaneleyo.