I-Antibiotics "Maxipim": imiyalelo yokusetyenziswa, iifanekiso kunye nokuhlaziywa

Ukufunyanwa kwe wokuqala zintsholongwane (penicillin yonke eyaziwa namhlanje) phakathi kwinkulungwane yamashumi amabini yaba impumelelo amayeza. Ebudeni beMfazwe Yehlabathi II, eli yeza wasindisa ubomi amawaka abavikeli le looMawokhulu.

Ukususela ngoko, eziphilayo ishishini lamachiza ephuhlisa ngokukhawuleza kwaye inikeza abathengi ngakumbi nangakumbi antibiotics. Enye yezinto eziphambili kakhulu esisetyenziswa ngokubanzi kwiinkalo ezahlukahlukeneyo amayeza yi "Maxipime" nto leyo kwakhona ukulawula esi sixhobo njenge kakhulu, ziyasebenza ezahlukeneyo kwezifo.

Isakhiwo kunye Nokuhlanganiselwa

Eyona nto iphambili esebenzayo yale ichiza tsefepimadigidrohlorida monohydrate. Thomas Production - powder bulubhelu nombala ezimhlophe ukuba isisombululo yolawulo intramuscular okanye efakwa ezilandelayo. Xa iidosi eziliqela umenzi inika abathengi imveliso yazo "Maxipime." Olwa zingathengwa yedosi iibhotile 500 mg 1 g

Ukubunjwa ukulungele nolawulo ukuze kugcinwe kwiqondo lobushushu gumbi ngenye imini. Phantsi kweemeko ubomi ifriji kwithala yesisombululo uzilungiselele lanyuka ukuya kwiveki 1. Xa ifomu olungumgubo xa kulungiselelwa igutyana stoppered ingagcinwa iminyaka emi-3. Zinto zifuneka kuqala - lobushushu ukuze + 30 ° C kwaye zikhuselwe ekukhanyeni. Ukutshintsha umbala isisombululo asixhomekekanga kuchaphazela umsebenzi ichiza.

impembelelo kwemithi

"Imiyalelo Maxipime 'ukuba ukusetyenziswa iya ibekwe njenge-arhente antibacterial elilelethu 4 iqela isizukulwana cephalosporins. imiphumela simiso ukutshatyalaliswa kweendonga iseli ye iintsholongwane strains. Eli chiza spectrum ezibanzi nempembelelo ngokunxulumene kuluhlu ezincinane Igram-akhabayo kunye navumelanayo-Igram, luphawulwa ukulwisana kwabo aminoglycosides kunye antibaktrialnym kuthetha iqela cephalosporin lesithathu-ngezizukulwana.

Kuba "Maksipima" uphawu yokumelana beta-lactamases kunye asebenzayo ngokuchasene inani elikhulu Igram-akhabayo kunye navumelanayo-Igram aerobic (zichazwe kuluhlu - kwi imiyalelo ukusetyenziswa). Kodwa iyeza ayisebenzi nxamnye metitsillinoustoychivym staphylococci, pneumococci penitsillinoustoychivye.

Emva ukuqaliswa "Maxipime" isibulala-zintsholongwane (umyalelo manual luquka ulwazi) bathi bafakwe ngokupheleleyo. Therapeutically lamanani ezifanelekileyo candelo engundoqo eqhubayo ibonakele umchamo, inyongo, netuwa inyumoniya, le ndlala wesinye fluid peritoneal.

Kwisiqingatha ubomi malunga neeyure ezimbini. Kuba kuthelekiswa, sinokuthi, umzekelo, izigulane abadala iintsuku 9 ngu efakwa wafumana 2 g beziyobisi kunye ixesha lokuphumla phakathi unyango iiyure eziyi-8 cefepime sokuzuza umzimba ayifumaneki. Inani elikhulu kwazona kwi umchamo (elibukelweyo ukuya kwi 85% ye iidosi isigulane ekuqaleni wafumana cefepime ngokuba ingaguqukanga).

Ubungqina obubonakalayo buxela

imiyalelo Antibacterial "Maxipime" ukusetyenziswa bayakhuthazwa ukuba bonyule xa iintlobo ezahlukeneyo ngezifo endalo esosulelayo kunye arhabaxa. iziphumo ezintle afunyenwe kwi unyango lwezifo ukungaphefumli iphecana (inyumoniya nokukrala kuquka) kunye imibhobho wokuchama (zombini hayi inzima, kunye nezigulo kuquka pyelonephritis). dynamics HIV iqatshelwe unyango ezahlukeneyo izilonda ezasulelayo intra-esiswini (hayi ngaphandle biliary usulelo phecana kunye peritonitis).

Kwakhona, "Maxipime" lisetyenziswa ziingcali zempilo ukunyanga losulelo yamanina, usulelo yesikhumba nangokujaduka kwizihlunu ezithambileyo, septicemia (nokudumba). Xa unyango kwezigulane neutropenia febrile, "Maxipime" manual kucetyiswa unyango enokwehla.

Enye indawo eziphembelela ichiza - meningitis yintsholongwane ebantwaneni. Apha, le zintsholongwane kwakhona kakuhle aqinisekisiweyo.

Njengenyathelo lokuthintela ichiza isetyenziselwa ukuthintela usulelo ngexa zotyando esiswini.

Ngokubanzi sinokuthi "Maxipime" ukusetyenziswa ovumelekileyo phantsi zonke izifo ezosulelayo, naphuhliso olo olwaye ukumqumbisa kuyokwenzeka ukuba iintsholongwane nobunzima. Ukuze ukuchonga kumzimba causative kwaye babone (okanye abo) uvakalelo kule zintsholongwane ebekumele ukuba benze iimvavanyo. Noko ke, "Maxipime" kuchaphazela uluhlu olubanzi Ngeentlobo iintsholongwane kwaye oko njengoko monotherapy unako kuhluthwa noko phambi kokuba kokuchaza gciwane. Xa kukho ingozi yokuba ingxubevange usulelo (aerobic-anaerobic), ngoko ukuba iimvavanyo kwi Recognition of iintsholongwane yayintsholongwane eyosulela uqale unyango "Maksipimom" ngokubambisana kunye ichiza echaphazela anaerobes.

Umthamo kunye nomthamo iirejimeni

Oyidlayo kunye nolawulo form (w / w okanye w / o) uzimisele ngokuxhomekeke nobuntununtunu iintsholongwane, ubungqongqo karhulumente sifo yesigulana kunye nezintso. Kwaye I / O umendo idla ngaluphi kwiimeko apho usuleleko kunzima engozini ubomi yesigulane.

Abantu kunye nezintso esempilweni nezinobunzima ngaphezulu kwama-40 kg iinaliti ezenziwe emva kwesithuba iiyure 12 idosi emiselwe ngugqirha wakho. Ukuphazamiseka ze womchamo ngobulali ukuba aqine ngcathu, ezinye izifo ezenzeka kwi ngobunzulu enye, bathi banyangwe iidosi ka 0.5-1 g, elawulwa yegazi okanye intramuscularly (njenge ugqirha ugqiba). Ukuba kuliwe izifo ezinzulu benze yegazi yayisalawulwa 2 g iziyobisi (periodicity iyafana - Iiyure ezi-12). Kuba nzima kakhulu kwaye ephethe kusisisongelo kubomi yosulelo yomguli kunye idosi efunekayo 2 g, kodwa periodicity - zonke iiyure ezisi-8.

Zintsholongwane "Maxipime" lisetyenziswa influenza kuphela kwiimeko apho ahlobene kwegciwane kumsinga igciwane lohlobo.

Iikhosi lwemisebenzi zoqhaqho (iyure-1 phambi kokuba) prophylactically butofelwe ngaphezu 2 iyure okhokelayo g 'Maksipima "ngoko bophalazwa ezongezelelweyo mg 500 metronidazole. Kwangaxeshanye ilawulwa izinto ezimbini akufanele.

I-avareji Isixa ichiza izigulana ubunzima umzimba sele ayifikelelekanga 40 kg, xa unyango lwezifo womchamo (zinzima kwaye lula), kwizihlunu ezithambileyo kunye nesikhumba (hayi zivalwe), nangokurhala yemiphunga kunye nonyango somgaqo-fever neutropenic yi-50 mg ubunzima bomzimba ikilogram. Iinaliti ezenziwe emva kwesithuba iiyure ezili-12. Xa meningitis bacteria kunye nomkhuhlane neutropenic efanayo-50 mg / kg ezilawulwa bacebisa izithuba phakathi zonyango, lingana iiyure ezisi-8.

Kuba izigulana ezingaqhelekanga kwimisebenzi kidney, kufuneka ukunyenyisa idosi yesondlo. Zintsholongwane "Maxipime" inkcazelo ichiza (idosi ngokuxhomekeke kuhlobo pathogen kunye ubungqongqo usulelo iya ubuthwe yi igqirha khona) uncoma ukuba umthamo lokuqala ichiza ukuba iyafana nje abantu ezintsweni esempilweni, ngoxa idosi hlengiswa kuxhomekeka imilinganiselo yokususwa creatine.

Abo izigulane zithathe 'Maxipime "kunye nehemodialysis usisisulu, ekhuthazwayo ekupheleni kwenkqubo ukuba baphinde bangene idosi elitsha zintsholongwane elingana yokuqala. Oku kuyimfuneko, okt. K. Kuba 3 iyure dialysis uzakususwa umzimba ukuya 68% yemali iyonke "Maxipime" iziyobisi (umsebenzisi iqulathe olu lwazi).

Izimo "Meksipima"

Nangona uluhlu olubanzi kakhulu yeziphumo antibacterial kweli chiza, oko akanalo uluhlu olude Izimo. "Maxipime" yemiyalezo othintela abantu hypersensitivity ngamnye ukuya cefepime kunye L-arginine. Kwakhona, oku akwamkelekanga enikwa izigulane kunye abasabela ngayo hypersensitivity ngoko nangoko penicillins, ezinye iiarhente beta-lactam, antibiotics ezifana cephalosporin.

Ngenyameko ukuba isimo sakhe sempilo ngexesha unyango "Maksipimom" kufuneka baphathe abasetyhini abakhulelweyo kunye oomama lokonga, abantu abaphethwe zizifo ze phecana wokudla, ingakumbi izifo ezifana wenze umsebenzi okanye wenze zintsholongwane-ezinxulumene, enteritis lwengingqi.

Njengoko kuba impembelelo umsebenzi nezenzala, kufuneka kunokuthiwa na kwiimvavanyo zeklinikhi kwizilwanyana akukho iziphumo ezibi unina sele zichongiwe umbungu ziye. Noko ke, uphando kakuhle ezilawulwa ifuthe emzimbeni umfazi wakhawuleza kuthwalelwa phandle. Ngoko ke, abasetyhini abakhulelweyo zamkelekile "Maxipime" kuphela phantsi kweliso zonyango. Xa lwebele yabantu ichiza ubisi ngesi ibe ncinci kakhulu, kodwa akuyomfuneko ingozi. Ebudeni bexesha lokwaphusa kufuneka uthathe amayeza ngononophelo.

Ukongeza, zintsholongwane "Maxipime" manual icebisa ukuba usebenzisa ngononophelo olukhulu abo babandezeleka kakhulu ukusilela ezinganyangekiyo kwezintso. Uphononongo lubonise ukuba izigulane ukusilela ezingapheliyo kwezintso landa isiqingatha ubomi iziyobisi emzimbeni. Ngelo xesha, abantu abanesifo sesibindi, okanye abanesigulo esinganyangekiyo akuxhomekekanga ziviwa ngabemi naluphi na utshintsho pharmacokinetic ngenxa nokufunxwa kunye kukhuthaza cefepime.

ziziphumo ebezingalindelekanga, kwakuwo ye idosi obuvumelekileyo

Ngokubanzi sinokuthi "Maxipime 'Wanyamezela kakuhle, kwaye izehlo iziganeko ezibi ayikho phezulu. Kuzo zonke iimeko ingxelo it ikakhulu lalimalunga ukusebenza esiswini iphecana (ukuqunjelwa, urhudo, ukuqhina, isicaphucaphu, ukugabha), kunye nezenzo hypersensitivity (irhashalala, ukurhawuzelela, fever).

Ukongeza, ulwazi luyafumaneka kwi eli chiza njenge "Maxipime" isibulala-zintsholongwane - inkcazo yokulungiselela, imiyalelo ukusetyenziswa kwayo, - ubungqina indlela abasabela ngayo inxalenye yegazi ngokohlobo tachycardia (iyangongoza ngentliziyo) kunye neentlungu esifubeni. isixokelelwano sokuphefumla banokuthi ngokwayo umqala obuhlungu, iphika khohlo. Impendulo kungenzeka evela CNS uya kuba sokulibala, yintloko kunokwenzeka, isiyezi, ixhala, ukudideka, paresthesia. Phakathi kwezinye izinto singakwazi ukuthetha ukudinwa, හසුරුව isiphathi, ukubila, iintlungu, iqolo, nokudumba neuropathy. Kwakhona, njengoko iziphumo ebezingalindelekanga yeengcali zonyango sithethe nabo utshintsho kunokwenzeka parameters elebhu.

Ke impermissibly ukufumana ngeedosi lwe olwa "Maxipime" yemiyalezo yazisa malunga nokusebenza ihaemodialysis kwiimeko ezinjalo.

Oko kufuneka sinikele ingqalelo kuyo?

Weight iimeko ezahlukeneyo ngokungaqhelekanga basenokuba ngexesha xa emiselweyo antibiotics "Maxipime." Indlela yokwenza isicelo ngayo kule meko? Ukuba imvelaphi "Maksipima" kuphuhliswa nokudumba pseudomembranous kunye sorhudo elide, uyeke ukuthatha konke konke neziqhutywa vancomycin okanye metronidazole.

Ukuba isigulane unesifo kakhulu odityanisiweyo wesibindi nezintso ukungaphumeleli, abasebenzi bezempilo kufuneka baziphathe esweni okokoko xi kweziyobisi plasma igazi, kuxhomekeka parameters, ukunyenyisa idosi.

Ukuba zintsholongwane sele ifumaneka ixesha elide, kubalulekile ukuba esweni rhoqo ubume igazi peripheral kunye nezalathisi zokusebenza wezintso kwaye zesibindi.

Kwiimeko apho kukho ogulayo kugxininiswa ekude esosulelayo waphawula nokusasazwa meningeal (ukunwenwa kwamagciwane, zombini phakathi eziko, kwaye wonke umzimba), kukho urhano sokudumba kwenwebu yengqondo okanye isifo sele ifakiwe, kuyimfuneko ukuba ukwala unyango "Maksipimom" nabele kakoe- okanye arhente antibacterial kunye nokusebenza sokukhokhela ngenxa uxilongo.

Kukho kungenzeka ukuba iziphumo ezintle yokuhlolwa Coombs, lobuxoki-HIV - phambi glucose Umchamo.

"Maxipime" umkhuhlane kwaye akayi kuba kubanda (ngamanye lokosuleleka wentsholongwane egazini) ngempumelelo.

Intsebenziswano kunye nezinye izinto

Ukuba isigulane eyabelwe kufumana "Maxipime" isicelo engumzekelo namanye amachiza kufuneka abe phantsi kweliso elibukhali likagqirha. Le zintsholongwane ayihambelani pharmaceutically kunye namanye amayeza elwa kunye lweeHedfowuni.

Tubular Secretion bude cefepime kunciphise kakhulu xa idibene kunye womchamo, aminoglycosides kunye polymyxin B. Kunjalo Ukwanda ibhayisekili PM xi "Maksiprima" kwi serum igazi liya kwandisa de kuphuhliso nephrotoxicity nefronekroza. Ukongeza, ukuba andise nakwisiqingatha ubomi.

Ukudibanisa "Maksiprima" kunye NSAIDs (non-steroidal amachiza-ukudumba) ukubambezela i kukhuthaza cephalosporins lomzimba kwaye ingadala ukopha.

Ukusetyenziswa zidityaniswe kunye nezinye antibiotics bactericidal (aminoglycosides) kuya kubangela ngokubonakala lwamandla, kunye bacteriostatic - awunandaba.

amayeza analogue

Imithi analogs zikhethwa ngokusekelwe ngamazwe igama nonproprietary (inn), apha eyona nto ephambili esebenzayo (kuba "Maksipima" enjalo cefepime). Oothixo kakhulu ethandwa arhente antibacterial "Maxipime" izimvo kwiingcaphephe ekubhekiselelwe iziyobisi ezifana "Cefepime-Alpes", "Cefepime", "Movizar", "maxicef" "Cefepime abawaziyo."

Olu ayilo luhlu olupheleleyo, yaye igama "Cefepime", apha, ukongeza koku kungentla, kusekho "Cefepime-igutyana", "Cefepime-Agio" "Cefepime-Dzhodas" "Cefepime-Alkema," "Cefepime Hydrochloride ".

Kwakhona xa iintlobo ezahlukeneyo zamangenelela iintsholongwane ababoneleli amisele iziyobisi ukufumana "Ladef", "Efipim", "Kefsepim", "Tsefomaks", "chainsWe".

Ngokuphathelele amayeza ngoontanga, ukuze akasoloko kube yimpumelelo njengokuba ichiza mvume.

Ngokoluvo kwizigulane kunye nabasebenzi bezempilo

Ekubeni chiza uluhlu olubanzi izicelo ezininzi izifo ngeentsholongwane, ngoko ngokoluvo "Maksipime" kukho indlela ezintle, kunye navumelanayo. Abantu abaninzi sidle amayeza okubulala iintsholongwane, lanelisekile kunye neziphumo. zempilo eziphuculweyo, nkqu iintlobo okunzima kwezifo kwenzeka iintsuku 2-3 ukususela ekuqaleni unyango. Ngokutsho abasebenzi bezempilo, nalo eli chiza kwazicacaisa ngokwakhe ezahlukeneyo iimeko zonyango. Kunye nendleko isiyobisi akunjalo phezulu kakhulu (kukho amayeza atshiphu, kodwa ngaxeshanye, kukho kakhulu ibiza ngaphezu "Maxipime").

Nangona kunjalo, akukho uluvo babenethemba kangaka ngalo ichiza. Isikakhulu ezingakhiyo kuloo izigulane Ndilibonakalisile ngokwabo ngethuba yeziphumo ebezingalindelekanga zonyango. Ukongeza, uluvo ezingakhiyo wabonakaliswa iqela elahlukileyo labantu abenza antibiotics "Maxipime 'ukuba ifiva. Nangona kule meko isiphumo, sanga kulindeleke. Nayiphi abandayo bemvelo wentsholongwane egazini, yaye "Maxipime" - a germicide, umgaqo yayo isekelwe nefuthe ekutshatyalalisweni iseli inwebu le ntsholongwane.

Thenga yeza kuphela ukuba amayeza evela kugqirha. Kwaye kufanele: ugqirha kunye nolwazi olulodwa kunye namava, ngoko khetha elwa uze ubale ithamo ubuncinane olusebenzayo, ukuba zonke iingozi yeziphumo ebezingalindelekanga kuncitshiswe kunye neziphumo ezihle emzimbeni iya nkulu.