"Klofranil": umyalelo manual, ncomo, iifoto, analogue, imiphumela emibi

inkqubo yonyango ukudakumba akaphelelanga ngaphandle kokusebenzisa lakhula, eziquka iyeza "Klofranil". Manual uncoma ukusebenzisa yayo ngenxa yokususwa ukucalulwa ezahlukeneyo, syndromes iintlungu.

inkcazelo amayeza

Icandelo isiyobisi esebenzayo i hydrochloride clomipramine. Iveliswe yinkampani Indian "Ilanga Pharmaceutical Industries" ngokohlobo amacwecwe ngeenxa eluhlaza kunye ukutyabeka esingxotyeni.

izixa umthamo clomipramine hydrochloride 0,025 g.

indlela Action

Medicine "Klofranil" imiyalelo ukusetyenziswa ibhekisela lakhula tricyclic kunye nesakhiwo. Nge inxaxheba timoanalepticheskaya wakhe Zenziwe umsebenzi psychoactive, anxiolytic, alpha adrenotormozyaschim nesiphumo ocothayo nozolileyo. Ipropati yokugqibela kunokwenzeka ngenxa enozalwano receptors H ₁ histamine.

iintlungu ezahlukeneyo, kunye gistaminoblokiruyuschim antiserotoninovym impembelelo. Ephelisa ukuvuza yezizwe umchamo ebusuku ayisayicinezeli umnqweno ukuba adle.

ukusebenza Imiboniso anticholinergic lomlinganiswa neuropathy central kwabangela tinyiketela ukuba holinzavisimym iimanyano receptor.

Drug "Klofranil" libhekisela iziyobisi antiarrhythmic ezifana quinidine, uvimba channels sodium. ngeedosi konwaywa clomipramine ukuba zinqanda Uhanjiso le ventricles intliziyo.

umsebenzi bucala kungenxa yokwanda kwamanqanaba noradrenaline kwi luvo yeengongoma zoqhagamshelwano kunye umxholo serotonin luvo. Ezi neurotransmitters ke accumulated ngenxa yokuba inwebu iineuron presynaptic buthathaka bamthwala reuptake.

ukusebenzisa ixesha elide kubanga ukwehliswa umsebenzi esebenza kuzo ilitye le serotonin receptor lohlobo beta-adrenozavisimyh ise ingqondo, oko kunceda ukubuyisela adrenergic kunye serotonergic kokufuduswa, ubambe intsalela kweenkqubo kwakhona, nto leyo iimpawu depressive kwamcaphukisa. Tablets "Klofranil" uncedo ukumelana uhlobo abazizidalwa lengqondo, imo udandathekile, imvakalelo ukuxhala.

umsebenzi iintlungu walibonakalisa utshintsho xa kumanqanaba monoamine enkqubo luvo.

ukusebenza Anxiolytic kwenzeka kunye nokuphungulwa excitation of nuclei apha esikhondweni ebuchotsheni, nto leyo kulawulwa umsebenzi receptor beta- kunye alpha 2 adrenergic-uhlobo kunye noradrenaline wesekethe.

Umsebenzi bucala kuye kwaphawulwa iintsuku ezisi-7 emva kokuqala unyango.
Xa clomipramine kuthelekiswa imipramine isiphumo ngokuphembelela lifinyele, yaye xa kuthelekiswa ne amitriptyline, umsebenzi umthomalalisi kucacile kangako.

Kutheni kufuneka uthathe

Medicament "Klofranil" imiyalelo zokusetyenziswa ziyacetyiswa kuphuhliso kakuhle ukuba ndidandathekile ezahlukeneyo luphawulwa iimpawu ezithile.

Iyeza omiselwe syndrome ubhalo edakumbisayo ohambisa iimpawu seSkitsofreniya, iintlungu ixesha elide, ukugula ngokwasemzimbeni ukungavisisani. Athatha iinkqubo uhlobo presenile kwaye saka kunye obubonakala zabo ebuntwaneni.

Iziyobisi "Klofranil" imiyalelo ukusetyenziswa, nto leyo inikezelwe ngezantsi ifoto ibonisa ukusetyenziswa izifo ukuba likhoboka lento ethile enxulumene ukucalulwa, ukuphakuzela uloyiko kwi ubuhlungu ngamaxesha athile Oncology, migraine, isifo samathambo.

Inceda izilonda post-herpetic le luvo kwimida, kwaye post-traumatic peripheral neuropathy, sobuthongo, catalepsy. Ichiza ithathwa kuthintelo iintlungu entloko migraine.

Indlela yokusebenzisa

Xa uhlobo arhente tablets "Klofranil" umyalelo ncwadi ikhuthaza ukusetyenziswa xa odlayo ukutya okanye emva kwesidlo ukunciphisa eku- ukuya kwiinwebu kodonga isisu.

Kuba unyango usebenzisa umthamo encinane, le migaqo isebenza abantu abadala esakhula.

Depression, ukuba likhoboka lento ethile kunye ukucalulwa ngayo idosi ezahlukeneyo 0,025 g amathamo-3 ngosuku. Kwiveki yokuqala, idosi yemihla ngemihla inyuswe, ngosuku lincitshiswe 0,100 ukuya 0,150 g Ukuba kuyimfuneko, sebenzisa ngeedosi phezulu ngakumbi. Xa imeko yophuculo kubonakala unyango inkxaso, oko kukuthi ukusuka 0,050 ukuya 0,100 g beziyobisi.

Isifo kunye Uhlaselo catalepsy ukuphelisa iipilisi kunye idosi yemihla ngemihla ukususela 0,025 ukuya 0,075 g clomipramine. ndinentlungu engapheliyo iphathwa idosi yemihla ngemihla ukususela 0,100 ukuya 0,150 g leyo kudityaniswe analgesics kwamanani, inani lokugqibela ukuba kancane kancane.

Ukuze ukuphelisa uphaphazele kuqala ukusetyenziswa yonke imihla 0,010 iigrem ichiza, leyo zinokudityaniswa kunye benzodiazepines. Ukuba iyeza ukunyamezeleka kakuhle, esi sixa landa inkangeleko utshintsho ezintle. Koko bachithe kokuphathwa ngokuthe ngcembe-arhente benzodiazepine. Unyango with "Klofranil" manual ucebisa ukuba ukurhoxisa emva konyaka onesiqingatha kuphela kungekhona ngaphambili. Ngeli thuba ixesha obuyimfuneko bokwenza unciphiso kancinane inkxaso nomthamo.

Xa therapy yobudala emiselweyo idosi yemihla ngemihla ka-0,010 ukuya ngoko iintsuku ezili-10 ukwandisa isixa medicament ukuya kwinqanaba kangangoko, leyo isusela ukususela 0,030 ukuya 0,050 g Le ithamo kusetyenziswa lonke unyango.

sequela angafuneki

Njengazo zonke lakhula kunokubangela amayeza "Klofranil" iziphumo ebezingalindelekanga. ukusebenza Anticholinergic ubonisa ungapheleli umsebenzi olubonakalayo paresis accommodative, mydriasis, ukukhulisa uxinzelelo ngaphakathi iliso, ukwandisa izinga intliziyo, kwisisu ngomlomo owomileyo, isizathu kucaca, ingqondo, ukuqhina, ofe amathumbu nonconduction ubhalo Kyea yazingcolisa umchamo, umbilo gumbi encinane.

Utshintsho luvo luphawulwa ukozela, inkqubo asthenic ebangela nokudideka, ixhala, ukuphazamiseka, iveze, manic okanye utshintsho hypomanic. Kwakhona, iziphumo ebezingalindelekanga luphawulwa ndlongo, memory iyaphelelwa, depersonalization, ingqalelo amahlwempu, sokulibala, amabi, asthenia.

iimpahla intliziyo ngayo Ezingalunganga negazi sibonakalalisiwe ngokuvusa okanye sinus isingqisho kwentliziyo utshintsho, ukuyisonga intolerance ukusilela Uhanjiso uhlobo Ukwahluka xi ventricular.

Lithetha "Klofranil" umyalelo zokusetyenziswa sichaza utshintsho kwinkqubo yokwetyisa, nto leyo ichazwa zikwimeko bankwantyisayo hepatitis senyongo, heartburn, iintlungu kwindawo esiswini, ukwanda okanye ukuncipha nokuba ndinqwenile ukuyidla nani, stomatitis, iingxaki zamazinyo, utshintsho nokukhethwa incasa, lo blackening kolwimi.

ukuphazamiseka kwamadlala luphawulwa ukukhula nokudumba wamatyhalarha unamadlala thoracic kumadoda kunye namabhinqa ukwanda, idosi ngokugqithisileyo prolactin, galactorrhea, umnqweno aphezulu okanye asezantsi ngokwesondo, ukwanda kokungazinzi amandla, hyper- okanye hypoglycemia, hyponatremia, ukukhululwa ezingafanelekanga of hormone antidiuretic.

Ukutshintsha umsebenzi oyinxalenye amalungu enxulumene ukuncitshiswa leukocyte kunye neeseli igazi zegazi, purpura, ukwanda kwamanani eosinophils.

uxabane angenzeka ngohlobo irhashalala kunye ukurhawuzelela, ukoyika eyingozi, nokudumba angioneurotic.

iziphumo ebezingalindelekanga ezinxulunyaniswa kunye nokuncipha iinwele phezu kwentloko, petechiae, isimo eshushu okanye ebandayo, ekulibazisekeni okanye rhoqo ukuchama, kunye ukuncitshiswa egazini abasuka iiproteni kunye syndrome febrile lobushushu eliphezulu.

Ngenxa yokurhoxiswa ngesiquphe ichiza kungabangela isicaphucaphu, ukugabha, esiswini, iintlungu, intloko ebuhlungu, umkhuhlane, efuna, amaphupha. A ukunciphisa amayeza ithamo ungenza umntu udikwa zibangele imo motor Mzoli.

abantwana

syndrome ukuba likhoboka lento ethile unobumba ziphathwe nomthamo lokuqala 0,0125 14 iintsuku bachitha ukunyuka kancinane ingqondo, ucinga ukuthwala le medicament. Ithamo kwiiveki ngemihla 2 0.100 g ezilinganayo okanye ebalwa ubunzima umntwana, apho wonke 1 kg ubunzima akhawunti ngenxa 0,003 g into esebenzayo. Emva ilandelwa yi ukunyuka kancinane xi kweziyobisi ku 0,200 g okanye wenze recalculation ngokobunzima iintsuku ezili-14.

Ukwalathelwa lithetha "Klofranil" abantwana bafanele ingxelo uhlobo esihle nokunyangwa enuresis zasebusuku. unyango lokuqala iphethwe idosi yemihla ngemihla isixa 0,020-0,030 g ngenxa kweminyaka emi-5 ukuya kwesi-8, kuba abakwishumi elivisayo ukusuka kwiminyaka-9 ukuya ku-12 kusetyenziswa 0,025-0,050 g; emva kweminyaka 12: 0.025-0.075 g

oyidlayo Ukwandisa athwale izigulane ekungekho wanceda unyango emva kweentsuku 7 unyango. Ithamo yonke imihla amayeza emiselweyo ukusela isicelo esisodwa ngokuhlwa emva kokutya. Xa Ukuchama ngokuzenzekelayo ebusuku xa ulele, isiqingatha idosi emiselweyo lisele kwiiyure 17. Xa sele iphumelele ziphumo zinqwenelekayo ichiza musa ukunika omnye iintsuku 90, apho kwenziwe unciphiso kancinane kumazinga amayeza.

Medicine "Klofranil" nabalingani

Kukho iziyobisi ezininzi ngokusekelwe hydrochloride clomipramine, zithathwa interchangeable.

Enye ezinjalo isixhobo sesona siyobisi Italian "Anafranil", apho iveliswa "Novartis Pharma". Kwakhona iquka lakhula tricyclic series. Ngokutsho iziyobisi psychotropic ngayo iinkqubo edakumbisayo nokuphazamiseka engqondweni. Amalungiselelo "Klofranil" yaye "Anafranil" kwi ezakheke nto clomipramine obambeleyo hydrochloride ityiwa.

medicament Iveliswe ngokohlobo amacwecwe aqhelekileyo kunye ukukhululwa ngokuzinzileyo. Simple umthamo wayo ngu 0,025 g, kwaye 0,075 g kunamandla inezi isithako esebenzayo. macwecwe oluqhelekileyo ke ukukhanya iswekile etyheli camera. ifomu iziyobisi elide iqulethe nokwaleka pink.

Kukho uhlobo ulwelo lwe amayeza, nto leyo limelwe isisombululo for efakwa ulawulo vnurtimyshechnogo kunye ml-2. Izikali "Anafranil" ziphene ukulungiselela 0,025 g clomipramine hydrochloride, nto leyo unyityilikiswa emanzini abulawe glycerin.

Enye indlela ezinjalo sisiyobisi "Clomipramine", efumaneka azipilisi lolawulo ngomlomo. Kuba ukhuselo, bona camera inkqubo isifo yokwetyisa. Idosi ichanekile 0,025 g clomipramine hydrochloride. elikroliweyo "25" ukubhekisela kuyo ekhompyutheni ngasinye. Isiphumo ichiza ejoliswe ekulweni uxinezeleko. Xa amayeza kuyanda psychostimulants, timolepticheskoe kunye nomsebenzi umthomalalisi. Umsebenzi yokugqibela esidityaniswe abhalwe olubiyele ukuthathwa neuronal serotonin molecule ukuphucula isimo nomonde.

It isetyenziselwa unyango iinkqubo edakumbisayo, ezo zibangelwa yezizathu ezahlukeneyo. Ichiza waphathwa kakuhle psihopatiiyu, schizophrenia, ukucalulwa, one-, umlinganiswa ukuba likhoboka lento ethile, cataplexy, sobuthongo. Abantwana abaminyaka mi-5 emva kokuba wamiselwa ukuphelisa ngumchamo kwasebusuku.

Xa ichiza "Klofranil" analogue inokuba liqulathe esisebenza ngaphandle hydrochloride clomipramine. Umzekelo, ichiza "SONEX" kumafa yawo yeyona nto zopiclone esebenzayo, nto leyo uqulathwe idosi enye ye medicament ngu 0,0075 ukuqala ubuthongo, ebonisa ukuzola, anticonvulsant kunye izihlunu neziphumo relaxant. Umgangatho iyonke iimveliso "Klofranil" yaye "SONEX" yi iipropati zabo umthomalalisi.

Ifumaneka enkampanini eyenza Belarusian "Rubicon" ngokohlobo amacwecwe ngeenxa zonke, lenticular, ngesigqubuthelo, lisesingxobeni emhlophe kunye nomngcipheko uqhekeko kwisiqingatha. Isetyenziswa ukunyanga izifo kakhulu ukulala khona ukuphuthelwa lobume kunye okwethutyana.

amayeza "Truksal"

Kukholelwa ukuba ezifana ngokusekelwe hydrochloride chlorprothixene analog leyo ithe tioksantenoviy. It iveliswa yinkampani Danish JSC "Lundbeck". Ukulungiselela inxulumene arhente neuroleptic, okuye antipsychotic, umthomalalisi kunye nomsebenzi onomoya bucala.

Kukho iidosi ezine ezahlukeneyo ichiza: 0,005, 0,015, 0,025 no 0,050 grams. Ngokwemithamo ezintathu zokuqala kufumaneka ngohlobo iiyunithi tableted brown nemilo biconvex ngeenxa kunye ukutyabeka esingxotyeni. Ithamo eliphezulu kumela tablet elimbhoxo nomphezulu biconvex.

umsebenzi Antipsychotic ikhutshwa phandle ziyibuyisela iimanyano dopamine receptor. Xa kuvalwe iindlela kwezi nkalo kukho antiemetic kunye iintlungu nefuthe ichiza. Drug abangaphangeliyo i-5-HT2 receptor umbutho, α1-adrenergic kunye H1-receptors gistaminozavisimye ebangela adrenoblokiruyuschee, umsebenzi antihistaminic.

Le medicament ibekwe namachiza neuroleptic kukupholisa impembelelo, ekuthi kujongwe ukuba ukunyanga ukuhlaselwa ngengqondo, seSkitsofreniya kunye crazy.

Isetyenziswa ukuphelisa ebuntwaneni ngendlela etenxileyo, injongo ukoyisa ibhabhalaza ekubalekeni syndrome xa utywala neziyobisi, ukuba silwe ukungahlaliseki, inkqubo ocaphuka msinya, ukudideka ebudaleni.

Ichiza iyasebenza edakumbisayo utshintsha zikarhulumente Besson nevroznom.

Kunye amayeza amayeza iintlungu "Truksal" ishenxisa iinkqubo sifo.

Thelekisa izixhobo "Klofranil" kunye nabo

Esondelene kumafa nezenzo zezi medicament yi "Anafranil" ngokohlobo amacwecwe kunye yokukhululwa eziqhelekileyo. Iifom Izikali mfumba zamatye a umthamo 0,075 grams kunye isisombululo ukusetyenziswa intramuscular kwaye efakwa ayinakuze ithelekiswe kunye yeQela Indiya, ekubeni ayikho kule fomu.

Izigulane ezininzi bathuthunjiswe umbuzo: wenza njani "Klofranil 'ukusuka' Anafranil"? Okokuqala, kukho umahluko nokwakheka bako engasebenziyo. Ukubakho ekulungiseleleni Indian brilliant oluhlaza, isodiyam carboxymethyl starch, hypromellose 2910, macrogol 6000, azikho amayeza Italian, uthi ngomahluko phakathi ngoontanga ezimbini. Ezi izithako emacwecweni "Anafranil" indawo stearic acid, glycerol 85%, neselulosi hydroxypropylmethyl, copolymer of vinylpyrrolidone kunye IVinyl acetate, crystalline sucrose, polyvinylpyrrolidone K30, oxide intsimbi yellow-5%, titanium dioxide, macrogol 8000.

Ubukho zombini eswekile iziyobisi milk kuphucula bioavailability ukwimo esebenzayo. Nangona kunjalo, ubukho lactose kwenza ukuba akafanelekanga ukuba abantu abane ukunyamezelana ukuba eli candelo.

Ezinye izithako abangabancedani le analogue ezimbini ukutshintsha amandla umthondo, ofunxayo ifuthe clomipramine hydrochloride zinomgutyulo emzimbeni. Kwakhona noxanduva lokuphuhlisa zonke iziphumo ebezingalindelekanga kunokwenzeka.
Ngokungafaniyo "Anafranil 'ukusuka' Klofranila" ngenxa ixabiso. iziyobisi Italian kubiza kancinane ngaphandle umfuziselo Indiya.

Ukuba sithelekisa yintoni na enamandla: "Truksal" okanye "Klofranil", kukholelwa ukuba ichiza wokuqala sine ngokomelela, uzole kwaye inhibitory, nto leyo evumela ukuba boyise zezigulo ezahlukeneyo ngengqondo.

Ngendlela yempembelelo, ama-neuroleptics ahluke kakhulu kwizidakamizwa ezixinzelelekileyo. Isenzo sonyango "i-Truksan" ijoliswe ekunciphiseni umsebenzi we-psychic umsebenzi, ukunciphisa umsebenzi wezinto ze-neurotransmitter. Ngokuncediswa kweziyobisi "Clofranil" umsebenzi wabo uqiniswa kwaye uvuselelwe.

I-Dopamine excretion igxininiswe ngama-neuroleptics, kwaye umphumo weengcinezelo zonyango uxhaswa ngumveliso wale nto.

Izimvo zomonde

Ngokubhekiselele kwilisiza "I-Clofranil" ukuhlaziywa kuya kuviwa. Izigulane ezininzi ezixinezelekileyo, esi sixhobo sinceda ukukrazula iingcamango ezimbi kunye nokugqithisileyo, kwakukho uvuyo ebomini.

Abanye abantu bamisela iyeza lokunxiliswa kotywala ngokuxhomekeka kokwemvelo kwengqondo. Emva kwenkqubo yokuthatha amayeza, isigulane sifike kwisimo esaneleyo, esilungeleyo, esilungeleleneyo, ulwaphulo luhamba.

Kwimichiza "I-Clofranil" imiyalelo yokuphononongwa kokusetyenziswa iqulethe iimeko ezintle nezimbi. Oku kungenxa yokuba inqaku elithi "Impendulo engalunganga" liqule uluhlu olukhulu lwemiphumo engathandekiyo enokuthi ivele ngexesha lokonyango. Ngokwenza oko, oogqirha abaninzi baqaphele ukunyamezeleka kwezi zonyango, into ephambili kukuba ukhethe ngokuchanekileyo umthamo ochanekileyo kwaye uyilungise ngexesha xa kuyimfuneko.

Ukuchaneka kweso sigqirha "i-Clofranil" ukuhlaziywa okuhambelana nokubonakaliswa kwempumelelo yayo ngexesha elifanelekileyo, ezifunwa ngumenzi weziyobisi. Kwakhona, ukufumaneka kwayo kwisicwangciso sezemali kuyamkholisa. Amachiza aqala ukusebenza emva kweveki emva kokuqala kokusetyenziswa, nto ibaluleke kakhulu ekususweni kokuhlaselwa okubi kwesi sifo.

Ukungalungi kukuba le nkunkuma ayikwazi ukukhawuleza ihoxiswe, kodwa ukunciphisa ngokuthe gqithwa kwi-dosing kuyadingeka.

Izigulane ezineengxaki zokuphazamiseka kwiinkalo zokuqala zonyango ziye zandisa ukhathazeka. Isalathisi sibonakaliswe ngethuba lokuqala, kwaye emva kweeveki ezimbini sinciphisa.