Iibhilethi "Bergolak": ukuhlaziywa, imiyalelo, amaxabiso

"I-Bergolak" isilwanyana se-dopamine receptor agonists kunye ne-cabergoline, into ephambili yesilwanyana esivela kwi-ergoline. "I-Bergolak" inempembelelo enkulu kwinkqubo yokukhululwa kweprolactin. Ngenxa yokungena kwayo egazini, inqanaba leprolactin liyancipha, ukuvelisa kubuyiselwa kwaye umjikelezo wesini uya kupheliswa. Ukuchaphazela amadoda, isichengululo sinciphisa ubunzima bokubonakalisa ezithile ze-hyperprolactinaemia.

Pharmacokinetics

Kukho ukulungiswa okulungileyo kunye nokusabalalisa okufanayo emva kokusebenzisa i- "Bergolak". Ukuphononongwa kubonisa ukuba ukutya okungekho mveliso kuphazamiseka kwezi zikhombisi. Njengoko kuchazwe kwimimiselo, ukuxinwa okuphezulu kweziyobisi kubakho kwi-plasma yegazi kwiiyure ezimbini iiyure, ngelixa iqela eliphambili libopha kwiiprotheni zalo ngo-41-42%.

Emzimbeni kukho imetabolism esebenzayo ye "Bergolak". Izinto ezakhiwe ngenxa yolu hlobo zixhaswe ngamathumbu (malunga nama-72%) kunye neentso (malunga ne-18%). Kwi-urine, i-2-3% yesithako esisebenzayo sinokungatshintshi.

Iimpawu zokusetyenziswa

Isilwayo sinqunywe ukuba sibe nezicubu ze-pituitary gland kunye nokungabikho komntwana. Ukusebenza ngokugqithiseleyo kokukhathazeka kokuya esikhathini kubonisa iindlela eziseleyo emva kokonyango "Bergolak". Ukupheliswa kwe-lactation ngenxa yokuthatha le nkunkuma kunokwenzeka. Isidingo sokuphelisa le nkqubo sinokuvela emva kokukhipha isisu nokubeletha. Ukubambisana akunakucinywa nje kuphela, kodwa kunqatshelwe.

"I-Bergolak" ikuvumela ukuba uqede iziphazamiso ezibangelwa yi-hyperprolactinemia. Izibonakaliso zokusetyenziswa kwezidakamizwa ziyi-prolactin yokuvimba i-adenoma ye-pituitary gland, i- hyperprolactinemia idiopathic. Ngokusekelwe kwilisi "i-Bergolak" inokunyangwa izigulane ezine-syndrome, ebizwa ngokuthi "isiliti esingenanto saseTurkey" kwaye sikhuliswa yi-hyperprolactinaemia.

Unonophelo olukhethekileyo kufuneka kuthathwe ngexesha lokunyanga xa uphatha umntwana kwaye uncelisa. Ukwamkelwa kweemali kwizigulane ezinokukhubazeka kwesibindi kufuneka zenziwe phantsi kolawulo logqirha.

Ukungqinelana

Umyalelo osele kwi "Bergolak" uthetha ukuba uhlolo lwabagqirha lubonisa ukuba kukho ukungqinelana oku:

• Ukunyanzeliswa kwezinto kumacandelo;
• Ubudala beminyaka (abantwana abangaphantsi kwe-16);
• Ukunyuka okwaneleyo kwe-glucose kunye ne-galactose;
• Ukungahambisani nendawo kunye ne-galactose kwiifom ezingaqhelekanga;
• Ukungabikho kwama-congenital lactase;
• Iengqondo ezavela emva kokubeleka;
• Iingxaki ngokuphefumula, ukungafihleki komsebenzi wentliziyo, ngenxa yeenguqu ze-fibrotic emzimbeni, kubandakanywa ne-anamnesis;
• Ukunyuka okuqhubekayo kwingcinezelo yegazi, okungalawulwayo.

Xa uphatha abantu abadala, isiza kufuneka sithathwe ngokuqapha. Kuyafana nezigulane ezinesibindi esifo.

Ukusetyenziswa kwemveliso yonyango, umyinge

Njengoko kuboniswe ngongoma lokushiya emva kokufumana isilungiso se "Bergolak", i-lactation inokuthintelwa okanye iphazamiseke. Ngokuxhomekeke kumsebenzi, i-dosage yile:

• Ngaphambi kokuphuhliswa kwesilayilo - 1 mg yesilwanyana, ehambelana namacwecwe amabini, okumele achithe ngexesha elilodwa emva kokuzalwa komntwana (ngosuku olulandelayo);
• Emva kokuphuhliswa kwayo - 0.25 mg, ehambelana nesiqingatha sebhebhile, ekufuneka ithathwe iintsuku ezimbini kunye nexesha elide leeyure eziyi-12.

Ukuba kukho ezinye izibonakaliso, oogqirha badla izigulane "Bergolak" kwisilinganiso se-0.5-1 mg kanye okanye kabini ngeveki. Isiqhelo esiphezulu esivumelekileyo seveki ngu-4.5 mg yesilwanyana. Ngexesha elifanayo, awukwazi ukutshintshela ngokukhawuleza ukuya kumlinganiselo ophezulu, kuphela ngokunyuka ngo-0.5 mg ngenyanga, ukuba kuyimfuneko. Isilwanyana sidliwa ngokutya.

Izigulane ezisetyenziselwa "i-Bergolak", ukuphonononga ukunciphisa iprolactin kwi-hyperprolactinemia yekhefu ihamba kakhulu. Iziphazamiso ezibangelwa yile nkqubo ziphathwa ngokusebenzisa i-dose yokuqala yeveki ye-0.5 mg. Kunokwenzeka ukwahlula le dosi zibe ngamayeza amabini e-0.25 mg yeziyobisi. Kule meko, iziyobisi zingasetyenziswa kabini ngeveki.

Abasetyhini abancinciweyo bayamiselwa imithi ngendlela engaphantsi kwe-0.25 mg yesichengiselwano ixhomekeke emzimbeni ngexesha. Ngaloo ndlela, kunokwenzeka ukuphelisa inani leempembelelo ezingahambiyo.

I-dose yokwelapha, ejoliswe ukuba isetyenziswe ngeveki enye, ngokuqhelekileyo ayikho ngaphezu kwe-2 mg. Nangona wonke umntu kunye nesigulane ngasinye ugqirha ukhetha uhlobo oluthile lwamanyango.

Abafazi abathi ngexesha lokukhulelwa besetyenziselwa "i-Bergolak", ukuhlaziya ikhefu ngolwazi malunga nesidingo sokusetyenziswa ngokufanelekileyo kwesi sidakamizwa. Kwixesha elinjalo lobomi, ukusetyenziswa kwalo kuyenziwa phantsi kweliso eliqhelekileyo logqirha kwaye kuphela kwimiqathango ephakanyisiweyo. Nangona kungenakucetyiswa ukuba kusetyenziswe amacwecwe kubasetyhini abakhulelweyo, kwiimeko xa inzuzo kumzimba kamama ingaphezu kweengozi ezibangelwa umntwana, oku kuvumelekile. Ukunxiliswa kunye neyeza "iBerggolakom" ishiyiwe.

Iziphumo eziPhakathi

Ukuphendula okungathandekiyo kunokungafani, kwaye ubunzima babo buyahlukahluka. Kwiimeko ezininzi, zonke izibonakaliso ezingonakalisayo zinyamalale emva kweentsuku eziyi-14 zonyango okanye emva kwexesha elithile emva kokuhoxiswa kweziyobisi.

Ukuqwalasela ukuba ukuhlolwa okushiye ngamayeza "Bergolak" kubonisa ukuba kunokwenzeka ukuba utywabile, ukulala nokubuthathaka, imeko yezempilo ngokubanzi ingadluka.

Kukho umngcipheko wokuhlaselwa kwezilwanyana ezichaphazela ulusu. I-pallor ebonakalayo yesikhumba ngenxa yokubanda. Kukho utshintsho ekusebenzeni kwendlela yokugaya ukutya, umzekelo, ukuqhawulwa, isisongela. Ezinye iziphumo ezichaphazelekayo ziquka ukudibanisa kwamanzi, ukumisa umlomo womlomo.

Ukusebenzisana kwezidakamizwa

Siza kufumanisa ukuba ngaba kungenzeka ukusebenzisa "iipilisiki" ze-Bergolak zonyango oluhlangeneyo. Ukugqithiswa koogqirha kubonisa ukuba kunye neyeza elide le nkunkuma akufanele isetyenziswe ngokubambisana ne-ergot alkaloids, iziphumo zazo.

Kufuneka ukhunjulwe ukuba abanye abaphikisanayo be-dopamine receptors bangathintela kakubi isenzo se-cabergoline, kunye ne-macrolides-ukwandisa inqanaba lomsebenzi osebenzayo weziyobisi "Bergolak" egazini. Utywala wenza ukuba iziyobisi zingasebenzi kakuhle.

Amachiza, enyathelo elijoliswe ekunciphiseni uxinzelelo lwegazi, ngelixa lonyango lichazwe ngokulumkisa.

Imiyalelo ekhethekileyo

Ukuba ukucwangciswa kucetywayo, kuvunyelwe kuphela emva kwexesha elithile emva kokugqitywa kweyeza, ngokuqhelekileyo ngenyanga. "I-Bergolak" ithathwa kuphela emva kokuvavanya ngokugqithiseleyo kwintsimbi ye-pituitary. Ngethuba lokunyanga, imeko yomzimba kufuneka ihlolwe rhoqo.

Nangona unyango luqhutyelwa, ayikhuthazwa ukuba isebenze imoto nezinye izithuthi, zibandakanye kwimisebenzi efuna ukuphendula ngokukhawuleza kunye nokunyuka kwengqalelo. Kubalulekile ukulandela zonke iingcebiso zegqirha.

Iindleko, ukuhlolwa

Kubantu abaninzi bacwangcisela ukuthatha iBerggolak, ixabiso, ukuhlaziya rhoqo kusetyenziswa ulwazi oluqulethe ulwazi oluncedo, olukuvumela ukuba wazi kwangaphambili iindleko zonyango, iimpawu zonyango kunye neempembelelo ezingafunekiyo izigulane ezijamelana nayo ngexesha lonyango, ukujonga ukusebenza kwayo .

Iindleko ezilinganiselweyo zamathebhulethi (2 pcs ukuya ku-0.5 mg) ngama-ruble angama-235-260. Ngokubhekiselele kwisicelo se "Bergolak" ngenjongo yokumisa i-lactation okanye ukuyikhusela, ukugweba ngeempendulo, le nkunkuma ayisoloko iqhuba kakuhle nale mi sebenzi. Kodwa xa usebenzisa i-drug ye-hypoprolactinemia, abaninzi banokuqaphela impumelelo yesiphumo esifanelekileyo. Nangona kunjalo, kukho umngcipheko wokuphuhlisa imiphumo yempembelelo, apho abanye abantu baqaphela kwisigaba sokuqala sonyango.

Abaninzi bayakuvuyela isenzo esheshayo kunye neendleko eziphantsi kweziyobisi xa kuthelekiswa nezinye iziyobisi ezifanayo. Eminye imiphumo emibi, maxa wambi ukugqithiswa, ukulala, kunye nentloko emancinci.