"I-Nitrosorbide" - ezifanayo. Imiyalelo, isicelo, inkcazo yokulungiselela

Ukungaphumeleli kwintliziyo engapheliyo kuyinkathazo enkulu kubabini abakhulileyo nabaselula. Unyango oluxhasayo lubaluleke kakhulu. Isigulane kufuneka sithathe rhoqo iipilisi ukuze siphile ubomi obuqhelekileyo. I-cardiologist efanelekileyo kufuneka imisele iyeza. Amacwecwe "i-Nitrosorbide" ayathandwa phakathi kweengcali. Iilwimi eziqhelekileyo zisetyenziswe rhoqo.

Ifomu yokukhutshwa nokubunjwa

Amacwecwe aphuma kwiqela lezilwanyana ezichasayo. Isithako esisebenzayo sisisosorbide dinitrate. Njengezinto ezincedisayo, i- magnesium stearate, i- lactose monohydrate, i-polyvinyl acetate ne-talc isetyenziswe. Iibhulile zifumaneka ezimhlophe, zibe nomlo ojikelezayo.

Isithako esisebenzayo, esiyi-nitrate ye-organic, sinceda ukukhulula iindonga ezihamba kakuhle zeempahla. Isiphumo asikho kuphela kwimibhobho, kodwa nakwiimvini. Ukunciphisa ngokukhawuleza ukuthunyelwa kwegazi egazini, kunciphisa ukubuyela kwintliziyo. Isosorbide dinitrate inefuthe elihle leklinikhi . Umyalelo wokusetyenziswa uthi inkalo ephambili ngokukhawuleza ifakwe kwigazi. Siyabulela oku, umphumo wokwelapha uza ngokukhawuleza kwaye unaphakade.

Pharmacokinetics

Emva kokungena esiswini, iipilisi zichithwa phakathi kwemizuzu embalwa. Kwiiyure eziliqela unokwazi ukubona iziphumo zokuqala zonyango. Iipilisi zifakwe ngokukhawuleza. Ubuninzi bokufumaneka kwezidakamizwa ngu-22%. Isiphumo esiphezulu siphumelelwe kwiiyure ezimbini emva kokuthatha ithebhulethi ngaphakathi. Isithako esisebenzayo esikhulu sibophelela kwiiprotheni zegazi nge-30%.

Iyeza liyakususwa ngokupheleleyo emzimbeni emva kweeyure eziyi-12. Akukho mpu Isosorbide dinitrate isetyenziswe kwisibindi. Kule meko, i-metabolite esebenzayo ye-isosorbide mononitrate yenziwe. Isilwanyana sisuswe ngokupheleleyo ngomchamo.

Iinkcazo

Kuphela isifo se-cardiologist esifanelekileyo singabhalwa iipilisi "Nitrosorbide". Iinguqu ze-Analogues nazo zonyulwe ngcali kwiingcaciso. Isilwanyana singasetyenziselwa isifo senhliziyo yesichemicic, ukuba unyango lwangexesha elide kunye namanye amayeza aluzange lube nesiphumo esihle. Iibhilebhe zinokuthintela ukuhlaselwa kwe-angina pectoris.

Ngonyango oludibeneyo, isiza esibizwa ngeNitrosorbide sinokumiselwa. Iingalogu zingasetyenziselwa oku: "I-Cardiket", "Izo Mik", "Dikor Long". Ezi zi yobisi ziya kuchazwa ngokuncinane. Iibhulile zingasetyenziswa ngokubambisana ne- cardiac glycosides, i- diuretins okanye i-inhibitors.

Yintoni enye iipiritsi ze-Nitrosorbide? Iyeza liyakunceda ne-infyoction ye-myocardial. Amachiza anqunywe emva kokuthathwa njengeprophylaxis. Njengenxalenye yonyango oludibeneyo, isicatshulwa singasetyenziselwa ukukhusela i-angina pectoris. Iibhulile kule meko zinokuthatha ixesha elide.

Unyango kunye neNitrobide inokwenzeka ngexesha lokukhulelwa kunye ne-lactation. Nangona kunjalo, sebenzisa iyeza ngokulumkisa. Iyeza lichazwe kuphela ukuba inzuzo engenako kumama ingaphezulu kweyona nto inokulimaza umntwana.

Ukungqinelana

Amachiza anikwa kuphela ngumyalelo. Oku kugwema ukusetyenziswa kakubi kwezibhebhile ngezigulane. Inyaniso kukuba i-drug "Nitrosorbide", efana ne "Cardiket Retard", inokuphikiswa. Akunjalo na kufuneka usebenzise iyeza ngexesha le-infyoction ye-myocardial enzima xa unesifo esiphezulu se-hypotension. Kule meko, iipilisi zingaba nempembelelo echaseneyo. Akukho mayeza anikezelwe ukuba i-glaucoma evaliweyo, i-hypovolemia, ukungaqiniseki kwamathambo. Ungathathi iyeza ze-craniocebral trauma.

Kukho nemida yobudala. Iibhilethi "I-Nitrosorbid" okanye "I-Cardiket Retard" inokumiselwa kuphela kubantu abadala. Ezinye izigulane zinokuthi zandise ukwanda kweetitrate. Ukuba unamava aphilileyo, uyeka ukuthabatha imithi ngokukhawuleza kwaye ufune iingcebiso kwi-cardiologist.

Imiyalelo ekhethekileyo

Ukuyeka ukuhlaselwa kwe-angina , amaphilisi "iNitrosorbide" ayinakusetyenziswa. Kuyafana oku malunga namayeza "Izo Mik", "Kardiket" kunye ne "Dikor Long". Zonke ezi ziyobisi zingasetyenziswa kuphela ngenjongo yokuthintela. Ukuba uhlaselo aluphepheki, unyango ngamanye amayeza luya kufuneka. Ngexesha lokusetyenziswa kwamacwecwe e-Nitrosorbide, kuyimfuneko ukubeka esweni rhoqo isantya senhliziyo kunye noxinzelelo lwegazi. Izigulane ezinonyango ezingapheliyo zonyango zifuna ukunqandwa esibhedlele.

Ukupheliswa kweziyobisi akukhuthazwa. Ukutyiwa kwe "Nitrosorbide" ekuqaleni kweyeza kunokuba negalelo ekunyuseni kwinani lokuhlaselwa kwe-angina pectoris. Impembelelo efanayo iya kugqitywa kunye nokukhishwa kwezidakamizwa ezibukhali. Ukubamba amaxinzelelo ngexesha lonyango, i-nitrate ephezulu isetyenziselwa ukuba ikhethwe. Ukuzinyonga kunokunika iziphumo ezingalindelekanga.

Musa ukuqhuba isithuthi ukuba usebenzise ukulungiselela okuqukethe i-isosorbide dinitrate. Imiyalelo yokusetyenziswa ithi le nto ingabangela ubuthongo kunye nosizi. Akukhuthazwa ukulawula nayiphi na indlela enzima ngexesha lokunyanga.

Isistim

Iibhilethi zinokuthatha ixesha elide. Izigulane ezinokukhubazeka kwentliziyo zimiselwe i-20 mg kanye ngosuku. Kancinci, umlinganiselo wanda. Umgangatho osemgangathweni awufanele udlule iipilisi ezintathu ngosuku. Kwiimeko ezinzima, isenzo eside (40 mg) sinokumiselwa. Izigulana zithatha ihafu yepilisi kabini ngosuku. Ukwandisa isilinganisi ngokulumkisa kwaye kuphela phantsi kolawulo lwezonyango.

Utyando luqala ngamanani amancinci kwaye ngokunyuka ukwandisa isiqhelo ukuya kusebenza ngokupheleleyo. Yenzelwe ukusetyenziswa kwexesha elide lethebhulethi "iNitrosorbide". Ii-Analogs zenzelwe ukuba unyango lwexesha elide. Ukunyangwa ngokukhawuleza kunyango akukhuthazwa. Imiphumo emibi ingakhula.

Ukugqithisa

Ngokukhawuleza kwisinconywa sogqirha, kuyimfuneko ukusebenzisa iipilisi ze-Nitrosorbide. Uphononongo lubonisa ukuba ukugqithisa ngaphezulu kunokususa ukuphuhliswa kweziphumo ezibi. Ziyabonakala zivame ngokwendlela yokuzondloba, isicathulo, ukuhlanza. Ngaphantsi kaninzi, ukusabela kwesikhumba kunokwenzeka, njengokutshiza, ukuhlambalaza. Ukususela kwicala le-cardiovascular system, isigulane sinokuvakalelwa ngokunyanisekileyo kwixinzelelo lwegazi, iintliziyo zentliziyo.

Unyango lwe-overdose lwenziwa kuphela kwisibhedlele. Okokuqala, isisu sageza. Kwixesha elizayo, unyango olungumqondiso luyalelwe. Ukukhawuleza ukuzinzisa imeko yesigulane, i-activated charcoal ingasetyenziswa.

Iziganeko ezimbi

Xa zisetyenziswe kakuhle, iipilisi nazo zingahlakulela imiphumo emibi. Kwiimeko ezininzi, zisesigxina kwaye azikwazi ukukhanselwa. Izimpawu ezingathandekiyo ekuqaleni kwonyango zingenza iipilisi "Dikor Lorg", "Izo Mik", "Kardiket". Ekuqaleni, izigulana zinokuba neentloko, ezingagqithwanga naluphi na unyango kwaye zihamba ngokwazo iintsuku ezimbalwa emva kokuqala kweyeza. Kukho nokuba kukho i-tachycardia, ukunciphisa uxinzelelo lwegazi.

Kulo nxalenye yesistim sokutya, iziphumo zecala zibonakaliswa ngolu hlobo lweentlanzi, intlungu yesisu, isifo sohudo. Ukuba ukuhlanza kwenzeka, funa uncedo ngonyango ngokukhawuleza.

Ukusebenzisana kwezidakamizwa

Isilumkiso kufuneka sisetyenziswe iipilisi "i-Nitrosorbide" kunye nayiphina imithi ye- vasodilator. Ukusebenzisana okunjalo kunokukhokelela ekuphuhlisweni kwemiphumo emibi. Amacwecwe e-Dihydroergotamine angasetyenziswa kuphela emva kokubonisana nodokotela. Ukusebenzisana kwezidakamizwa kunokukhokelela ekunyuseni kwe-dihydroergotamine egazini kunye nokuphucula umonakalo wayo wokuxilonga.

Ukhuthaza ukuphucula ukusetyenziswa kwegazi kunye nesipilisi "iNitrosorbide" ye-acetylsalicylic acid. Ngaphandle kweentengiso, iilisi ayikhuthazwa. Ukusebenzisana okunjalo kuya kubangela ukuhla kwe-bioa availability of the drug.

Analogues

Amacwecwe "i-Nitrosorbide" ayathandwa phakathi kweengcali. Ixabiso leziyobisi liphantsi, kwaye linemiphumo emihle emzimbeni. Kodwa akusoloko kunokwenzeka ukufumana iziyobisi kwikhemistiki. I-cardiologist iza kuhlala isinceda ukuthabatha amanani afanayo. Iibhilethi "I-Cardiket" iyakwazi ukujamelana kakuhle nomsebenzi. Isithako esisebenza ngokusisigxina sesilwanyana sifana ne-isosorbide dinitrate. Isilwayo simiselwe ukuthintela i-angina pectoris, kunye ne-myocardial infarction.

I-analogue eyabiza kakhulu iipilisi "iDicor Long". Njengamacandelo ancedisayo kumacwecwe asetyenziselwa isitashi sommbila, i-lactose monohydrate, i-silicon dioxide colloid, i-magnesium stearate, i-titanium dioxide. Iibhilebhe zinganikwa abantwana, kunye nabasetyhini abakhulelweyo esibhedlele.

Iiblulethi "Izo Mik" - esinye isixhobo esithandwayo esingashenxisa isilwanyana "Nitrosorldide". Isithako esisebenzayo sisisiseko se-isosorbide dinitrate. Kuwo onke amayeza adweliswe, oku kubiza kakhulu.

Ukuphonononga malunga namacwecwe "I-Nitrosorbid"

Isilwayo sinempembelelo enhle kwindlela ye-cardiovascular system. Kwintliziyo engaphumeleli kwinqanaba elide lokuqala lazo zonke iipilisi "i-Nitrosorbidum" zonyulwa. Ixabiso leyeza likholisa izigulane. Enye ipakethe ingathengwa iiruble ezili-15 kuphela. Ukuhlaziywa okungahambiyo kunokunxulumana neziganeko ezimbi ezenzeka ekuqaleni kweyeza. Kufanelekile ukuba sikhumbule ukuba zisesigxina nje.

Akukhuthazwa ukuba usebenzise iyeza. Unyango kufuneka lwenziwe ngokukodwa phantsi kolawulo lweengcali eziza kuthatha isilinganisi esifanelekileyo kwimeko nganye. Ukurhoxisa ngokukhawuleza ukwelashwa akufanelekile.