Analogs "Ksarelto": ixabiso, imiyalelo zokusetyenziswa

Omnye iziyobisi, lalo kwiqela amayeza-arhente anticoagulant, ichiza "Ksarelto". Eli chiza abangaphangeliyo factor nagyo, yaye oko, nayo, isisahlulo prothrombin isilumeki kunye njengenye yeekhomponenti yokubonelela coagulation igazi ngexesha (propati kunye analogue "Ksarelto").

Namhlanje kwenziwe iinzame ezininzi lilize ukurhoxisa ichiza, nto leyo eya kuba nefuthe ofanayo ngaloo ukunika ubuncinane yeziphumo ebezingalindelekanga. Emva umzamo ethatha ixesha elide ezininzi umfuziselo ofanele - ichiza "Pradaksa". Ichiza - kuphela ababambeleyo ukuba ngokupheleleyo zingasetyenziswa endaweni ukulungiselela "Ksarelto". iimpawu zayo phantse twatse kungasentla, umahluko kuphela - isiqulatho isithako esisebenzayo, nto leyo kuwo omabini amalungiselelo i rivaroxaban.

pharmacodynamics

Zonke analogue "Ksarelto" kuba nemiphumo efanayo. Ekuphela kwento ahluke - isalathisi ubuninzi nobulunga yeziphumo ebezingalindelekanga. Ixesha kwiwotshi yamanani kuphela ufanelwe ichiza, nto leyo iba nefuthe ofanayo kuyo, sisiyobisi "Pradaksa".

Eli chiza kunye elilingana neli Russian of "Ksarelto" iziyobisi ngqo uyakhetha kakhulu ukuba zinqanda isenzo Factor nagyo, okt zinqanda oko. Eli chiza a bioavailability eliphezulu ngomlomo, indlela kunjalo enteral lolawulo ngundoqo kuyo.

indima engundoqo kwi ndachithelwa coagulation factor X lokuvula kudlala kuleyo biotransformation factor nagyo nge indlela coagulation lwangaphakathi nolwangaphandle.

ubungqina

Ngokuqhelekileyo, analogs "Ksarelto" kunye nokulungiselela ngokwayo lisetyenziswa kwi meko zilandelayo:

• Uthintelo kunye prophylaxis kokubetha kwakhe.
• Uthintelo kunye ukukhululeka Embolism lwenkqubo.
  
  (Kwiimeko ezinjalo, i-medicament kuboniswe kwizigulane kunye fibrillation atrial, nto leyo imvelaphi non-valvular.)

• Nokususwa okanye ukuthintelwa wokufaka of deep vein thrombi.
• Prevention of ungaphinde Embolism miphungeni.

Drug "Pradaksa", nto leyo efanayo, kananjalo eboniswe nokuthintela iziganeko lwemithambo thromboembolic kwizigulane abaye unenzondelelo utyando endaweni enye kwengubo yentsimbi imilenze asezantsi.

Izimo

Nayiphi elingana Russian "Ksarelto" na Izimo zilandelayo (zinokuba ezahlukeneyo, kodwa kuphela kangangoko elincinane):

• ubuntununtunu okanye ingozi leyo ibangelwa kukwalisa izinto eziqulathwe kule medicament;
• ukopha esebenzayo kulo informativeness esinzima ngu kuxilonga (umz, ukopha intracavitary okanye legazi ebuchotsheni);

• imeko apho kukho nengozi eyonyukileyo nokopha umthamo, umz, iinkqubo isilonda esebenzayo kwisiqwenga zesisu;
• agents Unyango lweziyobisi ilifa ngeempawu ezifanayo - coagulation ekunqandeni;
• usebenzisa lweeHedfowuni unfractionated kwi idosi kuyimfuneko ukusebenza ngokwanelisayo le catheter;
• izifo zesibindi ezahlukeneyo, uphuhliso esinokubangela ukopha of umyalezo ezahlukeneyo;
• yonke into nabalingani "Ksarelto" ukuba contraindicated kwizigulane kunye insufficiency kwezintso, ivela ngathi na isigaba;
• ukunyamezelana lactose, isiqulatho elingonelanga galactose emzimbeni;
• ukukhulelwa kunye zisanyisa;
• kwakhona kwi eziyobisi analogs ezahlukahlukeneyo "Ksarelto" kukho umda yobudala 18.

Udidi labantu ingathatha eli chiza ngononophelo kwaye phantsi kweliso oyingcali

Ngononophelo kwaye phantsi kweliso gqirha icebisa ukusetyenziswa kwemiyalelo "Ksarelto" zokusetyenziswa (njengoko analogue) kwezi meko zilandelayo:

• iziguli abaye sengozini enkulu yokuba ukopha kumiswa;
• kutshanje zidluliselwe isifo sisilonda ukuba ukuthambekela ibuye;
• unyango ukusilela kwezintso ezingafani zidityaniswe kunye iziyobisi ukwandisa isiqulatho rivaroxaban kwi umzimba yesigulana;
• Izigulane ezibekwe amachiza onyango esikwaziyo ukuphakamisa hemostasis;
• amalungiselelo leyo bayakwazi ukwandisa umgangatho rivaroxaban, umz, iziyobisi nokubola iqela azole;
• amacwecwe neziyobisi analogue "Ksarelto" into contraindicated kwizigulane ezine-HIV, ukuba bathabatha nje ezahlukeneyo inhibitors protease kwale ntsholongwane.

Ukusela ngethuba lokukhulelwa nokuncancisa

Ukuza kuthi ga ngoku, ukuba akuyi ncam, njengoko impembelelo "Ksarelto" analogue beziyobisi kwi ukusebenza kunye nokhuseleko abafazi abakhulelweyo.

Amalinge zaqhutywa izilwanyana elebhu baye ityhefu abuthethileyo ukwimo esebenzayo yokulungiselela kwi izinto umama okhulelweyo, njengoko ichiza ibangela ityhefu kakhulu okuzala omzimba ababhinqileyo.

Ngokutsho ziphumo elebhu, ichiza "Ksarelto" analogu into efanayo kubo yesenzo amayeza uyakwazi kuwela ngumkhaya, ngoko contraindicated ichiza.

Kwakhona ngexesha lwesicelo of "Ksarelto" abafazi akufuneki silibale malunga namanyathelo eyiyo zokucwangcisa, ukususela ekuqaleni, okuhambisana okunanisa ichiza, kunganeziphumo kuchaphazela Palsy.

Injongo izigwebo malunga nefuthe beziyobisi ezisetyenziswa kwithuba zisanyisa, kwi ayisekho mzuzu, kodwa izifundo laboratory izilwanyana zaselebhu bacebisa ukuba into esebenzayo - rivaroxaban - uyakwazi lokugaya kwaye kwazona ngobisi lwebele. Ngoko ke, ibele kufuneka alahle ukusebenzisa iziyobisi.

Ngokusekelwe idatha enikwe ngu izifundo laboratory, sinokuthi rivaroxaban aluchaphazeli isakhono a omzimba oqolileyo ngesondo ukudala inzala athembisayo kumabuzi, kodwa abantu lo hlobo experimenti olusaleleyo luqhutywe.

Ukutya uze kubulawe indlela

Kuba reception enteral kukho iindlela ezintathu lweenkomo, leyo kunxibelelana omnye kwisithathu inani lilonke iziyobisi non-umzimba:

• kukhuthaza womchamo;
• kukhuthaza endleni;
• ngokupheliswa nge kukhuthaza umgca kwezintso (kulo mzekelo, phantse akukho into umzimba kwaye ziphelisiwe kwifom unmodified).

Biotransformation rivaroksaba eyenziwa iindlela ezizimeleyo kwinkqubo cytochrome.

The main indlela - igcwala yeqela morpholino kunye nokwandiswa imixokelelwane amide ngamanzi.

Studies olwenziwe vitro, ungenza kulugweba rivaroxaban sisiseko P-glycoprotein kunye protein ebonelela ukumelana nezifo ibele oncological.

Ngokuqhelekileyo, ukususwa metabolites yenziwa ngexesha leeyure 5-9.

imiphumela emibi

Uthi imiyalelo ukulungiselela ukuba zisetyenziswe: analogue "Ksarelto" okanye amayeza self kufuneka kwenziwe kuphela xa kagqirha. Umyalelo ngokwayo ichaza ngokweenkcukacha umthamo ichiza, okanye analogue yayo. Qinisekisa ukuba ufunda ulwamkelo uqeqesho!

Ngezantsi ibonakalisa zonke iinkqubo okungafunwayo zinto waba "Ksarelto" analogs iziyobisi. iipilisi Price - evela engange-900. Oku ayibizi xa ucinga ukuba uninzi yeziphumo ebezingalindelekanga Niyazi ukuba umthetho.

• side effects ziye zaphawulwa xa ukuvavanya igazi kunye nenkqubo emithanjeni, ezi anaemia kunye thrombocythemia, apho kubonakala kungeyonto ayenza rhoqo.
• Tachycardia - basabela kuphela ezingalunganga xa uthatha eli chiza.
• Yokopha.

Ezi Izimo amanqaku ukuba ichiza "Ksarelto" umyalelo.

Analogs kweli chiza kunokubangela i ukungasebenzi le wokugaya: nokopha, iintlungu lobulali, iimpawu dyspeptic, ngamanye amaxesha - umlomo owomileyo.

Ngenxa kusungulo reactions zasekuhlaleni rivaroxaban inokwenzeka: nangecesina, ukudumba kuyo inaliti xa kulawulwa parenterally indlela, yokuswela amandla, umkhuhlane.

Ukuvela yezi nkqubo igalelo ukulungiselela "Ksarelto" noogxa. Ixabiso ichiza, njengokuba umthetho, yinto eqhelekileyo kuzo zonke imixokelelwane ekhemesti.

Iindlela yokuSebenzisa Izikali

iinkcukacha ezithe vetshe malunga ukwamkelwa oluchanekileyo weenkonzo ichiza mhlawumbi ngokupheleleyo "Ksarelto" umyalelo. Analogue beziyobisi ngokuphathelele oku bohluke kuzo ngokupheleleyo.

Eli chiza ifumaneka azipilisi, ngoko kwipilisi sithathwa enterally. Ukuba isigulana ngenxa yesizathu esithile ayikwazi ukuginya cwecwe - oko kwenziwe phantsi aze axutywe kulwelo efanelekileyo (iti, amanzi).

Emva kokufumana eli chiza kufuneka ngoko nangoko balandele isidlo.

libanda

Ukungaphumeleli ukuthobela imiqathango yolwamkelo "Ksarelto" libanda kunokwenzeka, leyo baphathwa ngokubanzi symptomatically, njengoko chiza iyeza elithile.

Ukwenzela ukunciphisa adsorption beziyobisi emathunjini amancinci inokuba yiyo nayiphi sorbent, ezifana carbon yasebenza. Kwakhona ukukhawulezisa kukhuthaza metabolites eziyimfuneko ukubonelela diuresis unyanzelekile, oluqhutywa nge ukusetyenziswa oluninzi ulwelo kunye nokusetyenziswa womchamo.

amaxabiso

Kuxhomekeka umenzi, ixabiso yi "Ksarelto" iziyobisi yahluka ukusuka 899,00 engange. tablet 10, nto leyo eziqulathe 10 mg esisebenza, ukuya 1740,49 miri.

Package, apho 30 iingqalutye, zingathengwa ngenxa 3300,00 engange.

Le phakeji inkulu iqulathe 100 njengezingxobo, kubiza 8600 engange.

Policy lwentengo "Pradaksa" isiyobisi kuxhomekeke kwisiqulatho ubungakanani esisebenza capsule nganye:

• 75 mg - 716,00 bagcobe;.
• 110 mg - 1574,00 bagcobe;.
• 150 mg - 1676,00 bagcobe.