ALT landa. Yintoni ukwenza ntoni?

alanine aminotransferase (ALT) enzyme equlethwe isibindi kusetyenziswa isibonisi ukubona ukuphazamiseka imisebenzi yayo. Ikuxelela ntoni into, ukuba amanqanaba ALT ukwanda?

Phakathi enzyme ezininzi zizalathisi ukuphazamiseka hepatocellular, i iluncedo kakhulu kwaye ezifunekayo aminotransferase alanine (ALT) kunye aspartate aminotransferase (AST). Ngabo ekhawulezayo yodluliselo reaction kwi gamma-gamma band ketoglutarate alanine kunye namaqela aspartate. Ngenxa yale nkqubo wavelisa pyruvic kunye oxaloacetic acid.

Kwaye ALT AST - zeselula enzyme kwizintso, isibindi, intliziyo. Noko ke, aminotransferase alanine, ikakhulu ibekwe esibindini kwaye yeyona ezisisiseko isibonisi yayo, kunye aspartate aminotransferase -. Njengenxalenye abaninzi (ngaphandle kwezo zidweliswe ngasentla) amalungu kunye zomzimba, kubandakanywa izihlunu skeletal, ingqondo, njl Kungenxa yoko le nto AST iqhosha enzyme azixhaphakanga njengoko sisalathisi umsebenzi kwesibindi, kwaye kuthatha inxaxheba acid acid ukutya.

Ukuba kukho yintshabalalo kweeseli zesibindi, intliziyo, izintso, alanine aminotransferase (ALT) e ukuwa egazini. Ukunyuswa transcriptase yeselula kwi ekwakhiweni igazi ibonisa izifo angasebenzi. Xa ukuhlola kubonisa ukuba amanqanaba ALT aphezulu, ukuze aphuhlise izifo unzulu egazini, ezifana:

- kwesibindi,

- hepatitis egazini,

- myocarditis,

- umhlaza wesibindi,

- ukusilela intliziyo;

- isifo sentliziyo.

Kwaye ke aminotransferase ukunyuka aspartate egazini kungakhokelela

- ukuhlaselwa yintliziyo,

- umhlaza wesibindi,

- muscular dystrophy ,

- pancreatitis,

- paroxysmal myoglobinuria,

- hepatitis,

- dermatomyositis,

- ukusilela intliziyo.

Ukuba, ke, ireyithi iyonke AST kunye ALT anda, kusenokubakho:

- olubanzi necrosis hepatic,

- toksinogennye kwesibindi kukwenzakala,

- severe hepatitis egazini,

- ukuwa elide nemithambo.

Phantse zonke izifo zonke izifundo igazi labantu zibonisa ukuba izinga kunye AST, kunye ALT kwanda, oko kukuthi, umgangatho zombini enzyme kula macala phantse efanayo kwaye ibonisa ubukho ngezifo. Kodwa kukho nenye umahluko. Ukuba ngaba amanqanaba ALT izazekile kakhulu ngaphezu aminotransferase aspartate, nto leyo ibonisa ukuba okuthatha losulelo hepatitis B. Ukuba ACAT igazi ngakumbi, ngakumbi ngokufuthi neengxaki ngentliziyo.

Xa umntu okunempilo okuqulethwe zezi enzayim cellular kufuneka ibe kwinqanaba:

- ezingabantu ukuya kwiiyunithi 41 ilitha nganye (U / L);

- kwabasetyhini ukuya kwiiyunithi 31 ilitha nganye (U / L).

Ukuchonga inqanaba le-enzayim, iiproteins ukutya, thabatha chemistry igazi. ISithethe ALT kulo 28-190 nmol / (c l) okanye 0.1, 68 mmol / (ml hr) kunye ACAT - 28-25 nmol / (c l) okanye 0,1-, 45 pmol / (ml hr). Lo mthetho kuzo zombini iimeko ziyanikezelwa indlela Reitman-Frankel (indlela colorimetric uphando).

Ngokuqhelekileyo, iimvavanyo zegazi alanine aminotransferase olwenziwe ukufunda malunga nemeko kwesibindi, kunye aspartate aminotransferase - ukubona imeko myocardium (ngentliziyo kwezihlunu). Ukuba uhlalutyo lubonisa igazi labo eliphezulu, oko kuthetha ukuba iinkqubo Unxunguphalo ukufa kweeseli kwenzeka ngala mabhunga. Ngoko ke, ukuba AST wagqithisa inqanaba layo egazini izihlandlo 2-20, ngoko kusenokwenzeka uphuhliso iposi engabalulekanga. Ukuba ngaba amanqanaba ALT banda, kukho inkqubo zophendlo lwezifo esibindini.

Phantsi kuncitshiswa olubonisa alanine igazi aminotransferase kunye neengcali aspartate aminotransferase bayazi ukuba ukungabikho umzimba ngayo pyridoxine (vitamin B6). Ngokuqhelekileyo oku kwenzeka ngexesha lokukhulelwa, kunye ihaemodialysis rhoqo kwaye ukusilela kwezintso.

Ngelishwa, ukusuka igazi serum lomntu sisempilweni ezi enzayim ayaziwa, ngoko ke engavakaliyo kunye indlela yabo yokusebenzela (izinga isantya unyango plasma, ezinye bioliquid kunye nezihlunu naziphi na izinto ngenxa ngokutsha zabo, biotransformation, ukupheliswa ivela emzimbeni).