Ithumba marker HE4: umbhalo. Iimpawu umhlaza ovarian kwabasetyhini

ngonyaka ngamnye, izigulane ezinomhlaza ziyanda. Oku kuhlaselwa engenalufefe nabani. Oosonzululwazi kunye noogqirha basazama ukujongana isenzeko kwenza umhlaza ze bafumane iindlela ezisebenzayo unyango. Ngelishwa, kwi zigaba yokuqala sifo nazimpawu. Izigulane ezininzi beze ugqirha kunye nezikhalazo, fumanisa ukuba zingqubane iintsizi ngalo ukuba alwe emva kwexesha. Ngenxa yoko, izinga lokusweleka ngenxa yomhlaza iphezulu. Kodwa izazinzulu baye bakwazi ukusondela le ngxaki. iintlobo ezininzi zomhlaza kungabonwa xa sisaqala, kanye ngexesha ukutyelela oogqirha kunye nokunikela igazi iimvavanyo. ubuchule Special laboratory avumela ingadibani igazi "Nezinto" yabantu -onkomarkery, kwenzeke ingxaki. Oku kukuvumela ukuba ubone esi sifo isaqala, nto leyo eza kwandisa nge izihlandlo eziliqela amathuba achache.

Ukuza kuthi ga ngoku, omnye lo mhlaza boyika olibhinqa - umhlaza ovarian. Yokufa kulo lelona liphezulu phakathi kwezinye ezinezigulo nobufazi. Musa ukuphaphazela. Ngapha koko, amisele ekuqaleni sifo inokuba nisaqala lokuyiphuhlisa kunye nokunciphisa imingcipheko enobungozi. ukufunda olukhethekeliyo igazi ubukho ithumba isiphawuli HE4 ukugcina engozini.

Izinto ezibangela umhlaza ovarian

Nika izizathu ngqo ukuba nangezilonda ovarian kwabasetyhini, akunakwenzeka. Kukho iqela lemiba ukuba bawaphikise Uphuhliso yamathumba:

• Utshintsho kwi kwisiqalo hormone. Amaninzi, kukho ukungalingani kwamadlala kwenzeka kwabasetyhini ngexesha ukuya exesheni. Ngeli xesha, ukwandisa inani hormone sex basetyhini emzimbeni. Ngenxa yoko, oku kunegalelo ukuvela yamathumba somhlaza, kuquka ovarian. hormone naye ukwenzeka, kwaye amantombazana kunye namabhinqa aselula. Ngoko ke, abantu imijikelo wokuya kufuneka sinikele ingqalelo ekhethekileyo kwimpilo.
• nemikhwa emibi. Wonke umntu sane uyazi ukuba ukutshaya, utywala, ukutya okungekho mpilweni - abancedisi ze zizifo ezahlukahlukeneyo. Akukho ngaphandle, kunye nomhlaza ovarian. Umzekelo, abasetyhini kakubi iimveliso eziqulathe amafutha olun, carcinogens, idayi kunye nezinye nezongezelelo eziyingozi waphawula emngciphekweni onkovracha.
• Inguqu esisigxina nabo ngesondo, ukuqhomfa. Ukuba abantu ashintshe iiglavu, ayengawenzi ngempilo yabo, ngoko ukubamba izifo, izifo ezidluliselwa ngeentlobano zesini, kulula. Kwixesha elizayo oku kuya kunciphisa amajoni omzimba asekuhlaleni kwaye, ngenxa yoko, xa kukuvela yobubi. ukukhulelwa okungafunekiyo inokuba wemiphumela ukulalana. abafazi abaninzi, engaboni enye indlela yokuphuma kwezisu. Olu ngenelelo ngoncedo ngotyando - a xi enkulu umzimba nemazi, nto leyo etshintsha intsalela hormone. Isiphumo - nenzalo, zomhlaza.
• Imisebenzi ku zamaqanda, ekhuthaza ukuyilwa iiseli Nedlac epithelial welungu.
• Imizila yemfuza. Izazinzulu lubonise iimeko apho ubukho zofuzo kwikhonkco DNA ikhuthaza imbonakalo yamathumba amabi ebantwini.
• Ithumba kwe isizalo amabhinqa amaxesha eyenzeke ngenxa nezinye izifo oncological.

Iimpawu zesi sifo

Kumanqanaba okuqala zomhlaza ovarian ukufumanisa cishe engenakwenzeka. kuvela Iimpawu xa sifo wambetha umzimba nzulu. Eyona engundoqo iimpawu zomhlaza ovarian kwabasetyhini:

• ukuphazamiseka kokuya;
• Ukuchama rhoqo;
• ngokucinezela imvakalelo esiswini asezantsi;
• nokuqaqamba intlungu isizalo;
• iingxaki nge defecation;
• ukungakhululeki, ubuhlungu xa neentlobano.

Lwezi Mbonakaliso sifo ayikwazi kuqwalaselwa ezithile umhlaza ovarian. Ngoko ke, ukuze uphephe le ntlekele, kuba utyelelo kunyanzelekile ngumbelekisi.

ekuxilongweni

Nokuhlola yesiqhelo esitulweni yamanina uya kumisela utshintsho kubume ovarian. Ukuze uqinisekise uxilongo lokuqala isigulane sibhekiswe ukwenza iqela lezifundo instrumental:

• iimviwo ultrasound amalungu esini;
• biopsies zeethishu ukumisela ubume ngumhlaza;
• MRI - indlela ngawo lizwe kunye nemida yamathumba bubonakala iinkcukacha;
• -X-reyi kwaye nesisombululo umahluko kwakhona kuya kwenza ukuba ubone indawo nethumba.

Kwakhona, kuba lokufunyaniswa izigulane ezinomhlaza ovarian wathumela ukuba uvavanyo lwegazi, leyo ukubona ubukho amakishayo ithumba. Xa ingqalelo kugweba ubukho besi sifo. Ukuze ubone lokuphumelela igazi umhlaza ovarian ekubhaqeni amakishayo ithumba ezimbini - CA125 kunye HE4. Kutshanje Uhlobo yokugqibela ngummakishi sele iqalile ukuchaza, kodwa ibonisa kakhulu nangokuchanekileyo ukuqhubela phambili kwesifo.

Yintoni HE4?

Ithumba - into ethile, oqala ukuvelisa ephilayo kunye izitshanguba naliphi ithumba omzimba. Kwakhona, amagosa amakishayo can be yenziwe ngumntu oluqhelekileyo usempilweni, kodwa ukuba andise ukufumaneka beengcali umhlaza zibone- babukele ukuba iqukuqele.

HE4 - ithumba isiphawuli umhlaza ovarian kwabasetyhini, iveliswa hi mpimo lowutsongo emzimbeni ukugcina umsebenzi esempilweni nokomzimba. Ukuba epithelium achaphazelekayo zomhlaza ovarian, xi okuneproteni ethile liphume.

Ngaphambili, ukuqinisekisa uxilongo, "umhlaza ovarian" kusetyenziswa CA-125 elimakishayo, leyo ugqibe uvavanyo kwegazi ethile. Kodwa le ndlela ayisebenzi, ngokuba xi le elimakishayo ukwandisa nezifo non-neoplastic okanye yamathumba zeminye imibutho. Kumanqanaba serum ye CA-125 abe phezu 3 okanye isigaba 4 sifo. Kumanqanaba okuqala kwesi sifo ukuba kusetyenziswa lo omakishayo ngathi akunakwenzeka. Amaninzi, umgangatho "CTLI" ngakumbi xa ukubonisa iimpawu kwezonyango zomhlaza ovarian kwabasetyhini.

HE4 has a Okukodwa ephakamileyo (95%) kunye novakalelo (76%) xa kuthelekiswa CA-125. Kukho izifundo eziye abonise ukuba abasetyhini kunye izinga igazi HE4 elimakishayo CA-125 uhlala eqhelekileyo. Ngoko ke, ngokuba ukuqingqwa umhlaza ovarian kusekwangoko kungcono ukusebenzisa, nto leyo ebonisa indlela HE4.

Ngokuba iziphumo ukuba ipesenti enkulu okuchaneka, iingcali ukuchaza nje ezimbini marker ithumba (CA-125 kunye HE4). Emva koko sebenzisa algorithm ekhethekileyo lwezibalo kungenzeka ngakumbi ukuvumela ukuba bathethe malunga nophuhliso iinkqubo oncological kwi zamaqanda. Okukodwa nobuzaza yale ndlela kwandisa kumaxesha amaninzi (ukuya kwi-96%).

Ithumba marker HE4: abafazi eziqhelekileyo

Ukuxilonga, ezijolise kuphela kwiziphumo zohlalutyo, nto leyo ebonisa ukuba HE4 ayamkelekanga. Kuba isebenzisa diagnostic nje izixhobo ezibanzi uhlolo Indlela kunye neendlela zokwenza isigqibo uvavanyo zabamakishi ithumba. Kuhlalutyo, kuya kumiselwa amakishe umhlaza ovarian kufuneka kuboniswe, kwenzeka kwabasetyhini ukuya exesheni okanye hayi, njengoko Uludwe lamaxabiso amabhinqa ukuya exesheni ngasentla.

Xa abafazi phambi koku- HE4 isalathisi kufuneka ibe ngaphantsi kwe-70 pmoles / ml.

Lo mfazi kubanjwa exesheni, inqanaba HE4 kuyinto eqhelekileyo xa zabonisa 140 pmol / ml.

Ithumba marker HE4: yombhalo

Kodwa nantsi eyona nyaniso. Ukuba HE4 ithumba umaka eziphakamileyo, libonisa kukuvela somhlaza epithelial ovarian. wazi nje ukuba ezinye iintlobo zomhlaza we zamaqanda (umzekelo, mucinous) isixa-serum HE4 siyongezwa.

Le xi aphezulu HE4 akusoloko kubonisa zomhlaza ovarian. Ngamanye amaxesha inqanaba le elimakishayo kwaphakanyiswa ukusilela kwezintso, umhlaza wemiphunga, endometrial, kidney abanesigulo.

alungiselelwe ukuba uhlalutyo kwakhona kuchaphazela umgangatho isiphawuli egazini.

Ukulungiselela ukuhlaziya

Ukuze ubone ithumba igazi isiphawuli HE4 losana apho iphuma khona of wazila. Ngoko ke, ngaphambi kokuba isandla phezu kuhlalutyo, iiyure ezili-12 phambi kokuba inkqubo akakwazi ukutya okunamafutha, utywala, ziilekese, inyama, awukwazi ukutshaya. Ngosuku analysis ndingasela amanzi kuphela imali encinane.

isiphelo

Ukubeka Uxilongo oluchanekileyo kunokuba kuphela ngugqirha, sithembele data evela iintlobo noxilongo. Ukuze siphephe iingxaki zempilo, ukufumana umkhwa ukuba kanye ngonyaka itshekhi-ups. Ngapha koko, ukuba uyazi ukuba yintoni na isempilweni - kuba nanto.