Yintoni "Lyrics" tablet? Ukusebenzisa amanani

Medicine "lyrics" (amacwecwe), ixabiso ovela engange 700 ukuya 4000, -. Ngokwaneleyo ezaziwayo-kakuhle iziyobisi. into esbnzyo - pregabalin - analog gamma-aminobutyric (Gaba) acid (Gaba). Kamva kweli nqaku liza kunikwa ukuvula ukuba amayeza. Makhe sibone ukuba yintoni iipilisi "ezipheleleyo 'usebenzisa izigulane.

indlela isenzo

Pregabalin liveza ukusebenza kwayo ukunyanga peripheral seswekile kunye neuralgia postherpetic, apho iipilisi "lyrics" isantya emiselweyo ukuya kwiiveki 13 ngezinga lwamkelo imihla amaxesha 2 ukuya kwezingama-8, ka-3 ngosuku. Ngokuchasene yangasemva uphuhliso indlela lubonise iziphumo ebezingalindelekanga efanayo. Ezinxulumene udinwe ngokucacileyo ukuncitshiswa obonakalayo iimpawu iintlungu Point ngexesha uthatha ngokwemithamo lwemithi 300-600 mg ngosuku. idosi yemihla ngemihla ka 450 mg kunye 600 mg singachasaniswa yokufaneleka, kodwa yokugqibela kunyanyezelwa kangako kakuhle. Ichiza kunciphisa ubungqongqo sokuwa, apho iipilisi "lyrics" bacebisa ikhosi kwiiveki 12, ka-2 okanye ama-3 ngosuku. Ngexesha yokwamkela kwenzeka indlela efanayo yeziphumo ebezingalindelekanga kunye nokusebenza ichiza kule idosi. sokuwa frequency iqala ukunciphisa sele kwiiveki zokuqala zonyango. Symptomatology of ngokubanzi ixhala disorder ubonisa umkhwa ehle kwiintsuku ezisixhenxe zokuqala zonyango. Emva kweeveki ezisibhozo 52% kwizigulane iziyobisi abafumana pregabalin ne-38% ezigulane abafumana placebo, wabonisa ukuncitshiswa 50 ekhulwini iimpawu ze-Hamilton isikali (ham-A).

Pharmacokinetics

Le medicament "lyrics" (ekhompyutheni) - Umsebenzisi iyakungqina oku - ngokwemithamo nsuku kunye pharmacokinetic kwicala linearity ebonakala, ephantsi (<20%) Ukwahluka interindividual. isicelo okuphindiweyo le pharmacokinetics beziyobisi linakho ukuqikelelwa ngokusekelwe iyunithi lwe data balawule. Ngoko ke iliso uyondelelwano lwee- isithako esebenzayo rhoqo akuyomfuneko. Pharmacokinetic Ipharamitha iziyobisi "ezipheleleyo 'e ntliziyo esempilweni, izigulane sokuwa abafumana unyango antiepileptic, kwakunye kokufumana ichiza ngenxa abathintela syndromes iintlungu ziyafana.

Absorption nokuba kubulawe

Emva kokuthatha kwi isisu pregabalin engenanto ako ngokukhawuleza kakhulu. emva kweyure enye, plasma Cmax iphunyelelwe njengoko xa isicelo okokuqala, yaye ngokuphindaphindiweyo. Ngomhla imvelaphi bioavailability yomlomo pregabalin yi kwi ≥90% kwaye uzimele umthamo. Lizama yimpumelelo xa ezama iyaphindwa kwisithuba seeyure 24-48. Ukuba ichiza isicelo emva kwesidlo, i Cmax ukuze kungancitshiswa ngama- 25-30% nokwandisa ixesha layo mpumelelo iiyure 2.5. Nangona kunjalo, akukho isiphumo ngokwezonyango ebalulekileyo kukufakwa ichiza zange abe izidlo. Ngokomthetho ichiza idubule yi izintso ingatshintshanga. T1 / 2 avareji iiyure 6.3.

Pharmacokinetics kwiimeko ezizodwa

Ukuba sengozini umsebenzi kwezintso, oko kuyimfuneko ukuze bakuthathele ingqalelo peculiarity of ukucoca pregabalin, kuba umlinganiselo ngqo yokususwa creatinine. Ngokomthetho ichiza idubule yi nezintso, ngoko kuyimfuneko xa besaphula imisebenzi yawo kukunciphisa idosi. Ngaphandle nezintso, lo medicament lungasuswa ngempumelelo ukusuka plasma ngu olugqitha esikhumbeni (iseshoni ihaemodialysis iiyure-4 inika 50% ukwehla xi kweziyobisi plasma) kunye nedosi ukuqeshwa neziyobisi ngoko kunqweneleka ngakumbi. Uphononongo eyodwa pharmacokinetics zee-arhente "ezipheleleyo 'xa izigulane umsebenzi kwesibindi kakuhle azikhange kuqhutywa.

Pregabalin umzimba phantse ayengaseleki, iyavezwa kunye nomchamo ekwimo ingaguqukanga, kunjalo umsebenzi isibindi kakuhle ayikho kakhulu kuchaphazela ukufumaneka beziyobisi plasma. Xa ichiza anikwe izigulane kwiminyaka engama-65 ubudala, kufuneka sikhumbule ukuba ukhulile kugqitywe Pregabalin kuyaphela bunciphe. Ukuba umntu abadala lehla ekusebenzeni kwezintso, oko ukuncipha imfuneko ithamo amayeza emiselweyo.

balawule

Isixa ngemihla yokulungiselela kuchaziwe 150-600 mg ngosuku. Ukwamkelwa wenziwa kabini okanye kathathu amaxesha, kungakhathaliseki ukuba ukutya. Le medicament "lyrics" (tablets) yesikhokelo incoma ukuyihamba kunye neentlungu neuropathic kwi mg 150 ngosuku. Ukuba isiphumo iphunyelelwe kwaye tolerability entle ngeveki enye idosi yemihla ngemihla ukuze kwandiswe ku 300 mg (ityumbe "lyrics 300" tablets). Ukuba kuyimfuneko, idosi iphezulu 600 mg ngosuku maliqhutywe emva kweveki enye. Ngokufanayo kubalwa ithamo kwi unyango ukuxhuzula. Njengoko kukhankanyiwe ngasentla, bubulumko kweziyobisi ngenxa yonyango udinwe, leyo amacwecwe "lyrics" ibhalwa umthamo we-75 mg ngosuku ngeedosi ezimbini. Ekwandiseni ithamo ku 300 mg kuchaphazela isiphumo iphunyelelwe kwaye tolerability. Ukuba akukho nemiphumo emihle, ukwandisa ithamo ku 450 mg, kwaye xa kukho imfuneko - iveki enye ukuya 600 mg. Phatha ngokubanzi ixhala disorder siqale ne nedosi ye-150 mg. Kwakhona ngeveki, ukugcina isiphumo iphunyelelwe kwaye tolerability, idosi yemihla ngemihla landile ukuya 450 mg, yaye emva kweentsuku-7 - up to 600 mg (ukuba kuyimfuneko).

ukususwa ichiza

Ukuba kuyimfuneko, ukupheliswa unyango kucetyiswa ukuba wenze oko ubuncinane ngeveki ukunciphisa umthamo. Izigulane ezisanda kakuhle umsebenzi kidney, wenziwe ukhetho ngamnye amathamo. Kwimeko apho iziphumo ezibi kakhulu izigulane abafumana lithetha "Lyrics" ipilisi-ezilingana ikhetha ingcali. Phakathi ndlela eqhelekileyo ukususela efanayo kuchazwe iziyobisi "Mydocalm" "Apizartron" "Sedavit" "Ambene".

ubungqina

Amayeza kuyacetyiswa lokuphelisa intlungu neuropathic, njengoko kunyango adjunctive ngenxa uxhuzula buso yexhuzula, ukuba zihamba okanye ezingahambi gabalala eziziisekondari. Iindlela eboniswe nexhala disorder nolahlo ngokubanzi indalo, ngokunjalo nomzimba udinwe.

Izimo

Akukho data kwi ngokusetyenziswa kweziyobisi abantwana abafikisayo iminyaka ukuya ku-17 ebandakanya wonke. Malunga nalo iyeza yabelwa kuphela abadala. Izimo ziquka izifo ilifa njengoko galactose ukunganyamezelani, yelactose izivuka, kwakunye malabsorption glucose / galactose. Esi sixhobo hayi eboniswe hypersensitivity. Ukugcina ukusetyenziswa ngenyameko beziyobisi izigulane ukusilela kwezintso nentliziyo.

imiphumela emibi

Ngokutsho amava lwesicelo kwezonyango medicament, xa ukozela uphawu kunye nesiyezi njengokuba neziphumo ezingathandekiyo. La akholisa ukubakho okukwiqondo eliphakathi okanye ethambileyo. Phakathi kwezinye ziziphumo ebezingalindelekanga kubangele ukupheliswa unyango ngamachiza, kufanele kuphawulwe asthenia, ukudideka, ukungaboni, incoordination, Ataxia, nokudumba neuropathy. Kwakhona phakathi neziphumo ezibi waphawula intloko ebuhlungu, ilahleko osezingqondweni, ukuxhuzula, ukudumba ulwimi, urhudo, isicaphucaphu, keratitis. Kunqabile ukuba ulusu silume kunye indlela angioneurotic. Kukho ukugcinwa wokuchama, nokudumba yemiphunga nezengekho gynecomastia. Phakathi kwezinye ziziphumo ebezingalindelekanga kuthiwa ukudinwa.