"I-Cardiomagnet": ukuchasene, izibonakaliso, ukusetyenziswa

Isilwanyana "iCardiomagnol" sibhekisela kwiqela lee-pharmological agents ezineempembelelo ezichaziweyo. Iqukethe i-acetylsalicylic acid njengesithako esisebenzayo. Le nkunkuma isetyenziswe kwisenzo seklinikhi iminyaka engaphezu kwe-130 kwaye isiqinisekisile ukusebenza. Ngokumalunga nokunyuka kwenani leenhliziyo kunye neengcambu ze-vascular kwi-overall disease and mortality, imibutho yamazwe ngamazwe e-cardiologists (i-European Cardiac Society kunye ne-Conservative American Heart Association) icebisa ukusebenzisa i-acetylsalicylic acid i-cardioforms njengeziyobisi ezikhuselekileyo.

Ukubaluleka kokusetyenziswa kwabo kubangelwa ukwehla okukhulu kwenani leemotocardial infroction and brain in the presence of an atherosclerotic lesions of vessels. Ngokufanayo, ukusetyenziswa kwe "Cardiomagnola" ngesifo somlenze we-varicose kulungile. Oku kunciphisa umonakalo we-thrombosis yamasebe e-pulmonary artery kunye ne-pelvis encinci. Ngoko ke, nayiphina i-aspirin cardioforms inezinto ezininzi ezintle zesicelo kuneziphumo ezibi.

Ubume beNkqubo

Umyalelo othi "I-Cardiomagnal" imigaqo malunga nokusetyenziswa kweenkcazo zokuchasana ngokubanzi ngokunokwenzeka. Esi sisisixhobo samanje nesiphakamileyo, esiyimfuneko ngokwenene ekliniki. Inokuhlawuleka kwaye kufuneka isetyenziswe ngokuqhubekayo, ukuba impilo yesigulane iyayivumela.

Njengoko isithako esisebenzayo, i-acetylsalicylic acid isetyenziswa. Isisombululo esinamandla sokuthintela ukuhlanganiswa kweplatelet kunye nokuqala kokubunjwa kwe-thrombus yindlela ebalulekileyo ekukhuseleni imicimbi ye-coronary acute. Kule meko, izilwanyana "iCardiomagnesium" ingqinisiso ngenxa yokusebenzisa i-membrane yefilimu ye-enteric kwaye i-cytoprotector ishintshile kakhulu kwinqanaba lokunciphisa xa kuthelekiswa nokuqala, i-ACS ye-gastric-soluble cardiac heart.

Iimpawu zokusetyenziswa

Kwisiza "Cardiomagnesium" ukuchaswa ngenxa yefom e-soluble engabalulekanga, nangona oku kungabonakaliswa kwinani lezibonakaliso. Oku, njengama-cardioforms esisisu, isetyenziswe kwezi ziko zilandelayo:

• Nge-infarction ephawulekayo ye-myocardial kwisigaba sokuphakama kwesigaba se-ST kwaye ngaphandle kwayo;
• Nge- angina engaqinisekanga yongxamiseko kunye nexesha elide lokunyanga;
• Nge- stroke ye-ischemic kwixesha elibi kwaye lilandelelana, kunye nexesha elongezelelweyo lonyango;
• Ngokuhlaselwa kwe-ischemic kwangoko kwexesha elide lokonyango;
• Ekukhuselweni kwe-myocardial infarction, xa isigulane sikhathazekile nge-angina pectoris;
• Ukuthintela ukubetha kwe-ischemic kwimvelaphi yokuhlaselwa kwe-ischemic;
• Ngesifo se-varicose esibuhlungu besifo se-pelvis kunye namalungu angaphantsi;
• Kwiprophylaxis ye-thrombosis ye-Shunts emva kwe-CABG, i-BPSH;
• Ekubeni kwesoxinzelelo segulane kwizigulane ezinomngcipheko we-cardiovascular risk.

Isibonakaliso sokugqibela sifuna ukuqeshwa kwesilwanyana "iCardiomagnolo", ukuchaswa kwezinto ezingabalulekanga ngaphezu kweempembelelo zonyango. Ekubeni kwiyiphi na iimeko zeklinikhi ezichazwe apha ngasentla kweziyobisi zinokubaluleke kunokuba zenzeke okanye zilimale, zibhekwa njengokukhuselekileyo kwaye zicetyiswa phambi kweengozi zokuphuhlisa i-infarction, i-myocardium okanye i-pulmonary artery thrombosis kunye neenqwelo zokuhamba.

Ukungqinelana

Nangona ubukho be-intestinal-soluble ifom yezilwanyana "Cardiomagnum", kukho ukuchasana kumachiza okufanayo. Ziquka imiqathango apho ukusetyenziswa kwe-acetylsalicylic acid kubonakala kunobungozi kunokuba luncedo. Kwiimeko ezinjalo zekliniki, "iCardiomagnolo" ingathatyathwa yinto efana neklasi - isiluleko seClopidogrel. Ukungqinelana oku kulandelayo:

• Ukuphazamiseka kwe-clotting yegazi (i-hemophilia, i-diematic i-diathesis, i-thrombopenia);
• Izifo ze-Organic zesisu (ukuguguleka, izilonda ezinzima ze-duodenum, izilonda ezinzulu zesisu, naluphi na ukuphuma kumgudu wokutya);
• Ukukhulelwa kwimizi yokuqala neyesithathu;
• Umbuso weectation;
• Ukuxakeka okukhulu kwe-hepatic ne-creinine imvume engaphantsi kwe-30 ml / min;
• Ukuhluleka kweengso (kule meko kwilisiza "iCardiomagnolo" izibonakaliso kunye nokuchasana zichongiwe ngabanye);
• Ukuphendulela kwezilwanyana kwi-salicylates;
• I-asthma yeBronchial kunoma yiphina isigaba seklinikhi kunye neqondo lokubonakalisa;
• Unyango nge methotrexate;
• Ubudala ukuya kwiminyaka eyi-18.

Iimpembelelo kunye neziphumo ezidibeneyo

Kungokwemvelo ukuba malunga naliphina iilisi zineziphumo zonyango kunye nemiphumo emibi. Isiqalo esifanayo sisasebenza kwi "Cardiomagnolo" ithuluzi. Ukungqinelana, iimpembelelo kunye nokuzikhethela kokusetyenziswa kwayo kufuneka kube yinkqubo yokumisela xa ugunyazisa iyeza kumguli. Isiphumo esibi kakhulu esiyingozi kakhulu ukuphazamiseka kokuveliswa kweeseli zesisu ne-intestinal epithelium enomngcipheko wokwanda kweembrane kunye nezilonda ngokuphuma kwegazi ukusuka kwiphepha eliphezulu lesisu.

Ubungozi bomonakalo esiswini kunye namathumbu akhula kunye nokusetyenziswa ngokufanayo kunye neziyobisi "Methotrexate" kunye nezinye i-cytostatics. Zonke ezinye i-NSAID zandisa imiphumo yesigqirha esicatshulwayo kwaye ayikhuthazwa ukuba isebenzisane ngokubambisana nayo.

Isilwanyana "Cardiomagnolo", ukusetyenziswa kunye nokuchasene noko kuhambelana, kunokunyusa ukuphulwa kwemisebenzi yesibindi, ukuba isigulane sisebenzisa utswala ngexesha lonyango. Kwakhona kunokwenzeka ukuba kuphuhliswe i-allergy to salicylates. Iziphumo eziqhelekileyo ezibangelwa yi-bronchospasm, ukuphuma kwegazi, intloko, ukulala. Ubonakaliso obunqabileyo bungabizwa ngomsindo ezindlebeni, utyumbe, ukulala. Ubunokwenzeka bokuthi utyhefu yiziyobisi kuphela kwimeko yokuthatha enye iipilisi ezingama-60 okanye ngaphezulu ezingama-75 mg.

Ifom yenqanaba

Iyeza "iCardiomagnolo" (ukuchasana kunye nemiphumo ecaleni ibhekwe ngasentla) ibhekisela kwizidakamizwa ezikhuselekileyo zisesimweni ngenxa yobungqina bengubo. Kukho nakweminye iminye imichiza efana nale, njengoko le meydi eyaziwayo ye-pharmacological ifom ye-gastric-aggressive form. Imveliso ifumaneka kwiipilisi ezenziwe ngendlela yentliziyo.

Ukubunjwa kunye nesilinganisi

Isilwanyana sifumaneka kumlinganiselo omgangatho we-75 no-150 mg. Ziyalelwe ngokuxhomekeke ekunyamezelweni kwe dose kunye nemeko yeklinikhi. I-dose esetyenziswa ngokuqhelekileyo ingama-75 mg. Kunconywa ukwamkelwa kwexesha elilodwa emva kokutya ngokulandela izibonakaliso ezichazwe ngasentla.

Ithebhulethi iqukethe i-acetylsalicylic acid 75 mg, i-magnesium hydroxyde 15.2 mg. Ukongezelela, kukho izinto ezincedisayo kwi-composition: i-magnesium stearate-150 μg, i-microcrystalline cellulose-12.5 mg, isitashi sommbila - 9.5 mg, isitashi somthamo - 2.0 mg.

Zonke iingongoma ezibalulekileyo malunga nokulawulwa kweziyobisi "iCardiomagnolo" (ukungqiniswanga, ixesha lokumkelwa, ukufumana iziphumo ezibi kunye nokulawulwa kwazo), kufuneka kuthethwe ngudokotela oya kwiindawo. Ukutyunjwa kwedoloji kunye nokulawulwa kweyeza kulawulwa yi-cardiologist okanye umgqirha.

Uphononongo lweengcali malunga nokulungiselela

Kubalulekile ukucacisa ubunani beenkcukacha zeenkcukacha eziqinisekisa ukufaneleka kwesilwanyana. Ngoko ke, zonke i-cardioforms, kubandakanywa nezondlo, ukunciphisa ukufa kwabantu ngama-16% phakathi kwezigulane ezinobungozi obuphezulu benhliziyo. I-Acetylsalicylic acid iyanciphisa amathuba okuba i-thromboembolism yamarriyamu yamapulmoni kunye nokushaywa kwe-ischemic ngekota.

Kwakhona, "iCardiomagnum" inciphisa umngcipheko we-thrombosis ebalulekileyo ye-pelvic kunye neephantsi kwe-29% phambi kweemvini ze-varicose. Eyona nto ibaluleke kakhulu kukunciphisa ukunciphisa ubuncipheko be-myocardial infarction phambi kwayo nayiphi na uhlobo lwe-cardiac ischemia engapheliyo. Yonke le miphumo inokunyusa ukulindela ubomi kweso sigulane esinomngcipheko wokuhlaselwa kwesifo senhliziyo yengqondo kunye nentliziyo. Kwakhona, i-40% ye-cardioforms ye-acetylsalicylic acid iyanciphisa umonakalo we-thrombosis we-shusts kwanoma yimuphi umsebenzi wokuhlaziya.

Ukujonga iimpawu zeengcamango zezigulane

Ingxelo yezigulane malunga neziyobisi ayisoloko ibonisa, kuba akukho ndlela esheshayo yokufumanisa ukusebenza kwalo myeza. Ngoko ke, umntu onikwe "uCardiomagnola" amiselwe kufuneka athembele kwiingcebiso zegqirha. Eli liziyobisi elikhuselekileyo ngokuqhelekileyo, kunye nokusetyenziswa okufanelekileyo kweziphi iziphumo ezicuthayo ezincinci. Nangona kunjalo, uhlalutyo oluqhubekayo lweengxelo zezigulane lufakazela ukuba "iCardiomagnum" ixhomekeke kangcono kunanoma yiphi i-cardioforms yesisu.

Izixhobo zoMsebenzi

Ukuqwalasela ukubonakaliswa kweengxelo ze "Cardiomagnolo", ukuchasana kunye nobubanzi befuthe lokunyanga, ugqirha uya kuncomela umyinge unyango. Ngokuqhelekileyo, ngokubhekiselele kwiziphakamiso ze-ESC 2014 kunye ne-AHA 2014, i-75 mg isetyenziswe. I-150 mg ye-acetylsalicylic acid isinconywa kwizigulane ezinomlinganiselo ophezulu kunye nobubanzi (i-stenoses ewandisiweyo) yeemithariyali ze-coronary.

Isiza kufuneka sisetyenziswe ngokuqhubekayo kwaye, ukuba imeko yeklinikhi iyimfuneko, ikhutshwe kancane kancane ngenxa yokuba kunokwenzeka ukuba i-thrombosis eqaqambileyo kwiintsuku ezilishumi zokuqala ukwenqaba ukungena. Ngokweziphumo zezifundo ezininzi ze-pharmacokinetics kunye ne-pharmacodynamics ye-asidi, inqabileyo kakhulu ithathwa njengokwamkela emva kokutya nge-1.5 iiyure ngaphambi kokulala.