"Quinidine": imiyalelo ukusetyenziswa, ukwakheka, inkcazo kunye nohlolo

Kutheni kufuneka sibe isixhobo ezifana 'quinidine'? Imiyalelo yokusebenzisa, ixabiso, kunye nohlaziyo ukuqeshwa ichiza zithiwe thaca apha ngasezantsi. Kwakhona uya kufunda ukuba yintoni na iimpawu amayeza uphawu ichiza, nokuba kwicala isenzo kwesimilo kunye ingaba unazo naziphi na izithintelo zokusetyenziswa.

Ekwakhiweni, imilo, inkcazo

Ziziphi uhlobo iinkampani ezixuba amayeza ukwenza iziyobisi 'quinidine "? Imiyalelo Sebenzisa, eqhotyoshelwe kule ndlela, kukuba zingathengwa ngokohlobo amacwecwe tyaba kwaye ngeenxa zonke. Zinelungelo isiphumo elide kunye bhanya-camera.

Eyona nto iphambili yale yeza quinidine sulfate. Imiyalelo, lencazelo akuthethi ukunika nayiphi na ingcaciso izinto ezongezelelweyo.

Imithi Pharmaceutical Products

Yintoni iipilisi 'quinidine "? Imiyalelo yokusebenzisa, inkcazo, ncomo baxele ukuba isicombululo Class IA arrhythmia. Oku uyakwazi ukwehlisa ukuthuthwa ion ngeetshaneli Na ezindongeni nkqi cardiomyocytes nokunciphisa isantya umda depolarization nokwandisa ixesha okunamandla intshukumo kunye eliyinjubaqa (ngempumelelo) ubude bexesha.

Yokwamkela medicament attenuates excitability engabalulekanga, ukucola ukuzenzekela kunye AV-Uhanjiso kwiindawo, bundle block isebe, atrial kunye nezinye izakhiwo. indlela Kwakhona koqwalaselo ukusebenza vagolytic ubonisa ukusebenza m-anticholinergic, kunciphisa umsebenzi (contractility) kwemisipha sentliziyo ibangela ukwehliswa uxinzelelo lwegazi.

iimpawu ichiza

Yintoni ephawulekayo na iyeza njengoko 'quinidine'? Imiyalelo yokusebenzisa ithi ukuba ube nefuthe elibi inotropic. Oku kwenzeka ngenxa yokuba deceleration zangaphakathi inkqubo conversion samandla mitochondria. Ngokuphathelele iimpawu antiarrhythmic beziyobisi, ukuba zinxulunyaniswa ubukho kumaqela amide kulwakhiwo molecule into esebenzayo.

Ngokutsho iingcali, ukuthathwa le medicament nto ngokubonakalayo kunciphise excitation kwaye andise uqina, nto leyo ehambisana ne ukungakhuseleki icandelo kweziyobisi esebenzayo kwinkqubo depolarization.

Abathintela ezenza m-cholinergic, ingqalelo ichiza ivuselele AV-Uhanjiso. Maxa amathamo zonyango liveza iipropati iqinile ezinxulumene ne ngokunciphisa ithoni imithambo peripheral kunye yegazi, kwakunye nefuthe elibi inotropic.

Asikwazi ukuba eli chiza uyakwazi ukubonisa isiphumo kukucaphukisa yasekuhlaleni. Kwakhona unalo iintlungu kunye antipyretic iimpawu ezi zinto zinxulumene nempembelelo ngxelo imbi kwi ebuchotsheni.

Ezona mpawu pharmacokinetic of

Wendele nokuba njengempembelelo esebenzayo yale neziyobisi quinidine sulfate? Imiyalelo yokusebenzisa yazisa ukuba yokwamkela-arhente ngomlomo ikhuthaza xi kakhulu zalo egazini emva kwemizuzu 95.

Reaction yalo kunye iiprotheni medicament imalunga 77-80%. biotransformation lwayo lwenzeka esibindini. Noko ke, ezinye avela endiyibumbileyo inyathelo cardiotonic.

Isiqingatha-ubomi esi sixhobo nama-7 iiyure. Kuye imizi nezintso. Xa Ukuba muncu umchamo zinomgutyulo medicament uyanda kwaye xa alkalization yayo - elinganeno.

Ukususela oko kumiselwe?

Zintoni ezibonisa ukuba ukusetyenziswa kwe-chiza "quinidine"? Imiyalelo Sebenzisa ithi injongo ichiza bugwetyelwe kuphela kwezi meko zilandelayo:

• e atrial tachycardia, AV-tachycardias, extrasystoles ventricular kunye supraventricular, ukuhlaselwa fibrillation atrial enomoya;
• ukuthintela ukuhlaselwa tachycardia (supraventricular kunye ventricular), kunye ventricular fibrillation;
• emva kokuba cardioversion ukugcina sinus isingqisho.

Siphelisa ukusetyenziswa

Yintoni imeko yomguli ukuthintela ukusetyenziswa iyeza "quinidine"? Imiyalelo zokusetyenziswa (ixabiso amayeza ezidweliswe ngezantsi) iingxelo Izimo beziyobisi, ezifana:

• yashiya cardiogenic;
• AV-block (isidanga yesibini okanye eyesithathu);
• purpura thrombocytopenic, awathi emva ezithatha ichiza;
• disorder (elimandundu) Uhanjiso intraventricular;
• bundle block isebe;
• digitalis ukunxila, nto leyo sikhatshwa ezingaqhelekanga Uhanjiso;
• i uxabane ukuba ichiza;
• myasthenia gravis.

Medicament "quinidine": imiyalelo yokusebenzisa

Yamkela i sixhobo kufuneka sibe ngaphakathi kwimizuzu engama-60 phambi okanye emva kwemizuzu 125 emva kwesidlo kunye iglasi ezele ngamanzi. Ukuba ufuna ukunciphisa isiphumo esahlala beziyobisi phezu inwebu kwiinwebu phecana wokudla, kuyimfuneko ukuba indawo amanzi kunye nobisi.

ichiza elide ayikhuthazwa ukuhlafuna okanye eyo.

Umthamo standard igqalwa 200-300 amacwecwe mg kane ngemini. Ukuba tachycardia supraventricular (kunye paroxysms) esi sixa banda 400-600 mg qho kwiiyure ezi-3 phambi kokuba ukukhululeka ngokupheleleyo paroxysm. Xa fibrillation atrial, medicament abafumana 200 mg zonke 2 chasa (5-8 amaxesha yonke imihla). Apho ithamo yesondlo 200-300 mg kane ngemini.

Iirejimeni ezizezinye: 400 mg (ukuba ukuhlasela zange zimi, i-200 mg) yonke imizuzu engama-60 de ukupheliswa ngokupheleleyo ehlaselwa, okanye ukuphumeza idosi abayi-1 g

Xa engekho ziziphumo ebezingalindelekanga emva kwedosi yokuqala yokwamkela elandelayo isixa medicament ukuba lenyuke ku 600 mg. Ukuthatha ichiza elingaphaya grams 4 ngosuku akuvumelekanga.

Nomthamo abantwana

Xa ithamo amayeza emiselweyo abantwana "Dyuruls quinidine"? Imiyalelo yokusebenzisa, oogqirha babantwana ratings uxele ukuba idosi eqhelekileyo yale arhente iintsana 6 mg / kg izihlandlo ezi-5 ngosuku. Prescribers kufuneka ibe kuphela ngugqirha onamava, ngqongqo yesingqino.

Iintshukumo ngu-lomsebenzi

Yiyiphi imiphumo emibi kunokwenzeka emva ukusebenzisa iziyobisi "quinidine Durules"? Imiyalelo yokusebenzisa, inkcazo kweli chiza kubonisa abasabela ezibi zilandelayo:

• asthenia, nokwandisa interval QRS, myasthenia gravis;
• ethunjini beats ventricular, ubuthulu;
• ukungabi namdla, fibrillation ventricular, thrombosis esimbaxa, uxinzelelo lwegazi asezantsi;
• ukuphazamiseka ezibonwayo, ventricular tachycardia, paroxysmal, ukuduma,
• asystole;
• isicaphucaphu, sinus bradycardia, hepatitis, iintlungu esiswini, ukudideka;
• gastralgia, intloko ebuhlungu, ukugabha, thrombocytopenia, urhudo, isiyezi, igazi hemolytic;
• fever, lupus-ezifana syndrome, irhashalala.

amacala libanda

Ziintoni iimpawu libanda kunokubangela amayeza "Dyuruls quinidine"? Imiyalelo, izimvo kwiingcaphephe bethetha izinto ezifana ukuduma, ukudandatheka umsebenzi kwentliziyo, ukuhla uxinzelelo lwegazi, isiyezi, enomoya atrial, diplopia, quinidine othukile, kuzwa.

Ukuze ukususa ithi abachaphazelekayo emiselweyo lavage esiswini, ioksijini, ii-arhente unesifo, isantya, ihaemodialysis kunye mpilo.

imithi

Indlela yokuphatha ichiza esinxibelelana ekhobokisayo njengoko umkhwinini? Imiyalelo zokusetyenziswa (nokubuyekezwa ixabiso medicament iza kwenziwa ekupheleni nqaku) bachaza ukuba olu dibaniso kwandisa ubuthi zombini.

Kwakhona, "quinidine" iipilisi basebenzisane amayeza zilandelayo:

• iziyobisi Antiarrhythmic ukwandisa amanyathelo cardiodepressive.
• Anticholinesterase iziyobisi amayeza ukuphucula iziphumo kalisodergaszczye "Quinidine".
• iziyobisi Anticonvulsant ekunciphiseni amanqanaba igazi "Quinidine" nokunciphisa ukusebenza yayo ngenxa ukukhuthazwa ukutya kwayo.
• Laxatives ukunciphisa ukusebenza kunye lwee- ichiza egazini phantsi ngokutsha.
• Imithi alkalising umchamo, kwandisa umngcipheko basabele ezinetyhefu.
• Iziyobisi "amiloride" yaye "Amiodarone" ukunciphisa ukusebenza "Quinidine" kwaye wenze bude interval QT wayo, ngokulandelelana.
• Acetylsalicylic acid liphela ukopha, petechiae kwaye ikhuthaza opha izitho zokugaya.
• Imithi "Warfarin" yaye "Verapamil" - eyomeleziweyo isiphumo anticoagulant yereyithi wokuqala nowesibini yehlise zinomgutyulo.
• Drug "Haloperidol" - kwandisa umxholo wayo egazini kwaye kwandisa umngcipheko basabele ezibi.
• Iziyobisi "Hydroxyzine" yaye "dextromethorphan" - kwandisa amathuba arrhythmia eqatha ulwamkelo lokuqala kunye yesibini egazini.

ulwazi oluthile

Ngononophelo ekhethekileyo ekuthethwa ngazo apha namayeza akhuthazwayo kwisigaba sisifo sentliziyo esinganyangekiyo 2-3, tachyarrhythmia (ventricular) kunye lokuphumla zobude QT, sinus node, AV-yaye kuvalwe 1 degree, isifuba, hyperthyroidism, hypotension, izifo ezihlasela zosulele esosulelayo, emphysema , engile-ukuvalwa neglaucoma, hypokalemia, ukusilela isibindi, thrombocytopenia, prostate hyperplasia, ezondeleyo kwezintso ukusilela, zisanyisa, ukukhulelwa kunye ukhwekhwe.

Abantu myocarditis kunye nezinye izifo engabalulekanga xa befumana "Quinidine" kufuneka ulawulo unyango rhoqo. Phambi unyango, isigulane kufuneka enze ulungiso iimpawu hypokalemia kunye nokungaphumeleli kwentliziyo.

Uthomalaliso kufuneka esweni rhoqo idatha ECG igazi neuropathy hemodynamics.

ngendlela efanayo, ixabiso

analogue Drug ngazo lukhulu. Iingcali bathi kubo ndlela zilandelayo: "Kinidin Durules", "Bretilat", "procainamide", "Etatsizin" "Lidocaine", "Amiokordin", "Propanorm", "Amiodarone" "Verapamil", "Propranolol", "Ritmonorm ".

Ke amaxabiso amayeza afana "quinidine" yaye "quinidine Durules", abemi belizwe lethu, ukuba ezingaziwayo ngenxa yokuba la machiza engasekho kuthengiswa eRashiya. Noko ke, zingathengwa Ukraine. Iindleko iziyobisi kweli lizwe malunga 540 670-679 hryvnia, ngokulandelelanayo, leyo ilingana no 1380 kwaye 1760-1780 engange.

reviews

Yintoni Abantu bathi oogqirha medicament ingqalelo kunye nabanye abasebenzi? Ngokutsho kwabo, esi sixhobo abonisa ukuba ichiza kakuhle kakhulu antiarrhythmic, yona ilungileyo, fast ngokwaneleyo ukuze ukunyanga izifo ezifana ventricular kunye tachycardia supraventricular. Nakuba kunjalo, kufanele kuqatshelwe ukuba khangela 'quinidine "Ipilisi ezikhemisti Russian akwenzeki. Oku kungenxa yokuba le amayeza wanqanyulwa ejikeleza simahla kwaye engasekho kusetyenziswa ezibhedlele. Oogqirha achaze le meko yokuba kukho ikhuseleke kwaye isebenza kakuhle kwakunye kunoogxa afikelelekayo kwimarike zamayeza, nto leyo eli esetyenziselwa okukhomba efanayo. Kulo mzekelo, iingcali zithi quinidine sulfate iyaqhubeka kusetyenziswa usemthethweni kwezinto multicomponent iziyobisi ezininzi anti-arrhythmic.