Prodrug "Parnavel": imiyalelo yokusebenzisa

Ukulungiselela "Parnavel" yemiyalezo ichaza nje prodrug, nto leyo ngumqobo ACE kwaye nesiphumo esiphawulweyo kuniko umfutho. Utyando esi sixhobo na inhibition ukhuphiswano yomsebenzi ACE, kamva ekhokelela ukuhla uyondelelwano lwee- angiotensin II. Ngokuthatha amayeza "Parnavel" (imiyalelo zokusetyenziswa it qinisekisa) yancitshiswa ukulayisha, afterload (OPSS), kwaye uxhathiso kwi imithambo yegazi pulmonary, kwaye yandisa xi nokunyamezelana. Ngokubhekisele iimpawu pharmacokinetic kwe-arhente, ngoko wavakalisa iqala iphawulwe ukusebenza iqinile ngexesha kwimizuzu mnye zaba ngamashumi omathandathu emva kulawulo, ufikelela iphezulu emva kweeyure ezine okanye ezisibhozo kwaye qhubekeka imini yonke.

iziyobisi efumanekayo "Parnavel", ixabiso apho yahluka ukusuka amabini, anamanci mahlanu ukuya engange ezimakhulu mathathu, ngokohlobo iipilisi ngeenxa oluqhelekileyo. Ukubunjwa tablet omnye njengoko element engundoqo esebenzayo uphantsi imihlaba perindopril erbumine milligrams ezine.

Thatha amayeza "Parnavel" umyalelo manual icebisa ukuba injongo kuphela unyango iifom okondeleyo sisifo sentliziyo okanye lwegazi. Ithamo lokuqala ichiza, ngokuqhelekileyo phakathi enye milligrams ezimbini ngosuku ngexesha, kunye nokugcinwa - milligrams ezimbini ukuya kwezine ngosuku.

Sebenzisa tablet "Parnavel" iingcali sicebisa ngamandla ukuba abantu abane ukunyamezelana ngamnye perindopril erbumine ngokunjalo kubo bonke abo babe ukuthambekela kuphuhliso angioedema. Ukongeza, uluhlu Izimo ngqo ukusetyenziswa ziquka ukukhulelwa kunye kweminyaka elishumi elinesibhozo. Ixesha lokwaphusa ifana kufuneka ayiyeke ezithatha ichiza "Parnavel". Imiyalelo yokusebenzisa Notes kunye undesirability yokusetyenziswa kwayo kwimeko lwegazi kakhulu okanye elisekwe ukusilela kwezintso. Abantu abanengxaki intswelo ulwelo kesodiyam, phambi kokuba baqalise izifundo unyango kufuneka inyanzelekile ukuba enze ebizwa ngokuba amanzi kunye electrolyte kungalingani ulungiso.

Ukongeza, kufuneka usebenzise ngenyameko kwicwecwe "Parnavel" ngaxeshanye amayeza kunokubangela ukunyuka okubonakalayo kwizinga potassium.

Xa ndiqukumbela, kufuneka athi malunga abasabela kunokwenzeka ezingalunganga ezinokuthi ezinokubangelwa ngokuthatha eli chiza. Umzekelo, iingcali phawula emngciphekweni olude ophezulu ukhohlokhohlo owomileyo, intloko ebuhlungu, isiyezi, ukuphazamiseka kwendlela incasa kunye umlomo owomileyo. Ukongeza, kusenokuba kukho utshintsho rhoqo isimo, kwekhono ngokwesondo, irhashalala, angioedema, ukuxhuzula, erythema, isikhumba bomvu, ukurhawuzelela kunye ezindlwini. Ukongeza, ukuncitshiswa kunokwenzeka isalathiso haemoglobin nokunyusa umgangatho uric acid kunye creatinine ngenxa yokufakwa "Parnavel".