"Pradaksa" - analogue. "Warfarin", "Ksarelto": ncomo, amaxabiso

Phakathi arhente antithrombotic kusetyenziswa ukususa thromboembolism ngemithambo emva kotyando, eyiyo ubonisa ukulungiselela "Pradaksa". analogue alo ezibonisa ngokubanzi ukusetyenziswa yaye ezakheke zezithako ezahlukileyo ezisebenzayo. Anticoagulants ziyafumaneka kwifomu idosi eziqinileyo kunye iidosi ezahlukeneyo.

Inkcazelo "Pradaksa" iziyobisi

Umenzi antithrombotic kunye namayeza anticoagulant "Pradaksa" inkampani "Boehringer Ingelheim Pharma GmbH & Co. KG. KG ". iindlela Ifumaneka njengezingxobo nzima, aqulathe zithutha ngaphakathi ezincinane ezimthubi. Le into dabigatran etexilate esebenzayo ingqalelo uhlobo opholileyo, inani apho kugqiba umthamo amayeza. Kusenokuba 75 mg, 110 mg 150 mg.

Yintoni iziyobisi "Pradaksa" lisetyenziswa

Eyona njongo ephambili yale njengezingxobo edityaniswe kunye ekuthinteleni thromboembolism lwemithambo emva kumasebe utyando kwinkqubo musculoskeletal.

Indlela isixhobo "Pradaksa"

It linxulunyaniswa kwezithandani balo matshinana umsebenzi thrombin yesenzo iziyobisi "Pradaksa". Analogs ukubonisa iimpawu kancinane. Ukuba molecule encinane, dabigatran etexilate akukho senzo imithi.

Kuphela wangena umzimba womntu, le nto iya kwahluka emva haydrolisis ukuya dabigatran sikhululekile esebenzayo ingathityazwa ngqo inhibitor lokhuphiswano thrombin enzyme. Indima thrombin iyabophelela ukuya fibrin, thrombin, ukunciphisa iseli udibaniso lwe zegazi okubangelwa umsebenzi thrombin.

ezi zixhobo

Unayo "Pradaksa" kunoogxa iziyobisi. Kodwa kumafa yayo, bona azinamgaqo dabigatran etexilate, indawo yayo kunye nezinye izinto anticoagulant. Hi xikombiso, indlela efanayo esebenzayo nto "Warfarin" lithi warfarin, kwi medicament "Ksarelto" liqulethe rivaroxaban. ukulungiselela Izithethantonye "Pradaksa" othi "Marcumar" kunye "Fenilin" ziquka phenprocoumon kunye phenindione ngokulandelelana.

Inkcazelo "Warfarin" iziyobisi

Sele kuluhlu, banayo "Pradaksa" kunoogxa iziyobisi. Ngoku makhe siqwalasele ngokweenkcukacha omnye wabo.

Le medicament "Warfarin" evela ngokohlobo amacwecwe kunye umthamo esisebenza, 2.5 mg. Umenzi ichiza nkampani Russian "imveliso Kanonfarma."

Kukho nezinye idosi (1 mg, 2 mg, 3 mg kunye 5 mg) amazwe amayeza ezisekelwe warfarin. Imilo, umbala kunye nobukhulu amacwecwe yahlukile kwi ngapha nangapha ithamo enokusebenziseka xa mg.

Kuba oko kusetyenziswa ichiza

Reception "Warfarin" kunokwenzeka:

• thrombosis kwenkqubo lwemithambo okanye sifuze;
• ngokuba unyango umbala we thrombosis kunye thromboembolism;
• e thrombosis lwemithambo etsolo ngexesha Embolism kwi ijwabu lung;
• e thrombosis postoperative;
• etsolo umsipha engabalulekanga;
• ngexesha utyando kunye nonyango thrombolytic of thrombosis;
• sihlaselwa ezidlulayo kobuchopho;
• unyango elide thrombosis nezolo lwemithambo;
• ngexesha isivingco prosthetic entliziyweni.

Indlela-arhente

izinto ezithile zenkqunto "warfarin" ukwehlisa izinto igazi ekunqandeni zinqanda nokuveliswa (X, IX, VII, II), vitamin K-abaxhomekeke igazi kunye abangele coagulation. iiproteni Hepatic Anticoagulant C no S ukuba kuhlelwe kangangoko ongaphantsi phantsi kwempembelelo ichiza. Konke oku kunciphisa ukuyilwa amahlwili egazi ezikhokelela ukuyilwa egazi.

Ukuphelisa oogqirha thrombosis lwemithambo ukumisela unyango kunye anticoagulants ngqo. Oku kwakhona ukuphuhlisa thrombosis, nto leyo ibangele iingxaki.

Ukubalwa ithamo of warfarin ngamazinga ahlukeneyo INR

Ukutyunjwa "Warfarin" lweziyobisi olunokubakho emva uviwo oluneenkcukacha, apho ichaza zonke Izimo. Uhlalutyo unyango olunye ezikhethiweyo ngenani elithandekayo medicament "Warfarin". Ithamo ngosuku mayingagqithi mg 5 ukwimo engundoqo esebenzayo. Ukususela zaneleyo kwezonyango yonyango wenziwe izilungiso. Kucetyiswa ukuba abhale ithamo ezifunyenweyo, amanqanaba INR kunye neziphumo athe uhlalutyo unyango.

Phantsi INR (ratio nganye ezinga malungu abantu ngamazwe) abonisa umgangatho wokubala umsebenzi lweziqalelo igazi ekunqandeni. izinqumisi igazi nefuthe ixabiso isalathisi. Kubalulekile ukuba esweni INR xa efumana "warfarin" Ukwabiwa apho bomzimba umlinganiselo ukuba igazi ekunqandeni. Ngenxa yoko, xa umlinganiselo ophezulu nganye ezinga malungu abantu ukucola kwamahlwili kwaye kwandisa hypocoagulation.

Xa lithi ezahlukeneyo kufuneka esweni INR ethile.

1. Kuba ephilayo esempilweni, norm yalo malunga 1.0 (okanye ayisatenxi kancinci - ukususela 0.85 ukuya 1.25).
2. Chronic fibrillation atrial xa befumana "Warfarin" zithutha kufuneka sikhatshwe umlinganiselo nganye ezinga malungu abantu iiyunithi 2.0 ukuya 3.0.
3. Mechanical sokwenziwa vana ebalasele INR we 2.0 ukuya 3.0, i mechanical ezase isivalo mitral ukusuka 2.5 ukuya 3.5.
4. Xa yonyango thromboembolism kwi pulmonary kwaye ezinye iziphene intliziyo kufuneka isalathiso kwinqanaba 2.0 ukuya 3.0.
5. Ukuthintela thrombosis ngemithambo enzulu emva kutyando ukunyanga thrombosis lwemithambo, ukubambelela amaxabiso wexesha 2.0-3.0.

Ichiza "Warfarin" kufuneka kwenziwa esweni ngenyameko kwisalathisi INR kunye kweliso zonyango engqongqo, ukuba abe nako ukunyenyisa idosi. Ukuqina ratio nganye ezinga malungu abantu kunye nokukhethwa anenani elifunekayo medicament lwenziwa malunga enye ngeveki, ze emva koko rhoqo emva kweeveki 4 eli xabiso iyakhangelwa.

Ukuze zivela isiphumo sesicelo of "Warfarin" beziyobisi, indlela ukuthatha kunokuba ukuhlamba phantsi kwaye nokuba indibanisela ukutya, kufuneka ukwazi. Iipilisi ukusela kabini ngemini, hayi edibanisa kunye nasekusebenziseni ukutya. Yahlanjwa phantsi ngamanzi kunye ziyathathwa ngexesha elifanayo. Ukongeza, ukunikezelwa wohlalutyo kwi INR kufuneka kweli lixa kwaye elabhoratri ngokusisigxina. Xa les amathamo obuyimfuneko bokwenza lo ingxenye elandelayo ixesha reception.

Ngamazinga angaphantsi kwe-2.0 INR igqalwa igazi elingqingqwa, ichiza kuphumelele, ke ngoko, kuyimfuneko ukuba kusetyenziswe idosi "warfarin" ngaphezulu.

Ngokwemiqathango ngaphezulu kwe 3.0 igazi ulwelo INR kucingwa, ukopha Inokwenzeka, ngoko kuyimfuneko ukuba isicelo ubuncinane idosi eziphakamileyo ichiza.

Ixabiso iyeza "Warfarin"

Xa kuthelekiswa ichiza isiJamani "Pradaksa" elilingana neli Russian of "Warfarin", ixabiso ovela engange 80 pack nganye, kutshiphu kwaye ayafikeleleka kakhulu.

Inkcazelo "Ksarelto" iziyobisi

Xa medicament "Pradaksa" analogs babe kwiipropati anticoagulant, unempembelelo ngqo. iziyobisi "Ksarelto" libhekisela kubo. Yavelisa kuyo ngohlobo ifilimu amacwecwe wawutyabeka ngeenxa kwi nkampani isiJamani "Bayer".

Ukubunjwa uye rivaroxaban ngohlobo micronized. Tablets "Ksarelto" are iidosi zilandelayo: 2.5 mg, 10 mg, 15 mg-20 mg.

indlela isenzo

Rivaroxaban ekubhekiselwe akwiqela ngqo inhibitors njengoko uyakhetha kakhulu nagyo ukuba babe bioavailability eliphezulu baqaphela emva ulawulo ngomlomo.

Le kubangela coagulation ukhandwa kokuba uqalile okanye ipoti ye factor X, leyo, ngenxa indlela coagulation lwangaphakathi nolwangaphandle iguqulelwa kwi factor nagyo. Eli candelo inxaxheba lokusekwa prothrombinase compound ukusuka inyathelo apho prothrombin is kuguquka thrombin. Ezi nkqubo zenza ihlwili fibrin, kwaye usebenze neeplatelets. Kukho "ukudubuleka" apho ngenxa ngumba Xa zinemoletyhule ukuba kuhlelwe ukuba amawaka enye yezi egazi.

Ukusebenzisa inhibitors ikhetha ukuba zokunciphisa umsebenzi isilumeki kwenzeka ukuyeka "thrombin dubulo". Action rivaroxaban ngqo ukutshintsha iziphumo uhlalutyo ethile okanye ngokubanzi kwelabhoratri ukuqikelela imo kwinkqubo coagulation. umsebenzi Factor Xa kuyahlukana nedlela idosi inhibitor, leyo isebenza ichiza "Ksarelto" (15 mg iipilisi okanye enye idosi ngayo).

Oko iphathwa nalo eli chiza

Le ncwadana ichaza ukusetyenziswa medicament kuthintelo ukufa emva kwezifo sentliziyo ezinxulumene engabalulekanga izihlunu ngentliziyo kunye etsolo semithambo syndrome. Medicine "Ksarelto" amanqaku nesimilo afunyenwe yonyango indibaniselwano ngempumelelo kunye aspirin okanye aspirin kwakunye thienopyridine.

Indlela ukuthatha ngeedosi ezahlukeneyo ichiza

Ichiza ilungiselelwe ukusetyenziswa lwangaphakathi. Tablets zonke amathamo ezithathwe kunye nokutya.

Ukuze kupheliswe etsolo coronary syndrome bayacetyiswa ukuba athathe enye elucwecweni 2.5 mg kabini ngemini. Kunye yokulungiselela "Ksarelto" (ratings kubonisa ukusebenza usebenzisa udibaniso eso) kungenziwa ilawulwa acetylsalicylic acid idosi yemihla ngemihla ukususela 75 ukuya kwi-100 mg, kwaye indibanisela aspirin kwakunye clopidogrel xa isixa-75 mg ngosuku. Olu nyango kufuneka kweliso zonyango rhoqo bayigcine lentsalela, nto leyo lisisiqalo kwi kwicala elinye kungabangela iingxaki kobuchopho okanye ukopha. Ukuthatha ichiza elide kwaye kuthatha malunga enye ngonyaka, kwezinye izigulane ukuya kwiminyaka emibini.

Amacwecwe umthamo 10 mg rivaroxaban kuthatha ixesha enye ngosuku. Nomnikelo wokuqala emva kweeyure 6-9 zotyando kwintsimi hemostasis olusebenzayo. Ubude unyango kwesesikweni lobungakanani beziyobisi ukuba isigulane ngamnye, ngokuxhomekeke ingozi thromboembolism lwemithambo, ukuntsonkotha kunye nohlobo lomsebenzi.

Xa ulawulo ichiza elithi "Ksarelto" hip replacement (10 amacwecwe mg) ithatha iiveki-5, ngexesha edolweni arthroplasty kokuba kuthathwe iintsuku ezili-14.

Ukuba isigulane ulibele ukuba usele idosi enye rivaroxaban, kufuneka ngoko nangoko bagqitywe, yaye ngosuku olulandelayo ukuqhubeka unyango, 1 tablet.

iidosi eziphezulu ka-15 mg okanye 20 mg ungazithatheli ungatyanga.

Ukuze kuthintelwe imeko-stroke kunye Embolism ubhalo systemic ne non-valvular fibrillation atrial intliziyo zendalo atrial ukusebenzisa ifoni idosi enye mg 20 kanye ngemini.

Xa ukusilela kwezintso, xa izinga creatinine yokuhluza isiqingatha ubomi ml ngaphantsi kwe-30 ukuze komzuzu 1, esebenzisa umthamo we -15 mg 1 ixesha ngosuku.

Ubude unyango kuxhomekeke kubukho isoyikiso lweStrowuku kunye karhulumente thromboembolism ngobuchule.

Idosi iphezulu nokunyamezeleka ngemihla akufuneki ibe ngaphezulu kwama-20 rivaroxaban mg.

Thrombosis, nzulu umthambo echaphazela, kuthintelo ukwenzeka sifo kunye thromboembolic ezichaphazela pulmonary, usebenzisa i idosi yokuqala ka-15 mg kabini ngemini ngexesha kwiiveki ezintathu zokuqala. Kamva ukuya amacwecwe ka-20 mg rivaroxaban kanye ngosuku unyango lwexesha elide kunye nokuthintela kwakhona thrombosis kunye nezolo Embolism nezengekho miphungeni.

Akusoloko kungenzeka ukuba izigulane ukuginya yonke cwecwe, ingakumbi ubukhulu enkulu, ngoko ke ukuba ukugaya nokuhlanganisa ngamanzi acocekileyo okanye ukutya ulwelo phambi ukutyiwa. Ngoko nangoko emva kokuba ezithatha ichiza isigulane adle.

Kungenzeka kwakhona ukuba kungafundiswa iipilisi otyunyuziweyo gavage, indawo apho kwinkqubo kokudla elungelelanisiweyo kwangaphambili kunye nogqirha wakho. Imibandela ukwenza amacwecwe usityumze ngale ndlela sikuko kuxutywa ichiza omncinci amanzi kunye ezilandelayo nolawulo. Emva koko uya kuzala ulwelo encinane ukususa iintsalela kweziyobisi ukusuka probe. Emva amayeza obuyimfuneko bokwenza lo ekudleni enteral.

Ixabiso ichiza "Ksarelto"

Esi sixhobo isebenza kumachiza elizweni kunye neendleko eziphezulu. Umzekelo, ichiza "Ksarelto" ixabiso ithamo sincinane uya kuba ngowama-56 zithutha malunga 950 engange. Kuyinto kakhulu kubiza ngaphezu analogu yayo Russian - amayeza "Warfarin". Xa amayeza "Ksarelto" ukunyuka kwamaxabiso kuxhomekeka yokwanda balawule. Ngoko ke, ixabiso 14 amacwecwe 15 mg rivaroxaban ziya kuba malunga 850 engange, lo gama i ukupakisha (pieces 28 amacwecwe) kunye idosi iphezulu (20 mg inqununu esisebenza) iya kuhlawula 1450 engange.