"Ramipril": analogue, ingxelo kunye nomyalelo. "Ramipril-C3"

Phakathi izifo unga nciphisa ngokubaluleka ubomi kwaye kuchaphazela umgangatho wayo, ngokwahlukileyo bemi lwegazi. Uqala ngcembe yaye ngokuthe ngcembe kuchaphazela iimpahla yegazi, ingqondo, izintso, kunye myocardium. Kumanqanaba okuqala isigulana kunzima ukuqonda esi sifo, kuba kubonakala izikhalazo encinane okanye hayi.

Kamva ke kuvela, kwaye isigulane wathi uxinzelelo lwegazi lakhe liphezulu kakhulu kunesiqhelo. Le meko ifuna kokuqalisa unyango amayeza, nto leyo kunokwenzeka nokusetyenziswa kweeklasi 5 iziyobisi. Yaye "Ramipril" lolona egqibeleleyo kubo, nokuqinisa ngenxa monotherapy okanye njengenxenye yonyango multicomponent zidityanisiwe.

System embalini yemveliso

"Ramipril" analogue beziyobisi, kwakunye epheleleyo iimpiliso zingabameli umfutho. Ramipril ngokwayo - isithako esebenzayo oko kuqulethwe amalungiselelo amaninzi. Le ACE inhibitor ekwaziyo evalela i enzyme nokunciphisa uxinzelelo lwegazi. It ikuvumela ukuba kakhulu ngcono ALS ke sifo ebantwini abadala.

Xa zophononongo zibonise ukuba ramiprilat, lo metabolite asebenzayo "Ramipril" enamandla kakhulu abangaphangeliyo enzyme angiotensin-ukuguqulela. le "Ramipril" analogue Ngenxa kunye neemveliso ezimbaxa na ukukhetha iindlela kunye nzima ukulawula lwegazi.

analogs

Ekubeni ichiza zinokuyithintela kanobom ACE kwaye inceda ulawulo uxinzelelo oluphezulu lwegazi, ukulungiselela "Ramipril" nucleoside ezininzi. Bonke bephela esetyenziswa ukunyanga wegazi ngempumelelo. Ngaphezu koko, lo ramipril isiyobisi original yi "Tritatse". Bonke abanye - iziyobisi zalo generic, ogama ukusebenza kufuneka kuthelekiswa naye. Ukwamkelwa ukuthengiswa kufuneka kuqinisekiswe bioequivalence iziyobisi "Tritatse".

Okwangoku, uludwe analogue kwezi zilandelayo: "Amprilan", "Vazolong", "Dilaprel", "Korpril", "Oontanga", "Ramepress", "Ramigamma", "Ramikardiya", "Tritatse," "Hart". "Ramipril" Kwakhona enziwe kwakhona ziinkampani Russian "Tatkhimpharmpreparaty" "Biocom" yaye "North Star". Products yokugqibela ngokuba "Ramipril NW".

iidosi Standard and amalungiselelo ezintsonkothileyo

Umfutho amayeza "Ramipril" kulula ukuba makenze nokufumana. umsebenzi wayo kubonisa unit iidosi ezintathu ichiza. Oku 2.5 mg, 10 mg 5 mg. Ipilisi izihlwele zithathwa kabini ngemini. amayeza ehlanganisiweyo khona equlethe ramipril kunye hydrochlorothiazide: "Amprilan ND", "Amprilan NL", "Vazolong H", "Remazid", "Triapin", "Tritatse Plus", "Hart D", "Egipress". Apha, isixa ramipril isusela ukusuka 2.5 ukuya kwi-10 mg, kunye nedosi hydrochlorothiazide - ukususela 12.5 ukuya 25 mg ipilisi nganye.

Udidi lwesibini kweemveliso complex - indibaniselwano "Ramipril" kunye ochasene calcium - "Amlodipine". Umzekelo ichiza "Egipress" efumaneka ezisemgangathweni iidosi ezimbini: 10 mg kunye ramipril 5 mg amlodipine kunye 10 \-10 mg. Ukongeza kule udityaniso, kukho olunye uhlobo kuqulunqo equlethe i-ACE inhibitor "Ramipril" kunye calcium ochasene "Felodipine". Oku "Triapin", aqulathe 2.5 mg ramipril kunye felodipine 2.5 mg.

Izibonelelo imiyalelo yokusebenzisa

Ukongeza izindululo ugqirha isigulane kufuneka athathe ingqalelo imiyalelo ukusetyenziswa. Iqulethe ulwazi malunga ukwalatha, ziziphumo ebezingalindelekanga, idosi ufumane iindlela, Izimo kunye amanyathelo. Kukwaqhotyoshelwe kwi "Ramipril" imiyalelo iziyobisi zokusetyenziswa ucacisa imfuneko yokulahlwa utywala unyango lwegazi.

ubungqina

"Ramipril" analogue beziyobisi kunye generic "Tritatse" bonisa kwi:

• BP kubalulekile ;
• ngayo unyango multi-class entsonkothileyo ukusilela kwentliziyo ezingapheliyo;
• nephropathy seswekile kunye nezinye zonyango okanye subclinical, sinxulumana sezintso umfula stenosis ;
• ku wegazi lingaze;
• kuthintelo iposi engabalulekanga, ukunciphisa lokufa ezinesifo kwentliziyo, kwakunye ukuba unyango nomfutho ne risk sentliziyo high iyonke.

Uphawu eyinhloko lwegazi. Esi sifo rhoqo ubudala oluphakathi kunye nabadala, efuna ukulungiswa. "Ramipril" Kwakhona, ichiza okanye enye inhibitor ACE kufuneka ilawulwe kwizigulana ngexesha zokuqala iintsuku 2-9 kwexesha etsolo iposi engabalulekanga. ithamo ichiza kufuneka ibe ubuninzi ukunyamezeleka naxa isigulane awehlelwa wegazi. Oku ngenxa yeziphumo abanamandla cardioprotective ka-ACE inhibitor.

Izimo

Ukulungiselela "Ramipril SOC" akufuneki isetyenziswe linembali nokudumba angioneurotic naziphi na iziyobisi analogue, kwakunye nayiphi na uxabane nawo, nto leyo iphuhlisiwe yokwamkela yayo. ukuqeshwa Contraindicated phambi hemodynamically stenosis ebalulekileyo kwemithambo kumacala omabini. Ukuba stenosis yi unilateral nomonde umsebenzi ngokuqhelekileyo nezintso zombini, ukuqeshwa babe ngononophelo kwaye phantsi kweliso GFR.

Ukulungiselela "Ramipril" (5 mg, okanye acetyiswe nayiphi na idosi) alisebenzi xa hypotension ngezantsi mmHg 90. Art. Kwakhona, ichiza kufuneka ingasetyenziswa hemodynamically ebalulekileyo stenosis of aortic vana okanye mitral, kunye cardiomyopathy hypertrophic obstructive, hyperaldosteronism zaseprayimari, ukusilela esinganyangekiyo kwezintso ngesalathisi ngenxa yokususwa creatinine (GFR) engaphantsi kwe-20 ml / min.

Iqhaganyishelwe kule ncwadi yesikhokelo "Ramipril" umyalelo iziyobisi (olu xwebhu akukho analogue) iqulethe lubonakalisa ekungakwazini ukusebenzisa iziyobisi ngexesha lokukhulelwa kunye zisanyisa. Kwakhona engamkelekanga ukusebenzisa amayeza abantwana. Xa ndandineminyaka eli-18 yamava lwezonyango ayanelanga kwaye asikwazi ukuqinisekisa ukhuseleko.

iirejimeni nomthamo

Ukuqulunqwa osisiseko ichiza "Ramipril" - tablets. I njengezingxobo lingaphantsi eqhelekileyo. Kulo mzekelo yokuqala ithamo elicetyiswayo yi 1.25 mg. Ithamo zincinane chiza - 2.5 mg, kwanyanzeleka ukuba umsantsa kubini. Ubukho umgca phezu cwecwe ikuvumela ukwenza oku lula.

Xa naziphi na iintlobo ithamo lwegazi ekuqaleni 1.25 mg kanye yonke imihla. Ngoko ke ithamo ebegqwese kabini kwi tolerability elungileyo. Umthamo titration lwenziwa de kufike ixesha uxinzelelo lwegazi kuzinzile. Le kwingongoma nganye unyango olusebenzayo lwegazi - igazi njalo, ezinyuka ziye kunqabile yedwa.

amanyathelo okhuseleko

Ichiza kufuneka athathwe phantsi kolawulo koxinzelelo, ingakumbi ngexesha ukuqeshwa sokuqala. Kubalulekile ukuba uxinzelelo lwegazi iSystolic yehla alithe gangqa 90 mm. HG. Art. Xa uxinzelelo lwegazi iwela ngaphantsi kweli nqanaba kucetyiswa abasebenzi abanaluncedo. Ukuze kuthintelwe ngamathontsi wegazi akukho Kucetyiswa ukuba basebenzise "Ramipril" kunye ngezithako, udidi I iziyobisi antiarrhythmic ( "Procainamide") kunye Alpha-blocker 1 ( "Alfuzosin," Tamsulosin ").

Ichiza kufuneka athathwe rhoqo yaye ngokukhethekayo elo lixa. Oku kwenza kube lula ukuqhelana inkqubo renin-angiotensin-aldosterone, olawula uxinzelelo lwegazi. Kwakhona, ungaphoswa amayeza ukuthatha ukuba inokuchazwa kakhulu lobunzima unesifo. ukulahlwa Kubukhali reception kunokubangela stroke, iingozi ezo linyuke kweli xesha.

Izimvo lezigulana amayeza

"Tritatse" kunye generics zayo - iimveliso ezikumgangatho ophezulu ukuba kakuhle alawulwa uxinzelelo lwegazi. Ukuza kuthi ga ngoku, eli chiza yeyona arhente kunawo umfutho. Nale baqinisekiswa nomonde ngayo kwi lonke ezintle. Bachaza ukuba ichiza ethembekileyo olomeleleyo na kakuhle alawulwa uxinzelelo lwegazi. Ingakumbi ebalulekile iimpendulo ezo izigulane abaye ngaphambili elinye iziyobisi kweli qela.

Izigulane waphawula imali encinane reactions emibi ne yokudla. noFaro High ze-ACE, kwakunye idosi isiyobisi encinane ezikhawulezileyo inani lweziphumo pathways ngokumandla ingafuneki xa wasebenzisa. Kubalulekile ukuba inani iingxaki nokusetyenziswa rhoqo "Ramipril" eliphantsi kakhulu. Noko ke, ukupheliswa kwabo ngokupheleleyo akunakwenzeka ukuba monotherapy.

Izimvo oogqirha malunga ichiza

lwegazi manani uxinezeleke. Uqinisekisa ukubaluleka kwale sifo imithi mihla. Kwakhona kubalulekile ukuba ngezifo kunciphisa kakhulu ubomi bakho. Lwegazi kuphuhliswa ngenxa hormone of renin, nto leyo eyandisa umthamo wegazi angiotensin. Inhibition yale enzyme kukhokelela ekunciphiseni uxinzelelo. Kuyimfuneko ukuba nokuthintela kodonga sclerosis semithambo kunye ukuvela yeengxaki ezinzima wegazi.

Njengoko iintlobo zophononongo emva, kwiimeko ezininzi fibrillation atrial kunye nesifo sentliziyo kobuchopho emva ogulayo kwabanye xesha kwaphuma lwegazi. Ngenxa ngokubaluleka ngonyango yeyabahlali. Kwaye okona kubaluleke kakhulu, ngoko ke ukuba uyakwazi ukuphelisa ubukho sifo qela ACEI iziyobisi. Phakathi kwabo, "Ramipril" isekhona enamandla kakhulu nolusebenzayo.

Oogqirha ngayo bubungqina noncedo lwezo zinto. Amalungiselelo kulula ukuyisebenzisa, uye reactions kwicala ezimbalwa kwaye isebenza ngokwaneleyo. Noko ke, nangona ezi mpawu, mhlawumbi kunokunganeli ukunyanga wegazi kakhulu. Yinto phantse 40-50% kwamatyala zonyango.

Kuba unyango lwabo kufuna yesekethe indibanisela esenokuba inhibitor ACE, a umchamo, a ochasene calcium beta blocker ngamanye amaxesha. Njengoko i angiotensin ukuguqula enzyme inhibitor "Ramipril" kakuhle. Ngenxa endaweni yayo unyango nomfutho kungathatha, nanini na oku kwamkelekile. Nangona izigulane ezininzi ukufumana ngenxa yokungabikho ixabiso layo eliphezulu.