"Klarotadin": imiyalelo ukusetyenziswa. Apho ukuthenga "Klarotadin"? Ukusuka ntoni? Iipilisi "Klarotadin" Analogs "Klarotadina"

ziyabagulisa - umxholo kakhulu, ingakumbi kubazali. Ngapha koko, iqela ebizwa ngokuba "komzimba" luyanda minyaka yonke. Ngoko ke, thina ngoku siqwalasele ngokweenkcukacha ekulungiseleleni "Klarotadin". Imiyalelo zokusetyenziswa ziza kuqalisa ukubuyekeza yethu beziyobisi. Worth ukubona oko ngaphambi kokuba uyisebenzise. Thenga "Klarotadin" kuyo nayiphi na ekhemesti kwidolophu yakho, kwaye ngaphandle kagqirha.

nini isicelo

Le medicament zingasetyenziswa conjunctivitis komzimba, angioedema, kunye urticaria (etsolo ezingapheliyo kunye idiopathic). Ichiza "Klarotadin" sincede ngexesha lonyaka-ngeenxa okanye nokuthimliswa ngokwamaxesha; pseudoallergic xa reactions zibangelwa histamine iyekelela; abasabela ezinambuzaneni izinja ezahlukeneyo; kwakunye dermatoses ukurhawuzelela. Uluhlu zingahlonyelelwa.

Yini iveliswa

Makhe siqale sibone ukuba imveliso "Klarotadin" -sirop. ngokusetyenziswa imiyalelo yakhe iya kunikwa ngezantsi. Izikali - 5 mg / 5 ml. Loratodina (esisebenza) enye mlligrams milliliter of isiraphu nganye. Excipients: propylene ethers, iswekile, benzoic acid, ethyl utywala, citric acid, tropeolin, amanzi okuhlamba, neencasa ukutya.

Yathengiswa ibhotile yeglasi emnyama, umthamo apho nekhulu ngeemililitha. Le bubble na ibhokisi yekhadibhodi. Ikhithi kwakhona iquka yokulinganisa icephe okhethekileyo.

Ngoku cinga ipilisi "Klarotadin". tablet nganye milligrams ezilishumi loratodina. Ukusuka nezincedisi - MCC, lactose, calcium stearate, glycolate, starch sodium. Ibekwe kumadyunguza, ngamnye iziqwenga zibe sixhenxe okanye elishumi. Le iibhokisi babe ukusuka kwelinye ukuya eziba ezintathu amacwecwe.

pharmacodynamics

Eli chiza fanele ukuya H1-antihistamines, kuwo akukho anticholinergic kunye nesenzo central. Uyaqala kangangesiqingatha seyure emva ukusela kunye nezenzo imini yonke. Kubalulekile ukuba ulawulo ezingapheliyo beziyobisi akuthethi ukumelana nayo. Kufuneka kuqatshelwe ukuba loratodin kweziyobisi kunye metabolites zayo akanako ukuba zingene BBB.

Pharmacokinetics

Ke ukuba ukuthathwa, ngexesha lokuthathwa ngokwemithamo ekucetyiswa ngumvelisi, icandelo engundoqo loratodin ngokukhawuleza ngokupheleleyo bangene egazini iphecana zesisu. Ukufumaneka ongayi sele imisele, avele ekwakhiweni plasma yegazi imizuzu elishumi elinesihlanu emva kokutya. Njengokuba ixesha ukufikelela Cmax e plasma loratodina, loo iyahluka ukusuka iyure enye imizuzu engamashumi amane ukuya kwiiyure ezimbini imizuzu engamashumi amathathu.

Kodwa ixesha ukufikelela Cmax metabolite yayo esebenzayo malunga neeyure ezintathu. Nje sikhumbule ukuba ukusetyenziswa ngaxeshanye ukutya kunye iyeza uyakwazi isantya impumelelo Cmax loratodina kunye metabolite ngendlela ebonakalayo plasma ngeyure enye. Ngelo xesha Cmax ezi zinto ziya kuba ayitshintshanga, yaye ukutya engakwazi nangayiphi na indlela ukuphembelela isiphumo.

Ngoku abantu abadala. "Klarotadin" (umyalelo kwi kumanqaku isicelo), ukuba kwenziwe ngaphandle ubhukisho eyodwa ubudala. Nje sikhumbule ukuba ixesha ukufikelela Cmax linyuke iiyure enye enesiqingatha, ngokuchaseneyo nabantu abatsha. Malunga umonakalo kwesibindi utywala, ngokuxhomekeke nobungozi besi sifo ngoxa ekuphumezeni Cmax zakhula.

Egazini umxholo plasma loratodina metabolite yayo esebenzayo ifikelela uninzi lwezigulane kwinqanaba umile ngomhla wesihlanu emva kokungenisa. A nokuzikhanyeza iiproteni zesiyilelo - 97%.

lokugaya

Kwesibindi loratodin into esebenzayo umzimba ukwenza metabolite dezkarboetoksiloratadina esebenzayo. Oku kwenzeka ngenxa yokuba kwimpembelelo cytochrome P450 isoenzyme CYP3A4. Impact cytochrome P450 isoenzyme CYP2D6 ikwachaphazela, nangona kangangoko engaphantsi. Kektonazol ngoku, i inhibitor of CYP3A4, kusivumela loratodinu ajikwa dezkarboetoksiloratadin. Oku kungenxa kwimiphumo CYP2D6.

yokuza-

Ukurhoxiswa ichiza "Klarotadin" (imiyalelo ukusetyenziswa kwaye ekhankanywe) nge nezintso, kwakunye kunye inyongo. I-avareji T1 / 2 loratadine ondoqo iiyure ezisibhozo nemizuzu engamashumi amabini (uluhlu inokuba ukusuka iiyure ezintathu ukuya amabini). Ngokumalunga metabolite esebenzayo, umlinganiselo walo iiyure ezingamashumi amabini anesibhozo (range kuba iiyure ezintandathu imizuzu mane iiyure ezingamashumi amathathu anesixhenxe).

Le dezkaboetoksiloratadina median ziiyure elinesixhenxe kwaye imizuzu engamashumi amathathu (uluhlu, iiyure ezilishumi elinanye ukuya kumashumi amathathu anesibhozo). Ukuba kukho utywala isibindi sisilonda esidumbileyoesingaphakathi, i-T1 / 2 uya kwandisa kunye ngokwandisa ubukhulu izifo. Kodwa abaguli kuba ukusilela kwezintso kunye nehemodialysis usisisulu, hayi pharmacokinetics ingakumbi zatshintsha.

ukukhulelwa

It ingenakuthatyathwa yi abafazi abakhulelweyo ichiza, ngokuba abantwana "Klarotadin" bakulo esizalweni, kungadala umonakalo. Ukuba kuyimfuneko ukusebenzisa le umama oncancisayo leziyobisi waba, ngoko kuyimfuneko ukuba uyeke ukuluncancisa logama nje igqityiwe unyango.

Izimo

Njengoko kunye nezinye iziyobisi kuye Izimo kunye "Klarotadin". Imiyalelo isicelo ithi ichiza kufuneka ingasetyenziswa xa isigulane unalo hypersensitivity nakweliphi na la malungiselelo. Ukukhulelwa kunye lokwaphusa nazo iimeko apho sixhobo ongaphathiswanga okanye efunyenweyo. Izigulane kufuneka isibindi, kufuneka uthathe ichiza "Klarotadin" ngobulumko.

imiphumela emibi

Ngoku kuyimfuneko ukuba ukuxelela malunga nendlela oku kuchaphazela ichiza ngokungalunganga emzimbeni womntu. Iimpawu kunokwenzeka ukuphazamiseka kwenkqubo luvo, oko kukuthi, ixhala, asthenia, hyperkinesia, okubangelwa umntwana, somnolence, lafa, paresthesias, ukudandatheka kunye kunesifo. fat ongama kunye nesikhumba kusabela amacandelo amayeza dermatitis.

Ukuba sithethe malunga nenkqubo genitourinary, ngoko inxalenye yakhe inokuba inguqu umbala umchamo, isigulane usenokufuna ukuchama, nto leyo eya kukhatshwa ziintlungu. Kusenokwenzeka kananjalo ziqulunqe හසුරුව isiphathi, seTrojan kunye menorrhagia.

Ngomhla inxalenye yenkqubo yonyango kunye nokuhlukunyezwa kunokwenzeka. Weight angandiswa, isigulana siya Ndinxaniwe, kwaye kungandisa ukubila. inkqubo Musculoskeletal nayo lenziwe izitenxo emsebenzini wabo. Oku amahlaba umlenze kunye myalgia, kunye arthralgia.

Le nkqubo yokusila nazo ubunzima. Uhlaba ukungcamla, ukuqhina okanye isifo sorhudo, ukudla, gastritis, ukungacoleki kokutya, kwanda, stomatitis kunye flatulence - konke oku kunye namathuba athile kunokwenzeka xa usebenzisa i "Klarotadina".

Othambekele ukungaphumeleli kunye isixokelelwano sokuphefumla. Ukunyhashwa babonakalise njengoko bronchoconstriction, khohlo, sinusitis, kwaye kome inwebu imazi ibonakalisa empumlo. Ngaba kananjalo ziqulunqe conjunctivitis, umbono aphazamiseka, iintlungu ezindlebeni namehlo. Inkqubo yegazi kuxhomekeke kwakhona ukuba imiphumela enokuthi ibonakale njengoba iyangongoza, ukwanda koxinzelelo lwegazi, nokunciphisa ngayo.

Amatyala negazi lakho, ebonakalaliswe kule fomu angioedema, pruritus, urticaria kunye photosensitivity. Ungafumana kananjalo iqolo, ifiva, hoarseness, iintlungu esifubeni, kuthibaza, blepharospasm, kunye neentlungu ibele.

Njengoko ubona, ezi ziphumo bezingalindelekanga kuba kubi kakhulu, ngoko musa ukulibala ngayo. Uthethwano efunekayo zombini phambi ulawulo lokuqala kweziyobisi kwimeko ubhaqo kule ngxaki zichazwe ngentla apha.

Sebenzisa nokuba umthamo

Isiraphu and tablets "Klarotadin" ukusuka apho - ukuqonda. Ngoku makhe sithethe kufuneka kuthathwe ngayo. La machiza zilungiselelwe ukusetyenziswa lwangaphakathi. Abantwana abaneminyaka engaphezu kwama elinambini, kwakunye kucetyiswa inani umntu omdala imihla milligrams ezilishumi. Oku ephuma ezimbini isiraphu elulwelo okanye tablet enye. Kodwa abantwana ukusuka kwiminyaka emibini ukuya elishumi ubudala, ubunzima bomzimba ngaphantsi kwe ngeekhilogram ezingamashumi amathathu, kucetyiswa ukuba ukuthatha milligrams ezintlanu. Le scoop elinye okanye nesiqingatha tablet. Le idosi yemihla ngemihla akufuneki ngaphezu kweli nani. Ukuba ubunzima ngeekhilogram ngaphezu mathathu, idosi iya kuba ngokufanayo abadala.

libanda

Ukuba nithe anasiphulaphula ukucetyiswa uze uthathe iziyobisi izixa ezikhulu, kunokubangela iimpawu abadala, nesiza kuluhlu. Le tachycardia, intloko kunye ukozela. Kunye nabantwana bawo ubunzima lingaphantsi kwe mathathu eekhilogram, libanda kunokubangela iyangongoza, kunye neempawu extrapyramidal.

Ukuba isigulane amkelwe libanda, kufuneka ngoko nangoko uqhagamshelane nogqirha. Kuyimfuneko ukuba athathe amanyathelo ukuqinisekisa ukuba ichiza yasuswa kule iphecana zesisu kwaye inciphise ukufunxeka. Oku kwenziwa ngokuphembelela emesis, lavage esiswini, kunye nokusetyenziswa carbon yasebenza. Kwimeko unyango kwangumqondiso enokwenziwa kuvele imfuneko. Kufuneka kukhunjulwe ukuba into esebenzayo i loratadine ayikwazi obunokuthelekelelwa umzimba olugqitha esikhumbeni. Kwakhona, akukho data kwi kukhuthaza lwesi sakhi ngexesha dialysis peritoneal.

Intsebenziswano kunye namanye amachiza

Ukuba sisebenzisa "Klarotadin" kwi idosi enyangayo, isiphumo potentiating yeziselo ezinxilisayo wafunyanwa. Kwaye ke isicelo beziyobisi nemithi ezifana "Cimetidine", "Erythromycin" yaye "ketoconazole" uya kwandisa ingqalelo loratodina plasma yegazi. Le nto ke ayithethi abonakalise ngokwezonyango, kwaye akukho ukusebenza electrocardiogram.

Kukho ubungqina bokuba inductors of microsomal igcwala, eziquka ethanol, phenytoin, barbiturates, rifampicin, ziksorin, lakhula tricyclic, phenylbutazone, ungawuhlisa ukusebenza kweli chiza.

oyi

Izigulane abaphethwe umsebenzi othile hepatic kwaye apho kukho insufficiency kwezintso (ukuhluza glomerular iye ngesantya esingaphantsi kwama-amathathu ml / min) ithamo ekucetyiswa sokuqala "Klarotadin" mayingagqithi milligrams ezilishumi (oku tablet enye okanye amacephe amabini ukulinganisa umgangatho isiraphu) kwiinkalo zezifundo ezimbini ngosuku. Okanye ngaba kuyinika eli chiza kubantwana, ogama ubudala ngaphantsi kweminyaka emibini.

Bonke abo baqala ukuthatha eli amayeza kufuneka ayekiswe ngethuba lokuqhubeka kweeseshoni nyango naluphi na uhlobo lwemisebenzi ezinokuba yingozi ezifuna yoxinaniso ophezulu kunye reactions isantya lengqondo.

analogs

Kuyinto elungileyo ukuthi akukho namnye umntu uhlobo sisiyobisi "Klarotadin". Analogue babe phakathi iziyobisi basekhaya amazwe. "Amanye" eqhelekileyo kwamanye amazwe liyeza "Claritin". iimpawu zayo phantse iyafana naleyo ichiza ingqalelo ngentla-"Klarotadin". Ixabiso - yiloo umahluko omkhulu. ukulungiselela phesheya uziindleko kakhulu. Ixabiso zasekhaya kuyafana, ngokuxhomekeke kuqwalaselo. Ngoko ke, apakishe iiPC 7. Kuya kukubiza imali engange malunga 100 ekupakisheni wekhadi nentaba 10 x 3 -. Nama-270 engange, kunye 100 ml isiraphu -. Malunga 135 engange.

akayi kuba apha sithethe ngento ukusebenzisa ngcono - "Klarotadin" okanye "Claritin". Lo ngumbandela labucala, kwaye kuya kufuneka ukuba isigqibo ngokwakho, bathenge imveliso yasekhaya ezitshiphu, okanye ukuba zincede zikhethe kwamanye amazwe olubiza kakhulu. Kodwa kubalulekile ukuphawula ukuba kule minyaka kakhulu kakuhle nezingqinekayo imveliso "Klarotadin". Analogs ngaloo mayibonakale yonke imihla.

Enoba kunjalo, ngaphambi kokuba uqale ukuthatha la machiza kwaye ngakumbi ke ukuba amisele abantwana babo, qiniseka ukuba udibane nogqirha wakho. Oku kuza kukunceda ukuba iziphumo ezingalunganga kunokwenzeka enokuthi yenzeke ngenxa ukunganyamezelani leziyobisi, ukusetyenziswa ngokungafanelekanga lwe libanda yakhe. Kufuneka kusoloko kukhunjulwe ukuba iziphumo ezifana ezinokudala ingozi enkulu kwimpilo yakho, impilo yabantwana benu, kunye nobomi bakho.