Iconjugated linoleic acid: ukusebenzisa kunye nemiphumo emibi. Iconjugated linoleic acid: ukuphononongwa

Kungekudala, unokuva ulwazi oluninzi malunga neenzuzo ze-bioadditive, apho iqela lidibene ne-linoleic acid. Yintoni enye i-linoleic, kwaye ingakumbi idibeneyo, abantu bambalwa kakhulu bayazi. Kuye ongeyena ngcali kwi-chemistry kunye neyeza, kuphela igama elithi "asidi" liqondakala kakhulu okanye lingaqondakali. Ukuthenga iimveliso kunye nezilungiselelo eziqulethe esi sithako, ininzi kuthi silandela ulwazi kwimfundiso kunye nethemba lemiphumo yemilingo. Makhe sizame ukufumana oko kufuneka silindele kule mveliso.

Acid, linoleic

Ubomi obunempilo kunye nokusebenza ngokuqhelekileyo kuzo zonke izitho zomntu, kuyimfuneko ukuba umzimba ufumane i-acid acids, equka i-linoleic. Ingqungquthela yomgca wee-athomu ze-carboni, ezibalwe ukulungelelanisa i-biochemists. Kuphakathi kwe-9 ukuya kwe-10, kunye naphakathi kwee-athi ye-12 kunye ne-13, kukho ukubophelelana olulodwa lwabafaka indawo kulo. Iim atom ze-carbon, ezingabonakaliyo, eziye zahlula, zithintelwa ezi zibophelelo ukuba zingathinteli, yintoni eyenza iipropati zexabiso. I-Conjugated acid e-linoleic inokufunyanwa njengomphakathi ngexesha lokuguqulwa kwe- linoleic acid e- acidic acid . Zonke ezi zintathu zibalulekile kwi-metabolism yabantu. Ngaphandle kwe-fatty acids, ngokukodwa i-linoleic, iinkqubo ze-metabolic ziphazamiseka emzimbeni, inkqubo ye-cardiovascular, ukujikeleza kwegazi, i-arteriosclerosis ikhula kwaye isondlo sazo zonke izicubu ziba nzima. Ininzi ye-linoleic asidi iya kulungiswa kweembrane zeeseli zomzimba womntu. Ngoko ke, kubalulekile ukutya ukutya okuqulethe.

Yintoni idijitated linoleic acid

Kulo mdlalo, izibophelelo ezifaka indawo zitshintsha indawo yazo. Omnye wabo uphakathi kwee-6 kunye nee-7, kwaye enye enye phakathi kwe-8 ne-9. Indawo esondeleyo ibenza bakwazi ukuba nompembelelo komnye nomnye, kunye ne-bond kuphela yamahhala e-carbon. Ukwahlula okwesibini phakathi kwamacidi adibeneyo e-alungiselelo lwe-bond-substituents ezihambelana ne-plane ye-chain. Kwi-plain linoleic yi-fis-fomu, oko kukuthi, ngakwesinye icala, kwaye ekudibeneyo kunokwenzeka ukuba kukho ukuhamba kweefom-trans, okuhlukileyo. Ngenxa yokwahlukana okunjalo kubonakala kungabalulekanga, i-conjugated linoleic acid ithola iipropati ezintsha. Ngokukodwa, uyakwazi ukwenza imisebenzi emibini - ukucima umsebenzi njengomthuthi weempahla ezivela egazini ukuya kwiiseli, i-lipoprotein lipase, kunye kunye nokuqinisa ukucola kwamafutha omzimba, ngelixa i-linoleic eqhelekileyo, ngokuchaseneyo, ikhuthaza ukuqokelela kwamafutha. Omnye umehluko wokumangalisa kukuba i-linoleic acid igalelo ngokukhethekileyo ekukhunjuleni kwe-cholesterol ekuphenduleni kwe-oxidation, kwaye i-conjugated ithombise.

Ukufunyanwa kwezinzululwazi zaseMelika

Nangona i-teknoloji yakutshanje, i-conjugated linoleic acid (CLA) yafunyanwa ngokutsha nje. Ngowe-1979-1980 iqela lezinzululwazi ezivela kwiYunivesithi yaseMerika eTexas yenza uchungechunge lwezifundo malunga nemveliso eyahlukeneyo kwimisebenzi ebalulekileyo yomzimba. UMichael Peyriz, owayengumncedisi, waphawula ukuba inyama ebisiweyo iphazamisa ngokungaqhelekanga utshintsho kwi-DNA yeeseli ezinamahlunu kwizilwanyana. Kwaqulunqwa ukuba le propati ibanjwe yixabiso elitholakala emzimbeni. Izifundo ezongezelelweyo ziye zafumanisa ezinye izakhiwo ezincedo zento entsha, ngokukodwa amandla okukhusela ukuphuhliswa kwezicubu zomhlaza. Oku kwasebenza njengamandla amakhulu ekufundiseni ngokunyanisekileyo iinkqubo ze-biochemical zomsebenzi we-conjugated acid linoleic acid.

Iimpawu eziwusizo

Kulo nqanaba lokufunda, kwafunyanwa ukuba i-conjugated linoleic acid (CLA) ikwazi uku:

• Ukukhawulezisa imetabolism emzimbeni;
• Ukwandisa ubunzima bemisipha;
• Cholesterol ephantsi;
• Ukunciphisa umngcipheko wokuba nesifo sikashukela ngokuxhatshazwa kwe-insulin;
• Ukwandisa ukhuseleko;
• Kunenzuzo ekunciphiseni iziganeko zokutya kokutya.

Izidakamizwa ze-KLK zivimbela inkqubo yokuqokelela amafutha, ngokukodwa kwi-peritoneum (kwindawo ye-visceral). Olu hlobo lweentlawulo zeoli, ezinokubamba isibindi, intliziyo kunye nemithambo yegazi, yingozi kwaye ihlala ikhokelela ekuhlaselweni kwentliziyo, imivimbo, iintlungu kunye nezinye iingxaki. I-KLK ikhulisa uvakalelo lweeseli ezinamahlunu ukuya kwi-insulin, ngokunjalo i-fat, kunye ne-glucose, idlulise ngakumbi ngokubambisa kwiimbumba, ngaphandle kokucinywa "kwindawo yokugcina." Ngenxa yoko, ipesenteji yeoli iyancipha, kwaye ubuninzi bomzimba buya kwanda.

Uphando lweLebhu kunye novavanyo

Nangona i-acid e-conjugated linoleic inezinto ezininzi ezimangalisa, iingcamango zoogqirha kunye nabaphandi ngeyona nto ingabonakaliyo. Oku kubangelwa kukuba kweli nqanaba lokusetyenziswa kwezidakamizwa ezininzi iimvavanyo zenziwa kwizilwanyana. Ngaloo ndlela, kwiinqanda zondliwa imihla ngemihla ngesinambisi esisikiweyo, inkqubo yokubunjwa kwesisu ivalwe kakhulu. Enyanisweni, akunakwenzeka ukufumana ukuba yeyiphi inqanaba elithile le nto eyenzekayo - kwinqanaba lokuqala, elihamba phambili okanye lokugqibela, xa umhlaza uqala ukunika i-metastases. Kukho isiphakamiso sokuba isilwanyana sisebenza kuzo zonke ezintathu. Ukongezelela, kwiigundane, iigundane, kunye nakwizinkukhu, i-CLA iphakamisa kakhulu amandla omzimba, ngelixa izilwanyana ezincinci zikhuthaza ukukhula okukhulayo. Kwelinye iqela lezilwanyana - onogwaja kunye ne-hamsters - I-CLC inqanda ukunciphisa imithwaba eyenziwa ngama-atherosclerotic plaques. Kwimiphakathi, loo mvavanyo ayizange iqhutywe, ngoko kusenokwenzeka ukuba ifikelele ekugqibeleni izigqibo.

Ukulahlekelwa ukuhlolwa kwezesisindo

Kunokwenzeka ukuhlangabezana namabango adibanisa i-linoleic acid anceda ukukhulula kakhulu umzimba. Iingcamango zabantu abazithengayo ngokwabo nazo ziyamangalisa. Abanye banelisekile, abanye babengaqapheli umphumo. Ngo-2000, izazinzulu zaseSweden zashicilela iziphumo zovavanyo zazo kunye neqela lamavolontiya alahlekelwa isisindo ngoncedo lwe-CLC. Bonke badla 3.4 g ye-acid conjugated ngeentsuku ezingama-64. Akukho nxaxheba omnye olahlekelwe isisindo. Ngomnyaka ofanayo, abanye abaphandi abazimeleyo bapapasha iziphumo zokuvavanywa ezenziwa kwelinye iqela labantu abaninzi. Ngokwale nkcukacha, ukulahlekelwa kwesisindo kuboniswe kulabo bathatha amalungiselelo e-CLK. Olunye uvavanyo lwaqhutywa ngabaososayensi baseNorway. Bahlula abathathi-nxaxheba kumaqela amane, nganye apho ulawulo lwe-CLA lwama-1.7 g, 3.4 g, 5.1 ne-6.8. Ukunciphisa ubunzima kwenzeka kuphela kwiiqela ezimbini zokugqibela, ezithe zandisa ukunyuka kwamayeza.

Amava kunye nezigqibo zikaMichael Peiris

I-conjugated acid e-linoleic ithinta njani abantu, kungekhona nje izilwanyana, njengendlela yokulahlekelwa isisindo? Uphando lwenziwe ngezinga elikhulu. Ukuthatha inxaxheba kwabesilisa nabasetyhini babo bonke ubudala, abavela kwiintlanga ezahlukeneyo. UMichael Peiris, umfumbuzi waloo nto, esetyenziswe ekuhloleni iqela labantu abathanjisiweyo (amavolontiya angama-71). Bonke bathatha i-3.4 g yesilwanyana imihla ngemihla kwiinyanga ezimbini kwaye babone ukutya okungekho izitya ezenza ukuba kuzuze ubunzima. Iqela lolawulo lalahlekelwa isisindo kuphela ngoncedo lokutya, ngaphandle kokuthatha isicatshulwa. Abathathi-nxaxheba beprojekthi banciphise ubunzima, kodwa emva kokutya kwakhona kwaqala ukuqwalasela, kwaye ukuthabatha inkunkuma kwandisa ubunzima be-muscle, ngelixa iqela lokulawula liphinde landisa amaninzi omzimba. Ezi nkcukacha zavumela inzululwazi ukuba yenze ingxelo yokuba i-CLC ayinciphisi kuphela ubungakanani beefowuni, kodwa iyanqanda ukwanda kwazo. Olu vavanyo lubonise ukuba isicatshulwa sikwazi ukwandisa ukugcinwa kwe-insulin kwizigulane ezine-type 2 zeswekile kwaye ukunciphisa ixabiso le-glucose egazini. Iziphumo ezinjalo zaphawulwa malunga neyesibini kwizithathu zokuvolontiya zokulinga.

Amalungiselelo enyango ngeCLC

Abaninzi banomdla kumbuzo wokuba i-conjugated linoleic acid iqulethwe kuwo amalungiselelo. Nazi ezinye zezinto ezifakelwayo kwi-pharmacy kunye nezitolo zezemidlalo kunye nalesi sithako:

1. "Linofit." Iphakheji iqulethe iifomsile ezingama-60, nganye iqukethe i-800 mg ye-asidi. Ixabiso kwiimarike zaseRussia zivela kwi-ruble ye-1500. Kanye kunye ne-CLK kwiifomsile, iodine kunye ne-vitamin B6 zikhoyo, ezandisa kakhulu izakhiwo ezixhamlayo ze-supplement supplement.
2. Reduxin Light. Iiphakheji ze-30, 90, 120 ne-180 capsules ziveliswa, nganye ziqulethe i-500 mg ye-acidi conjugated, kunye ne-vitamin E. Ixabiso liphuma kwi-ruble elingu-1 000 ukuya kwi-2,720 (ngokuxhomekeke kwinani leefomsile).
3. "Ishokoleta yobomi." Iphakheji iqulethe iibhonki ezili-10 ze powder kunye ne-KLK, apho isiphuzo silungiselelwe khona. Ixabiso livela kuma-ruble angama-300.

Kukho amazwe angaphandle: i-Zerofat, i-CLA, i-CLAextrim kunye nabanye. Ixabiso elilinganiselwa kubo liphuma kwiidola eziyi-15.

Imithombo Yendalo

Kukho izixube ezimbalwa zokutya ezivela kubakhiqizi abahlukahlukeneyo, apho iqela eliphambili lidibeneyo i-linoleic acid. Ubungqina bathengi bahluka ngendlela efanayo neziphumo zophando zenzululwazi. Kukho abantu abaninzi abaye baphawula umphumo omuhle. Ngelo xesha kuninzi lwabantu abangenalo ukulahleka kwesisindo okanye bengabalulekanga. Ukongezelela kwizibonelelo zokutya, i-KLK ifumaneka kwiqela elikhulu lemveliso yemvelo, ngoko banokudliwa imihla ngemihla ngaphandle kwemimiselo. Amanani etafileni obisi, inyama kunye namaqanda kubhekisela kwizilwanyana ezikhulile ekudleni kwemvelo.

Ukungqinelana

Aphawuleki ukuba ukusetyenziswa okufanelekileyo kwezi mveliso zingentla kubangele ukuphendula okungalunganga komzimba (ngaphandle kwe-immunity individually). Xa usebenzisa iziyobisi apho idijitated linoleic acid yayilunxweme, imiphumo emibi, ngelanga, yavela. Ngoko ke, abanye abathengi abasebenzisa izongezo zokutya kunye ne-CLC, kwakukho ukuxakeka kwezidumbu ezikhoyo ngaphambili, ukungaqhelekanga kwindlela yokugaya, ukukhawuleza, isisulu somsanqa. Ngethuba lokulinga eSweden, abantu abangama-47 kuphela aba-60 abaye bathatha inxaxheba kulo mvavanyo bakwazi ukugqiba lonke ikhosi. Abanye baphoqelelwe ukuba bayeke ngenxa yeengxaki zempilo.