"Fraksiparin": imiyalelo yokusetyenziswa, ukuhlaziywa

Iyintoni injongo yeso sidakamizwa njengo "Fraksiparin"? Imiyalelo yokusetyenziswa kweziyobisi, ifomu layo kunye nokubunjwa kwalo kuya kuboniswa ngezantsi. Kwakhona kwizinto ezikule nqaku uza kufunda malunga na ukuba le michiza ineempembelelo kunye nezichaso.

Ifom, ukupakisha, ukubunjwa

Ngaluhlobo luni lokupakisha ukuba isilwanyana "Fraksiparin" sithengiswa? Imiyalelo yokusetyenziswa ibonisa ukuba umkhiqizo ukhutshwe kwisirinji, leyo leyo, ibe yona ibekwe kwi-pack blister kunye nekhadibhodi.

Isilwanyana esibuthakathaka esichaphazelekayo esenzelwe ukwenziwa kwintsimbi engaphantsi komzimba ngumbane ongenakubala kunye nokucacileyo. Ingabandakanya i-9500, i-5700, i-2850, i-3800 okanye i-7600 IU ye-anti-Xa supraparin calcium. Ukongezelela, ukubunjwa kwesilwanyana kubandakanya izinto ezinje njengamanzi ahlambulukileyo, isisombululo se-calcium hydroxide, i- hydrochloric acid.

Iinkalo ze-Pharmacological ne-pharmacokinetic

Yintoni iyeza "Fraksiparin"? Imiyalelo yokusetyenziswa, isetyenziswe kwisiza, ibonisa ukuba le yintsebenziswano ephezulu kunye ne-anticoagulant.

Into esebenzayo yeziyobisi i-heparin yesisindo esisezantsi. Ifunyenwe yi-depolymerization kwaye ibonisa ubuchule obuphezulu kakhulu bokubopha kwiiprotheni zamaplasma. Esi siphumo sikhokelela ekwenzeni ukwanda kwe-factor Xa.

Emva kokufakelwa kwe- subcutaneous injection, umsebenzi ophezulu olwa no-Xa uyagcinwa emva kweeyure ezintlanu. Isilwayo sithathwa ngu-88%.

Ukuba la mayeza alawulwa nge-intravenously, ukuxinwa kweyona nto ephezulu egazini kubonwa emva kwemizuzu engama-10. Isiqingatha-ubomi sokuphelisa iiyure ezingama-2.

Isilwanyana esibindi sisetyenziselwa ukuxhomekeka kwe-depolymerization nokuchithwa.

Iimpawu zokusetyenziswa

Kutheni usebenzisa i-drug "Fraksiparin"? Imiyalelo yokusetyenziswa (imifanekiso yezilwanyana onokuyifumana kule nqaku) ichaza ukuba loo mayeza aqhelekileyo anqunywe ukwenzela ukukhusela iingxaki ze-thromboembolic, kubandakanya emva kokungenelela kwindlela yokugonywa kunye ne-orthopedic.

I-Anticoagulant inconywa kubantu abanomngcipheko ophezulu we-thrombosis, kwakunye nokubandezeleka kokuphefumula okanye ukukhubazeka kwentliziyo kwimeko efanelekileyo.

Ukungqinelana kokusetyenziswa

Ngaphantsi kweemeko zingaphakanyiswa ukusebenzisa izidakamizwa "Fraksiparin"? Imiyalelo yokusetyenziswa iqulethe uluhlu olulandelayo lweenkcazo:

• Ukulimala kwamalungu kunye nokuphuma kwegazi;
• I-Thrombocytopenia, eyenziwa ngokusesikweni kokusetyenziswa kwe-supraparin esikhathini esidlulileyo;
• Ubudala bomntu ongaphantsi kwe-18;
• Ukuhlamba okanye ingozi eyongeziweyo yokuphuhliswa kwayo, ehambelana nokunyuka kwe-hemostasis;
• Ukungaphumeleli kweentso, ngakumbi kwiimeko ezinzima;
• Intracranial hemorrhage;
• I-endocarditis echaphazelekayo kwifom elula;
• Ukuhlinzwa okanye ukuxhwaleka kwamehlo, umlenze womgudu okanye ingqondo;
• Ukunyanzeliswa kwesigulane kwizidakamizwa.

Kwakhona kufuneka kuthiwa "i-Fraksiparin", ekuhlaziywa kwayo okungahambelaniyo, kufuneka ithathwe ngokuqaphela okukhulu kwi-renal okanye ukungafihleki kwe-hepatic, utshintsho kwi-circulation blood kwi-retina okanye kwi-choroid, i-eye hypertension yesohlo, ingozi ephezulu yokhuseleko, izifo ezandisiwe Ingozi yokuphuma kwegazi, izilonda zamapilisi ngexesha elidlulileyo, kunye nexa zidibene nezinye i-anticoagulants, emva kokuhlinzwa kunye nezigulane ezinomlinganiselo ofikelela kwi-40 kg.

Isiza "Fraksiparin": imiyalelo yokusetyenziswa

Xa i-IVF imithi "i-Fraksiparin" imiselwe ukuba iphuculwe imilinganiselo ye-rheological yegazi kwaye iququzelele ukufakelwa.

Sebenzisa le chiza kufuneka imiselwe kuphela ngugqirha. Kumele ilawulwe ngaphantsi kwesisu, ishintshe phakathi kwamacala asekhohlo kunye namacala. Ngaloo ndlela isigulane kufuneka sibe kwindawo efanelekileyo. Kwezinye iimeko, iyeza lijojowe emthonjeni.

Ungayithatha njani iFraksiparin? Inaliti kufuneka ifakwe kwi-pependicular to the skin of the skin, eyenziwa yiminwe yesandla samahhala. Kule meko, umlindi kufuneka agcinwe ngexesha lonke. Emva kokuba isilenze senziwe, indawo yokuxilisa akufanele ihluthe.

Yintoni ekumele ibe yiyilithi yeliza "Fraksiparin"? 0.3 ml imiselwe ukukhusela i-thromboembolism kwindlela yokungenelela (2850 olwa-XA ME). Amachiza alawulwa iiyure ezine ngaphambi kokusebenza, kwaye emva koko - kanye ngosuku. Unyango luya kuqhutyelwa ubuncinane ngeveki enye okanye ixesha elipheleleyo lomngcipheko we-thrombogenis (ukomzekelo, phambi kokutshintshela ukubeka iliso kwi-patient).

Ngoku uyazi injongo ye-drug "Fraksiparin" (0.3 ml) inokumiselwa.

Ukongeza kwintsebenzo, esi sixhobo sisetyenziswa ngokuthe ngqo ukukhusela i-thromboembolism kwimathambo. Ilawulwa ngaphantsi kwe-38 ye-Ha IU ngekg yesisindo somzimba. Le dosi inganyuswa ngamaxesha ama-1.5, kodwa kuphela ngosuku lwesine emva kokungena kwamathambo.

Kubantu abanomngcipheko ophezulu we-thrombosis, isilwanyana "i-Fraksiparin" silawulwa ngokukhawuleza kanye ngosuku ngemali ebalwe ngokuxhomekeka kubukhulu besigulane (ngaphantsi kwama-70 kg, i-3800 anti-Ha IU ngosuku, kunye no-5,700 olwa-Ha IU).

Xa unyango lwe-thromboembolism, i-anticoagulants ngendlela yamacwecwe kufuneka ilawulwe ngokukhawuleza. Ulwaphulo "I-Fraksiparinom" aluyeki kuze kube yinjongo yexesha leprothrombin .

Ukugqithiswa kweMpawu

Ngoku uyazi indlela yokugxotha uFraksiparin. Kufuneka kuqatshelwe ukuba xa usebenzisa izilingo eziphezulu zezi zibisi, isigulane sinokuphuma ngegazi kwiindawo ezahlukeneyo. Nangona kunjalo, ukuphuma kwamandla angapheliyo akudingi unyango oluphuthumayo (kubalulekile kuphela ukunciphisa umthamo okanye ukuyeka i-injection elandelayo).

Ngokubhekiselele kwi-overdoses eqinile, i- protamine sulfate inceda ukunciphisa i-anticoagulant effect ye-heparin. Ukusetyenziswa kwayo kuyadingeka kuphela kwiimeko ezinzima.

Iziphumo eziPhakathi

Ziziphi iziphumo ezibi ezingabangela "uFraksiparin"? Iingxelo zezigulane zithi le nkunkuma ikhuthaza ukuphuhliswa kwegazi kwiindawo ezahlukeneyo, i-thrombocytopenia, i-eosinophilia, i-enzyme yesibindi kunye ne-hypersensitivity. Kwakhona, izigulana zinokuphuhlisa ii-hematomas ezincinci kwi-site injection. Kule meko, unyango nge "Fraksiparin" kufuneka luyeke.

Ukusebenzisana kwezidakamizwa

Umngcipheko we-hyperkalemia unyuke kakhulu xa le nkunkuma iphathwa nge-ACE inhibitors, i-potassium isalts, i-angiotensin receptor blockers, i-potassium-sparing diuretics, i-Tacrolimus, i-heparins, i-Cyclosporin, i-NSAID ne-Trimethoprim.

Kwakhona kufuneka kuthethwe ukuba ukudibanisa ne-acetylsalicylic acid, i-NSAID, i-antiticoagulants engqalileyo, i- "Dextran" okanye i-fibrinolytic idibanisa iziphumo zamachiza.

Ukukhulelwa kunye nexesha lokulahlwa

Ngaba kunokwenzeka ukuthatha uFraksiparin xa ukhulelwe? Imiyalelo yokusetyenziswa ekukhulelweni (ukuphononongwa kwisiza kuza kuboniswa ngezantsi) ithi i-calcium supraparin (into esebenzayo yeziyobisi) ilula ngokungena kalula kwi-placenta. Kwakhona, eli candelo leziyobisi lixutywe kunye nobisi lwebele.

Ngokumalunga nazo zonke ezi ngasentla, kufuneka kuqatshelwe ukuba ii-injection ze-"Fraksiparin" xa zithwele umntwana kwaye ngexesha lokusondeza azinconywa. Nangona kunjalo, kwezinye iimeko, eli lonyango lisalunikwe izigulane.

Ngoko indlela yokusebenzisa isilwanyana "Fraksiparin"? Izikhokelo zokusetyenziswa ngexesha lokukhulelwa kufuneka ziphuhliswe kuphela ngongcali onolwazi. Ngaloo ndlela umfazi kufuneka abe ngumlawuli oqhubekayo kugqirha.

Iintetho, ixabiso

Ezi zi yobisi zilandelayo zifana nale nkunkuma: "Heparin-Pharmex", "Athenativ", "Enoxsarin", "Wessel Douay F", "Cibor", "Heparin", "Fragmin", "Heparin-Biolek", "Flenox", " Heparin-Darnitsa "," Novoparin "," Heparin-Indar "," uClexane "," Heparin-Novopharm ".

Ixabiso leziyobisi "Fraksiparin" liphezulu kakhulu. Iipiringi eziyi-10 (0.3 ml) uza kufuneka uhlawule malunga nama-ruble angama-2500.

Uphononongo malunga neziyobisi

Izimvo zesigulane malunga neziyobisi ezithandwayo ziyizinto ezingenangqondo. Omnye uncede le nkunkuma kakuhle, kodwa umntu ukhononda ngokungahambi kwakhe. Ukongezelela, kukho ukuhlaziywa okumbalwa ukuba "i-Fraksiparin" ibangela inani elikhulu leempendulo ezimbi.

Iingcali azicebisi ukuxhomekeka kwimbono yabasele basebenzise le michiza. Isizathu sokumisela isilwanyana, ukuphumelela kwayo kunye nobungozi obuchaphazelekayo, sinokuhlolwa kuphela ngutitshala onolwazi.

Kufuneka kwakhona kuqaphele ukuba akukho zibuyekezo ezimbi malunga nale nyeza ngexesha lokukhulelwa.