I-Indapamide - imiyalelo yokusetyenziswa

I-Indapamide "- isilwanyana seqela lama-diuretics-like diuretics, inefuthe elichasayo. Amachiza "i-Indapamide" ibonakaliswa ukusetyenziswa phambi koxinzelelo lwegazi.

I-Pharmacotherapy yesilwanyana "Indapamide"

Amanqaku okufundisa ukuba izixhobo ze-pharmacological zezilwanyana zihlobene ne-thiazide diuretics. Impembelelo yeziyobisi, ezinokubethwa kwe-calcium "ephuculwayo" ekhethiweyo, igalelo ekwenzeni ukwanda kweendonga zombutho, ngokunciphisa ukuxhatshazwa kwemisipha yendawo.

"I-Indapamide" ayitshintshi i-carbohydrates metabolism, eyamkelekileyo kwizigulane ezineesifo sikashukela, kwaye ayichaphazeli i-lipids kwi-plasma. Amacwecwe "I-Indapamid" uncedo lokunciphisa i-hypertrophy kwi-ventricle engasekhohlo yentliziyo, ukunciphisa ubuzwe beendonga ze-vascular ukuya kwi-noradrenaline kunye ne-angiotensin II, ukukhuthaza ukuhlanganiswa kwe-prostaglandin E2, ukunciphisa umkhiqizo we-oxygen radicals. Ngokuqhelekileyo, ngomhla wesi-5 we-7, unyango lubonisa umonakalo ochasayo, oqhubekayo nomtya owodwa ngosuku.

I-Pharmacokinetics yokulungiselela "i-Indapamide"

Umyalelo uthi iyeza libhekiselele kwi-bioavailability ephezulu (93%) kunye nokuxhamla kwindlela yokugaya. Isantya sokumitha sithinteka ngokutya. Ukugqithisa okukhulu kweziyobisi egazini kudalwe kwisithuba seyure okanye ezimbini emva kokuthatha isilwanyana kwisixamali esingu 2.5 mg. Iyeza lixhaswa ngesibindi. I-60% -80% yexabiso lithengiswa ngeentso ngendlela yemetabolites, malunga ne-20% - ngamathumbu. Isilwanyana asinakho amandla okunyusa.

Imiqondiso yokusetyenziswa "i-Indapamide"

Umyalelo uchaza ukusetyenziswa kweyeza ukunciphisa uxinzelelo lwegazi. Kwakhona, isilwanyana sinconywa kubantu abanesifo esingapheliyo senhliziyo.

Ukungqinelana

"I-Indapamide" inqatshelwe apha:

- i-hypersensitivity kuyo kunye nezinye iziphumo zeqela le-sulfonamide,

- anuria,

- hypokalemia,

Ukungenakunyaka,

- ixesha lokulahlwa,

- i-pathologic acute of circulation circulation,

- ukukhulelwa,

- ngaphantsi kweminyaka eyi-18 ubudala (ngenxa yokungabi nalwazi),

- ukusetyenziswa ngexesha elifanayo lamachiza okwandisa ixesha le-QT.

Ngoqaphele misela eli chiza phambi kwentsholongwane kunye nesifo sikashukela kwisigaba sokuhlawula.

Indlela yesicelo kunye nokulinganisa kweyeza "Indapamide"

Umyalelo uncoma ukuthatha amacwecwe ngaphakathi ngaphandle kokuhlafuna. 2.5 mg (idosi yemihla ngemihla) isetyenziswe kakuhle ekuseni okanye emva kwemini. Kwimeko xa ikhosi ye-1-2-nyanga yonyango eneziyobisi ayifuni imiphumo efunwayo yokunyanga, ukunyuka kwesazi akukhuthazwa ngenxa yengozi yokwanda kwemiphumo emibi. Kule meko, enye i-arhente intsimbi, engeyona idayuretic, kufuneka ifakwe kwi-scheme yonyango lwe-drug of hypertension. Xa uphathwe izidakamizwa ezimbini ezichasayo, umthamo weziyobisi "Indapamide" uhlala ufana.

Ukugqithisa

Iimpawu zokunqongophala obuthathaka obuthathaka, umsebenzi ongenakunqwenelekayo kwendlela yokuxhamla isisu, isisongela, ukuhlanza, ukuphazamiseka kwamanzi-electrolyte. Kwezinye iimeko, ukugqithiseleka kokuphefumula nokuphefumula ngokweqile kwexinzelelo lwegazi kuyenzeka. Kwizigulane ezine-cirrhosis zesibindi, i-coma e-hepatic ingenzeka .

Kwimeko yokudlula ngaphezulu kuyimfuneko ukufezekisa ukulungelelanisa ukulinganisela kwamanzi-electrolyte: ukugcoba isisu kunye neyonyango.

Ukusebenzisana

Uqinisa umphumo wamanye amayeza kunyusa uxinzelelo lwegazi. Akukhuthazwa ukudibanisa kunye namalungiselelo aqukethe i-lithium, i-vinamine, i-potassium-ukukhupha i-diuretics.

Imiphumo emibi yeliza "Indapamide"

Kuyafana, njengamaxesha okudlula ngaphezulu. Ukuphulwa kwintliziyo yesingqimba ngenxa yokulahlekelwa kwe-potassium. Kwakhona, imiphumo engabonakaliyo ingabonakalisa ubuthathaka, ukunyuka okucuthayo kwingcinezelo xa uzama ukuma, isicathulo, intlungu esiswini, isifo sohudo, ukuxhatshazwa, ukuphazamiseka. Kwiimeko ezinqabileyo, kunokubakho uxinzelelo lwe-gout, ukuxinwa.