"Fosfomycin": analogue, uqeqesho kunye nengxelo

Nangona arhente antibacterial kufuneka inani elikhulu yeziphumo ebezingalindelekanga, akusoloko kusenzeka ukuba ukwala isicelo sabo. Into esemqoka ukuba ichiza onyuliweyo ngokuchanekileyo kwaye unike iziphumo ezinqwenelekayo.

ukusebenza eziphakamileyo unyango lwezifo iyahluka medicament "Fosfomycin". analogue Drug kuba nemiphumo efanayo. "Fosfomycin" ikhutshwa ngokohlobo granules kunye nomgubo ngamanzi-enyibilikayo senzelwe ukuba isisombululo, asinto ibe spectrum umsebenzi ngokubanzi elwa.

Indlela yokusebenza ye ichiza

Antibiotics ngempumelelo izifo kuphuhliso yabo ngenxa yeziphumo kwi umzimba iintsholongwane eziyingozi (Igram HIV kunye Igram negative). Isiphumo elwa ifunyanwa ngeendleko iziyobisi fosfomycin trometamol esebenzayo. isenzo Antibacterial ikhutshwa phandle waphula ukuyilwa ezindongeni yebhaktiriya.

Pharmacokinetics

Xa ingqalelo enkulu isithako esebenzayo, umsebenzi ichiza ubuninzi waphawula "Fosfomycin" ekhoyo kwi plasma yegazi. Guide ibonisa ukuba oku iiyure 2-2,5 emva ukungena beziyobisi emzimbeni. "Fosfomycin" ezifanelekileyo zolawulo parenteral kunye ngomlomo. Drug sokungenisa, ukufunxile ngokukhawuleza ukusuka iphecana zesisu, acazulule zibe trometamol fosfomycin. Absorption kwi uluhlu-34% ukuya kuma-65% (isidlo kunciphisa index, ngoko ngcono isiselo amayeza ungatyanga). Kuba inxenye-ubomi efunekayo 4 hr. Fosfomycin trometamol kwazona ngokupheleleyo endleni kunye nomchamo, isikakhulu izintso (malunga ne-90%).

Ubungqina obubonakalayo buxela

Ngokuqhelekileyo "Fosfomycin" analogs medicament sithathwa ngomlomo izifo ezosulelayo kwinkqubo womchamo. Drug aphathe ngempumelelo Ngokuzimela kunye urethritis umyalezo yebhaktiriya, bacteriuria omkhulu, nto leyo maxa wambi kwenzeka abasetyhini abakhulelweyo yaye akukho ukuzibonakalisa. Kweli xesha postoperative, le arhente antibacterial ukunqanda ukuvela ezimbi esosulelayo.

Injecting eboniswe unyango inani elikhulu izifo ezibangelwa intshabalalo bacterium umzimba:

• ubovu unepleurisy;
• Ngokuzimela olunamandla;
• pyelonephritis;
• adnexitis;
• septicemia;
• pneumonia;
• bronchiectasis;
• usuleleko zangasese.

Kwiimeko kakhulu impatho indibaniselwano kunokwenzeka, ngaphandle xa "Fosfomycin" ezinye babesebenzisa antibiotics. Ngokomthetho "Fosfomycin" (analogs) ezisetyenziswa kunye antibiotics beta-lactam.

Izimo nokulinganiselwa

Ichiza ke yayisalawulwa ubuthathaka ephakamileyo ukuya esisebenza kunye namacandelo abangabancedani. Ichiza contraindicated kwizigulana abafunyenwe ukusilela kwezintso (ukucoca creatinine ngaphantsi kwe-10 ml / imiz.).

Xa ukunyhashwa "Fosfomycin" imisebenzi wesibindi, nezintso isetyenziswe ngobulumko ngexa lokukhulelwa kunye lokwaphusa - kuphela phantsi kweliso yincutshe.

ukusebenzisa ofunekayo unyango izigulane abangaphantsi kweminyaka engama-5 kunye engama-75 ubudala (abantwana abangaphantsi kweminyaka emi-5 "Fosfomycin" emiselweyo ezinqabileyo).

Ukusetyenziswa "Fosfomycin"

Ngaphakathi ukusetyenziswa zithutha ngaphambili unyityilikiswa emanzini iinaliti ukuba isisombululo injectable olulungiswe ukulungiselela umgubo "Fosfomycin". Analogs, yaye esi sixhobo lisetyenziswa ngokwemithamo isincomo yi igqirha khona. Oyidlayo ixhomekeke sifo kunye namandla aso.

Lo myalelo uthetha idosi esicaciswe xa yenkampani: abantwana - 2 grams ngemini, kuba abadala - 3 grams ngosuku. Umntwana ufakwe yegazi akukho ngaphezulu kwe 100-200 mg / ubunzima bomzimba kg, abadala - hayi ngaphezulu kwe 2-4 g Granules kanye kuthathwe, ngenxa yokungabi okanye iiyure ezi-2 emva kokutya. Kulo mzekelo isidlo esilandelayo Akulula ngaphambi kwe emva 2 hr. Uyacetyiswa ukuba ukuthatha amayeza phambi kokuba uye kulala emva lokusula isinye.

imiphumela emibi

Product equlethe trometamol fosfomycin, analogs zesixhobo, kwakunye naziphi na ezinye antibiotics kungakhokelela kuphuhliso basabele ezingafunekiyo. Ezibangelwa zilandelayo kwi phecana zesisu:

• ukutshintsha phakathi kweenyawo;
• flatulence;
• isicaphucaphu, kulandelwe ukubuyisa.

I-luvo wambi wabona uvalo kakhulu, isiyezi, intloko ebuhlungu, umntu usoloko ufuna ukulala.

Izitofu kungabangela intlungu kuyo inaliti, imvakalelo lunxano. Emva lolawulo beziyobisi ngale ndlela ezinye izigulane kufuneka thrombocytopenia, leukopenia, ukususela negazi - mothuko anaphylactic, isikhumba ukurhawuzelela, irhashalala, urticaria. imiphumela emibi kwakhona ziquka ukubonakala nokudumba peripheral, nokuxutha izinto. It is hhayi ngaphandle ukubonakalalisa ezinye iziphumo ebezingalindelekanga.

Xa libanda ngayo ezingafunekiyo kugqame kakhulu. Kubalulekile ukuba usele iziselo, ukongeza, kuyimfuneko ukwenza unyango nomqondiso.

Emva kokuchaza iziphumo ebezingalindelekanga iziyobisi "Fosfomycin" umyalelo ukuthintela ukusetyenziswa kwayo phambili. kufuneka zenziwe Doctor replacement iziyobisi.

oyi

Kufuneka ithathelwe ingqalelo intsebenziswano beziyobisi kunye nezinye izinto. Ayikhuthazwa ukuba bathabathe "metoclopramide" kuthetha, okt. To. Isiphumo lokusetyenziswa kwazo ngokudibeneyo kukunciphisa ukusebenza "Fosfomycin".

Musa ukuthatha amayeza e kwizigulane ziyathanda ekubonakalisweni komzimba. Njengoko ichiza ludlulele ubisi lwebele, unyango ngexesha webele-lwebele kufuneka ayekiswe okanye kwenziwe ngobulumko.

"Fosfomycin" analogue, ntonye beziyobisi bathabatha izifundo. Ngexesha unyango, amayeza ayikwazi awukho, kuyimfuneko ukusebenzisa amathuba alinganayo ngokuqaphela. Xa kwakukho yokupasa ithamo efunekayo kufuneka kuthathwe (kuphela xa kuthe ukuba akukho mfuneko yokuba athathe idosi elilandelayo kwixa elizayo) ngokukhawuleza kangangoko kunokwenzeka.

ukubuyekeza Analogs

Endaweni yoko, ichiza "Fosfomycin" linokusetyenziswa iziyobisi, analogs kunye neziyobisi-ntonye. Kodwa kufuneka ukhethe ugqirha okunyangayo. Kubalulekile ukuphawula ukuba "Urofosfabol" yaye "Monural" lidla izakusetyenziswa endaweni ingxelo izixhobo. Angaba kakhulu ngempumelelo endaweni "Fosfomycin". Analogue e Ukraine thaca ngala machiza. Ezi Amachiza ukumelana kakuhle imisebenzi kwaye zingasetyenziswa ukunyanga izifo ezifanayo "Fosfomycin". Njengoko kunye nezinye izinto antibacterial, banalo neziphumo ebezingalindelekanga. "Urofosfabol", "Monural" ingenakuthatyathwa bakulumkele kakhulu, into enye kusebenza ichiza "Fosfomycin". Savulwa eRashiya, nto leyo ithandwayo - kwiikhemesti "Monural", kodwa "Urofosfabol" nazo.

"Monural" lidla ezimiselweyo yonyango womchamo izifo ezihlasela zosulele ezosulelayo ezifumaneka ngaphandle iingxaki ezibangelwa amagciwane basengozini ichiza. Ichiza asetyenziswe imisebenzi kunye neenkqubo yoxilongo. "Urofosfabolom" nokunyanga izifo ezosulelayo kunye ukudumba, kodwa kuphela abo enovakalelo kwizinto zayo esebenzayo. Kukho iinketho ezimbalwa ukuba ungakwazi esikhundleni "Fosfomycin". Analogue of Ukraine neRashiya zisebenzisa efanayo.

Ukuphonononga kubonisa ukuba "Fosfomycin" asikwazi kusoloko kufunyanwa ezikhemisti, kwaye iindleko oko kwazi, Kuphezulu, asinguye wonke umntu unako ukuthenga. Kodwa "Monural" esoloko ikhona. Kutshiphu, kodwa hayi kabi. Abo bamkela "Fosfomycin" isaziso ukuba unalo ziphumo zinqwenelekayo ngokukhawuleza ngokwaneleyo. Noko ke, asingabo bonke uyalibona kwezi nguqu zintle. Ngamanye amaxesha, ukuze ukunyanga esi sifo, kuyimfuneko ukuchonga kwelinye ichiza. Kwezinye iimeko, reactions ezingalindelekanga, okt. K. Umzimba lomntu ngamnye wahlukile kwaye aphendule izinto ezikhoyo kumalungiselelo ngenye indlela.