Epinephrine hydrochloride: imiyalelo zokusetyenziswa, inkcazo yokulungiselela

A ukuncipha elibukhali uxinzelelo lwegazi ngenxa komzimba, ngaphezulu amayeza okanye ezinye oonobangela kukhokelela kwiziphumo vuhlayiseki emzimbeni kunye nokufa. Ukuza kuthi ga ngoku, le nkqubo lezamayeza ukususa isigulana kule uburhulumente kusetyenziswa hydrochloride adrenaline. It, kuxhomekeke kubunzima le meko, izigulane elawulwa kwesikhumba, intramuscularly okanye butofelwe, yaye kwiimeko ezininzi kakhulu - intracardiac.

imiphumela kwemithi

Isiphumo iphambili ichiza inxulumene ngqo ifuthe uA kunye b-adrenergic receptors, nangeendlela ezininzi ezifana nemithambo ifayibha neziphumo excitation. Xa aziswa epinephrine hydrochloride ikhuthaza vasoconstriction onke amalungu esiswini kunye nezihlunu ngokungaphelelanga skeletal. Ngenxa nokwehla okungaka amajelo igazi le mithambo kwenzeka ukunyuka koxinzelelo lwegazi.

Nakuba kunjalo, kufanele kuqatshelwe ukuba isiphumo yoloyiko azinampembelelo umzimba, ngenxa ifuthe b-adrenergic receptors, rhoqo ngaphantsi xa kuthelekiswa ne noradrenaline. Isimilo utshintsho umsebenzi intliziyo sinzima kakhulu. Emva ukukhuthazwa receptors adrenergic kunegalelo izinga lentliziyo rhoqo ngakumbi nokwanda, yaye kwangaxeshanye, xa uxinzelelo lwegazi liphuma, iziko le-luvo yimincili vagus, apho abangaphangeliyo umsebenzi kwentliziyo. Kungenxa yoko le nto ebudeni hypoxia lokuphatha ichiza kungadala arrhythmia.

Ukongeza, ichiza ebangela umfundi komlomo, ukuthanjiswa izihlunu emathunjini kunye bronchi. Oku kubonakaliswa ukuba izigulane okukhawulezileyo inyama ukutya kunye glucose avuke egazini emva nedosi enye ye-isixhobo ezifana epinephrine hydrochloride. Imiyalelo yokusebenzisa kwaye iqulathe ulwazi malunga ukuba amayeza ibuyisela amandla esebenzayo skeletal esiqwini izihlunu, kuquka ne ukudinwa.

Ngokunxulumene nenkqubo luvo, idosi kwezonyango beziyobisi, njengoko umthetho, musa ukuba nempembelelo ngokukhawuleza kuyo.

Ukubonisa ichiza?

Ukusetyenziswa epinephrine hydrochloride kunye nokuncipha elibukhali kwi uxinzelelo lwegazi (ezifana imeko yezonyango isigulane ekuthiwa ukuwa). Kuvela i ingxaki enjalo kungabangela imithi yabantu libanda, impovane kunye abasabela zosulele komzimba.

Enye inkomba ichiza - hypoglycemia, olwenzeka xa libanda kwencindi. Kule meko, isigulana liyehla kakhulu uxinzelelo lwegazi yokusebenza nje kuphela, kodwa inqanaba iswekile yegazi.

Zamehlo imithi kwizigulana noxinzelelo intraocular (glaucoma). Ngo-ENT indlela abasebenza ngayo isetyenziswa njengendawo vasoconstrictor.

Ukongeza kwezi okukhomba, epinephrine hydrochloride yenziwa izigulane ventricular fibrillation.

inkqubo nomthamo kunye nendlela yokusebenzisa

Kuxhomekeka sifo kunye neziyobisi yayo nangokubandezela isigulane iboniswe kwesikhumba, intramuscularly kunye yegazi. Ngaloo ndlela usebenzisa 0.1% nesisombululo 0.2 / 0.3 / 0.5 okanye 1 ml. Izigulane kubanjwa etsolo cardiac ilawulwa 1 ml yokulungiselela, wasebenzisa idosi enye, kunye ventricular fibrillation. Kufuneka kuqatshelwe ukuba wesekethe beleni kuphela ugqirha ukuba kwimeko nganye ikhetha.

Zamehlo ukuphumeza isiphumo vasoconstrictive lasekuhlaleni epinephrine hydrochloride lusetyenziswa kwiinwebu esweni.

isifuba inyumoniya isikiwe ulawulo kwesikhumba amachiza 0.3 - 0.5 - 0.7 ml. Kodwa amathamo zonyango kwezisombululo epinephrine ukusetyenziswa parenteral, ngoko, njengoko umthetho, ukuba ziqulunqwe ukuze izigulane abadala 0.3 - 0.5 - 0.75 ml. Ngokosana, ukuba kuyimfuneko isicelo sale medicament ehamba nobudala ephathwa 0.1-0.5 ml.

Ukubunjwa ichiza

Epinephrine hydrochloride ngohlobo olusulungekileyo pink kancinane okanye ezimhlophe powder crystalline. Phantsi yempembelelo oksijini kwaye ukukhanya unako ukuyitshintsha. Noko ke, ngefomu, ukulungiswa ayikho anikiwe umsebenzisi. Phambi kokuba ungasetyenziswa yezonyango kwiimeko aseptic kwi mveliso zoxubo ngayo bungxengwe nesisombululo zehydrochloric acid. In usebenzisa usokhemisi njengoko kwisigcinakaliso sodium metabisulphite kunye chlorobutanol.

Kuphela emva koko ezikhemisti, izigulane ukufumana isisombululo epinephrine hydrochloride, ngokupheleleyo ilungele ukusetyenziswa.

uhlobo Ukukhutshwa ichiza

Ukuza kuthi ga ngoku, ichiza ifumaneka kuphela kubathengi ngohlobo 0.1% solution efumaneka ezineengqayi kunye ampoules. Volume Okokuqala ml-30, kodwa ke wesibini - ml 1 kuphela. Ampoules leePCs 6. zahlanganiswa kwibhokisi ibhokisi.

Imbonakalo kufane Isisombululo ngokupheleleyo ulwelo transparent, akukho kwenze kunye iziqalelo nerastvoronnyh ezahlukeneyo.

Le ichiza contraindicated?

Ukuba sicinga ukuba ebonisa siphambili ukusetyenziswa kweziyobisi - ukunyuka koxinzelelo lwegazi ngenxa licuthe imithambo yegazi, kusengqiqweni ukuba ngokupheleleyo ayikwazi ingasetyenziswa kwizigulane unesifo. Kwakhona lithetha esalelweyo ngqo kwi yegazi, hyperthyroidism seswekile, kuba isiphumo amayeza beziyobisi akakwazi kubi kuphela ngexesha zifo zikhankanywe apha ngasentla, kodwa kusenokukhokelela nemiphumo eyingozi kakhulu. Umzekelo, iposi engabalulekanga, stroke kunye nabanye.

Akukho hydrochloride epinephrine esebenzayo ngexesha lomsebenzi utyando, cyclopropane okanye Ukubulawa halothane.

Kufuneka kuqatshelwe ukuba ichiza kuyathintelwa ngexesha lokukhulelwa kunye zisanyisa. Kwaye ngokudibene ne ichiza "yioxytocin" iziyobisi kukhokelela ekwandeni letyhefu.

imiphumela emibi

Nangona ukuba izifo ezininzi ichiza unako ukusindisa ubomi yesigulane, kanye njengokuba kusenokwenzeka, ibe buhlungu xa ngaba uthathe ingqalelo iimpawu ngamnye yomguli okanye ngaphezulu idosi avumelekile.

Ngoko ke, nokuba xa isetyenziswa kakuhle, imithi umntu azive nesiyezi, ixhala, komhlaba, ixhala kunye ubuthathaka jikelele. Ukongeza, isigulane emva ulawulo ichiza ibonakala pallor (ngenxa vasoconstriction), ebila kunye nokwanda zezomzuzwana wegazi. Nakuba kunjalo, iimpawu ezibi, ngenxa yokuba ixesha layo elifutshane, akunyanzelekanga ukuba ukulungiswa lonyango okanye ukupheliswa ngokupheleleyo ichiza.

Abo hydrochloride adrenaline eboniswe, yemiyalezo ulumkisa malunga kuphuhliso arrhythmias kwentliziyo, tachycardia, ukunyuka okukhulu uxinzelelo lwegazi kunokwenzeka. Xa izigulane kwemithambo abasebenzisa ichiza kwandisa umngcipheko yokuhlaselwa angina.

libanda

Wonke umntu uyazi ukuba amayeza amayeza kulindeleke ukuba asetyenziswe idosi ngqo kwaye kuphela kagqirha. Kungenjalo, impilo yomguli usengozini enkulu. Kwaye epinephrine hydrochloride akuyona umnyinyiva.

Xa edlula umxube idosi obuvumelekileyo (naxa elawulwa kwesikhumba) umguli nangoko phuhlisa ngokukhawuleza mydriasis kunye noxinzelelo lwegazi. Ukongeza, odlisa ubomi kakhulu umlinganiselo intliziyo, leyo kwezinye iimeko inkqubela ukuya ventricular fibrillation. Kwaye ukuba isigulane kwandisa ngamandla uxinzelelo hydrostatic nasezimpahleni lincinane yegazi kunye permeability kodonga capillary pulmonary, ukuze aphuhlise kwizihlunu nokudumba miphungeni.

Indlela ukuvimba imiphumela emibi ichiza?

Lisindwa iqela lamanyathelo ebuhlungu yoloyiko antagonistically zokubambela nge α- kunye β-blocker. Ezi ziquka iziyobisi "Inderal" "Tropafen", "Phentolamine" kunye nabanye. Ngokuqhelekileyo oogqirha ukuba asuse imiphumo adrenaline kunye nokusetyenziswa fast nitrites. Nangona kunjalo, ukusetyenziswa amaqela ngentla amayeza kusebenza kuphela xa ukukhanya yakha uthotho yeziphumo ebezingalindelekanga iindlela ezifana iadrenaline hydrochloride (ifomyula: 1-1- (3,4-dihydroxyphenyl) -2-methylaminoethanol hydrochloride).

Ukuba isigulane xa usebenzisa eli chiza waphawula iingxaki ezininzi kakhulu ezifana ventricular fibrillation okanye nokudumba olubanzi pulmonary, isicelo-high speed of nayitrayithi kunye blocker ngokwaneleyo ezahlukeneyo. Kuba usindiso izigulane kwezi meko, oogqirha baye kwanonyango oluxandileyo, ukuze nkqu defibrillation yombane intliziyo.

Iimeko yonikezelo ichiza

Ngoko kusengqiqweni kuphela ukuba iyeza liyeza ngokusekelwe iadrenaline uyakuthintela ukhululekile ukuba athengise kumsebenzisi ekupheleni. Emva self kuthetha data kunokukhokelela elibi imiphumo ubunzima nkqu ukuthotyelwa ngokungqongqo nenkqubo nomthamo. Ukongeza, ezinye izigulane kunye nokuqaliswa imali encinane i hydrochloride iadrenaline (ingxelo kububungqina bale) sokungamelani namachiza okanye nezidlo esinokubakho.

Ngoko ke ngaphambi kokuba uye ekhemesti ngala machiza, kufuneka udibane nogqirha oza kubhala kagqirha. Yiyo le xwebhu, equlethe ulwazi malunga nenani kunye umthamo ichiza, ayinikiwe mayinikwe xa bethenga amayeza.

imithi

Wonke ugqirha uyazi ukuba ukusetyenziswa adrenaline kunye symptomatology ezahlukeneyo kuyathintelwa. Ngapha koko, ukuhlanganiswa onjalo onesiphumo additive kwaye ikhokelela ukunxila.

Musa ukusebenzisa oku amayeza ngenxa unyango izigulane abenza ipilisi zokulala kunye analgesics ezidakumbisayo. Ukongeza, aleji, leyo ngokucwangcisiweyo kusetyenziswa antihistamines, nawuphi na ugqirha, kakhulu, uyala ukuba ubhale kagqirha. Iadrenaline hydrochloride kule meko nje kuphela ingozi yempilo - oku kusenokuba yingozi kakuhle.

Akuvunyelwanga ile kweziyobisi kunye ndindisholo inhalation, njengoko oku kukhokelela kuphuhliso kwezifo ezinzima kwentliziyo xa isigulane.

analogue iyeza

Ngenxa yokuba izazinzulu awanqandi kwi kwiziphumo ezifunyenwe nokuqhubeka ukusebenza ekudalweni amachiza amatsha kwi iindlela epinephrine hydrochloride kuba namhlanje sele uluhlu khorwisaka analogue. Nangona kunjalo, ukhetho iziyobisi, efanayo isenzo iadrenaline, ikhutshwa phandle kuphela ngugqirha khona. Kulo mzekelo, ingcali ilawulwa kuphela ifomu kunye nobukhulu izifo yesigulane, kodwa uthathela ingqalelo iimpawu zawo.

Faka epinephrine hydrochloride udokotela angase iziyobisi ezifana "Epinifrin", "Tonogen", "Glaukozan" "igeza hydrochloride" "Suprarenalin" "Epinephrine hydrochloride," "Levorenin", "Eppie", "Renostiptitsin", "Suprarenin" "glauconite", "Epirenan", "Adrenamin", "Gipernefrin", "Stiptirenal", "Paranefrin", "Glaukonin" et al.

Nangona uluhlu onomtsalane kunezixhobo, omnye asifanele sicinge ukuba ingaba ngokukhululekileyo ukuthenga kwi ekhemesti. Ngokuthenga adrenaline hydrochloride, amayeza e-Latin kufuneka ukubonisa ayinikiwe. Kunjalo kufuneka ukuba unqwenela ukuthenga nayiphi na amayeza ngasentla.