"DioCore 160": imiyalelo ukusetyenziswa, kunoogxa yokwenene. "DioCore solo 160": imiyalelo, real

Inani elikhulu labantu wambi ubunzima ukusuka uxinzelelo oluphezulu lwegazi. Noko ke, imeko zophendlo lwezifo ezifana cha kuphela ukungaphatheki ebalulekileyo kwisigulana, kodwa kusongela ubomi bakhe. Ngoko ke, kwimarike amayeza yanamhlanje kukho iimveliso ezininzi igalelo ekwehliseni uxinzelelo lwegazi.

Ethandwa kakhulu phakathi kwabo bantu abaphethwe rhoqo wegazi, usebenzisa ichiza njengoko "DioCore 160". Imiyalelo yokusebenzisa, analogue le amayeza, kwakunye nohlelo ngayo, iimpawu kunye neempawu uzakumelwa kancinane emva koko.

Ubume, inkcazelo, ukupakisha kunye nemilo

Medicine "DioCore 160", ingxelo uqulathwe kwibhokisi eyenziwe yekhadibhodi, yenziwe ngohlobo amacwecwe. Zibe film-camera and eziqulathe izithako ezifana valsartan kunye hydrochlorothiazide. Kwakhona le ndlela ingxelo iquka microcrystalline kwincindi, isodiyam lauryl sulfate, iitapile starch, talc, umbona starch, isodiyam croscarmellose, nemagnesium stearate, dust colloidal anhydrous kunye opadry II Orange.

Asikwazi ukuba iyeza enjalo, kwaye ingafunyanwa ku kwintengiso njenge "DioCore Solo 160". Ukususela elandulela eyahluke kuloo zithako yayo esebenzayo izenzo valsartan kuphela.

Umgaqo ekusebenzeni medicament

Yintoni na ichiza "DioCore 160"? Imiyalelo iingxelo zokusetyenziswa ukuba le arhente umfutho, nto leyo sakhiwa umchamo thiazide kunye angiotensin II receptor yokuqala.

Esi sixhobo enoluhlu olubanzi lweziphumo komzimba leyo zithathwa njengokuba ongangqalanga ngqo inxaxheba kumgaqo uxinzelelo lwegazi. Angiotensin II yeyona arhente vasoconstrictor enamandla esibangelwa isiphumo pressor ngqo. Kwakhona ilibaziseke sodium kwaye lukwakhuthaza secretion of aldosterone.

Valsartan wabiza esebenzayo kunye ezithile angiotensin II receptor yokuqala. It yenzelwe zolawulo yomlomo emane osebenza kwi AT1 receptor okuninzi zinoxanduva kwimiphumo angiotensin II. umsebenzi agonist Partial kwi AT1 receptor okuninzi, lwesi sakhi ayibonisi.

Kwakhona valsartan Musa zinqanda ACE, oguqula angiotensin mna angiotensin II, bradykinin angatshabalalisi. Anayenza kunye neziphumo ebezingalindelekanga okubangelwa bradykinin.

Xa abantu abane lwegazi, ichiza ebangela ukwehla uxinzelelo lwegazi. Kulo mzekelo, oko alunasiphumo kwi izinga intliziyo.

Izigulane ezininzi emva nedosi enye ye ichiza yesifundo ekuqaleni umsebenzi umfutho waphawula kwisithuba seeyure ezi-2, kunye nokunciphisa uxinzelelo lwegazi iiyure ezi-6.

Isiphumo umfutho beziyobisi sithatha ngaphezulu ngemini. Xa pill rhoqo kangangoko zonyango ifunyanwa kwisithuba seeveki ezine kwaye kulo lonke ikhondo unyango ixesha elide.

Pharmacokinetics

Zeziphi iimpawu ezingundoqo kwikinetiki le medicament "DioCore 160"? Imiyalelo yokusebenzisa (tablets kufuneka emiselweyo ugqirha kuphela) uthi emva ezithatha ichiza ngaphakathi ukufunxeka hydrochlorothiazide kunye valsartan ikhawuleza kakhulu. I-avareji bioavailability ingundoqo yale arhente 23%.

Le kinetics of valsartan ezi yomgama. ukusetyenziswa okuphindiweyo beziyobisi ongazaliyo naluphi na utshintsho. Nge ipilisi enye ekufumaneni kwabo ayinamsebenzi.

Valsartan lubotshelelwe iiproteni plasma kwi 94-98%. kukhuthaza kwayo lwenziwa kunye endleni kunye nomchamo. Xa ethatyathwe kunye AUC yokutya valsartan yehliswa ngama-48%.

Emva kokufumana iipilisi ngaphakathi hydrochlorothiazide yokufunxa kwenzeka kunokuba ngokukhawuleza (2 iiyure). Ngaphezu koko, bioavailability yalo 60-80%. Uyixhome yokuchama.

Ngenxa indibanisela valsartan kunye bioavailability hydrochlorothiazide lwenkqubo yemfundo yokugqibela kuncitshiswa nama-30%.

Iimpawu tablets

Kuphantsi kwaziphi iimeko isigulane banokuthi banyulwe iziyobisi "DioCore 160"? Imiyalelo yokusebenzisa, oogqirha yokwenene ingxelo ukuba esi sixhobo kakuhle kakhulu ubonakala e lwegazi, kwakunye nokungabikho ngempumelelo kwesi sifo yedwa.

Izimo ukuya kuthabatha amacwecwe

Ngaba ubusazi ukuba kwamanye iimeko, iipilisi awusosimiselo "DioCore 160"? Manual ukuba iyeza loo contraindicated xa ukunyamezelana ngamnye izithako yayo.

Ukongeza, ukuba akuvumelekanga ukuba isetyenziswe izigulana cholestasis, kakhulu isibindi ongaboniyo, kunye ukuqina biliary. Kwakhona, oko ungamiselwanga abantu abaphethwe naluphi na uhlobo kwekhono kakhulu kwaye eliphakathi kwezintso, iliphawu anuria, kunciphise sodium kunye potassium amanqanaba egazini, hypercalcemia kunye hyperuricemia.

Tablets "DioCore 160": imiyalelo yokusebenzisa

Njengomthetho jikelele, ukuze kupheliswe kwegazi eliphezulu ekhaya kwizigulane bacebisa ukusetyenziswa elinye icwecwe "DioCore 80" kanye ngemini. Ke ukuba i "DioCore 160" beziyobisi, oko kumiselwe kuphela esibhedlele. Kulo mzekelo, isigulane kufuneka abe phantsi kweliso lomgadi ngugqirha.

Njengoko yokusebenza ibonisa, nemiphumo oqaphelekayo xa lwegazi strong waphawula kwiiveki 2-3 emva kokuqaliswa unyango.

Kuba abantu nokulolonga okanye ebalulekileyo lomonakalo hepatic okanye sezintso luyafuneka ukwenza kuyimfuneko ulungiso kuluhlu idosi (ngamnye).

Ubude unyango ngale amayeza kufuneka kumiselwa kuphela ngugqirha khona.

imiphumela emibi

Luhlobo olunjani effects isigulane kufuneka bazazi phambi kokuba usebenzise amayeza "DioCore Solo 160"? Imiyalelo Sebenzisa ithi ingqalelo amayeza azifane ebangela iziganeko ezibi ukuba babe ubhalo ezingazinzanga nabangaziphathi ichaziwe.

Malunga ne-1% ezigulane ngexesha uthatha eli chiza kwabonakala yintloko ababuthathaka, iqolo, ukudinwa, ukhohlokhohlo, isiyezi kunye nasopharyngitis.

Ngaphantsi kwe-1% bakhalaza iintlungu esiswini, ixhala, ubuhlungu entanyeni kunye esifubeni, ukudinwa, amalungu abe buhlungu, iphika serous, ukozela, laryngitis, ukuphelelwa umoya, ukuphazamiseka sorhudo, kunciphise ukwakhiwa, yehlisa izinkcwe, hypotension, gastroenteritis, paresthesia, ukubila ukwanda, ukuncipha novakalelo, amahlaba kwezihlunu, sokulibala, nokudumba peripheral, isicaphucaphu, usulelo indlebe, ukuxinana ngeempumlo kunye ukunyuka okungephi lobushushu emzimbeni. Ngamanye amaxesha isigulane sele kakuhle umbono, tachycardia ezingazinzanga kunye ukuduma. Kufuneka kuqatshelwe ukuba nolwalamano ngqo lubandakanywe ezi khemikhali yaye ichiza iye ayasekwa.

Ziziphi ezinye iziphumo ebezingalindelekanga kunokubangela amayeza "DioCore Solo 160"? Imiyalelo isicelo ibonisa ukuba xa usebenzisa esi sixhobo, kwakukho amatyala ekwanti ye ekuqaleni yabangxamayo, ukurhawuzelela nezinye kukwalisa, kuquka vasculitis, kunye nokugula serum. Ukongeza, ngamanye amaxesha izigulane ukuphuhlisa myalgias kunye nefralnaya kwekhono.

uhlobo inqabile kakhulu yeziphumo ebezingalindelekanga xa uthatha "DioCore 160" imveliso yi nokudumba lula ezingezo-cardiogenic ukuba inxulunyaniswa ukunyamezelana ngalinye hydrochlorothiazide.

Uphononongo lubonise ukuba ezinye izigulane ziphathwa esi sixhobo, sehla potassium egazini, ebeka creatinine kunye urea, kwakunye nokukhetha neutropenia wobulali.

iimpawu libanda

Ziintoni iimpawu "DioCore Solo 160" kunye ngeedosi eziphezulu na ichiza? Manual ithi iimeko ezinjalo ayaziwa ngeli xesha.

Ngumqondiso ophambili womntu ohlaselwe umthamo olongeziweyo kungaba hypotension kakhulu. Ukuba ichiza savunywayo ngokwentelekiso kutshanje, ixhoba kufuneka eyenziweyo ukuzama ukumgabhisa. Kwakhona hypotension ukulwa ukuze kwenziwa nolawulo efakwa of saline obuqhelekileyo.

Kufuneka kukhunjulwe ukuba akunakwenzeka baphethe ichiza ingqalelo ukusuka umzimba olugqitha esikhumbeni. Oku kungenxa yokuba valsartin, kubandakanywa ukwakheka yayo, idityaniswe iiproteni plasma. Nakuba kunjalo, kufanele kuqatshelwe ukuba hydrochlorothiazide iyapheliswa ngale ndlela kakhulu ngempumelelo.

imithi kunye namanye amayeza

Ngaba kunokwenzeka ukudibanisa kunye nezinye iindlela "DioCore 160"? Imiyalelo ithi ukuba udibaniso lwe eli chiza neqela namanye amachiza umfutho nga negalelo nokukhuthaza ifuthe lisibekele uxinzelelo lwegazi.

Ukusetyenziswa ngaxeshanye lo medicament kunye ongeziweyo potassium aqulethe, womchamo inobulali, solezamenitelyami kunye izinto ezandisa umxholo potassium emzimbeni, kufuneka rhoqo uvavanyo lwee- potassium serum egazini.

Xa ngaxeshanye ulawulo "DioCore" kunye ACE inhibitors ziye zachongwa ukwanda ingathityazwa uyondelelwano lwee- lithium egazini.

Ziziphi amayeza ungavele ukusebenzisa iziyobisi "DioCore 160"? Guide ingxelo ukuba monotherapy lwegazi esi sixhobo zange sebenzisa phi intsebenziswano kunye "glibenclamide", "amlodipine", "warfarin", "cimetidine", "digoxin", "furosemide", "indomethacin" Atenolol ".

Ekubeni ichiza ekwakhiweni phantsi ingqalelo ibandakanya iqela umchamo thiazide, neminye elandelayo kunokwenzeka:

• ukuncipha isiphumo umchamo beziyobisi xa isetyenziswa kunye NSAID (umz, salicylates okanye "Indomethacin");
• potentiation of relaxants kwezihlunu.

Yintoni Drug Ukusebenzelana nabanye kufuneka ukwazi ngaphambi kokuba uthathe i "DioCore 160"? Imiyalelo, ukubuyekeza zibonisa ukuba lo gama usebenzisa esi sixhobo kunye womchamo kaliynesberegayuschimi, salicylates, ACTH, amphotericin karbenokslolonom mhlawumbi ukuhla elibukhali kwi uyondelelwano lwee- potassium egazini.

Xa kusetyenziswa injectable nangomlomo amachiza antidiabetic kufuneka wenziwe ngabanye alungise balawule zabo.

Ayikhuthazwa ukusebenzisa medicament ingqalelo kunye womchamo iqela thiazide, njengoko oku zandisa iziphumo ebezingalindelekanga akhankanywe apha ngasentla iziyobisi kwaye baxabane hypersensitivity.

Xa isicelo ngaxeshanye methyldopa hydrochlorothiazide lisenokuba anemia hemolytic.

Xa iziyobisi edityanisiweyo "DioCore 160" kunye kolestiraminom liyancipha bioavailability yayo kunye nokufunxwa.

Phambi ichiza kunye ivithamin D egazini ikhalsiyam xi nga zandiswe kwizigulane.

Akuvunyelwe ukuba athathe "DioCore" kunye cyclosporine, njengoko oku kungabangela iimpawu kunye nemeko podagropodobnye giperurikekii.

iingcebiso ezithile pill

Into ekufuneka uyazi phambi kokuba usebenzise iziyobisi "DioCore Solo 160"? Imiyalelo yokusebenzisa, ncomo bathi phakathi unyango kunye nale arhente isigulane kufuneka ibe esweni rhoqo yamanqanaba serum of electrolytes egazini.

Ngenxa uphuhliso hypotension ochaphazelekayo kufuneka zitshintshwe zibe ngokuxwesileyo. Ukuba kuyimfuneko, enze nokubandakanywa efakwa of saline obuqhelekileyo. Emva uzinzo unyango loxinzelelo kufuneka yaqhubeka.

Abantu abane unilateral okanye amabini sezintso kwimithambo stenosis ukwamkelwa valsartan ingadala ukwanda serum creatinine okanye urea igazi.

Xa sabele medicament ukuba izigulane kakuhle kidney hlengiso umsebenzi idosi iyafuneka, kodwa ufuna esweni ngamaxesha of creatinine kunye uric asidi, kunye nesiqulatho potassium yegazi.

Kukho ubungqina bokuba womchamo thiazide singenza isimo systemic lupus zomzimba. nabo ukutshintsha unyamezelwano iswekile yomguli, ukunyusa uyondelelwano lwee- cholesterol, kwaye uric acid kwi triglyceride egazini. Kulo mba, izigulane seswekile angafuna hlengiso idosi-arhente yomlomo hypoglycemic okanye insulin.

Xa izigulane nokulolonga nezincinane zesibindi lomonakalo ngaphandle cholestasis kufuneka-hlengiso idosi. Kodwa phantsi kwezi meko ichiza kufuneka zithathwe ngokuqaphela okukhulu.

Kukho iingxelo ze photosensitivity ngexesha unyango kunye womchamo thiazide. Ukuba ngethuba unyango kunye oku kuthetha kukho indlela photosensitivity, unyango kufuneka kupheliswa.

Ukuba kuyimfuneko, ulawulo okuphindwayo a umchamo Kucetyiswa ukuba ukukhusela iinxalenye abasengozini ngenxa kwemitha yelanga eyenziweyo okanye ilanga.

analogue iziyobisi

Yintoni kuqwalaselwa endaweni indlela yethu? Ngokutsho iipropati abanobuchule ezifanayo iziyobisi ezifana "Air-ulwandle", "Dentokind", "Intsena", "Cinnabsin", "Softovak", "Medotsef" "Vinblastine-Teva".

Izimvo kulungiselelwa

Ke kaloku, ukuba uyazi ukuba mawuzisebenzise njani ichiza "DioCore 160". Imiyalelo yokusebenzisa iyeza sele ichazwe ngokwenkcukacha ngasentla.

Esi sixhobo zithandwa kakhulu abaguli kunye kumagqirha. Iingcali ingxelo ukuba ngempumelelo kuziveza phambi severe umfutho hyperplasia. Abasebenzisi sivumelana ngokupheleleyo oku. Ngokutsho iimpendulo zabo, ukuthatha ipilisi enye ikhuthaza nokubuyiselwa uxinzelelo lwegazi, kwakunye lula imeko yabo.

Akunakwenzeka ukuba uqaphele into yokuba chiza luhlobo elula sokukhululwa balawule. Nangona kunjalo, ukuthatha idosi a aphezulu ichiza kufuneka ibe kuphela esibhedlele, phantsi kweliso gqirha.