"Agapurin": imiyalelo, real

Yintoni na ichiza "Agapurin"? Imiyalelo zokusetyenziswa, ifom ukukhululwa kunye nokwakhiwa-mali kuya kwenziwa phambili umganyana. Ukongeza, kweli nqaku uza kufunda malunga iimeko apho ichiza eyabelwe xa ukusetyenziswa kwaso kuthintelwe, ngokuthe ngqo, nokuba kukho iziphumo ezingalindelekanga njalo njalo.

Yenziwe ngoobani kunye nefomu ichiza

Ingaba kukho igama ngamazwe kwi "Agapurin 'iziyobisi? "Pentoxifylline" - eli ligama lakhe yesibini.

Okwangoku ichiza iyafumaneka iintlobo ezimbini ezahlukeneyo:

1. tablets Biconvex camera (abamhlophe) kwaye ukuba ukhanye ecwebezelayo. Eli chiza iqulathe icandelo esebenzayo i pentoxifylline kunye zizinto ezongezelelweyo (monohydrate lactose, starch umbona, dust colloidal anhydrous, talc nezinki stearate). Malunga iqokobhe, oko kuquka izinto ezifana sodium carmellose, crystalline sucrose, sucrose engumgubo, talc, methylparaben, titanium dioxide, dust colloidal anhydrous kunye yomnga.
2. Solution (ecacileyo, ezingenambala) ukuze ngenaliti. Le medicament iquka pentoxifylline, sodium chloride namanzi ngenaliti.

Bendinga nam ndingakhe ukukhankanya into yokuba loo analogu iziyobisi inokufumaneka ngamatyathanga kwikhemesti njenge "Agapurin ungakhawulezi". Eyokuqiqa ka ichiza ithi ukuba i arhente yesenzo ixesha elide. Iyafumaneka emacwecweni, apho isale yayisoma film. Olu nyango iqulethe pentoxifylline kunye izinto ezongezelelekileyo ezifana hypromellose, povidone, talc, kunye nemagnesium stearate.

iipropati kwemithi

Yintoni na ichiza "Agapurin"? Imiyalelo Sebenzisa uthi ukuba le arhente yi antispasmodic kwaye lol kwiqela purine kulo. Iphucula kakhulu kwegazi, kwakunye neempawu zawo rheological. Le yokusebenza Umgaqo medicament bathi ukuba phosphodiesterase inhibition, nokwandisa okuqulethwe ATP e erythrocytes kunye Camp zegazi kunye lamandla bullet kufumaneka bantu. Oku kwenza vasodilation, lisibekele luvukelo iyonke nemithambo (peripheral), kunye ngomzuzu kwaye kwandiswe umthamo stroke ngaphandle utshintsho kakhulu izinga entliziyweni.

Indlela yokusebenza ye ichiza

Yintoni indlela yokusebenza "Agapurin 'iziyobisi? Imiyalelo yokusebenzisa ukunika impendulo alupheli lo mbuzo. Emva kokuba isicelo zithambe medicament nemithambo yenhliziyo, uze ukwandisa unikezelo ioksijini ezityeni pulmonary kunye myocardium, kuba isiphumo antianginal kwaye iphucule oxygenation yegazi.

Kufuneka kuqatshelwe ukuba kuqulunqo thaca bayakwazi ukwandisa nethoni yelo musculature yokuphefumla, ingakumbi i uvalo kunye intercostal kwizihlunu.

Xa efakwa Inaliti oko kukhokelela ekwandeni ukujikeleza akananto, kwakunye nokwanda umthamo wegazi elibaleka ngokusebenzisa i-tsu-kwicandelo 1. Ukongeza, eli chiza kubangela ukwanda kokuqulathwe adenosine ebuchotsheni kwaye imiphumo eyingenelo kwi umsebenzi bioelectrical-luvo.

Ngokutsho umyalelo, wathi medicament unako yokunciphisa viscosity yegazi, ukwandisa luthambe le inwebu erythrocyte nokuphucula microcirculation namaphephandaba kakuhle.

Ziziphi iinkalo na amayeza "Agapurin"? Imiyalelo zokusetyenziswa ithi izifo esimbaxa occlusive (peripheral) iziyobisi esebenzayo kunokukhokelela ekupheliseni amahlaba busuku amathole, umgama zobude ukuhamba kunye neentlungu ukuphumla.

Pharmacokinetics

Medicine "Agapurin" umzimba ngokukhawuleza esibindini. Oku kuvelisa metabolites esebenzayo. ingqalelo egazini izihlandlo eziliqela ngaphezu xi ukwimo esisiseko.

Ibonisa thaca medicament njengoko metabolites-mali ka-94%, kwaye intsalela - ngokusebenzisa emathunjini. Ngexesha iiyure zokuqala-4 emva nokudla beziyobisi kwakhululwa isixa-90% ye-lwendlela esetyenziswayo. Ngohlobo unmodified, uboniswa ngumqulu-2%. Kufuneka kuqatshelwe ukuba into esebenzayo kunye metabolites of pentoxifylline akazibopheleli kwiiproteni igazi.

umsebenzi sezintso Xa kakuhle decelerates metabolites kwimveliso. Ukuba umsebenzi isibindi ukungaqheleki baphawula kungoluka isiqingatha ubomi, kunye bioavailability ukwanda.

Drug "Agapurin" (tablets): imiyalelo yokusetyenziswa

Ngokutsho imiyalelo eziqhotyoshelwe medicament, kufuneka athathwe kwi enye ngexesha elifanayo mihla emva kokutya ukutya, amanzi plain okusela. Ichiza kuyo nayiphi na imeko akunakwenzeka ukuba idle.

umthamo lokuqala ichiza 200 mg kathathu ngemini. Ukuba isigulana ukuba unyango elide okanye yayikade ukunyamezelana abaziintsizana isiyobisi, ngoko idosi enye kungancitshiswa kanye kabini, kodwa ukugcina inani imisitho.

Kuthethwa idosi yemihla ngemihla mayingagqithi 1200 mg.

Ngoku uyazi ukuba mawuzisebenzise njani ichiza "Agapurin" (tablets). ngendlela efanayo ngokumalunga nemiyalelo isicelo kunye release eyandisiweyo iqulathe ulwazi malunga iidosi efanayo. Noko ke, xa usebenzisa kube lula ukunciphisa ubuninzi ulwamkelo.

Imiyalelo zokusetyenziswa isisombululo ukuba isitofu

Indlela yokusebenzisa ichiza "Agapurin"? Iipilisi ezimiselwe rhoqo ngaphezu izisombululo injectable. Ukuba nangasiphi na isizathu sigulane asikwazi ukuthatha amayeza ngomlomo, azimiselweyo iinaliti.

Le ukulungiselela ethengiswe ifomu isisombululo ukuba isitofu linokwenziwa yi ngenye yezi ndlela zilandelayo:

1. Iv. Imixholo ampoule kufuneka exutywe-5% isisombululo glucose okanye 250-500 ml chloride (0.9%) sodium chloride. Ichiza kufuneka ufakwe kancinci, hayi ml ngaphezu kwe-150 ngeyure. Ukuba isigulane ukumelana iyeza, idosi yemihla ngemihla ukuba ukwandisa ukuya ampoules ezimbini, okt 200 mg.
2. Intramuscularly. Ichiza yayisalawulwa 100 mg kabini ngemini. Akunamsebenzi yaze yangxenga ifuthe lomanyano imixholo igutyana.
3. Intraarterially. Unyango lwe isigulane kufuneka uqale ulawulo ampoule omnye, ekufuneka pre-exutywe 20-50 ml sisombululo sodium chloride isotonic. Ukuba ufuna unyango elide, ithamo kufuneka kwandiswa ukuya 2-3 ampoules. Kufuneka exutywe ukuba malunga ne30-50 ml.

Kufuneka kuqatshelwe ukuba imali ngokupheleleyo medicament thaca bubonwa kuphela gqirha, yaye kuphela ngethuba i cebiso ngamnye nomonde.

Medicament "Agapurin": zikhombisa ukuba ukusetyenziswa

Ngaphambi usebenzisa amayeza, kufuneka udibane nogqirha wakho uze baye kuzihlola. Ngapha koko, amayeza wabelwa kuphela phantsi ezinxaxhileyo ezithile. Uluhlu siza kuqwalasela ngakumbi.

1. izifo Trophic izicwili eziye zavela sizoku lwisana lwemithambo kakuhle okanye microcirculation esimbaxa (ezifana ekuboleni, izilonda varicose, frostbite, njalo njalo.).
2. izifo yegazi (peripheral) oluthi luqokelelane ngenxa yeenkqubo ukudumba, atherosclerotic kunye seswekile. amayeza njengoko kumiselwe ukuba claudication "ngakanye", oko kubangelwa yegazi, isifo esimbaxa occlusive, kunye angiopathy seswekile.
3. stroke kobuchopho Chronic kwaye etsolo, nto leyo imvelaphi kobuchopho. Kwakhona, ichiza isetyenziswa Cerebral kwemithambo yegazi, paresthesia, angioneyropatii, isifo Raynaud kunye akrozianoz.
4. kwegazi ongeva kakuhle kwi izitya amalungu ezibonwayo (ukusilela etsolo kwaye ezondeleyo yokujikeleza, imithambo kunye umnatha imifinya yamehlo).
5. State evela emva stroke kobuchopho okanye ukopha.
6. Ukuphazamiseka sendlebe eliphakathi imvelaphi semithambo, ezo zihamba kuzwa.

Izimo nokusetyenziswa

Xa awukwazi ukusebenzisa amayeza "Agapurin"? Ukusetyenziswa kweli chiza akuvumelekanga phantsi kweemeko kunye izinxaxhi ilandelayo:

• iposi engabalulekanga olunamandla;
• wavakalisa yegazi coronary okanye palsy;
• wavakalisa impazamo rhythm intliziyo;
• porphyria;
• hypotension lwemithambo eyenzeke;
• ukopha omkhulu;
• stroke sophele olunamandla;
• yokopha semehlo;
• ukukhulelwa, isikhuselo-lweehagu;
• kweminyaka engama-18 (ukhuseleko kunye nokusebenza akukasekwa);
• hypersensitivity ku pentoxifylline, kunye ezakha nezakhi kwiqela xanthine.

ukusetyenziswa sokuqaphela iyeza

Ngononophelo olukhulu isixhobo emalifakwe izigulane eneengcinga esimbaxa hypotension, uxinzelelo lwegazi labile, ukusilela intliziyo (chronic), ukuthambekela legazi, insufficiency kwezintso kunye hepatic, kananjalo kwi imeko emva kotyando.

imiphumela emibi

Ingaba kukho naziphi na iziphumo ebezingalindelekanga ezivela iziyobisi, "Agapurin"? isikhokelo macwecwe apho uchazwe apha ngasentla, kwakunye isisombululo ukuba isitofu kunokubangela eziliqela iziphumo ezingalunganga. Makhe sihlolisise ngokweenkcukacha ezingakumbi.

• inkqubo yokucola: hepatitis cholestatic, atony isisu, ukuqhubela cholecystitis, umlomo owomileyo nelahleko namdla.
• luvo: ixhala, sokulibala, isiyezi, amahlaba kunye yintloko.
• imithambo yegazi ulusu: ukudumba, izikhonkwane nkum ukugungxula yobuso, siwasebenzise phezulu esifubeni kunye nobuso.
• nemithambo yegazi: arrhythmia, angina lobuxoki, progressive angina sifuba, tachycardia kunye wegazi.
• OLawulo hematopoiesis kunye nenkqubo hemostasis: thrombocytopenia, leukopenia, pancytopenia, gipofibrinogenemia engaphezi isisu, isisu, emithanjeni ongama kunye ngenwebu yangaphakathi.
• amalungu Ukudideka: Umbono kakuhle kwaye scotoma.
• ziyabagulisa: pruritus, urticaria, angioedema , kunye anaphylaxis.

amacala libanda

Kwenzeka ntoni xa usebenzisa ngeedosi eziphezulu ichiza "Agapurin" (400 mg, 600 mg, 1200 mg) Kulo mzekelo, isigulane bangafumana iimpawu zophendlo lwezifo ezifana buthathaka, ephawulwe ukuncipha uxinzelelo lwegazi, isiyezi, tachycardia, syncope, somnolence, ngokubanzi ukuxhuzula indihlaziya-clonic, ilahleko osezingqondweni, komzimba, ukuba nochuku, iimpawu ukopha emathunjini (umzekelo, ukugabha " amabala ikofu ") kunye areflexia.

Kule meko kufuna unyango olungxamisekileyo kwangumqondiso leyo sibhekiswe ukulondoloza uxinzelelo lwegazi yesiqhelo kunye nemisebenzi zokuphefumla.

imiyalelo engqalileyo ngokusebenzisa ichiza

Oko umele ukwazi phambi kokuba usebenzise amachiza "Agapurin"? Izimvo oogqirha bathi yeza kakuhle lo msebenzi, kodwa ke unyango kufuneka ibe phantsi kolawulo olungqongqo of wegazi. Kulo mzekelo, xa izigulane ukusilela ngentliziyo (chronic) kufuneka ukuba bafumane imbuyekezo kwegazi.

Kufuneka kuqatshelwe ukuba izigulane unesifo "diabetes 'iziyobisi hypoglycemic, ukusetyenziswa kwale arhente ngeedosi enkulu ebangela hypoglycemia ngokukhawuleza. Ngoko utshintsho iidosi kuyimfuneko kubo.

Ukusetyenziswa ngaxeshanye beziyobisi kunye anticoagulants kufuneka esweni ngenyameko nemeko yenkqubo coagulation igazi.

Xa izigulane kutsha abaye baba utyando, kufuneka esweni rhoqo le yoxinaniso mpilo kunye hematocrit.

Umthamo elawulwa kufuneka zibhalwe izigulane obungazinzanga okanye ephantsi uxinzelelo lwegazi.

Abantu abadala kufuneka umthamo ezincinane.

Ngokutsho izifundo, ukutshaya kakhulu kunciphisa ukusebenza konwaywa ichiza.

ukuhambelana pentoxifylline kunye nezinye izisombululo ukumnika kufuneka zihlolwe kwimeko nganye.

Intsebenziswano kunye nezinye iindlela

Le pentoxifylline into esebenzayo kaninzi iphucula sisenzo arhente ezichaphazela ekunqandeni igazi. iziyobisi ezifana ziquka anticoagulants ngqo nengxelo-, valproic acid, thrombolytics, kunye anitibiotiki (umz, iziyobisi "Tsefamandol", "Cefoperazone", "tsefotetan").

Uthe arhente kwandisa impumelelo hypoglycemic yomlomo kunye neziyobisi umfutho, ngokunjalo insulin.

Asinako ukuba ichiza "cimetidine" kuphula lwee- pentoxifylline egazini. Oku kwandisa amathuba yeziphumo ebezingalindelekanga.

Co-administration "Agapurin" iziyobisi, ncomo zazo ziboniswa apha ngezantsi, kunye nezinye xanthines kukhokelela kakhulu uchulumanco luvo.

Iindlela ugcino yokulungiselela, ncomo kuyo, ixabiso

Drug "Agapurin" kuthengiswa phantse yonke ekhemisti. Thenga iipilisi 60 (100 mg), uza kukwazi ukuba ngaba sikhona nje kwama-250 engange Russian.

Baqinisekiswa yale medicament kakhulu positive. Kungenxa yoko le nto badla eminye imithi kwizigulana abanengxaki imithambo yegazi.

Kufuneka kuqatshelwe ukuba iyeza ethandwayo enkulu kangangoko "Agapurin" in abanxibe impahla. bodybuilders Ukubuyekezwa bathi esi sixhobo kufuneka ziqwalaselwe zodwa kwezinye iziyobisi kuphuculwe ukuhamba kwegazi. Ngapha koko, oku ngempumelelo kakhulu kodwa kangako.

medicament Active eya iimbaleki, njengoko iveliswa hayi kuphela ngohlobo isisombululo injectable, kodwa ifomu Icwecwe. Pharmacy le sixhobo zingafunyanwa phantsi kwezinye amagama ukuba ndivakala ngathi "Pentoxifylline" okanye "Trental".

Umsebenzi ophambili emelwe izenzo iziyobisi ukwanda ilizwi kwemithambo yegazi, ukunciphisa viscosity igazi kunye nokwandisa ithombo legazi. Yonke le ndlela leyikulu yokufeza zokumpompa ekuqeqesheni ezemidlalo, xa kukho yimvakalelo izihlunu enamandla ukusebenza zokumpompa.

Sebenzisa olu nyango bodybuilders banamava kufuneka silumke kakhulu, kuba oko kunokubangela ngokulula i libanda, kunye nenani yeziphumo ebezingalindelekanga.

Gcina "Agapurin" ekukhethwa kwindawo emnyama, eyomileyo apho kungekho ukufikelela kubantwana abancinane. Ngaloo lobushushu yokugcina ichiza degrees 10-15 kuphela. umhla wokuphelelwa eziboniswe nokupakishwa yiminyaka emibini. Emva eli xesha, ukusetyenziswa kweziyobisi akuvumelekanga.

Xa ndiqukumbela, siphawula kwakhona akufuneki ukuba self-bazimisele ukuthatha eli yeza. Ubude unyango kunye idosi kufuneka imiselwe ugqirha ukuba umntu othile.