"5-NOC" - ncomo kulungiselelwa

Ngaphandle kwento yokuba umzimba womntu sinikezwe sifo yaye uyakwazi ukumelana nezifo ezininzi kuphela, kukho iintsholongwane kunye nezifo zingaphunyezwa kuphela encediswa amayeza. nemithi kunganqanda okanye ukuyeka ukukhula eziphilayo yayintsholongwane eyosulela, ngaleyo ndlela asuse kwagxilwa komtshiso oko. Iipilisi ezi "5-NOC" Eli qela amachiza ezinjalo. Baqinisekiswa kubonisa ukusebenza zabo eziphakamileyo unyango lwezifo kwenkqubo genitourinary. Ukongeza, le sixhobo ugqibelele okuthintela ukwenzeka ukudumba kwiintlobo ezingapheliyo izifo.

into esebenzayo

into esebenzayo Nitroxoline yi ichiza esebenzayo "NOC-5." It is a ukuyilwa zokwenziwa, yemvelaphi-8-hydroxyquinoline. Ngalo eli candelo, ichiza ngokungenisa umzimba uqalisa ukukhangela iiseli kwaziwe zinqanda DNA zabo. indlela ukukhetha of ntshukumo ikuvumela ukunqanda kunyebeleziso iintsholongwane ebangela isifo kwaye hayi kakubi iiseli enempilo.

Ngaphandle nitroksolin ungena awasabela kunye asidi esebenzayo acid enzayim eziquka ngesinyithi khetshi zabo. Iziyobisi unika inkqubo kwakhona iintsholongwane yayintsholongwane eyosulela abe inyathelo bactericidal ngokuchasene spectrum ezibanzi amagciwane olomeleleyo. Ngaloo ngokuphumelelayo atshabalalise ezimelene nemithi ngamachiza namanye amaqela antibiotics. Medicine "ratings NOC-5 'iya kuqinisekiswa ukuba indlela ephumelelayo bangasukela kwizifo ezibangelwa nomngundo, iintsholongwane, yaye adala ezibangela izifo nokumelana eliphezulu kwamanye amachiza amanyathelo antibacterial kunye kubola.

ifomu Release komsindo

Le medicament alahlwa ngokohlobo amacwecwe camera. Baye-orenji okanye omthubi, ngohlobo ngeenxa, lenticular, kukho ukukhazimla isici. Le esisebenza eziphambili - nitroksolin. amacandelo Auxiliary of ubume: sucrose, E110 colorant, carboxymethylcellulose, lactose.

Ziziphi kwaziwe ekulweni iziyobisi

Qaphela ukuba kuqulunqo kunempembelelo zokukhomba kwaye kakhulu olusebenzayo nxamnye ezinye iintlobo kwamagciwane:

• Igram-HIV izinto aerobic kwaye anaerobic - Enterococcus faecalis, iStreptococcus spp. (Pneumoniae Ngeentlobo, neArcanobacterium).
• Staphylococcus spp., Abuthathaka aureus, subtilis inegciwane, Ezi spp.
• Anaerobic kunye amagciwane aerobic (gram) - Klebsiella spp, Proteus spp, Shigella spp, iSalmonella spp, Haemophilus influenzae influenzae, Enterobacter spp, Escherichia coli, Neisseria gonorrhoeae ......
• Izifo ezibangelwa of Mycobacterium tuberculosis, ka Mycoplasma hominis, Trichomonas vaginalis, ngenxa Ureaplasma urealyticum.

Jeli, dermatophytes, ifungi ka Candida, ezinye izinto ezibangela izifo ezinzulu ezinzwaneni - ezi zifo nazo ekunciphiseni iziyobisi "5-NOC". Izimvo oogqirha ukubonisa ukukwazi ichiza ukunciphisa adhesion eziphilayo uropathogenic eludongeni catheter (some umchamo izigulane) kunye wokuchama phecana epithelial umaleko.

xa ehanjiswa

Ngenxa kuluhlu kunokuba ezininzi izicelo ngamayeza ukumelana zigulo zilandelayo:

• Chronic, Okubuhlungu, isifo nezolo (esosulelayo umyalezo weimeyile) ochama ezibangelwa iintsholongwane nomngundo ezingalunganga-Igram kunye Igram-HIV.
• Epididymitis.
• Pyelonephritis: ifomu ezingapheliyo kunye bukhali.
• Urethritis.
• Ngokuzimela.
• Adenoma kunye carcinoma (HIV) ye endlaleni.
• izifo Ukuthintela (nezolo) womchamo.
• Faka emva iinkqubo zokuxilonga kunye zotyando kwi womchamo: utyando kidney, cystoscopy, catheterization.

Kubangel 'umdla ukwazi ukuba kwenkcazo unyango eyaneleyo ngokuxhomekeke ebukhulwini esi sifo kuba ngugqirha kuphela. Tablets "5-NOC" iingcali ngokutsha kuqinisekiswa ukuba bioavailability eliphezulu - malunga ne-90%. Bona baphilela ngokukhawuleza kwi phecana zesisu ifike plasma xi liphezulu kwisithuba seeyure 1.5-2.

Pharmacokinetics

Amalungiselelo unendlela eliphantsi ukudibanisa kunye iiproteni plasma. Ukufumaneka ephezulu into esebenzayo eboniswe umchamo lomguli. Ichiza umzimba kakhulu wesibindi, idubule yi nezintso. A imali elithile ichiza liyasuswa umzimba enyongweni - kwisithuba seeyure ezi-2 kufuneka kuqatshelwe ukuba idatha kwi pharmacokinetics beziyobisi abantwana, abantu abadala kunye kwizigulane kunye insufficiency kwezintso kunye wesibindi azikhange kufundwe .. Ngoko ke, kufuneka ufumane ugqirha thethwano abaqeqeshiweyo phambi emisela iipilisi "5-NOC". Iingcali Ukubuyekezwa uqaphele ukuba abantwana amayeza ukunyamezeleka kakuhle xa ngokuthobela ngokupheleleyo idosi kunye nonyango iirejimeni. ngokukhethekileyo kufuneka akhokele ukuqatshelwa umntwana, nto leyo eye bengekafiki iminyaka emi-3 ubudala.

Indlela ukuthatha

Kuyanconywa ukuba uthathe iziyobisi ngexesha izidlo okanye emva kwayo. Iipilisi musa ukuhlafuna, imginye yonke, ahlambe phantsi ngamanzi acocekileyo. ngeedosi ngokwanele:

• izigulane abadala - 100 ukuya 200 mg, ukuya ku- 4 ngemini. Qaphela ukuba phantsi imeko yokusetyenziswa okokoko izinga tablets ayikwazi ingadluli kwiintsuku ezingama-30. Nakuba kunjalo, izifundo kunokwenzeka unyango kunye alternation: iintsuku 14 ukusela iipilisi, kwiintsuku ezili-14 akazange athathe ichiza. Le ndlela yenza kube lula ukuba ukunika unyango iinyanga eziliqela.
• Uthintelo lwezifo ezosulelayo emva iinkqubo zotyando, iinkqubo zokuxilonga - 100 mg ukuya ku- 4 ngemini. Ezo mode reception medicament sisaqhubeka ukuya kwiiveki ezi-3. Izigulana umsebenzi kwesibindi nkene ithamo kwezintso lokuqala yi-50% ye-ekucetyiswa.

Kufuneka kuqatshelwe ukuba ichiza "5-NOC" Ngokuzimela, angqina nomonde ukuqinisekisa oku, ngokukhawuleza kunciphisa nangokurhala, ephelisa intlungu ezibukhali. Noko ke, nkqu xa kuthe nempembelelo entle unyango ayikhuthazwa ukuphazamisa ikhosi amiselwe ngugqirha, kungenjalo kukho ingozi ukuphinda.

Esithathwa abantwana

Khumbula ukuba idosi ezaneleyo ukuba umntwana ukuchonga kuphela ngugqirha ngokusekelwe kuphando. ichiza idla emiselweyo ngolu hlobo lulandelayo:

• Usana ukusuka kwiinyanga ezi-2 ukuya ku-12 ukubala senziwa, ngokusekelwe ubunzima bomzimba zosana: 25 mg / kg ngosuku. Onke amayeza kufuneka yahlulwe amathamo 4 rhoqo. Ubude unyango uvela kwiintsuku ezili-10 ukuya kwiiveki ezi-3. Kwimeko losulelo kakhulu - ukuya kutsho kwinyanga 1.
• Xa kweminyaka eli iinyanga ezili-12 ukuya kwi-14 emiselweyo lokuthathwa mg-50 ukuya kwi-100 ukuya ku- 4 ngemini. Le khosi emiselwe oyingcali, kodwa ukwamkelwa oluqhubekayo kulo ingadluli kwiintsuku ezingama-30. Xa imo eneSandi kwiiveki ezi-2 - ulwamkelo, yaye kwiiveki ezi-2 - ikhefu liyavunyelwa ukuba ukusetyenziswa elide ichiza "5-NOC". Bantwana, oogqirha ncomo ngale bonisa kuthetha kufuneka imiselwe kuphela kwiimeko kakhulu xa unyango kunye namanye amayeza kwaba angasebenzi.

ziphumo bezingalindelekanga kunokwenzeka

Qaphela ukuba iziphumo ebezingalindelekanga kwi izigulane zinqabile, kodwa kuyimfuneko xa kuthe kwazo nangoko qhagamshelana nogqirha. Ukuze rhoxisa ichiza aqhube unyango kwangumqondiso emva konyango "-NOC 5". Imiyalelo kwakhona oogqirha bathi wabonakala ezimbi zilandelayo kunyango:

• Ukugabha, umsebenzi engaqhelekanga isibindi, isicaphucaphu, ukudla, kwiimeko ezinqabileyo.
• Tachycardia.
• Paresthesia, polyneuropathy.
• ulungelelwaniso ongeva kakuhle, isiyezi, intloko ebuhlungu, maxa wambi ilahleko lokuqonda.
• neuritis yokubona (kunye iipilisi ukusetyenziswa elide).
• Urticaria, irhashalala, ukuhluba ulusu.
• Thrombocytopenia, maxa wambi umchamo amabala kwi nombala enzulu emthubi, ukwanda isalathisi acid uric kwi plasma yegazi.

Njengomgaqo, zonke iziganeko ezibi Kwathi ngokukhawuleza emva ukupheliswa ngokupheleleyo isiyobisi, "5-NOC". Baqinisekiswa kubonisa uziva mnandi, kuphela kwimeko libanda, okanye ukuthotyelwa kakuhle.

Izimo

Ukuba isigulane sine-uxabane okanye uvakalelo omnye amacandelo ekwakhiweni, oko Akuvunyelwe ukwabela ichiza. Ayikhuthazwa ukusebenzisa medicament ubisi lwebele, cataract, umsebenzi isibindi engaqhelekanga kunye nezintso.

Kubalulekile ukuphawula ukuba ichiza "5-NOC" amabhinqa ingxelo ngale show udla emiselweyo ngexesha lokukhulelwa. Oku akuthethi ukuseka iimeko nobungozi kwimpilo bobabini umama elizayo kunye olungekazalwa. Ngokuqhelekileyo, ichiza ezimiselweyo Ngokuzimela etsolo, usulelo lwelungu langasese kunye ibonwa fungal (thrush).

Akukho mfuneko ukuthatha amayeza ngexesha elinye kunye amayeza eziqulathe hydroxyquinoline. Ityhefu ityhefu nga oluphumayo babutha into esebenzayo emzimbeni.