Pemphigoid Bullous: iimpawu, unyango, neefoto

pemphigoid Bullous - isifo solusu eqhelekileyo kakhulu into efana wabonakala kwangaphandle pemphigus. Isifo kwenzeka ekwimo ezingapheliyo kwaye kungekho loxilongo ngokukhawuleza unyango kunokukhokelela nesohlwayo. Ngoko ke yintoni ebangela uphuhliso kwesi sifo? Ziintoni iimpawu ukuthi kuziveza? Ziziphi indlela yonyango zezonyango namhlanje kufuneka anikele? Iimpendulo zale mibuzo umdla kubafundi abaninzi.

Yintoni isifo?

pemphigoid Bullous imithi namhlanje saziwa ngamagama amaninzi - ukuba isifo lever, yaye pemphigus saka, dermatitis herpetiformis kunye saka. Kuyinto esingapheliyo isifo samathambo, nto leyo sikhatshwa imbonakalo yabangxamayo eluswini blister enkulu (iimpawu zangaphandle ngamanye amaxesha ifuze pemphigus oyinyaniso).

Kubalulekile ukuphawula ukuba uninzi lwezigulane kunye nale unesifo - kuba abantu abaneminyaka eyi-65 nangaphezulu. Ngokuqhelekileyo, amayeza eyaziwa ngaphandle, njengoko esi sifo ngezinye ebantwaneni kunye nezigulane eliqina. Esi sifo iphawulwa ikhondo nabungozi, kodwa maxa wambi kungakhokelela kubunzima. Lo mfanekiso kwezonyango wentsikelelo isalamane mzuzu kunye nexesha exacerbation. Kakade ke, kuba abantu abaninzi, umbuzo umdla kukuba i pemphigoid bullous. Iimpawu kunye nonyango esi sifo, kubangelwa - olu lwazi kufuneka ufunde ngenyameko ngakumbi.

Ezinye izifo ezifanayo

Kubalulekile ukuphawula ukuba pemphigoid bullous yinxalenye yeqela ekuthiwa dermatosis esinganyangekiyo. Ezi zifo ahluka ukusuka pemphigus oyinyaniso, kuba oko kuhambisana acantholysis. Iqela kwesikhumba izilonda iquka izifo ezininzi, umfanekiso lwezonyango leyo iyafana:

• Ebubonisayo pemphigus neakantoliticheskaya apho sifo sichaphazela kuphela ukuba isifo ngomlomo ngaphandle ibangela irhashalala kwezinye iisayithi. Isifo linophawu ikhondo elihle. Hi ndlela leyi, oko echazwe kuqala ngo-1959.
• Umkrwelo pemphigoid - kakhulu sisifo eyingozi esichaphazela inwebu kwiinwebu iliso kunye conjunctiva, ebangela ukuba yoma. Irhashalala kwi omzimba kunokwenzeka, kodwa kwenzeka kakhulu oko kungeyonto ayenza rhoqo. Iqela umngcipheko eziphambili - amabhinqa engama-50 ubudala, nangona ngamanye amaxesha sifo ibhalwe phakathi izigulane eyindoda.

Oonobangela kunye Pathogenesis of pemphigoid bullous

Ngelishwa, indlela ingenzeka le sifo nangoku ayiqondwa ngokupheleleyo. Noko ke, oosonzululwazi baye bakwazi ukuqinisekisa ukuba isifo samathambo ngokwendalo. Ngenxa yezizathu okanye omnye kukho ukusilela kumsebenzi kwamajoni omzimba, kwaze oko kwakhokelela asegazini bahlasele kuphela amazwe, kodwa kwakhona iiseli zomzimba ngokwakhe.

Ubungqina le ngcamango ziyafumaneka. Ngexesha serum wophando nomonde, kwakunye kwi ulwelo kuthatyathwa amadlu, omzimba athile baye bafunyaniswa umonakalo inwebu carcinomas ye ancedisana ulusu kunye ngenwebu yangaphakathi. Kwakhona, kufunyaniswe ukuba esebenzayo ngakumbi esi sifo sikhula, inyuka titer ezi antibodies.

Kukholelwa ukuba izifo samathambo zibangelwa imizila yemfuza. Kodwa ufuna ukuyicazulula ukuba uyakwazi ukususa i sifo. Oku ingaba:

• Ugonyo kwizifo ezithile;
• umonakalo okanye ukuluma kakhulu eluswini;
• sesichengeni sosasazeko lwemitha yelanga (Akukho nje elide, ukuxhatshazwa solarium, etc ...);
• ukutsha thermal nolusu;
• ukusetyenziswa rhoqo amayeza ezithile, ezifana "Furosemide", "captopril", "phenacetin", "amoxicillin" kunye nolunye;
• Ngamanye amaxesha sifo luvuliwe emva elingaphesheya unyango radiation nomonde;
• kwezintso ukufakelwa ukungafunwa, abohlukeneyo ngokuphindaphindiweyo.

Bullous pemphigoid: ifoto kunye neempawu

Kakade ke, okokuqala nje, kubalulekile ukuba uwazi iimpawu, kuba kungekudala isigulane liya kuhlawula ingqalelo ubukho ukunyhashwa uze ufune iingcebiso lonyango, i lula inkqubo unyango zenzeke. LeMfundo eluswini kuqhume vesicular kakhulu - iphambili apho lukhatshwa pemphigoid bullous (Ifoto ibonisa inkangeleko yabangxamayo). Amaninzi kuchaphazela isikhumba imilenze kunye nomzimba. Yabangxamayo kungenzeka kummandla creases ezinkulu zendalo ebusweni, Nentloko enesihlwitha yohambayo, kodwa kuyenzeka kunqabile.

Eyona miba kuqhuma - vesicles kunye namadyungudyungu nge emoto uneengxaki. Ngaphakathi bafumana ulwelo, ngokuqhelekileyo ngaphaya, kodwa ngamanye amaxesha ungaqaphela igazi. Ngokufuthi, inwebu le maqampu ebomvu.

Igama elithi "umphefumlo" kwingxelo kweentsuku ezimbalwa. Emva koko, baye ngokuzenzekelayo avuleka. Xa isayithi ye izitshanguba kwakhiwa kwiindawo ukhukuliseko kunye nezilonda ezincinane. Kuqweqwe phezu komhlaba baya ayakhekanga njengeendawo ilunga ngokukhawuleza epiteliziruyutsya.

Izinyathelo zokuqala zesi sifo-20% ezigulane aqala imbonakalo amaqamza kwi isifo ngomlomo, uze emva koko ungena yabangxamayo esikhumbeni. Namadyungudyungu phezu kwiinwebu impumlo, umqala, zokuzala, amehlo kuvela kunqabile kakhulu.

Izigulane akhalaze sokudlathuka kweenwele, yaye emva kokuvula i-amaqamza abanye ubuhlungu. Mhlawumbi ukunyuka kwamaqondo obushushu, nangona oku kunqabile. Kubantu abalupheleyo, umzimba olusele yi likakade rhoqo, kananjalo waphawula ukuhla ukutya, ukwehla kobunzima, ubuthathaka progressive.

Histogenesis, histopathology kunye patomorfologija

Pathology bullous pemphigoid kakhulu umdla. iinkqubo zokuqala cytoplasmic phakathi kwiiseli carcinomas kwasekwa vacuoles ezininzi. Ngokuthe ngcembe ngokuseka ziyadityaniswa ukuze zenze izakhiwo ezinkulu. Kunye nale, kukho elibukhali kunye nokudumba le dermis emzimbeni.

WaseTire lwesinye - na epidermal kwithishyu. Iiseli nengalo yayo, kodwa iibhulorho phakathi kwabo akukho yonakele. Njengoko esi sifo kuba babebona ngcembe kude iiseli epidermal. Kwangaxeshanye, izicwili epidermal ezintsha uza elintlangothi h, bamba ezantsi wayo - oko vesicles lisondela ngaphakathi ye sangaphandle kwaye ngamanye amaxesha podrogovoy umaleko.

Ngaphakathi iqamza kukho incindi equlathe lymphocyte kunye admixture of neutrophils. Kukho nemidzaluka fibrin, ezo molekyuli iiproteins kunye nezinye kusitsha.

Ukuba sicinga histogenesis of pemphigoid bullous, okokuqala kubalulekile ukukhumbula ukuba isifo samathambo. Xa isifundo izicwili yi electron microscope nga kuqatshelwe ukuba ekuthiwa-buhlungu ezisegazini BPAg1, ayaphuma ngethuba omzimba ibekwe nwebu carcinomas, ezizezi xa ukulungisa keratinocytes poludesmosom. Enye Isilwa - BPAg2 - nayo ibekwe kwindawo poludesmosom. Kukholelwa ukuba ukhandwa uhlobo collagen XII.

Kwakhona ngethuba lokwenza uphando kuye kwafunyaniswa ukuba macrophage kunye eosinophils kwesi sifo ekuqaleni inokuqokelelana inwebu carcinomas, uze ukuthutha ngalo kwaye uqale ukuba yande ngaphakathi lwesinyi phakathi kwiiseli Uhlobo Lokuqala. Kwakhona, kukho degranulation ebalulekileyo weeseli imasti.

Histologically, esi sifo babona xa exfoliation ye sangaphandle evela dermis, naphakathi oluthi luqokelelane blister subepidermal. Imithambo ancedisana eluswini sandisa, kukho iindumbisa kweemaleko yangaphakathi (endothelium).

iindlela Modern loxilongo

Ngokuqhelekileyo, akukho ubunzima kunye ukubonwa kwezifo ezifana pemphigoid bullous: iimpawu ezithile kakhulu, kwaye ke ngoko ugqirha wakho Basenokukrokrela isifo sele ngexesha lokuhlolwa eqhelekileyo. Kwi isikhumba yomguli amaqamza tight bayazibhijabhija, kwaye inkqubo epithelialization of erosions kwenzeka ngokukhawuleza.

Ahlangene test sangaphandle ezimbi. Ukongeza, ucingo ngaphandle imixholo yangaphakathi amaqamza kunye neemviwo ngakumbi histological kwenziwa. Ngexesha elebhu iimvavanyo ingafunyanwa kwi vacuoles ulwelo izinto histiocytic, eosinophils lymphocyte.

Kwelinye icala, uxilongo umahluko lugcwele ngamanye amaxesha nobunzima, njengoko umfanekiso yinto kusikhumbuza ephezulwana nezinye izifo zezikhumba, kuquka erythema multiforme exudative, ayinyaniso pemphigus herpetiformis dermatitis Duhring.

Yintoni unyango luthathwa ukuba abe nempumelelo?

Ntoni xa ubuyazi pemphigoid bullous? Unyango kule meko ifuna a ezintsonkothileyo. Ngaphezu koko, ukukhethwa zokuzonwabisa kunye namayeza kuxhomekeke kwizinto ezininzi, kuquka ubungqongqo esi sifo, ubudala kunye nempilo jikelele yomguli, ubukho comorbidities. Kuyo nayiphi na imeko, irejimeni yonyango lunokwenziwa kuphela ngugqirha khona.

Isiseko unyango - steroid amachiza-ukudumba equlathe steroid. Kaninzi zisetyenziselwa le njongo "Prednisolone". Ichiza ilawulwa yegazi kunye idosi ebegqwese lehla njengoko yokuduka iimpawu.

Kwakhona, nempembelelo entle cytostatics anikwe kunye arhente immunosuppressive zinceda ukubuyisela ukusebenza kwamajoni omzimba. Kaninzi, izigulane ezimiselweyo iziyobisi ezifana "Cyclosporin A", "Cyclophosphamide", "Azathioprine".

Kakade ke, eyona nto ibalulekileyo kukuba unyango lwe izilonda, erosions kunye nezilonda apha esikhumbeni. Kuyimfuneko ukuba ugcine ulusu icocekile. Izigulane ezilawulwa izisombululo kunye iidayi aniline (umz: "Furkotsin") eba ebulala okanye kukoma esikhumbeni. Kwiimeko kakhulu aqokele ukwenjenje kufuna namafutha aqholiweyo kunye steroids.

Unyango nge amayeza abantu

pemphigoid Bullous, okanye isifo lever - a ngezifo efuna unyango abanobuchule, abafanelekayo. Ukusetyenziswa kwamayeza ezahlukeneyo ekhaya kunokwenzeka, kodwa kuphela ngemvume ingcali. Phambi kokuba usebenzise nayiphi na indlela kufuneka udibane nogqirha wakho. Xa amayeza abantu basebenzisa iindidi zamachiza ezahlukeneyo.

• Kukholelwa ukuba isimo esihle yempilo yomguli kuchaphazela tincture ka Eleutherococcus. Thatha kufanele kube kabini ngosuku, 30 amathontsi.
• Kuba juice processing ukusetyenziswa irhashalala yangaphandle ukusuka amagqabi zekhala, nto leyo inceda zisulu ukurhawuzelela kwindawo efakwe, ithintela uphuhliso ukudumba, ibalekisa ngokutsha. Ijusi kufuneka yokunyakamisa umhlabelo, ngoko isicelo kwi kummandla ulusu ochaphazelekayo kwaye ulungise bandage. Kuba kangangoko, unako kukugubungela urhangqo kunye izisongeli zeplastiki.
• Ngenjongo enye, ingasetyenziswa juice entsha okanye decoction amagqabi umba. Ukuthoba eyenziwe inkqubo echazwe apha ngasentla.
• pemphigoid Bullous, okanye ngqo, iimpawu yayo zinciphe kunye decoction ekhethekileyo esintu. Ukuyenza uthathe isixa esilingana (50 g) ngamagqabi zomgamtriya, rhizomes coil iziqhamo Sophora japonica, namaqhina ezinde, yarrow, esipajini umalusi kunye ngamarhawu. amacephe amabini umxube uzilungiselele nasemifunweni ngokuhlwa, Ndimthulule iglasi yamanzi abilayo uze ushiye ubusuku. Ngentsasa nokuhlanganiswa kuyimfuneko ukuba izicoci uwahlule ube zahlulo zithathu - thatha nazo ebudeni bemini.

Kuyabonakala ukuba amayeza esintu ukuze isigulane ngasinye ukuze senze ngendlela eyahlukileyo. Nokuba arhente kunempembelelo entle, kuyo nayiphi na imeko musa ukunikezela unyango.

Le abane ukuba izigulane

Pemphigoid - isifo nabungozi kakhulu eluswini, ngoko kwenzeka kwiimeko ezininzi akukho kakhulu nzima. Ngaphezu koko, phantse nasiphi na isibhedlele isixeko esikhulu enze unyango yimpumelelo ngenxa sifo igama inzima kakhulu - pemphigoid bullous. E Orenburg, eMoscow, kunye nasiphi na esinye isixeko, uqinisekile ukuba ukufumana oyingcali elungileyo. Indawo yokuhlala iya kuxhomekeka ngaphandle iindleko zonyango, ukususela amaxabiso amayeza ezithile izinto kwikhemesti ezahlukeneyo azifani.

Xa kuqhutywa kakuhle unyango unako ukufikelela uyekelelo izinzile. Ukususela kumaxesha ngamaxesha kukho ezinye izigulane ndiphinde ndazisebenzisa, leyo, Kakade, mnandi, kodwa akubulali. Kwelinye icala, xa kungekho ndawo unyango lwe ukubunjwa izitshanguba libe esangweni for usulelo, ngokulandelelana akugqiba nangokurhala enkulu ngakumbi, suppuration imivumbo, afunxwe iintsholongwane yayintsholongwane eyosulela kwi kweemaleko isikhumba nzulu.

Ingaba kukho naziphi na iindlela zokuthintela?

Ngelishwa, akukho ndlela ezithile lokuthintela izifo ezifana ngokobuzwe bullous pemphigoid. Ngokuqhelekileyo, kubalulekile ukuba sifune uncedo ngexesha, yaye sisifo esingapheliyo, nkqu kumaxa isalamane kakuhle-ntle kufuneka esweni ngenyameko nemeko yobume bempilo yakhe.

Musa ukulibala ukuba esi sifo amayeza kuthathwa nomhlaza isiphawuli enokwenzeka. Kungenxa yoko le nto kukho esi sifo isigulane kufuneka bangenele uviwo esibanzi ukuqinisekisa okanye alawule phandle uxilongo of Cancer. Khumbula ukuba nasiphi na isifo kulula kakhulu ukuba bamelane ukuba uqale unyango kusekwangoko.