"Mesipol": imiyalelo ukusetyenziswa, nabalingani real

Yintoni na ichiza "Mesipol"? kwi isicelo yesikhokelo isixhobo, zayo contra-ezibonisa kwaye kuya kuxoxwa ngazo kweli nqaku. Kwakhona, uya kufunda le amayeza ziziphumo ebezingalindelekanga ukuba okanye hayi ukuba wayeza kuba kwimeko libanda, kwifomu apho ukuba ithengiswe noko kweziyobisi iqulethe.

Uhlobo ichiza nokubunjwa kwayo

Ukulungiselela "Mesipol" sele ithunyelwa iintlobo ezimbini ezahlukeneyo: iipilisi kunye isisombululo inaliti intramuscular. Zabo isimiso ukusebenza iyafana. Ukuba ulawulo yomlomo akunakwenzeka, kusetyenziswa inaliti.

Isisombululo "Mesipol" ine into esebenzayo ezifana meloxicam. Kwakhona iquka izithako abangabancedani zilandelayo: glycofurol, meglumine, sodium chloride, Poloxamer 188, isodiyam hayidroksayidi, glycine, namanzi ngenaliti.

Le isinyibiliko emthubi okanye zana-mthubi. Kuyinto ngaphaya. Kwakhona unalo livumba isici. Ibhokisi yi ampoules 3 (1.5 ml).

Phela, ukongeza iipilisi okanye izisombululo iinaliti intramuscular, iinkampani zamayeza baqalisa ukuvelisa amakhandlela "Mesipol" kunye Ukunqunyanyiswa elungiselelwe ulawulo ngomlomo.

Ezona mpawu amayeza ye ichiza

"Mesipol" isiyobisi a nonsteroidal arhente anti-ukudumba. Ichiza uyakwazi sizibhokoxe iintlungu nefuthe antipyretic. Isiphumo antiinflammatory ye indlela ezinxulumene kunye zokunciphisa umsebenzi enzymatic of cyclooxygenase-2, nto leyo efunekayo biosynthesis of prostaglandins kule ndawo ebushushwini babo.

Le meloxicam isiqalelo esebenzayo ubuncinane izenzo kwi cyclooxygenase-1, nto leyo ebandakanyekileyo ngqo prostaglandin yokuqaphela, olukhusela inwebu kwiinwebu emathunjini kwaye enza izinto ummiselo yokumpompoza kwegazi kwi kwizintso.

Pharmacokinetics beziyobisi

Drug "Mesipol" (iinaliti kunye tablets) ako ngokupheleleyo. Le bioavailability beziyobisi yi-100%. Emva Inaliti intramuscular (malunga 15 meloxicam mg), kukufakwa ubuninzi ekufikelelwe kuso emva kwemizuzu engama-65.

siye kuqwalaselwa ichiza enebana iiproteni plasma, kuquka albumin (99%). Lula udlula imiqobo ngegazi-tissue, kodwa lingena singene kulwelo synovia. Ukufumaneka ngazo-50% ye xi kweziyobisi plasma.

Le into esebenzayo ye medicament umzimba phantse ngokupheleleyo esibindini. Oku kwenza ezine metabolite imithi engasebenziyo.

Emva kokuba isicelo medicament oboniswe ngokulinganayo emathunjini kunye kwizintso (a metabolite). I-avareji isiqingatha-ebomini into esebenzayo ziiyure ezingama-20.

Ubungqina obubonakalayo buxela ukuba ukusebenzisa amayeza

Kwezinye iimeko, ukumisela "Mesipol"? Imiyalelo Sebenzisa ithi amaninzi bacebisa ukusetyenziswa NSAIDs kwi unyango kwangumqondiso kwezifo ezifana:

• ukudleka;
• isifo samathambo;
• Ankylosing spondylitis (okanye ankylosing spondylitis).

Ukongeza, ichiza "Mesipol" (iinaliti kunye tablets) kudla ezimiselweyo nezinye sisiba mandundu kwaye ezithintela ukosuleleka zizifo namalungu, nto leyo zikhatshwa iintlungu kakhulu.

Izimo ukusetyenziswa arhente non-steroidal

Kwezinye iimeko, iyeza ayikwazi ingasetyenziswa "Mesipol"? Imiyalelo zokusetyenziswa iqulathe uluhlu olukhulu Izimo. Ezi ziquka oku kulandelayo:

• Hypersensitivity ukuya element ebonakalayo ichiza okanye iinxalenye zayo abangabancedani;
• intlanganisela buso okanye epheleleyo sombefu, wayengabunyamezeli acetylsalicylic acid, polyposis (nezolo) sinus paranasal kunye kwisisu ngeempumlo, kunye nezinye NSAIDs, kuquka anamnesis;
• yobudala yabantwana (iminyaka 16-18);

• wenze okanye amanxeba ilunga le yangaphakathi inwebu 12 tiperstnoj emathunjini okanye isisu;
• lwebele;
• ukopha cerebrovascular okanye ezinye imvelaphi ukopha;
• ukopha esebenzayo ethunjini okanye isisu;
• ngexesha sokukhulelwa (nokukhulelwa);
• isifo wamathumbu yokukrala (umz isifo okanye okwenziwa sisilonda sikabhobhosi Crohn yakhe);
• isifo esiqhubekayo kwezintso, kuquka hyperkalemia (kuqinisekiswa);
• ixesha emva kwemithambo esa igazi;
• ukusilela kwezintso (kuboniswe) abantu abangazange phantsi dialysis (CC ngaphantsi kwe 30 ml / min);
• senhliziyo decompensated;
• esebenzayo phambili isifo sesibindi okanye ukusilela isibindi (elimandundu).

Sebenzisa ngononophelo obukhulu!

Ke kaloku, ukuba uyazi apho amatyala ungasebenzisa ichiza "Mesipol" (tablets, iinaliti), kwaye ngayo contraindicated. Nangona kunjalo, kukho iimeko apho siye ingqalelo neziyobisi kufuneka ilawulwe ngokuqaphela okukhulu. Qwalasela uluhlu Kwiimeko ezinjalo:

• yobudala advanced (engama-60);
• isifo sentliziyo;
• senhliziyo ezingapheliyo;
• izifo cerebrovascular;
• diabetes;
• dyslipidemia okanye hyperlipidemia;
• kwemithambo neuropathy;
• ukucoca creatinine ngaphantsi kwe 60 ml / min;
• ukutshaya;
• amanxeba sisilonda kwenkqubo zokwetyisa kwimbali;
• ukusetyenziswa ixesha elide amachiza non-steroidal, kwakunye nokusetyenziswa kwazo engalawulekiyo ngeedosi amakhulu;
• sisifo, eyaziwa ngokuba Helicobacter pylori;
• ukusetyenziswa rhoqo iziselo ezinxilisayo (nokuba ezinomthamo esezantsi utywala);
• ukusetyenziswa kwexesha elinye-of corticosteroids zomlomo, kuquka "Prednisolone" iziyobisi;
• ukungaqheleki somatic yayinzima;
• ukusetyenziswa ehamba anticoagulants (umz, iziyobisi "Warfarin"), ii-arhente antiplatelet (umz, acetylsalicylic acid kunye medicament 'Clopidogrel') kwakunye inhibitors (uyakhetha) reuptake serotonin (kuquka iziyobisi "Tsitmedialopram", "Fluoxetine", "paroxetine" yaye "sertraline").

iziyobisi Nonsteroidal anti-ukudumba "Mesipol": imiyalelo yokusebenzisa

ulawulo Intramuscular le medicament phambi kwethu iboniswa kuphela kwiintsuku zokuqala ezi-3 zonyango. Kwixesha elizayo, qhubeka unyango kunye neefom yomlomo amayeza, okt iipilisi.

Oyidlayo Kucetyiswa yomenzeli ngu 7.5 mg okanye mg 15 kanye ngemini. Imali enikwa beziyobisi ixhomekeke kubungakanani iintlungu, ngokunjalo ubungqongqo inkqubo arhabaxa. Le medicament ilawulwa ngenaliti enzulu intramuscular.

Ngaba kunokwenzeka ukudibanisa kunye namanye amachiza iziyobisi "Mesipol" (kuqhume)? Eyokuqiqa ka ichiza ithi ukuba okubhalwe ezineengqayi kuyo nayiphi na imeko akakwazi ugalelwe kwi isirinji efanayo kunye nezinye izisombululo. Oku kungenxa yokuba kukho amathuba aphezulu ukungavumelani kwe meloxicam into esebenzayo kunye namanye amacandelo zonyango.

Kufuneka kuqatshelwe ukuba, ukuba abe izigulane kuba nengozi eyonyukileyo reactions ezibi, ngokunjalo ukusilela kwezintso (kubonakaliswa) kwi ihaemodialysis izilinganiso iziyobisi nonsteroidal ngaphezulu kwe 7.5 mg ngosuku.

Kuyimfuneko ukuba ukukhumbula ukuba ichiza "Mesipol", analogue apho siya kuqwalasela ngakumbi, kuyo nayiphi na imeko ukuba abasayi kwenziwa yegazi.

Ithamo iphezulu yemihla ngemihla meloxicam element esebenzayo kufuneka-15 mg. Imali ofanayo medicament eza kulandelwa kunye nokusetyenziswa ezidibeneyo amacwecwe, Ukunqunyanyiswa, kuba ulawulo ngomlomo, suppositories, kunye inaliti intramuscular.

amacala libanda

Ingaba kukho amatyala libanda, evela ekusetyenzisweni "Mesipol 'iziyobisi? Iinaliti (reviews ngazo ziza kuboniswa ekupheleni kweli nqaku), iipilisi, suppositories kunye ukumiswa kunokubangela umntu olihlwempu xa kusetyenziswa ebuza imithamo emikhulu.

Iimpawu libanda zingaquka ezi meko zilandelayo: isicaphucaphu, ukwazi kakuhle, iintlungu epigastric, ukusilela etsolo kwezintso, ukugabha, ukopha esiswini okanye amathumbu, ukusilela isibindi, asystole, kunye nokubanjwa sokuphefumla.

Kufuneka wenze ntoni xa kwimeko libanda? Iingcali bacebisa lavage esiswini, kwakunye kwanonyango nomqondiso.

Hi ndlela leyi, ngexesha zophononongo zibonise ukuba cholestyramine inceda ukukhawulezisa ekupheliseni meloxicam. Ihaemodialysis libanda, kuba kuphumelele, ekubeni kukho unxulumano ophezulu kwiiproteni igazi.

imiphumela emibi

Oku kunokubangela iziphumo ezingalindelekanga iziyobisi "Mesipol" (kuqhume)? ekusetyenzisweni arhente non-steroidal Guide ithi ukuba kunokubangela inani elikhulu lweziqhamo ezimbi. Makhe siqwalasele ngokweenkcukacha ngaphezulu:

• wokugaya: ukuqunjelwa, urhudo, isicaphucaphu, perforation le wokugaya, iintlungu esiswini, ukugabha, flatulence, ukuqhina, ukwanda zezomzuzwana kwi transaminases (kwesibindi), Kunjani, hyperbilirubinemia, izilonda sisilonda okanye ilunga kwinkqubo yokwetyisa, esophagitis, stomatitis, ukopha ecacile nefihlakeleyo ukusuka wokugaya phecana, ukudumba, gastritis kunye hepatitis.
• Yesikhumba: irhashalala, pruritus, amaqhakuvana bullous, irhashalala, photosensitivity, Stevens-Johnson syndrome, erythema multiforme, epidermal necrolysis ityhefu.
• inkqubo hemopoietic: anaemia, thrombocytopenia, utshintsho ukubalwa egazini kunye leukopenia.
• Nokwaliwa: angioedema , kunye anaphylaxis.
• System luvo: vertigo, isiyezi, ukudideka, intloko ebuhlungu, lability ngokweemvakalelo, ukuduma, nokudideka kunye ukozela.
• isixokelelwano sokuphefumla: bronchospasm.
• nemithambo yegazi: amwela wegazi eluswini, nokudumba peripheral, iyangongoza kunye noxinzelelo oluphezulu lwegazi.
• Amalungu umbono: ifiphale okanye kakuhle umbono, conjunctivitis.
• inkqubo wokuchama: ukusilela etsolo kwezintso, hypercreatininemia okanye ukwanda urea igazi, nephritis Embi, hematuria kunye albuminuria.
• reactions Local: intlungu avuthayo kwisiza inaliti intramuscular.

Intsebenziswano kunye namanye amachiza

• Xa ukusetyenziswa ngexesha elinye-amanye amachiza nonsteroidal kwaye acetylsalicylic acid kwandisa umngcipheko kwethumba nangokujaduka ilunga le wokugaya, kwakunye ukopha kubo.
• Ukusetyenziswa ngaxeshanye kweziyobisi kunye antihypertensives kungenzeka ukunciphisa ukusebenza kwale yokugqibela.
• unyango ngaxeshanye amayeza "Mesipol" kunye nonyango lithium ikhuthaza ukuqokelela yokugqibela kunye nokwandisa imiphumela yayo ityhefu.
• Xa isicelo ngexesha elinye-of "Methotrexate" kuthetha ukwandisa iziphumo zalo ezisemacaleni kwinkqubo hematopoietic.
• ukusetyenziswa ngaxeshanye i "Mesipol 'isiyobisi kunye womchamo umncipheko ukusilela kwezintso.
• ukusetyenziswa kwexesha-Enye kunye cyclosporine kwandisa iziphumo nephrotoxic le meloxicam kweziyobisi esebenzayo.
• Ukusetyenziswa ngaxeshanye kunye izicwangcisi intrauterine kunciphisa ukusebenza kwale yokugqibela.
• Xa ukusetyenziswa ngexesha elinye-yokuba anticoagulant kunye arhente thrombolytic kwandisa umngcipheko ukopha.
• ukusetyenziswa ngaxeshanye i "Mesipol" iziyobisi non-steroidal kunye kolestiraminom siqaqambisa zinomgutyulo yayo nge amalungu zesisu. Oku kwenzeka ngenxa yokuba nomphetho owujikelezileyo meloxicam.
• Ezilahlwayo amayeza kunye inhibitors of (uyakhetha) serotonin reuptake kakhulu kwandisa umngcipheko ukopha ukusuka phecana zesisu.
• amachiza Myelotoxic ukwandisa ibinzana gematotoksichnosti meloxicam into esebenzayo.

isikhokelo ngqo malunga nokusetyenziswa kweziyobisi

• Drug "Mesipol" kufuneka ngononophelo kakhulu xa izigulane isilonda Peptic isisu kunye namathumbu, ngokunjalo abantu kwi unyango anticoagulant.
• Ngexesha unyango ngale amayeza eziyimfuneko ukulawula i parameters komsebenzi kwezintso, ingakumbi abadala kunye nezigulane kunye nokusilela ngentliziyo esinganyangekiyo.
• Izigulane ngaxeshanye ezifumana womchamo yaye lithetha "Mesipol", kufuneka usele iziselo.
• Ukuba ngexa unyango, isigulane kwabonakala allergies, ithamo amayeza kufuneka kupheliswa.

Analogue kunye nexabiso zeziyobisi

Yimalini kugqalwa wethu isiyobisi? Kwikhemesti Ifom injectable beziyobisi nga kuthengelwa engange 400 Russian. Njengoko tablet, ukumiswa kunye suppositories, ixabiso yabo kancinane.

Kuthekani ukuba nako ukuthenga ichiza "Mesipol"? Analogs-mali zithengiswa phantse zonke drugstores. Phakathi kwazo kukho ezi iziyobisi zilandelayo: "Amelotex", "Eksen-Sanovel", "Artrozan", "Matar", "M-Cam," "liberum", "Medsikam", "Melbek", "Melox", "Bible Xico "," Meloxicam "," Melox "," Meloflam "," Miksol-Aude "," Mirloks "," Movalis "," Movasin "," Moviks "," bu- "," Oksikamoks "njalo-njalo.

"Mesipol": Ukubuyekezwa medicament

Ngoku uyazi ukuba sisiyobisi thina sicinga. Lifikile ixesha ukufumana into izigulane bathi ngayo ukulungiselela "Mesipol". Izimvo yalo nonsteroidal iindlela anti-ukudumba antsonkothileyo. Kwelinye icala, izigulane babanga ukuba kulunge kuwukhulula syndromes intlungu ukuba sizalwa osteoarthritis, isifo samathambo, ankylosing spondylitis kunye nezinye izifo sisiba mandundu kwaye yokukrala amalungu. Kwelinye icala, izigulane badla bakhalazela ukuba ichiza ubangela iqela elikhulu ziziphumo ebezingalindelekanga, ngenxa apho kwanyanzeleka ukuba bayeke ukuthatha kuyo.

Ngokubanzi, ichiza phambi kwethu "Mesipol" alwa ngokupheleleyo umsebenzi wayo.