Ithumba Necrosis Factor: amalungiselelo

Ithumba necrosis factor (TNF) - iqela cytokines protini ethile - izinto hormone-ezifana eveliswe amajoni omzimba. Oku kubanga eninzi umdla amayeza ngenxa yayo - ukukwazi eyenza ukufa kweeseli (necrosis) izihlunu intratumoral. Le idabi ngokwenene amayeza, elikuvumela ukuba isicelo iimveliso kunye TNF ukuba unyango lomhlaza.

History of izovela

Ngu ekuqaleni kwenkulungwane XX e yezonyango ngayo ibonakele ipatheni: kwezinye izigulane kwabakho ukuncipha kunye / okanye Ukunyamalala ithumba lokusekwa emva ukudlulisela nawuphi na usuleleko. Emva koko umphengululi American uWilliam Coley olwaqaliswa ezilawulwa ngabom ngeziyobisi somhlaza equlethe ikhaya ezosulelayo (iintsholongwane nobumdaka zabo). Indlela ayifumanekanga ukuba iyasebenza, njengokuba enzile nefuthe zinetyhefu kwisigulana olomeleleyo. Kodwa sisiqalo inani yophando ekhokelela kokufunyanwa iproteni, ebizwa ngokuba ithumba necrosis factor. into Found ebangela ukufa ngokukhawuleza iiseli zomhlaza ingenisa ngaphantsi kwesikhumba yeempuku zovavanyo. Kungekudala emva koko, oko yedwa TNF ecocekileyo, leyo awavumelekanga ukuzisebenzisela ngeenjongo zophando.

Le into eyaba negalelo impumelelo kunyango lomhlaza. Ngaphambili, esebenzisa iiproteni cytokines nako ukunyanga ngempumelelo umhlaza nje izinto ezimbalwa Lezemfundo - wolusu nomhlaza wesikhumba, umhlaza zezintso. Noko ke, inkqubela ebonakalayo kulo mhlaba eye wavumela isifundo iipropati ubephethwe ithumba necrosis factor. Amalungiselelo ezisekelwe kuyo ifakiwe kule nkqubo ichemotherapy.

indlela isenzo

ithumba necrosis factor enza kwiseli ethile - target. Kukho iindlela ezininzi amanyathelo:

• Ngokusebenzisa ezenza TNF ezizodwa luqalisa indlela multi-nqanaba - ukufa kweeseli (apoptosis). Esi senzo sibizwa ngokuba cytotoxic. Ngelo xesha zihlolisisa Ukunyamalala epheleleyo yamathumba, okanye sinciphise ubukhulu bayo.
• Esebenzisa ukwaphulwa okanye ukupheliswa komjikelo cell. iseli Umhlaza uba akakwazi ukwahlula kunye nokukhula Ithumba wayeka. Esi senzo sibizwa ngokuba osebenzayo. Ngokuqhelekileyo, ewayo kuyo nokuba eyeka kukhula, okanye ukunciphisa ubukhulu.
• Ngokubhloka inkqubo ukuyilwa neovascularization of ithumba inyama kunye umonakalo emithanjeni okuqokelelwe-ekhoyo. Ithumba iyasuswa ukutya, necrotic, ucutho ekho.

Kukho iimeko apho iiseli umhlaza zezi ongenandaba ichiza ungabutofela ngenxa yemfuza. Ngoko ke iindlela akahambi kuvuka.

Ukusetyenziswa in amayeza

Ithumba necrosis into lisetyenziswa ekuthiwa unyango Cytokine - unyango kweziyi ezithile uzikise iiseli igazi elijongene nezifo. Inkqubo kunokwenzeka nakweliphi na inqanaba lenkqubo thumba kwaye contraindicated kubantu comorbidities - sentliziyo, kakuhle kwezintso, hepatic. Ukunciphisa ubungozi isicelo recombination ochaphazelekayo ithumba necrosis factor.

Unyango kunye cytokines - ezintsha ngokuqhubekayo nokuphuhlisa ebaleni Oncology. Ukusetyenziswa TNF ithathwa kakhulu ngempumelelo. Ekubeni le nto ityhefu kakhulu, nto isetyenziswa yi perfusion ebizwa ngokuba yi-lwengingqi. Indlela sikuko yokuba ezazinesifo thumba ilungu okanye umzimba inxenye ngoncedo izixhobo ezikhethekileyo sihlangulwe kwegazi jikelele. Ke okwenziwe ukuqala igazi kwegazi kunye zifakwa TNF.

nemiphumela eyingozi

Ukuziqhelisa lwezonyango, ithumba necrosis factor isetyenziswe ngobulumko. A Inani lezifundo babonisa ukuba TNF - njengelungu elingundoqo kuphuhliso nokudumba, ukothuka ityhefu. Ubukho le protini kwandise phathogenicity lwezifo yintsholongwane kunye wentsholongwane egazini, nto leyo eyingozi ngakumbi phambi kwe-HIV umguli. Kwakungqina ukuba TNF ebandakanyeke okubangela izifo samathambo (umz, isifo samathambo) apho amajoni omzimba ngempazamo ifumana ancedisana iiseli eziphilayo lwemizimba amazwe kunye umonakalo kubo.

Ukuze kuncitshiswe ifuthe eliphezulu zinetyhefu bagcine la manyathelo alandelayo:

• ukusebenzisa kuphela kwisiza ithumba kwenkumbulo;
• zihlangana nezinye iziyobisi;
• Basebenza kunye iiproteni ayinabungozi TNF njengesi;
• Administrator lwaze omzimba.

Ezi iimeko ukunyanzela Asebenzisa ithumba necrosis factor. Onyango kufuneka kakuhle.

lokuxilonga

Uvavanyo igazi awayiboni TNF e umzimba usempilweni. Kodwa inqanaba layo kwandisa kakhulu kuzo izifo ezosulelayo apho igazi kuza ubuthi gciwane. Ngoko kusenokuba khona nomchamo. Ithumba necrosis factor kulwelo lwamalunga of isifo samathambo utsho.

Kwakhona kwandisa zesi salathisi uthetha negazi, izifo umhlaza kwaye luphawu ukulahlwa amalungu zabaxhasi zilinywe. Kukho ubungqina bokuba ukwanda kwesi salathisi kunokubonisa ukuba izifo ezingasuleliyo ezinjengesifo ukusilela intliziyo, isifuba inyumoniya.

Xa immunodeficiency ezahlukeneyo (kuquka AIDS) kunye nezifo kakhulu viral ezikhoyo kwakunye zokonzakala nokutsha, iimeko badalwe leyo ukunciphisa ithumba necrosis factor. A iziyobisi onesiphumo immunosuppressive, ukunika isiphumo efanayo.

amalungiselelo

esekelwe kumachiza TNF ebizwa ekujoliswe - ukukwazi ukwenza ejolise kwi molekyuli elithile ziiseli zomhlaza, ebangela ukufa yokugqibela. Umphumo kwezinye izigqeba na omncinci, nto leyo lunciphisa ubungozi, nto leyo eye ithumba necrosis factor. iziyobisi ezisekelwe zisetyenziswa njenge TNF yedwa (monotherapy) kuhlanganiswa kunye nezinye izinto.

Namhlanje, kukho izinto ezininzi ngokusekelwe TNF, ezizezi:

• NGR-TNF - imveliso kumazwe angaphandle, eyona nto esebenzayo i yemvelaphi ye TNF. Oku uyakwazi umonakalo imithambo yegazi lo ithumba, angabi nalo bamandla ayo.
• "Alnorin" - uphuhliso Russian. Yeyokuba isebenza kakhulu xa zidityaniswe kunye interferon.

"Refnot" - ichiza elitsha eziqulathe ithumba necrosis factor kunye thymosin alpha 1. zinetyhefu Its eRashiya liphantsi kakhulu, kodwa ukusebenza lilingana TNF zendalo, kwaye zingaphezu walamla intshukumo immunostimulatory. Ichiza wadalwa 1990. Kuye ngempumelelo zonke ulingo lonyango kuyimfuneko yaye kuphela ngo-2009 kwakubhalwe khona, nto leyo enika imvume esemthethweni ukunyanga ngumhlaza zabo.

Self-ulawulo zonke iziyobisi ngokusekelwe ithumba necrosis factor ngokupheleleyo akuvumelekanga. unyango Cancer - inkqubo abamanyeneyo kakhulu ukuba kwenzeka kuphela phantsi kweliso yincutshe.