Ichiza "Aspekard": imiyalelo ukusetyenziswa, analogs, ncomo

Acetylsalicylic acid (ASA) libhekisela kumachiza kunye neziphumo antipyretic, anti-ukudumba kunye antiplatelet. Xa yezonyango isetyenziswa iminyaka engaphezu kwama-125, ngokuba yenye amachiza ezininzi ngaye. Uthe ngoko ASA ngoku ifumaneka njenge kardioformy ukunciphisa ingozi coronary kwimithambo thrombosis, ntoleyo ephazamisana uphuhliso iposi engabalulekanga. Omnye wemizekelo yoku ekulungiseleleni "Aspekard" leyo iqulethe acetylsalicylic acid kwindawo kangangoko uwadle ukusebenza antiplatelet.

Ulwazi kwifomu ukukhululwa kunye nomakhi

Umenzi ichiza nkampani Ukrainian "Stirolbiopharm". Ngako oko, ubuchwepheshe lemveliso esetyenzisiweyo, ekuveliseni iintlobo ifomu zheludochnorastvorimoy kwi ne nedosi ye-100 mg ipilisi nganye. Iindlela Amacwecwe layout:

• ibhokisi iipilisi 120 (namadyungudyungu-10 ukuya ku-12 tab.);
• isikhongozeli polymeric iipilisi 100.

Icwecwe "Aspekard" iqulethe 100 mg ka-ASA, microcrystalline kwincindi, isodiyam croscarmellose, colloidal lesilicon dioxide, stearic acid.

Izindululo zokuqeshwa

Xa Elungiselela "Aspekard" sicelo elimxinwa ngokwaneleyo, nangona iqulathe imiyalelo neziphakamiso ukunyanga izifo ezininzi, kuquka izifo rheumatism. Nomakhi wacebisa ukuba 'Aspekard "kwaye njenge-arhente antipyretic okanye iintlungu. Enyanisweni, xa umthamo amayeza acid acetylsalicylic kuphela isetyenziswe ngempumelelo ichiza ethintela zegazi udibaniso.

Iimpawu "Aspekard"

Kwi yokulungiselela "Aspekard" umyalelo malunga nesicelo, kwakhona iingcali zophando lwezonyango ze unike ulwazi oluninzi olunxulumene antiplatelet unyango. Oku kuboniswa kule meko zilandelayo:

• xa (ACS), syndrome coronary etsolo (kwinqanaba umphakamo etsolo iposi engabalulekanga, ukudakumba okanye ukusiwa ST ingxenye indawo, xa angina ezingazinzanga);
• ekutyhwakrazeni (stroke kobuchopho okanye kobuchopho);
• xa kwimeko eqinisekisiwe kwemithambo njengendlela yothintelo lwe syndrome etsolo coronary kunye ngesibetho;
• ekuthinteleni izigigaba nezolo of syndrome etsolo coronary kunye ngesibetho;
• kunye ubukho imithambo varicose;
• njenge arhente zothintelo, a thrombosis isilumkiso shunt emva CABG;
• ne nomfutho kwimeko emngciphekweni omkhulu sentliziyo.

umngcipheko omkhulu sentliziyo yi ingcamango aggregate equka ubukho umonakalo ekujoliswe sitho lwegazi kunye nezifo ezinxulumene: isifo seswekile sinwenwa, isifo kwemithambo, TSVB.

Amanqaku Iirejimeni umthamo ekucetyiswa ngumvelisi

Xa Elungiselela "Aspekard" umvelisi uqeqesho hayi iinkokheli engundoqo unyango yesigulane. Iqulethe ulwazi malunga nolawulo beziyobisi kwiimeko ezahlukeneyo clinical ukusuka ekuthinteleni iziganeko atherothrombotic kwi isifo sentliziyo kunye TSVB kunye nesiphelo kunye neengxaki zale ejikeleza kunye nentliziyo lobuchopho. Le into ithathwa sengqondo kwenkathalo kwaye engekho mgaqweni kumba kweziyobisi kunye nezinto ezihamba ulwazi. Oku kukwadala imiqathango ukwenzela ukupapashwa ubunzima lwamanqaku apho iidosi kucetyiswa zahluke.

Umthamo iirejimeni ngokwesiseko iingcebiso ngamazwe

Ngokusekelwe izikhokelo owenziwe yi-European Community of Cardiology (PrintPro) kunye American Heart Association (Tshotsho) kunye naphaya Ministry of Health, kwiindlela isicelo acetylsalicylic acid zimi ngolu hlobo lulandelayo:

• engxamisekileyo inyathelo ngexesha acute coronary syndrome kufuneka ukuba anike isigulane ukuhlafuna amacwecwe 3 "Aspekard 100". Imiyalelo yokusebenzisa alihoywa ukuze, kunye nedosi enye ye-300 mg;
• ischemia ezingapheliyo wentliziyo (isifo) kwindawo yolwamkelo rhoqo eyabelwe enye elucwecweni 100 mg ngokuhlwa emva kwesidlo;
• kunye lwegazi izigulane kuba nengozi ephezulu iingxaki sentliziyo, kwakunye varicose lwemithambo rhoqo eyamkelwe 100 mg (1 tablet) ngokuhlwa emva kwesidlo.

Nezinye iindlela zolawulo iziyobisi "Aspekard" umyalelo PrintPro kwaye Tshotsho ayinikezeli. Kubalulekile ukuba uqaphele ukuba idosi umgangatho "Aspekard" ngu 100 mg ye ASA. Kuba ekuthinteleni izifo ngasentla, ngokungqinelana nemiyalelo PrintPro kwaye Tshotsho, isicelo ithamo 75 mg. Noko ke, 100 mg eyabelwe izigulane emva CABG ukuthintela thrombosis le shunt. Kwezinye iimeko ke kucetyiswa ukuba isicelo 75 mg, ngamanye imali ASA, nto leyo enika ukusebenza ezaneleyo antiplatelet kwaye gastrotoxicity umngcipheko ubuncinane.

Kwakhona, umenzi ayiboneleli ngolwazi olubalulekileyo ukupheliswa ichiza. Ngokutsho manani, nomhla ngesiquphe unobangela 10.2% kweziganeko zosulele sentliziyo. Kwaye zifumaneka emva nama-10.6 kweentsuku ukusuka kumhla wokucinywa ka-ASA. Eli xesha umlinganiselo kwaye ibonisa ixesha apho bonke abantu lifinyele zegazi cyclooxygenase ukusebenza. Ngenxa yoko, ithuba egazi ebuyiselweyo. Ngenxa yokuba ichiza kufuneka aselwa okokoko, ngelixa ukuqeshwa kwenye arhente antiplatelet endaweni "Aspekard" imbonakalo iingxaki ukusuka iphecana zesisu iyafuneka.

Izimo "Aspekard" ukulungiselela

Ukhuseleko zonke iimveliso zamayeza lilinganiselwe, ngenxa yokuba iziphumo ezingalindelekanga. Ngelo xesha linye bakhubekise abanye Izimo. Ngokukodwa:

• enokuphazamisa of coagulation igazi (ukopha diathesis, kubazali bakhe A no-B);
• enokuphazamisa ye iimpawu isisu (erosions, izilonda nokoyika esiswini kunye duodenum 12);
• ngexesha ezintathu zokuqala zokukhulelwa kunye lokwaphusa;
• e lomonakalo kakhulu kwezintso okanye hepatic;
• xa kukwalisa salicylates;
• kubantwana abancinane ngaphezu kweminyaka eli-18;
• phambi sombefu inyumoniya;
• ngayo unyango methotrexate.

Ezi Izimo ke elililo, nangona ixesha elithile: zisanyisa, ukukhulelwa, ukhukhuliseko kunye nezilonda ze iphecana zesisu, ebuntwaneni. Kwaye kukho iqela uthi, ubukho esifuna esweni rhoqo ngugqirha. Le ukusetyenziswa ngaxeshanye unyango antiplatelet kunye anticoagulants, kunye nonyango kwizigulane emva coronary utyando kwimithambo esa. Ukuba umsebenzi kidney isicelo imiyalelo iziyobisi "Aspekard" ukusetyenziswa ifuna zokunciphisa oyidlayo okanye uzalise lokubhangisa chu ichiza.

imiphumela Joint "Aspekard"

Acetylsalicylic acid inenani yeziphumo eziphuhlisa okanye zisidimaze intshukumo kwamachiza eziliqela. Ngokukodwa:

• ASA kwandisa isiphumo sako nakuphi na anticoagulants kunye arhente antiplatelet;
• ASA kwandisa ukusebenza antipyretic kunye iintlungu of NSAIDs, inyusa isiphumo antirheumatic "Meloxicam";
• xa idibene ngeziyobisi cytotoxic uphucula gastrotoxicity zabo;
• xa kuthathelwa kunye notywala ingozi kubunzima isilonda okanye ukunyuka ukopha;
• glucocorticoids ukwanda gastrotoxicity "Aspekard";
• Eyo attenuates ukusebenza umchamo xa ludityaniswe womchamo "Furosemide", "torasemide", "spironolactone".
• "Aspekard" buthathaka isiphumo-arhente uricosuric, "Probenecid", "Etamid", "sulfinpirazon";
• nonabsorbable asidi ziyakwehlisa ngokubonakalayo kukufakwa "Aspekard".

Amathuba an libanda, kunye neempawu zayo

Kakhulu iziyobisi "Aspekard" umyalelo, impendulo kunye nokusetyenziswa manani kuqinisekisa umgangatho ophezulu ngokwaneleyo zokhuseleko enkhubyeni wa vukati ngokuvumelana ezibonisa kunye Izimo ngaphandle. Oku kuthetha ukuba idosi elimiselweyo 100 mg beziyobisi sikhuselekile ngokwaneleyo, nangona kolawulo imo yempilo kuyimfuneko. Ngaphezu koko, ngenxa abangoontanga izigulane utyekelo ukuzibulala, kunye nobungozi ukuba amacwecwe ASA uza kuthatha umntwana, iinkcukacha ezifunekayo amathuba libanda, kunye neempawu zayo.

salicylates Ityhefu inobulali, wamqumbisa ngokusetyenziswa yokulungiselela "Aspekard" ngaphandle iimpawu iingcebiso ugqirha ezi ithi zilandelayo: nesiyezi, intlungu podlozhechkovoy fossa, indawo yosana, ngamanye amaxesha iintlungu, ingakumbi xa izigulane isifo sezintso. Kwimeko libanda, njengoko ndandingcangcazela apho, ukugabha, ngamanye amaxesha, sizizifanya wamagazi. Eyokuqala yokubathumela yoqheliso yokufakelwa kwe emesis: amaninzi isiselo esibandayo, isebenze indlela wamalahle ehnterosorbentov isigulane unikezelo esibhedlele.

Okubalulekileyo, ngokwemithamo abanetyhefu "Aspekard" umyalelo manual ayicacisi. Bona ahlukile ubunzima ezahlukeneyo kunye nobudala isigulane. Umzekelo, xa umntu omdala iimpawu zabantu libanda, ubulali ASA bawa sokwamkelwa olunye malunga 5-7 grams acid. Abantwana kufuneka yanele ukuba libanda kakhulu umthamo 1.5 g enye. A libanda kakhulu kwenzeka xa isicelo 7-9 iigrem abadala kunye nabantwana 2-2.5 gram ASA.

Le iqondo libanda, iziyobisi eyaboniswa ukuphazamiseka ngasentla ezibandakanya imisebenzi ngokwasengqondweni. inqqalelo Lost iqala ukuduma yokucinga luthe udidekile, intetho yeentlanga ezichaseneyo. Ukuphalaza kudla ngokwenzeka, isigulane ngokukhawuleza ulahlekelwa ulwelo evela nokugabha, ukuphefumla ophilisayo, kukho ukugcinwa etsolo wokuchama, ubushushu bomzimba ukwanda. Ukuncedisa isigulana kwimeko enjalo akunakwenzeka ukuba ngokuzimeleyo - kufunwa kwi Tutul ukulapha iimela yesoda, ukunikezelwa sodium zincancise.

Iimpawu of action unyango "Aspekard"

Okuqhotyoshelwe ichiza "Aspekard" yokusebenza myalelo iquka ibonisa ulwamkelo tablet omnye ngosuku (100 mg / ngosuku). Le ithamo ASA kwanele ukuze kuthintelwe zegazi cyclooxygenase. Isiphumo inhibition of Yindibanisela thromboxane A2, apho abangaphangeliyo ngokupheleleyo ukukwazi weseli zegazi udibaniso. Oku kushenxisa ithuba thrombosis, nto leyo unobangela infarct engabalulekanga okanye lobuchopho.

Ukubonelela isiphumo antithrombotic of acetylsalicylic acid kufuneka uzifake egazini. Noko ke, abanye esisebenza ngayo esiswini kwaye ziyibuyisela cyclooxygenase-1 kunye isoforms ayo isifo welungu. Isiphumo sale ndlela na isiphumo ecaleni - yokuhla muco-zokuzikhusela umqobo carbonate. Oku kwandisa ubungozi erosions kunye izilonda esiswini, ivuselele emathunjini-ukopha. imixube ama abakwaziyo aqhubela ukopha, kodwa rhoqo kwale isiphumo icala, baye encinane kakhulu.

Ukukhulelwa ne zisanyisa

uluvo Expert, ngokusekelwe kuvavanyo-manani kunye uthotho amalinge, sivumele ukuba babe nolwazi olucacileyo isicelo of "Aspekard" ichiza ngexesha lokukhulelwa. Ngokukodwa, 1 ezintathu ukusetyenziswa kwaso kuthintelwe. Kwi-2 no-3 ezintathu isicelo kuvumelekile, kodwa emva kokuba uvavanyo ukusetyenziswa kwayo zonyango nokuthelekisa imingcipheko ulwamkelo. Xa uninzi lwesifo iimeko ukuqeshwa ASA ngokungeyomfuneko, nangona ezinye NSAIDs kwakhona bakwazi kwandisa ingozi kwesisu.

Ngexesha zisanyisa, sebenzisa ichiza "Aspekard" analogue kuye, generics, kwakunye onke amayeza kunye acetylsalicylic acid kwi ekwakhiweni akuvumelekanga. Isizathu soku kukuba ukubetha beziyobisi ngobisi lwebele. lihlaba naye ngomzimba wosana olo. Kwaye ingozi yayo basengozini enkulu yokuba syndrome Reye ngayo - into Encephalopathy ezinzima kakhulu hepatic, nto leyo ebangela ingqondo ukudumba nokufa umntwana. Ngenxa yezizathu ezifanayo, kuthintelwe ukusetyenziswa kweziyobisi phambi kweminyaka yobudala engama-16-18.

Ukucacisa Uhlaziya izifundiswa kunye nezigulane

Eziphawula ichiza "Aspekard" ingxelo nomonde kwiimeko ezininzi uphambene. Bona ngokuqinisekileyo kuhlolwa amaxabiso ichiza, ekubeni phantse ophantsi phakathi koontanga. Noko ke, izimvo ezinxulumene nokusetyenziswa ngendlela ebonakalayo omnci kubonisa ekungakwazini ukuvavanya iqondo izigulane zokunciphisa umngcipheko thrombosis yegazi. Ngokwezi iziphumo ebezingalindelekanga ingxelo zizigulane, ichiza iphawulwa njengoko ngokwaneleyo ekhuselekileyo.

Imibono leengcali zicacile: okokuqala, beziyobisi iyasebenza ekunciphiseni ubungozi thrombosis, yaye okwesibini, izigulane ukunamathela antiplatelet unyango iphezulu ngenxa eliphantsi "Aspekard" ixabiso ichiza. Analogs kwiklasi-arhente antiplatelet ukuba aphezulu kakhulu. ukulungiselela Domestic ama "Atsekardol" ibiza kakhulu nge-50%, ngelixa iindleko ongenisa ephakamileyo nge izihlandlo 7-10. Kodwa esekelwe kwi-arhente ambalwa ziziphumo ebezingalindelekanga ama, kwakunye ezifunyanisiweyo kwezoqoqosho, kungakuhle ukuba abeke kuqala "Atsekardolu". Iindleko zonyango yenyanga iya kuba malunga ne-20 engange.

Ukunqongophala Injongo kardiopreparata "Aspekard"

Okuqhotyoshelwe ichiza "Aspekard 100" umyalelo manual uthi ichiza ifumaneka amacwecwe. Baya inganyityilikiswa esiswini bavelise ingqalelo eliphezulu. Ukunika ukusebenza gastrotoksichesky zasekuhlaleni, ichiza ulahlekelwa Safety Ezinye iziyobisi, eyile ama. ingozi ukopha kakhulu esiswini xa kusetyenziswa yokugqibela lingaphantsi kakhulu.

Imizekelo amachiza ezikhuselekileyo zezi zilandelayo: ". Aspirin Cardio" "Atsekardol", "Polokard", "Cardiomagnyl", Ngaphezu koko, uthe iindlela nazo zibandakanya wemagniziyam hayidroksayidi, nako ukukhusela isifo ngenxa yokwenzakala yi acetylsalicylic acid. Noko ke, ichiza "Aspekard" zingasetyenziswa kuthintelo thrombus benazo, nangona kunye nezithintelo. Noko ke, izigulane ukuba ukhukuliseko mucosal, isilonda 12 duodenum okanye isisu, kuquka yezigulo ezondeleyo, kucetyiswa ukuba ukuthatha ama kardioformy acetylsalicylic acid.

isicelo Vneotraslevoe kardiopreparata "Aspekard"

Uninzi imiyalelo ekhoyo ukuze zisetyenziswe ebonisa ubukho antiinflammatory kunye neempawu antipyretic iziyobisi "Aspekard 100". Enyanisweni, unyango egcwele iziphumo zonyango ngokuphindwe 5 idosi enye - 500 mg. Le umthamo 100 mg siku kwentliziyo, kunye nefuthe layo alanele ukunciphisa ngempumelelo ubushushu izifo ezosulelayo.

Kardioforma ukulungiselela yenziwe ne nedosi ye-100 mg, kumlungele na intlungu isiqabu nangecesina kuphela idosi enye amacwecwe-5. Ngaloo selectivity kwayo ukuze cyclooxygenase 1 limisela ubukho ezininzi kuThixo ngayo icala. Ngoko ke, njengokuba febrifuge iipilisi "Aspekard", Kakade, ezifanelekileyo. Noko ke, ngalo mzuzwana kukho iqela inani iziyobisi ezikhuselekileyo bembonisa selectivity ngakumbi cyclooxygenase 2. Baye iziphumo ebezingalindelekanga ezimbalwa ezinxulumene ekugxojweni zixhaphakile epithelium zesisu.

Safety nabalingani class "Aspekard" iziyobisi

A intsingiselo efanayo iqatshelwe unyango lwezifo rheumatism. Kwaye ziqhotyoshelwe apha kule ichiza "Aspekard" imiyalelo ukusetyenziswa iqulathe ulwazi malunga nonyango lwabo. Noko ke, ithamo elicetyiswayo yi zomyalelo 5-8 grams ngemini.

Esi sixa acetylsalicylic acid ubonisa gastrotoxicity obungako onamandla ukusebenza ngaphezu xa "meloxicam" Pharmaceuticals, "celecoxib", "Roferoksib" kunye nabanye. Kwaye antipyretic analogu iklasi kakhulu kubaluleke "ibuprofen".