"Farmadipin" (amathontsi) ukusuka ntoni?

Okwangoku, kukho amayeza ezininzi ezahlukeneyo lwegazi kunye stenokardicheskie nokuhlaselwa. Omnye kubo kwakhona ezifana amayeza (amathontsi) "Farmadipin". Ntoni eli chiza, kuxoxwe ngokubhekele ngokweenkcukacha.

isakhiwo

Le nto esebenzayo kule meko nifedipine (nifedipine). 1 ml manzi, oko kwenziwe imali ethile. Oko kukuthi, kwi-100%, ezisekelwe phezu owomileyo-uhlobo iziyobisi - 20 mg. Kungcono ninikane amathontsi amathathu.

"Farmadipin" (amathontsi), umyalelo apho isicelo kuya kuxoxwa ngezantsi, kwi sakhiwo ubukho izinto abangabancedani ezifana polyethylene ethers 400 no-96% ethanol.

iipropati kwemithi

Eli chiza a pharmacodynamics yinqobo kuye. Njengoko sele kukhankanyiwe ngentla, i "Farmadipin" (amathontsi) iqulethe into nifedipine ebonelela umfutho kunye anti-anginal amanyathelo. Kukhuthaza uvimba ungeno lwe ion calcium ibe cardiomyocytes kunye neeseli kwezihlunu kwamagingxi imithambo ezithile peripheral kunye nemithambo ngokusebenzisa amandla ombane ayi-uhlobo imijelo ezicothayo ezahlukeneyo ingaphandle cell. Le kwempahla ebalulekileyo. Nifedipine ikwanika ukuthanjiswa nemithambo izihlunu agudileyo, ukwanda neuropathy kunye nemithambo yenhliziyo, kubulawe aqaqambayo. Oku kunciphisa uxinzelelo lwegazi, ukumelana semithambo systemic, afterload ezesifuba imfuno ioksijini engabalulekanga. Kwakhona, xa ukuthatha eli chiza iyaqhubeka ukubonisa iimpawu ezithile. Oko kukuthi, kukho ukuhla okungephi contractility engabalulekanga nokusebenza intliziyo, kwakunye kuyehla zegazi udibaniso.

Pharmacokinetics

Kule nkalo, "Farmadipin" (amathontsi), imiyalelo zokusetyenziswa egqalwa kule ngxelo, uneempawu zawo. Xa ukwamkelwa yangaphakathi ebinazo lokugaya wendele kakuhle. bioavailability wayo malunga 40-60 ekhulwini. A isiphumo zophuhliso ingakumbi olukhawulezayo (emva 5-10 min) iqatshelwe ukuphunyezwa kulawulo sublingual. Kubalulekile ukwazi. Ngokuqhelekileyo, enempembelelo enkulu obubonakala imizuzu 30-40. Ukuphunyezwa nokudla akukho sisikhubekiso izinga kukufakwa yomenzeli. Ukubonakalalisa isiphumo hemodynamic uya kuhlala iiyure 4-6. Ngoko 90 ekhulwini nifedipine bebotshiwe iiproteni plasma yegazi. It umzimba ukulungiselela ezifana "Farmadipin" (drop) esibindini. Ubukho Ukususwa lilonke nifedipine uvela 0.4 ukuya 0.6 l / kg / hr. Oku ibonakala emzimbeni ikakhulu metabolites uhlobo engasebenziyo. Ixesha isiqingatha ubomi ingahluka iiyure ezi-2 ukuya ku-4. Kubantu abadala kunye izigulane kwesibindi, ukutya nifedipine lingancipha kakhulu. Ngenxa yoko, kufuneka isiqingatha ubomi indlela Isalathisi angandiswa malunga oluphindwe-2. Kule meko kuyimfuneko ukunciphisa ithamo kwaye kwandiswe lokuphumla phakathi imisitho ye kuqulunqo utshilo. umzimba Nifedipinv akukho cumulated. Kananjalo oko imali encinci kusichukumisa igazi-ingqondo kunye isithintelo placental. Kulo mzekelo, kubhaliwe kwizondlo ngobisi lwebele.

Ubungqina obubonakalayo buxela

Abamiselweyo "Farmadipin" (drop) kwezi meko zilandelayo:

• Kwimeko apho nomfutho eziyimfuneko kunye nomqondiso.
• Kuba unyango kunye stenokardicheskie nokuthintela nokuhlaselwa.
• cardiomyopathy xa hypertrophic.
• Xa isifo Raynaud kaThixo.

isicelo

Thatha "Farmadipin" (amathontsi) sublingually. Xa ukunyuka elibukhali kwi uxinzelelo lwegazi (umz: 180 / 100-190 / 110 mm HG. V.), A idosi enye lokuqala kweziyobisi ngenxa abadala ngokubanzi nama amathontsi 3-5 (2-3,35 mg). Izigulane ngeminyaka nayo wabelwa ukuba balawule ethile. Ezizezi - hayi ngaphezulu kwe-3 amathontsi (malunga 2 mg). Kwakhona, inani elithile nga zivuze kwi intwana encinane elomileyo lesonka okanye iswekile. isiguli sakhe kufuneka ubambe elide kangangoko kunokwenzeka emlonyeni. Okwabangela zaneleyo umthamo ichiza banda ngokuthe ngcembe de ayasebenza clinical. Kulo mzekelo, konke oko kuxhomekeka ngamnye. Xa ezibonisa ezilandelayo ukwandisa uxinzelelo lwegazi kufuneka bakhokelwe ncam ukuba idosi elimisiweyo. Kwakhona, kukho enye kwingongoma ethile. Ihlala yokuba ukuba uxinzelelo lwegazi lenyuka ukuya 190 / 100-220 / 110 mm HG. v., ke ngoko ukuthatha amathontsi ichiza ukuba yaba yintsimi 10-15 (6,7-10 mg). Kufuneka uthathe ingqalelo iinguqu xi umguli elinikiweyo. Kubalulekile ukwazi.

Kufuneka kwakhona ukuthathela ingqalelo ubukho Ukukhula kobuthathaka kwezinye izigulane kule neziyobisi "Farmadipin" (amathontsi), apho ncomo ezincomekayo. Kwiimeko ezinjalo, idosi kukhethiwe ngamnye. Qala ngamathontsi-3, uze emva koko ngokuthe ngcembe wavuswa 2-3 (1,34-2 mg) de kube mzuzu xa isiphumo lwezonyango ezinqwenelekayo kuyafikelelwa.

Kufuneka kukhunjulwe ukuba ezingaphezu kwedosi yokuqala ichiza kungabangela ukuhla elibukhali wegazi!

effect side

Xa isicelo sale alungiselelwe "Farmadipin" (imenyu xi), kusenokuba kukho iimpawu isicaphucaphu, tachycardia, hypotension, "amaza 'igazi ukuze ebusweni. Kwezinye iimeko, kunokubangela ziyabagulisa ngohlobo umlenze nokudumba, irhashalala. Kwakhona ukubonisa iimpawu zobuthathaka, isiyezi, intloko ebuhlungu.

Izimo

Ukwamkelwa isiyobisi enjalo, njenge "Farmadipin" (drop) Akuvunyelwe ukuthwala phambi eyandileyo uvakalelo amacandelo yayo, ukothuka cardiogenic, aortic kakhulu kunye stenosis mitral, hypotension, tachycardia, kwakunye ngethuba lokukhulelwa zisanyisa.

libanda

Kulo mzekelo, ezinye iimpawu ezimbi zenzeke. Angala libanda, amachiza afana "Farmadipin" (amathontsi), kufuneka sikhatshwe nasisihlo ukungaphumeleli kwentliziyo, ukothuka, lactic metabolic kunye unditsho, nokwehla okukhulu uxinzelelo lwegazi. Xa ukubonakalisa ezi mpawu kuyimfuneko ukubhenela amanyathelo ezithile ungxamisekileyo uncedo. Ziqulethe e lavage esiswini, carbon luvuliwe, calcium chloride kunye sympathomimetics intshayelelo, unyango nomqondiso.

ukusebenzisa Iimpawu

"Farmadipin" (imenyu xi) okanye ababambeleyo ukuba ukuba isetyenziswe kuphela esweni ngononophelo lwezonyango lwezigulane abadala kunye nezigulane abaye:

- angina ezingazinzanga.

- ukusilela ezinzima.

- cardiomyopathy hypertrophic.

- stenosis Acute aortic.

- lwegazi kakhulu miphungeni.

- stroke abukhali.

- Diabetes osegazini.

- umsebenzi kwezintso nesibindi.

Esithathwa kwamanye ngamayeza asetyenziswa nifedipine kufuneka abekwe ngabanye. glycosides wentliziyo nayo ingasetyenziswa ngexesha ulwamkelo amayeza afana "Farmadipin" (amathontsi), analogs leyo ziboniswa ngezantsi apha kwesi sicatshulwa.

Emva kokufumana isicelo ngaxeshanye nifedipine kunye efakwa wemagniziyam sulphate abasetyhini abakhulelweyo kufuneka ukusebenzisa esweni ngononophelo uxinzelelo lwegazi. Oku kufuneka kwenziwe ngenxa yokuba kukho amathuba ukuthoba uxinzelelo lwegazi enokonakalisa umama engekazalwa.

Izigulane hepatic ukusebenza kakuhle, nazo zifuna esweni ngenyameko. Kwiimeko kakhulu, ithamo kufuneka incitshiswe.

tsitohromichnuyu Nifedipine umzimba nge inkqubo P450 3A4. Ngenxa yoko, iziyobisi zinqanda okanye aqhubela indawo enzyme oluxeliweyo Ndiyijike isiphumo "transmission kokuqala" okanye imvume iziyobisi. Ukuba ukusetyenziswa ehamba nifedipine ngeziyobisi yolu hlobo kufuneka kulawulwe uxinzelelo lwegazi. Ukuba kukho imfuneko, kufuneka ukubhenela ekuthotyweni umthamo ichiza, njengoko "Farmadipin" (amathontsi).

Ukuqhuba imifuniselo nangokwahlukeneyo vitro phendla ubudlelwane phakathi ukusetyenziswa bachasene calcium kule nifedipine mzekelo kunye notshintsho eguqulweyo spermatozoa zengqo- echaphazela ukuvuthuluka ekukwazini yokugqibela ukuphumeza isichumiso.

Ukuthatha "Farmadipin" (amathontsi), kufuneka uyeke kwimisebenzi uhlobo ezinokuba yingozi, efuna ingqalelo engakumbi. Oko kukuthi, xa akuyomfuneko ukuba aqhube isithuthi kunye nokusebenza kunye nezinye iindlela, njalo-njalo.

intsebenziswano

"Farmadipin" (kwamathana) iye isenzo iqinile. Olu phawu kuphucula amachiza ukusuka blocker kudidi. Oko kukuthi, "Farmadipin" (drop) kwandisa β-adrenergic iziphumo, womchamo, nitrate, kunye nezinye umfutho arhente, amalungiselelo kunye neziselo eziqulathe utywala, yokunciphisa tricyclic. Kwezinye iimeko, nifedipine kunciphisa xi quinidine kwi plasma yegazi. Kodwa kurhoxiswe wakhe kwenyusa. Ngoko ke, esebenzisa uthomalaliso dibaniso Kucetyiswa ukuba esweni amanqanaba quinidine ingqalelo plasma yegazi.

"Diltiazem" kunciphisa zesigunyaziso ichiza njengoko "Farmadipin" (zamathontsana). "Fentanyl" iphucula kakhulu ngokubonakala ukusebenza iqinile. Ngenxa yoko, ngaphambi nolawulo chiza (iiyure ezingaphantsi kwama-36.) Ukuba ayiyeke lolwamkelo esikolweni "Farmadipina". ukusetyenziswa Joint of β-blocker kunye nifedipine kunokukhokelela hypotension. "Farmadipin" (ilahla) kuphucula uyazikhomba theophylline, carbamazepine kunye digoxin egazini. "Rifampicin" kukhokelela buthathaka isiphumo konwaywa nifedipine, ngaloo ndlela sikhawulezisa ukuziphatha ukutya kwayo. "Cimetidine" uphucula xi "Farmadipina" kwi plasma yegazi.

Imigaqo nemiqathango yokugcina

Kulo mzekelo, kukho imiqathango ethile. Store "Farmadipin" (drop) kufuneka zibe lobushushu igumbi kwindawo eyomileyo. Ichiza kufuneka zikhuselwe ekukhanyeni kunye kude ebantwaneni. Ukugcinwa kweli chiza yenzelwe ukuya kunyaka-1 kunye kwiinyanga ezi-6. Xa kuvulwa igutyana - iintsuku ezingama-28.

iholide

"Farmadipin" (ilahla) zinokuphunyezwa kuphela ngokumiselwa.

ebezithunyelwe

Xa nengqayi of ml-25 okanye ml-5. Benza utyalo-pack.

"Farmadipin" (amathontsi) analogue e Russia

Kukho substitutes ezininzi ichiza. Ezona ziphambili zezi:

- "cordipin".

- "Nifedipine".

- "Adalat".

- "Kordafleks".

- "Corinfar Uno".

- "Kordafleks RD".

- "fenigidin".

- "Osmo-Adalat".

- "kunamandla cordipin."

- "cordipin XL".

isiphelo

Ngoku uyazi into ezifana "Farmadipin" (ukuhla) iyeza, ukusuka apho abanceda ukuba zintoni na iimpawu. Xa kunjalo, ngaphambi kokuba eli chiza kufuneka udibane nogqirha abaqeqeshiweyo.