Calcitonin - ntoni na? Uhlalutyo for calcitonin. Calcitonin: abafazi eziqhelekileyo

Thyroxine kunye triiodothyronine - ezi hormone eveliswe le ndlala lengqula. Ukongeza C-izihlunu zomzimba bayakwazi secreting calcitonin. Yintoni na? Le hormone sisalathisi calcium ukutya kwaye bavelise nje kuphela nobubovu lengqula, kodwa namanye amalungu. Ingakumbi nempumelelo emiphungeni kunye thymus. Calcitonin libandakanyeka umthetho yezimbiwa ukutya kwaye isakhiwo imichiza entsonkothileyo kuqulethe kubekho udederhu asidi acid. Nayiphi na impatho embi le ulandelelwano kukhokelela ukuba hormone ulahlekelwa umsebenzi wayo omzalayo.

Calcitonin - ntoni na?

Ukuba kwenzeka ukuba naziphi na iingxaki emzimbeni, oogqirha bacelwa ukuba ukujonga ingunobangela uvavanyo lwegazi. Ngamanye amaxesha Yena utyhila imixholo isixa esikhulu njengento ezifana calcitonin. Yintoni na? Le hormone lengqula eveliswe yayo C-iiseli. Yena oncomarker ukufumanisa umhlaza lengqula nokujonga calcium yokucolwa emzimbeni.

Yintoni umsebenzi calcitonin?

Lo msebenzi ungundoqo calcitonin na ekuphunyezweni inyathelo zingavisisani ngokumalunga hormone parathyroid, nto leyo yenziweyo amadlala parathyroid kwaye ilawula calcium ukutya uze kwandisa nokuqulethileyo egazini. Calcitonin ikhuthaza ummiselo calcium phosphorus amanqanaba. Ezenza ukuba le into zifumaneka egazini (monocytes), ngumkhaya, umphunga, isibindi, iiseli ithambo kwinkqubo luvo, amalungu okuzala, izintso.

Amathambo kwale hormone ithintela iziniki ikhalsiyam, ukuba kukho inkxaso isakhiwo amathambo. Calcitonin kubaluleke kakhulu kwiimeko apho izimbiwa siyaphela ezininzi. Loo kwenzeka ngexesha ukukhula esebenzayo komntwana, ukukhulelwa kunye zisanyisa.

Igazi, le hormone nayo ibalulekile kwaye nefuthe hypocalcemic. Calcitonin ikhuthaza ukukhululwa neetyuwa kwi umchamo kwaye zehlisa capture yabo emathunjini. Kwakhona kwandisa amanqanaba igazi phosphorus, onesiphumo kwi lokugaya kunye nezintso.

Le ndlala lengqula ivelisa hormone hi mpimo lowutsongo, nokuqulethileyo egazini soze mkhulu. Ingaveliselwa ethunjini, kodwa ngeedosi miniscule kakhulu.

Calcitonin egazini

Kutheni kuyimfuneko ukwenza uhlalutyo kwi calcitonin? Of C-iiseli, avelisa le hormone, umhlaza ikhula lengqula - carcinoma medullary, okanye C-cell carcinoma. Ukukhula yamathumba ezinjalo kade, kodwa nzima kakhulu, esasaza metastases ukuba zamanzi entanyeni, kunye nezinye izigqeba ezininzi. Kunzima kakhulu ichemotherapy.

Ekubeni C-iiseli ukuvelisa calcitonin hormone, suka yayo elibukhali kwi Igazi kubonisa ubukho somhlaza lengqula medullary. Ukufunyaniswa kwangoko kwesi sifo isindise inani elikhulu ubomi babantu.

Ziziphi iimeko na egazini calcitonin?

iiseli Ithumba badla ilifa. Zonke izihlobo isigulane kufuneka unikele rhoqo ngegazi le hormone. Ngaphandle noxilongo ezinjalo asetyenziswa ukuchonga ukwenzeka ithumba. Ukuba ngexesha histology nokusebenza yaqinisekisa ubukho bomhlaza medullary, ngoko kamva calcitonin igazi kuza kufuneka ukuba qho emva kweenyanga ezi-3 okanye iinyanga ezintandathu.

Kukho ezinye izizathu ukuba abapase kulo uviwo:

• ukuchonga izifo ezivela ngenxa engaqhelekanga calcium ukutya;
• ngenxa uxilongo kwamathambo;
• ukumisela ukuvelisa ngamathumba;
• kunye Ukophuka rhoqo kunye neempawu izifo zabo.

uNorma calcitonin

Kufuneka kukhunjulwe ukuba akukho nto injalo nje esezantsi wabopha imigangatho hormone uvavanyo lwegazi ku calcitonin. UNorma iya kuba kunokwenzeka ukuba zero kwinqanaba egazini. Kubalulekile ukuba ayenzi igqithe ubukhulu eliphezulu oluqhelekileyo.

Kwiilebhu ezahlukeneyo izinga calcitonin egazini ungahluka. Oku kuchazwe yi kukuba wezenzi ezahlukeneyo kunye nezixhobo ezizodwa zisetyenziswe kwisifundo. Ukongeza, umphumo ixhomekeke yobudala kunye ngesondo. Uphando ngeendlela ezimbini: immunoassay transcriptase kunye immunohemilyuminestsentnym.

indlela Immunoassay unalo zilandelayo amaxabiso reference ihomoni ezinjengezo calcitonin:

• izinga amabhinqa - 0,07-12,97 nanziya / ml;
• izinga lamadoda - 0,68-32,26 nanziya / ml;
• sisithethe kubantwana - up to 79 nanziya / ml.

KwiSithethe kwi indlela immunohemilyuminestsentnom:

• Women - 1.46 pmol / L;
• oyindoda - 2.46 pmol / l.

Isiphumo uhlahlelo ungahluka abasetyhini ngexesha lokukhulelwa xa uncancisa.

Yintoni bathi inqanaba eliphezulu hormone?

Ukuba isigulane calcitonin banda, yaye kungakhathaliseki ukuba, xa kunjalo yingxaki enkulu kakhulu ukuba ufuna ngakumbi olunzulu Kuvavanyo kwiingcali kakhulu kunye nobuchule. Ukuba index ye calcitonin egazini ezingaphezu kwe-100 nanziya / ml, kunye phantse 100% ngokuqiniseka sithethe yobubi. Inqanaba ihomoni senze okungakumbi, ezona ngakumbi nethumba yaye inkulu amathuba okuba uzingela kwiindawo nkovu kunye namanye amalungu metastases yayo.

Ukuba umntu ogulayo maqhuqhuva lengqula, waza wamiselwa biopsy inaliti, nto leyo ebonisa ukuba ingozi, kwaye calcitonin igazi ihomoni banda, kuyimfuneko ukuba ukukholwa ngakumbi isiphumo uhlahlelo, ekubeni phantse akusoloko kunjalo. Xa ukwanda ngamandla kakhulu hormone igazi ngokuyimfuneko ukwenza utyando ukuze ukususa ngokupheleleyo esinobubovu lengqula kunye ezingqonge iindawo nkovu.

Ngaphezu koko amanqanaba umhlaza medullary hormone uya kuvuka xa zifo zilandelayo:

• C-cell hyperplasia;
• ; Ellison - Zollinger
• ukuqina utshwala;
• zomhlaza of neuroendocrine nemvelo;
• igazi intshabalalo;
• psevdogipoparatireoidizm;
• syndrome carcinoid;
• thyroiditis ne-pancreatitis;
• izifo zemiphunga ubuntu elihle;
• ukusilela ezingapheliyo kwezintso.

Phezu isiqinisekiso ezi zifo kufuneka uqiniseke ukuba abaphathe.

isiphelo

izigulane ezininzi, oogqirha ukumisela igazi unikezelo yovavanyo calcitonin. Yintoni na? Le hormone lengqula, leyo ukwandisa amanqanaba asenokubonisa ukuba kukho ithumba komzimba. Nge ubhaqo ngexesha umhlaza medullary kunye nonyango ngotyando angatsho ngokuzithemba ukuba le ngxaki akasekho. Ukongeza, esi sifo sibangela amanqanaba hormone ukwanda kunye nezinye izizathu ukuba unyango ngexesha ugqirha sinokunyangwa ngempumelelo.