4 (free): eqhelekileyo. Hormone T4 (free): uvavanyo igazi hormone

Kubaluleke kakhulu ekusebenzeni eqhelekileyo ye esinobubovu lengqula yinkqubo lengqula hypothalamic-yebhinqa. Inika olawula njini, imveliso kunye umsebenzi hormone.

Overview

Le ngxenye likhipha ifolokhwe (tireotro-pin-ikhuphe factor). Ngoko, ke, lukwakhuthaza ukukhululwa kunye Yindibanisela lengqula ekhuthazayo hormone (TSH - TTG). TSH libandakanyeka iinkqubo ezinxulumene kunye nezinye steroids. Ngokukodwa, uyayivuselela secretion, ulwandiso, ukutya kunye Yindibanisela triiodothyronine (T3) kunye thyroxine (T4). Kwama-99% yezi steroid ezimbini egazini elijikeleza ifomu iiproteni zothutho. Ngaphantsi kwesinye ekhulwini ingohlobo free. amanqanaba engadityaniswanga steroid kubantu abaninzi into amaqhina oqhagamshelwano kunye sokusebenza ngayo le ndlala lengqula.

iipropati thyroxine

Hormone T4 (free) iququzelela ummiselo yokukhula oqhelekileyo kunye nophuhliso, ukuqinisekisa ulondolozo lobushushu lomzimba kwaye ngokwenjenjalo egcina indlela nenqwaba ubushushu. Umchiza onesiphumo kuzo zonke izigaba carbohydrate ukutya, ngokuyinxenye - phezu vitamin kunye lipid ukutya. Hormone T4 (free) wenkqubo yinxenye ebalulekileyo yophuhliso Esibelekweni kunye periods lweentsana. Ukufumaneka ibonisa imeko kwezonyango iwonga lengqula, njengoko utshintsho kwinqanaba ngokubanzi thyroxine ukuze kuxhokonxwa yokuphazamiseka umsebenzi esinobubovu lengqula okanye inguqu kwinani iiprothini zothutho. Emini, isiqulatho ubuninzi steroid limiselwa iiyure ezisi-8 ukuya kwele-12, yaye ubuncinane - 23 yaye 3. Kulo nyaka, eli nqanaba liphezulu 4 (free) ifikelela ukususela ngoSeptemba ukuya kuFebruwari, ophantsi - ehlotyeni. Xa ixesha siswini (ngexesha yokumitha) thyroxine yoxinaniso landa, zifikelela kwinqanaba eliphezulu ukuya ezintathu ngokuthe yesithathu. Kuyo ubomi umxholo thyroxin kubantu kungakhathaliseki ukuba yindoda lihlala rhoqo kakhulu. hormone okwehlileyo kwaphawulwa emva kweminyaka engamashumi amane.

Yintoni uxelele izinga thyroxine?

Ukuba T4 (free) inyuke ngokucacileyo, ngoko kugqalwa isiqinisekiso hyperthyroidism. ingqondo okwehlileyo libonisa hypothyroidism. Ukuzimela umxholo steroid of thyroxine yokubopha globulin yenza kube lula ukuba ungayisebenzisa njengendlela yokuhlola diagnostic. Oku kubaluleke kakhulu ingakumbi kwiimeko zihamba ziinguqu kumazinga globulin thyroxine-yokubopha. Ezi ziquka izivimbela (ngomlomo), ukukhulelwa, ukufumana androgen okanye estrogen. Utshintsho uphawu kunye nabo yofuzo ilifa ukwandisa okanye ukunciphisa uyondelelwano lwee- globulin. Nikela igazi for T4 free ekucetyiswa ukuba uhlobo une hypothyroidism lesibini ngenxa ezimbi kwinqanaba hypothalamo-yebhinqa. Kulo mzekelo isiqulatho TTG akatshintshi okanye ukunyuka. Ngokuqhelekileyo, amazinga ephakamileyo thyroxine isenokuba ngenxa yamanqanaba aphezulu serum yibilirubin, ukutyeba, kwakunye tourniquet, xa na uvavanyo lwegazi. 4 (free) ayitshintshi phantsi kwezifo ezinzima kumsebenzi non-ndlala. Inqanaba thyroxine ogcweleyo bunciphe.

Ukulungiselela nokuvavanywa kweelebhu

Kwinyanga ngaphambi kokuba igazi ayibandakanyi ulawulo emzimbeni (ngaphandle kokuba kukho imiyalelo ethile endocrinologist). Iintsuku ezimbini okanye ezintathu ukunqanda ukusetyenziswa uhlahlelo amachiza ayodini-equlethe. Blood kufuneka sidlule ngaphambi izifundo zeradiyoloji usebenzisa agents umahluko. Obandulela ukwenziwa ngokunika igazi kufuneka uyeke ukusebenza komzimba, ukuphelisa iimeko uxinezeleko. Phambi kwesi sifundo, isiqingatha seyure, kufuneka umoya, ukuba ukuphefumla kwisiqhelo. Uhlalutyo lwenziwa kwi ungatyanga. Ndawonye nomnikelo lokugqibela kufuneka iiyure ungabi ngaphantsi kwe ezisibhozo (kodwa kukhethwa 12 iiyure). Akuyi kuvunyelwa ukuba usele ikofu, iti okanye isiselo. Ayikwazi amanzi kuphela.

Amanqanaba Ukuncipha thyroxine

4 (free) (abasetyhini yesiqhelo kunye namadoda - 9-19 pmol / l) kungancitshiswa kwixesha postoperative, xa hypothyroidism yesibini (ukudumba yebhinqa, tireotropinome, syndrome, Sheehan). Ukunciphisa xi Kuyaqapheleka ngokusekelwe anabolics yolwamkelo, thyreostatics, iziyobisi anticonvulsant, Lithium amalungiselelo. inqanaba Thyroxine liyancipha xa usebenzisa izivimbela, octreotide, methadone, clofibrate. Izizathu ezinokwenzeka kwakhona iquka ukutya kunye imali elinganiselweyo protein, intswelo-ayodini, ukusetyenziswa heroin, sesichengeni ukuba akhokele. 4 (free) ukuze zingaphungulwa emfundo ephakamileyo (luvo yobuchopho TBI), ababeyiqwebile, hypothyroidism naso (phakathi resection ngokubanzi nethumba kunye lengqula, thyroiditis samathambo, goiter ikho).

Ukwanda lamanani

Inqanaba hormone ezifana T4 (free) Mhlawumbi (abasetyhini eziqhelekileyo kunye namadoda kuboniswe ngasentla) inyuswe xa goiter ityhefu, TSH-elizimeleyo hyperthyroidism, ukutyeba. Ukwandisa xi kwenziwa imvelaphi syndrome nephrotic, unyango lweeHedfowuni. Izizathu nazo zibandakanya choriocarcinoma, yokwamkela thyroxine ngokusekelwe hypothyroidism, utshintsho kumsebenzi we esinobubovu lengqula, isifo sesibindi lwasemva kokubeleka. 4 (free) nga kwaphakanyiswa steroids syndrome ukumelana lengqula, yemfuza dizalbunemicheskoy hyperthyroxinemia, uthi, ukumqumbisa a xi nciphisa tiroksinsyazyvayuschego globulin.

Thyroxine nokukhulelwa

hormone ababandakanyeka phantse yonke inkqubo emzimbeni. Njengoko kukhankanyiwe ngasentla, ezi zinto ukulawula ukutya, kuchaphazela umsebenzi kwezinye steroid. Thyroid ngezifo kungenziwa zikhatshwe zombini ukwanda kunye ukwehla imisebenzi yayo. Eyona nto ibaluleke ngokukodwa besaphula kwimisebenzi omzimba abe ngexesha lokuzala. Utshintsho le sokusebenza se esinobubovu lengqula kuchaphazela ikhosi yokukhulelwa, ubuntu bakhe, yaye isiphumo ubume usana. Ayifane sidlula vynashivanie xa wavakalisa ezimbi yonyango. Izifo hlobo, njengoko umgaqo, kukhokelela ekubeni kwekhono nezenzala, ukungachumi. Kakhulu sivame ukuxilongwa ngexesha lokukhulelwa goiter (ukwanda lengqula nature kwentamo) kunye euthyrosis ulondolozo, kwakunye thyroiditis samathambo, utshintsho kwi ingqondo ngasemva hormone. Kuba ixesha siswini luphawulwa utshintsho sokusebenza ngayo le ndlala.

izincomo

Ukuze ngokuchanekileyo ukutolika iziphumo zeemvavanyo laboratory ngexesha lokukhulelwa kufuneka athathe ingqalelo amanye amanqaku. Ukubekwa T3 lilonke kwaye T4 ayikho ulwazi. Oku kungenxa yokuba ngexesha lokukhulelwa, ingqalelo inyuswe ngesiqingatha. Xa isifundo kwinqanaba thyroxine engadityaniswanga eyavela kufuneka imiselwe ngokudibene ne umxholo TTG. Thyroxine noko kwanda malunga-2% abasetyhini abakhulelweyo. Kwisiqingatha sokuqala ixesha oluqhelekileyo siswini iphawulwe ukunciphisa TTG (malunga ne-20-30% ezigulane kunye singletons kwaye onke amatyala lokukhulelwa multiple). Xa unyango lwe hyperthyroidism T4 kuphandwa kuphela (free). inqanaba thyroxine engadityaniswanga kwi zigaba kamva ukuba singathembeka lincitshiswe. Ngaloo TSH xi iya kugcinwa kwi kumqolo yesiqhelo.