Tiotriazolin: imiyalelo yokusetyenziswa

Ngaba uyazi le nkunkuma "Tiotriazolin"? Imiyalelo yokusetyenziswa kweli gama iya kuchazwa ngokucacileyo kwinqaku elichazwe. Ukongeza, siya kukuxelela malunga nefayili apho kuthengiswa khona, ziphi iimpawu, iziphumo ezibi kunye nokuchasene.

Ukubunjwa, ukupakishwa kunye nefom yokulungiselela

Yiyiphi indlela yesilwanyana "Tiotriazolin"? Uqeqesho lukwazisa ukuba luneendidi ezahlukeneyo. Ezona ziwayo zilandelayo zilandelayo:

• Isisombululo esenzelwe ijoyi le-intramuscular and intravenous. I-1 ml yale arhente iqulethe i-0.025 g ye-thiotriazoline. Kwakhona, amayeza anamacandelo ancedisayo ngendlela yamanzi engenayo. Isilwanyana sinokuthengwa nge-ampoules ye-4 ml (efakwe kwiipakethi zekhadibhodi).
• Iliso lehla "iTiotriazolin". Imiyalelo yokusetyenziswa kwesi sixhobo ithi 5 ml yesilwanyana iqulethe i-50 mg ye-thiotriazoline, kunye nezinye izinto. Isilwanyana sithengiswa kwiibhotile ze-polyethylene-droppers, zifakwe kwibhokisi yekhadibhodi.
• Iibhilethi "iTiotriazolin." Umyalelo wale fomu yesichengisi uthi inyeyibhile enye emhlophe ejikelezileyo iqulethe i-100 mg ye-morpholinium methyltriazolylthioacetate, okanye okuthiwa i-thiotriazoline. Njengengxenye eyongezelelweyo yale nkunkuma i-starch isitata, i-microcrystalline cellulose, i-low molecular weight povidone, i-calcium stearate ne-sucrose. Ngokuqhelekileyo, kwibhokisi yekhadibhodi kukho iipilisi ezingama-50.

Pharmacodynamics

Liliphi ikhambi elifana neTiotriazolin? Imiyalelo yokusetyenziswa ithi le nkunkuma ye-antioxidant. Ukusebenza kwayo ephezulu kuvela kwi-antioxidant, anti-ischemic, immunomodulating kunye ne-membrane-stabilizing properties.

Eli liyeza livimbela ukufa kwe-hepatocytes, likhuthaza ukubuyiswa kwawo, linciphisa izinga lokungena kwamanzi, likhokelela ekuqhelweni kweprotheni, i-carbohydrate, i-lipid ne-pigment metabolism, kwaye kunciphisa amathuba okuba i-centrolobular necrosis yelungu elinjengobindi. Ukongezelela, eli liyeza liphucula ukuhlukaniswa kunye ne-synthesis ye-bile, ngokuqhelekileyo kubandakanya ukusetyenziswa kwayo (iikhemikhali).

Iipropati zemveliso yeyeza

Ziziphi ezinye iipropati ezilungiselelwe ukulungiselela "iTiotriazolin"? Imiyalelo yokusetyenziswa kweli cilisi kufuneka ifunde. Emva kwakho konke, kuphela okukuyo unokufumanisa ukuba iyeza elikulo mbuzo linciphisa inqubo yeenkqubo ezinobungozi kumjikelezo we-Krebs, ukugcina ingxowa ye-ATP ye-intracellular, kwaye iphinde ikhulise ukusebenza (inkokhelo) ye-anaerobic glycolysis.

Kufuneka kwakhona kuqatshelwe ukuba emva kokuthatha iyeza, isithako esisebenzayo siqala ukusebenza kwenkqubo yokulwa ne-antioxidant, ukuvimbela iinkqubo ze-oxidative zamafutha kwiindawo ezingenakikimzimba zomzimba. Ukongezelela, eli liyeza liphucula iipropati (rheological) zegazi ngokusebenzisa inkqubo ye-fibrinolytic.

Iipropati ze-antioxidant zeyeza zibonakaliswa ngenxa yokuba kukho ion i-sulfuri kwisakhiwo se-tiotrazoline molecule, ebonakalayo nge-oxidation kunye nokunciphisa i-nitrogen, ebopha i-i-hydrogen ions.

Kufuneka kwakhona kuqaphele ukuba icandelo elisebenzayo leziyobisi liyakwazi ukuphendula ngeepidid radicals kunye neendlela ezisebenzayo zomoya. Oku kubangelwe kwiimpawu zokunciphisa izakhiwo zeqela le thiol. Ukongezelela, iyeza lithintela ukwakheka kweentlobo ze-oksijeni ezisebenzayo, ukuvuselela i-enzyme ezinjalo ezinxamnye ne-catalase, glutathione peroxidase kunye ne-superoxide dismutase.

Pharmacokinetics

Ingaba isichengululo "iTyotriazolin" sithatha? Umyalelo uthi ixesha lokuxhatshazwa kweyilisi maminithi angama-30, kwaye ukufumaneka kwe-bioa availability is 65.5%.

Uxinzelelo oluphezulu lweziyobisi egazini lufikelelwe kwiiyure 1.4 emva kokungeniswa. Ukuqhagamshelana neeprotheni akudluli i-10%.

Ngokwenani elikhulu, iyeza libuthelela kwiifomesi zesibindi, intliziyo, i-rectum, i-spleen kunye neentso, kunye neyona mincane-emathunjini amancinci kunye nemiphunga. I-Tiotriazolin idityaniswe kakhulu yizintso.

Iinkcazo

Ekubeni kukho naziphi na iziphene, iipilisi, ii-injections kunye namaconsi asehlohlo "I-Tiotriazolin" inokumiselwa? Izikhokelo zokusetyenziswa kwezi fom ziqulethe ezi zilandelayo:

• I-Cirrhosis yesibindi;
• Ukulimala kwesibindi, utywala, i-viral kunye nonyango (umzekelo, emva kokuthatha i-antibiotics, iyeza-antitiviral , i-antituberculosis kunye ne-antitumor agents, i-contraceptive oral and tricyclic anti-depressants);
• I-Hepatitis virus engapheliyo;
• Utywala obunxilisayo obuthathaka obunomdla ongapheliyo kwaye obuncinane;
• Dystrophy enesibindi.

Imiqondiso yokusetyenziswa kwamaconsi:

• Izifo ze-cornea;
• Ukutshisa okanye ukukhathazeka kwamehlo;
• I-Viral conjunctivitis.

Kutheni usebenzisa i-ophthalmologic drug "Tiotriazolin"? Umyalelo (amaconsi angathengwa kuyo nayiphi na ikhemisi) uyazisa ukuba eli gama lisoloko limiselwe ukuthintela amehlo anomileyo, i-asthenopia nezinye izifo ezivuthayo ezibonakalayo.

Isisombululo samathebhulethi

Ndingayisebenzisa njani iipilisi zeTyotriazolin? Umyalelo uqulethe ulwazi olulungiselelwe ukulungiswa kufuneka lithathwe kuphela. Njengomthetho, i-tiotriazolin imiselwe iipilisi ezi-1 okanye ezimbini ezine ngosuku ngemini eyi-25-30.

Ubude beli cirha kufuneka lugqitywe kuphela ngugqirha ngamnye (kuxhomekeke kwimeko yekhosi kunye nobukhulu besifo esikhoyo).

Isisombululo seMithi "Tiotriazolin": imiyalelo yokusetyenziswa

Izigulane ze "Tiotriazolin" zenziwe nge-intramuscularly or intravenously. Isilinganiso sabo senziwa ngugqirha (kuxhomekeke kwisifo). Nge-infyoction ye-myocardial kunye ne-hepatitis, isicatshulwa sijojowe ngokukhawuleza 2 ml 2-3 ngamaxesha. Xa unyango lwe-cirrhosis lulawulwa nge-intramuscularly (2 ml amaxesha amathathu ngosuku). Inkqubo yokonyango iintsuku ezingama-60.

Iliso lehla "iTiotriazolin": imiyalelo yokusetyenziswa

Amaconsi ngamehlo "iTiotriazolin" afakwe kwisigxobo esivumelwaneni . Ngokuqhelekileyo, i-dosage yabantu abadala i-2 iyancipha ukuya kumaxesha amane ngosuku. Ngokubhekiselele kubantwana, inani lamachiza lithethwa kuphela ngabazali bezingane. Ubude bonyango kunye namaconsi asehlohlo kufuneka kwakhona kusekwe kuphela ngudokotela.

Ngokuqhelekileyo, ubude bonyango le lonyango alikho ngaphezu kweveki ezimbini. Kodwa ukuba ingaphuculwa ingabonwa, le khosi inokunwezelwa kwinyanga.

Kwimeko apho izilonda zamalungu ezibonakalayo zikhulu kwaye zinzulu, ii-injections kumaconsi asehlohlo zichazwe ngokwengeziwe (amalungiselelo athile).

Ukuthintela ukomiswa kweebhokhwe (ngelixa usebenza kwikhompyutheni), kuyimfuneko ukusebenzisa iyeza zethambeka ezi-2 ngelilanga kunye nexesha eli-2 iiyure.

Iziphumo eziPhakathi

Ziziphi iimpembelelo ezichaphazelayo izidakamizwa "i-Tiotriazolin" (injections) ezibangela? Umyalelo kwesi sixhobo sithetha ukuba iyeza elinikeziweyo lihanjiswa ngokufanelekileyo. Nangona kunjalo, kunye neziyobisi ezithandwayo, iimpendulo ezingafunekiyo zisenokwenzeka.

• Inkqubo yesantya ephakathi: utywala, ubuthathaka jikelele, i-tinnitus.
• Iphepha lokutya: umlomo owomileyo, isicupunu, ukubhubhisa.
• Iinqwelo kunye nentliziyo: ukwanda kwengcinezelo yegazi, i-tachycardia, i-arrhythmia, intlungu entliziyweni.
• Inkqubo yokuphefumula: ukuhlaselwa kwesifuba nokuphefumula okufutshane.
• Ukuphefumula: umkhuhlane, ukuphendulwa kwe-hypersensitive, angioedema.
• Ukuphendula kwendawo: ubomvu kunye nokubetha kwiziko lokuxilonga.
• Impendulo yeDermatological: i- hypermia ye-skin, itching, i-hives.

Ngokubhekiselele kumaconsi iliso, kwakungekho miphumo emibi kwinqanaba lawo.

Ukusebenzisana kwezidakamizwa

Ngokweengcali, inkunkuma "iTiotriazolin" ingasetyenziselwa ukudibanisa namayeza asisiseko ekujoliswe kunyango lwe- coronary disease. Oku kubangelwe kukuba inyaniso isithi i-agent e-cardioprotective agent.

Kufuneka kwakhona kuqatshelwe ukuba le chiza livumelekile ukuba lisetyenziswe ngexesha elifanayo kunye neziyobisi ezimiselwe unyango lwe-hepatitis ye-etiology ehambelanayo.

I-Eye drops "Tiotriazolin" inokunikezelwa kwabasetyhini abakhulelweyo, kunye nexesha lokutya. Kwakhona kufuneka kuthethwe ukuba ifomu elikhankanyiweyo lonyango livumelekile ukuba lisetyenziswe kunye kunye nezinye izixhobo zonyango.

Utywala kunye neyeza "Tiatriazolin" zomeleza isenzo ngasinye. Kule nkalo, ukufumana kwabo ngexesha elifanayo akuvumelekile.

Imiyalelo ekhethekileyo

Iipilisi ezicatshangelwayo zibandakanya i-sucrose (kwisixa se-2.8 mg kwelinye ithebhulethi enye). Ngaloo ndlela, isantya esiphezulu semithi yesilwanyana sinokuqulatha malunga ne-22.4 mg yempahla. Kubalulekile ukwazi malunga nale nyaniso kwizigulane ezine-diabetes mellitus.

Izindlela kunye nexesha lokugcina

Ngokuqinisekileyo zonke iintlobo zeziyobisi "Tiatriazolin" mazigcinwe kwindawo ekhuselekile ekukhanyeni kwaye zingenakufikeleleka kubantwana kwiqondo lokushisa kuma-14 ukuya kuma-26 degrees. Ubomi bekhefu leziyobisi yiminyaka emithathu.