"Pipekuroniyu bromide": imiyalelo yokusebenzisa

Amayeza nangokukhulula izihlunu skeletal, ezisetyenziswa kuphela ngexesha iinkqubo zotyando ixesha eliphakathi elide, kodwa kwisenzo trauma ngenjongo Ukumiswa okanye amalungu zakhe. "Pipekuroniyu bromide" libhekisela relaxants iqela antidepolyarizuyuschih kwaye lonke ubuninzi ntshukumo imizuzu 50-70 ngokuxhomekeke iimpawu eziphilayo. Makhe siqwalasele imiyalelo ukusetyenziswa kweziyobisi, ingakumbi ukusetyenziswa kwayo practice iintlungu.

achaza kwemithi

Indlela yokusebenza ye ichiza ezinxulumene ne kuthintele ukudluliselwa zobuchopho kule synapse neuromuscular. Ngenxa oku, kukho inhibition yokuqhubeka elo olunokubakho kwi inwebu izihlunu ifayibha, yaye ngaloo ndlela, iseli izihlunu ithe amandla ayo ukuncipha.

Nangokuvela elide ukuba ichiza kwemiqathango "pipekuroniyu bromide" musculature skeletal buyasikhulula. Njengoko receptors nicotinic cholinergic lohlobo indawo nje kuphela kwindawo contact ka kwimicu efferent somatic luvo kunye iiseli zezihlunu zezihlunu skeletal kunye ganglia kwinkqubo yawo luvo, ukuqaliswa amathamo ezinkulu medicament yabangela isiphumo ganglioblokiruyuschimi buthathaka. Oku kungenxa ekuyekeni ukudluliselwa luvo angxamele ukuba inwebu postsynaptic zemithambo-luvo, nto leyo ekhokelela ukuba ukwehla zombini iziphumo enovelwano kunye parasympathetic.

Ubungqina obubonakalayo buxela

Ukulungiselela "pipekuroniyu bromide" Libonisa ukuba ukunyenyiswa izihlunu skeletal ngexesha utyando. Impumelelo ichiza ngenjongo tracheal ekumfakeni kwiifeni.

Izimo

Njengoko ichiza ukuba 'pipekuroniyu bromide "umyalelo, ichiza ngokupheleleyo contraindicated phambi hypersensitivity kwaye phambi myasthenia (ezinqabileyo, isifo zemfuza uzimisele, leyo kukwaphula excitation kuphuhliso synapse neuromuscular kunye nobuthathaka kwezihlunu).

Ichiza contraindicated kwi izigulane nisaqala yokukhulelwa. Kumanqanaba yamva ichiza lungasetyenziswa, njengoko unqumle njengomqobo placental ngezixa ezincinane.

imiphumela emibi

Ichiza kunganqanda umsebenzi kwenkqubo luvo, ukuba izenzakalo hypersensitivity.

Kwicala yeziphumo ebezingalindelekanga sentliziyo okubangelwa inhibition yokosulela cholinergic kule leesynapse. Ukwenza oko ukunciphisa izinga intliziyo, uxinzelelo lwegazi ephantsi, ukwenzakala kobuchopho engabalulekanga, ukonakala kwengqondo ezinxulumene ne yehle perfusion.

Xa baboniswa ukudandatheka kwenkqubo nokuphefumla komsebenzi yokuphefumla, kukuvela umoya okanye umoya kunokwenzeka (ingakumbi ngexesha Imiphumo beziyobisi).

Ichiza ichaphazela ukutya kwaye liyakwazi ukuba ukwanda kwinqanaba potassium igazi, ukunyusa umgangatho creatinine zemveli kunye plasma amanqanaba glucose asezantsi.

Drug "pipekuroniyu bromide" - imiyalelo yokusebenzisa

Ichiza ilawulwa kuphela phantsi kweliso yincutshe. Phambi nolawulo kweziyobisi kufuneka ufumane i-anticholinesterases ( "Neostegmina" okanye "Pyridostigmine") okanye anticholinergics ( "Atropine").

Emva ukuphululwa esweni isigulane rhoqo yenziwa ngexesha sokubuyisa ixesha ekuphulukenwe nalo emva kokuba zomzimba nomonde bunjani kwezihlunu.

Le umthamo medicament ngokusekelwe uviwo leqela le kumguli data zophando iindlela beyaleza. Xa kukho ukusilela umsebenzi kwezintso excretory, ukusilela isibindi functional, nokutyeba - idosi kufuneka ibe medicament asezantsi.

Isisombululo sikulungele ngokukhawuleza phambi kokuba yolawulo iziyobisi "pipekuroniyu bromide." release kweziyobisi Form - nengqayi powder lyophilized equlathe 0.004 g into esebenzayo.

Izigulana kakuhle imali eseleyo electrolyte igazi kunye nokulungelelana asidi-base nayo iyafuneka uhlengahlengiso idosi. Ukuncitshiswa Policy of ion yoxinaniso plasma yegazi, emzimbeni kunye nokusetyenziswa kwe glycosides kwentliziyo (ngexesha digitalization) bayakwazi ukuba zinde ixesha iziyobisi. Kwimeko kwemisipha zokwehlisa kweli qela izigulane kufuneka ekuqaleni ukubuyisela electrolyte igazi, yaye emva koko ukuze baphumeze zokwehlisa kwezihlunu. Kwimeko kwezigulane sisifo sentliziyo esinganyangekiyo, igazi kungenza ukwandiswa kwexesha abagxothwa ukusebenza iziyobisi (ukwanda ngexesha phakathi kolawulo kunye nokuqalisa kwe ukusebenza).

Uyakwazi ukusebenzisa ichiza abantwana ukususela kunyaka-1. Kule meko kufuneka kukhunjulwe ukuba umzimba umntwana kangako ukuba imiphumo relaxant izihlunu, kwaye ngokufanelekileyo, ukuze kufikelelwe isiphumo ezifunekayo, ithamo ichiza kufuneka zandiswe.

iholide kweziyobisi

Makaxele ichiza for "pipekuroniyu bromide" zokupheka Latin abakwazi ukuya gqirha. kwiziko lonyango ifumana izinto enamandla ukusuka kuluhlu A kuphela isicelo ngokusekelwe karhulumente. Kwelinye icala, "pipekuroniyu bromide" iresiphi unakho ukumisela ingcaphephe ngokusebenzisa ifomu "red" Noko ke, asingabo bonke womnatha esibhedlele banelungelo ekufezekisweni iziyobisi kunye neziyobisi, kuquka relaxants kwezihlunu.

amagama trade

Kwimarike zamachiza ichiza ekhoyo phantsi ezifana amagama zorhwebo njenge "Arduan" "Vero pipekuroniyu", "Aperamid", "pipekuroniyu bromide." Igama Urhwebo beziyobisi kuxhomekeke kumenzi, ukunika ichiza emarikeni yezemithi.

libanda

An libanda, beziyobisi kunye nesiphumo Ukwehla kunokwenzeka ngenxa yokuba kuqaliswe anticholinesterases. La machiza kunceda ukwandisa xi le acetylcholine neurotransmitter, ngaloo ndlela zikhuphisane relaxant kwezihlunu ngokuba ziyabophelela iziza kwi receptor.

Kwakhona, amanyathelo zonyango kwi libanda, eziyilelwe ukwandisa uxinzelelo lwegazi, ukugcina umzimba ebalulekileyo, kuquka ngeendleko umoya ngomatshini.

okwenziwa Drug

Ichiza asikwazi exutywe izisombululo iimela ezahlukeneyo, ngaphandle izisombululo isotonic sodium chloride kunye dextrose. Uphuhliso isiphumo isiyobisi lingancipha, idosi olusebenzayo unyango yaligqiba phantsi imeko wolawulo ipreoperative ukuba isigulane le cholinesterase inhibitors.

Xa isicelo kunye esihlunwini relaxant analgesics ezidakumbisayo ukudakumba kweziko nokuphefumla kunye nophuhliso elele kunokwenzeka.

Ukusetyenziswa kweziyobisi kunye depolarizing relaxants izihlunu uhlobo senzo zombini ukwandisa kwaye angafundisi isiphumo izihlunu relaxant iyonke. Le imeko kungenxa umthamo iziyobisi, ixesha lolawulo, kunye novakalelo ngamnye ukuya ichiza.

isiphelo

Siphethe kwemisipha zokwehlisa ngexesha utyando - yinxalenye ebalulekileyo ngendlela emanyanisiweyo zomzimba. Drug "pipekuroniyu bromide" lisetyenziswa yezonyango ukulungiselela ezi njongo ngempumelelo.

Kufuneka kukhunjulwe ukuba ukusungulwa ichiza kubangela nje ukuthanjiswa izihlunu skeletal intshukumo ngokuzithandela, kodwa ebangela ukushwabana izihlunu zifo. Ukuqwalasela oku, ichiza lisetyenziswa kuphela phantsi kweemeko kunye neeyunithi zotyando labagula kakhulu.