"Nimid" (tablets): Imiyalelo yokusetyenziswa kunye nengxelo

Abantu abaphethwe zizifo amathambo, amalungu kunye nezihlunu njenge oogqirha unyango kwangumqondiso badla ukumisela "Nimid" (tablets). Imiyalelo yokusebenzisa iqulethe iinkcukacha ukuba ichiza ususa nje intlungu, kodwa kumele inyathelo anti-ukudumba. Makhe sihlolisise ukusebenza imveliso ngokweenkcukacha kwaye ufumanise apho amatyala unako ukunceda.

ifomu Drug komsindo

Ngokumalunga iifomu ichiza, ngoko namhlanje ezikhemisti ungathenga unabo, ukunqunyanyiswa, granules kunye gel. Le esisebenza ephambili kubo nimesulide. ekuqulunqeni elucwecweni beziyobisi ngowe-10 iziqwenga kumadyunguza. Enye cwecwe 100 mg nimesulide, njengoko components abangabancedani kusetyenziswa oosokhemisti microcrystalline kwincindi, isodiyam stearate, isodiyam croscarmellose kunye Aerosil 200. Oko iqulethe ingcaciso malunga nokuqulunqwa imiyalelo yosetyenziso "Nimid" ukulungiselela (tablets).

Le umgubo yayivelisa tiye ithamo. Olu hlobo ichiza luncedo kunyango lwabantwana. Enyanisweni, ekwakhiweni, ngaphandle nimesulide, povidone K-30, tabletozy 80 no Aerosil 200 iqulethe excipients ezifana sodium saccharin, citric acid, kunye neencasa. happy abanqongopheleyo ukusela esimnandi iphekwe abazali bakhe therapeutic services "cocktail '.

Ngowe-1 ml enyityilikisiweyo yaye 1 g gel iqulethe 100 mg nimesulide. Njengesakhi abangabancedani kwezi ntlobo zimbini kusetyenziswa propylene ethers, isodiyam gidroskid, carbomer 940, disodium edelat, aromotizator, amanzi okuhlamba kunye methylparaben.

Isenzo amayeza ye ichiza

Nimesulide, leyo yeyona nto esebenzayo ye medicament bobabo kwiqela nonsteroidal anti-sulfonanilides. Xa emzimbeni womntu, oko emane abangaphangeliyo Cox-2 kwaye abangaphangeliyo ukuba Yindibanisela prostaglandins kwi kuwela arhabaxa. Iintlungu, antipyretic nesiphumo anti-ukudumba ifunyanwa emva "Nimid" Ipilisi enye. Imiyalelo yokusebenzisa iqulethe ingcaciso engaphezulu malunga amayeza balawule.

Ukongeza koku kungasentla, ichiza uyakwazi zinqanda ukukhululwa ioksijini radicals simahla kwaye zinqanda ukukhululwa myeloperoxidase, kunye nafuthe chemotaxis kunye neenkqubo phagocytosis.

Ke ukuba amanyathelo anti-yokukrala ichiza, oku kuphunyezwa sisakhono nimesulide ukuze kuthintelwe mediators ukudumba nokunciphisa imiba necrosis ithumba. Xa ziyibuyisela umva le Yindibanisela interleukin-6 kunye urokinase yokulungiselela "Nimid" (umyalelo manual kungqina oko) luthintela ukuthotywa proteoglycans kunye collagen intlala. Ukongeza, nimesulide ephethe iibhloko kwinkqubo azilawule intlungu nociceptive.

Xa siqwalasela indlela amanyathelo iintlungu, inxulunyaniswa inhibition kwenkqubo histamine nokukhululwa iiseli ezininzi lwemasti kunye nempembelelo compound esebenzayo nganye nezamkeli glucocorticosteroid.

Ukuba ugqirha wakho emiselweyo "Nimid" (tablets), imiyalelo yokusebenzisa kufuneka ziqwalaselwe ngononophelo phambi kokuba uthathe amayeza. Ngapha koko, eli xwebhu luqulethe iziphakamiso ekufuneka ithathelwe ingqalelo ngethuba unyango.

Pharmacokinetics

Emva kokufumana ithamo abawacebisayo ichiza ngenkuthalo etsalwe iphecana zesisu. Kwaye emva kweeyure 1.5-2.5 kubonisiwe yoxinaniso ubuninzi isithako esebenzayo kwi plasma yegazi. A phawu uphawu yokulungiselela kukukwazi eliphezulu ukusebenzisana iiproteni, kwakunye kwii-njengomqobo ingqondo igazi gematoplatsentarny. Xa lamanani aphezulu nimesulide kuxhomekeke kwibala kwiimfuno, nangokurhala, kwaye ulwelo synovia.

nethe kweziyobisi kwenzeka esibindini, njl, kuba inkoliso kwifomu ingaguqukanga metabolites esebenzayo, ikhutshwe nge izintso (in nomchamo), kwi - iingqatha. Isiqingatha-ebomini into esebenzayo kufikelelwa ngokusebenzisa iiyure 3.5-5. Iqulethe data pharmacokinetic ngakumbi ezithile "Nimid" imiyalelo ukulungiselela ukusetyenziswa.

ubungqina

Ngempumelelo medicament ngokuba ngumkhuhlane ohamba izifo phecana eliphezulu bokuphefumla phecana eliphezulu zemiphunga. Lidla amisele ichiza kubantu abanengxaki isifo samathambo, myalgia, osteoarthritis, bursitis, tendonitis, kunye nezinye izifo kwezihlunu, amathambo kunye edibeneyo, ekhatshwa iintlungu syndrome. Xa amazinyo kwaye yamanina ubuhlungu postoperative kunye postrevmaticheskih ayesebenzisa "Nimid" medicament. Imiyalelo ukusetyenziswa kwiimeko ezinjalo, kucetyiswa ukuba bathenge unabo, ngumgubo okanye granules.

Malunga ichiza ekwimo gel, ukuba senzelwe ukusetyenziswa mlonyeni kwi inyama asha (athambileyo) apho zibangelwa ezibuhlungu ezahlukeneyo. Kukubek 'kuthetha nayo kwiinkqubo ukudumba kunye nezigulo sisiba mandundu yenkqubo musculoskeletal, osteoarthritis, ankylosing spondylitis , kunye nabanye. Iqulethe uluhlu eyandisiweyo ezibonisa ukuba ukusetyenziswa kwemali "Nimid" imiyalelo zokusetyenziswa evela kumenzi.

iimeko Reception kunye nenkqubo nomthamo

Xa kuziwa iziyobisi ngohlobo amacwecwe, Ukunqunyanyiswa, kuyimfuneko ukusebenzisa kuphela emva kwesidlo. Kunqweneleka ukuba kudlule ubuncinane imizuzu eli-20 emva kokungenisa, kungenjalo isiphumo pharmacokinetic of nimesulide kusihla. Ngokubhekiselele kwiindlela nomthamo kunye nexesha unyango, ukuba le mibuzo kufuneka baphendule ngqo igqirha abaya kuthathelwa ingqalelo iimpawu ngamnye yomguli kunye neqondo ubungnqongqo sifo. Ngoko ke, siza kuqwalasela iingcebiso ngokubanzi kuphela, nto leyo iqulathe ulwazi malunga amayeza "Nimid" umyalelo manual.

Iipilisi babelwa abadala ngokuqhelekileyo kabini ngemini kwi-100 mg. Xa iintlobo kakhulu zesi sifo inokuba liphindwe idosi yemihla ngemihla. Entsha eyi-12 ukuya kwi-18 Kucetyiswa ukuba ukubala ithamo izinga lwemithi 1.5 mg 1 kg ubunzima bomzimba ngalinye. Ukuba unyango ifunwa umntwana ongaphantsi kweminyaka elishumi, ubunzima baso lidlula 40 kg, oko kumiselwe 100 mg beziyobisi ngosuku ngokwahlula izinga kumabanga amabini. Kwiimeko ezizodwa kakhulu, ugqirha kunokwandisa idosi ekhuthazwayo.

Kuthetha ngohlobo granules ezisetyenziswe abantwana ukusuka kwiminyaka-12 kunye nabantu abadala: 1 sachet kusasa nangokuhlwa. Imixholo asengxoweni exutywe 100 ml yamanzi ashushu kunye nokusela emva kokutya.

Ngokumalunga gel "Nimid", - akuyona amaxesha ngaphezulu kwe-4 ngosuku - umaleko obhityileyo (ngaphandle ngokuhlikihla) kwi inxalenye emzimbeni kunye iintlungu eziqatha. Emva kokusebenzisa amayeza, uhlambe izandla zakho ngesepha phantsi kwamanzi abalekayo.

Le ichiza contraindicated?

Musa amachiza kubantu abanesifo Peptic isilonda, okunzima wesibindi, nezintso, kwakunye ngayo hepatotoxic nembali nimesulide. Ngamandla contraindicated amachiza utyekelo ezahlukeneyo ukopha, insufficiency ezesifuba hypersensitivity amacandelo omnye okanye ngaphezulu medicament "Nimid Forte". Imiyalelo yokusebenzisa kwaye iqulethe iinkcukacha ukuvalwa ukusetyenziswa kwemali kunye namayeza ezinokuba hepatotoxic ukuba ifiva, ezifana nomkhuhlane ithi orhanelwa ngezifo oyingozi yotyando.

Ke imali eluhlobo ijeli, oko ungamiselwanga ukuba izigulane ngaphantsi kweminyaka eli-12 ubudala kunye nabantu abathanda negazi lakho. Andzise izifo ngexesha isicelo medicament kufikelele dermatitis, ukwenzakala ulusu kunye nosulelo, kwakunye isifuba inyumoniya, nto leyo zibangelwa yi-ASA. Kufanelekile ke ngoko ukuba indlela emiswe "Nimid" kwi ezimbi ngasentla. Imiyalelo amacwecwe ukusetyenziswa kwiimeko ezinjalo, kakhulu, ayikhuthazwa.

Xana ndzi nga wu amayeza ngexa lokukhulelwa?

Le oosonzululwazi bafumanisa ukuba bakwazi nisumelid ukuba nempembelelo ngokutyeba. Ngaphezu koko, oko abangaphangeliyo ukuba Yindibanisela prostaglandins, ezaziwa ukuba unobangela oligohydramnios, lwegazi yemiphunga, oliguria kunye exineneyo kwaphambi kwexesha Batalova duct. Kunokwandisa umngcipheko buthathaka zabasebenzi, nokudumba neuropathy kunye ukopha xa usebenzisa ichiza "Nimid". Imiyalelo ukusetyenziswa, amacwecwe kunye nezinye iintlobo amayeza akuvumelekanga ngokungqongqo zombini ngethuba lokukhulelwa ngexesha zisanyisa. Ngapha koko, le into esebenzayo ubisi lwebele unokufumana kumzimba womntwana baphazamise ukusebenza kweenkqubo zayo ebalulekileyo. Kwezo meko apho akunakwenzeka ukwenza ngaphandle amayeza kunye neenzuzo unina zinkulu kakhulu umngcipheko nobungozi umntwana, lo idosi ikhondo unyango emiselwe ngugqirha.

imiphumela emibi

Kwakhona iimpawu ezintle abaninzi amayeza, ukulungiswa nayo ine uluhlu umxhelo yeziphumo ebezingalindelekanga. Ngoko ke, makhe sibone ukuba uhlobo yokusabela ukuba zenzeka xa usebenzisa i "Nimid". Iipilisi (umyalelo in Russian yenza idata ekhoyo) ingabangela ukurhawuzelela, izigxala, amaqhakuvana ezahlukeneyo ulusu, angioedema, kwaye kwezinye iimeko ka-Stevens-Johnson syndrome kunye epidermal necrolysis. GI unako, yena, uphendule ichiza evela ukuqhina, urhudo, ngamanye amaxesha izigulane banamava iintlungu esiswini, isicaphucaphu. kunqabile kakhulu iipilisi kunokubangela perforation ye kwethumba kunye isilonda Peptic 12 isilonda duodenal.

Ekubeni inkqubo yokucolwa esibindini, oko unale kuyo. Ngoko ke, sebenzisa ixesha elide amayeza kwezinye iimeko, kunokubangela utshintsho transaminases, cholestasis, senyongo kunye hepatitis oyingozi. Ezifana njengoko nezitenxo esibindini hayi kuphela kunye granules kunye nomgubo, kodwa "Nimid".

Qaphela uchaza ngqo basabele yenkqubo enzala kulawulo iziyobisi. Kunokuba kuba nokudumba, dysuria, ukugcinwa wokuchama, kunye oliguria, ukusilela etsolo kwezintso, nephritis Embi. Isixokelelwano sokuphefumla inokuba dyspnea kunye bronchospasm, ukusetyenziswa elide kunokubangela uphuhliso sombefu.

Ukongeza kwezi ziphumo, isigulane lisenokuba tachycardia, lwegazi, emzimbeni, ukudinwa kunye nezinye izifo. Phantse bonke abasabela egwenxa Kucetyiswa ukuba ukucima iyeza bafune unyango ngoko nangoko. Ukuba babe kule meko, kufuneka balujongisise ngenyameko lonke ulwazi kangangoko malunga ichiza uze uthabathe "Nimid Forte" (tablets). Imiyalelo yokusebenzisa, leyo kumayeza impahla nganye kunokunceda.

Libanda kakhulu iziyobisi kunye algorithm zoncedo lokuqala

Ukuba ngempazamo igqithe idosi avumelekile, kufuneka ngoko nangoko uye esibhedlele. Ngapha koko, ngenxa yempazamo onjalo kuba ukozela, isicaphucaphu, ukugabha, iintlungu ngo espigastrii, silale, ukwanda koxinzelelo lwegazi. Olu luluhlu kuphela ukukhanya reactions ukuba idosi ephakamileyo ichiza "Nimid". Tablets - manual ulumkisa ngale - ezibanjiswe isixa amaqhosha 2-3 ngaphezu umlinganiselo ukuba, kunokubangela ukopha ngaphakathi kwaye ikhokelele ukusilela kwezintso. Xa yezonyango, nokuba esisigxina amatyala ezinqabileyo reactions anaphylactoid, ukudandatheka bokuphefumla isiqaqa ngenxa libanda kweli chiza.

Ukuba ithamo kuvumelekile wedatha na, silinde ezibonisa lonyango kuba zililize ekungekho nzuzo ngayo. Kufuneka ngoko nangoko iphume esiswini, uthathe isisu kwenza osmotic kunye chelators. Kukhethwa ukuba emva manyathelo angentla hamba uye esibhedlele, apho iingcali ziya kuqhubeka unyango nomqondiso. Kufuneka kuqatshelwe ukuba umhla akukho iyeza ngqo.

Yintoni bacinga malunga ichiza izigulane?

Kakade ke, xa nezifo lumngcungcuthekise phantse zonke izigulane basabela kakuhle amayeza ingqalelo. Bakuphawula abanikaziyo ukuba ifuthe lokusetyenziswa kweziyobisi kwenzeka ngokukhawuleza, nto leyo abangakwaziyo kodwa nemihlali. Kakhulu nezinye izimvo nga kuviwa xa isigulane sele yabelwe ikhosi elide unyango amayeza, "Nimid". Iipilisi (manual icebise ukuba ingqalelo ekhethekileyo kulo propati amayeza beziyobisi) okudambisa ngokukhawuleza iintlungu, kodwa emva kweentsuku ezimbalwa yolwamkelo bazenze iziphumo ebezingalindelekanga eyaziwa. I lokuqala uqala ukuba uyiphendule phecana nimesulide zesisu, luvo kamva (oku kuboniswa nochuku, utshintsho kwimo notyekelo bengenamdla).

Kakade ke, likhankanya ukuba eli chiza wenza akusingisi kokhona kulungileyo; akunakwenzeka. Ngapha koko, oko ndinceda ngokwenene. Kodwa nantsi ngaphandle ubungqina kunye nengcali indawo ukuthatha ayikhuthazwa.

Ukuba ezi nkcukacha zingentla wahlala uyathandabuza ukuba okanye hayi ukuthenga "Nimid" (tablets), imiyalelo, ncomo, namacebiso ugqirha izigulane nga kunceda ukwenza isigqibo esifanelekileyo.