"Mesakol": imiyalelo ukusetyenziswa, nabalingani real

okwenziwa sisilonda sikabhobhosi kunye nesifo Crohn kaThixo kuvandlakanywa izigulane kakhulu inqabile. Kodwa ke, nangona oku, kukho amachiza amaninzi ezinjongo ukunyanga ezi zifo. Enye yazo "Mesakol". Imiyalelo yokusebenzisa, ifomu, ingxelo, kwaye iindleko mali iya thaca ngezantsi.

Ekwakhiweni, ifomu ukukhululwa, ukupakisha kunye nenkcazo

Drug "Mesakol", izimvo zazo character ingacaci kakhulu, siqhubeka ekuthengisweni njenge macwecwe kubomvu-mdaka. Yokuba ama-camera yaye ifomu setyhula kunye lenticular.

Eyona nto iphambili sixhobo kuphuma mesalazine (5-ASA). Ukongeza kuyo beziyobisi ziquka amacandelo ezongezelelweyo ezifana umbona starch calcium phosphate dihydrate, talc nyulu, microcrystalline kwincindi, titanium oxide, hypromellose 2208, dust colloid, povidone K90, isodiyam carboxymethyl istatshi, lo copolymer acid methacrylic kunye imethyl eqobekayo बिट्स, oxide intsimbi ebomvu, macrogol 6000 kunye dibutyl phthalate.

Tablets "Mesakol" yenziwe ngezithandelo aluminiyam kwaye Imiqulu ikhadibhodi ngokulandelelana.

Pharmacology

Ngaba ubusazi ukuba sisiyobisi "Mesakol"? Imiyalelo yokusebenzisa zibonisa ukuba le arhente anti-ukudumba, isiphumo leyo yenzelwe emathunjini. Le impahla medicament ngenxa ngamandla ayo zinqanda Yindibanisela leukotrienes kunye prostaglandins, kunye neutrophil lipoxygenase.

Kufuneka kwakhona uqaphele ukuba ichiza ingqalelo lingancipha ukufudukela, phagocytosis kunye degranulation of neutrophils, kwakunye immunoglobulin secretion yi lymphocyte.

Ziziphi ezinye izakhiwo kufuneka unyango "Mesakol", ixabiso yayo eboniswe ngezantsi? Mesalazine Umsebenzi elwa kubo abathile cocci kunye Escherichia coli (kwi colon).

Pharmacokinetics

Zeziphi parameters amacwecwe azalwa kwikinetiki "Mesakol"? Imiyalelo yokusebenzisa ithi emva ulawulo mesalazine ukhululekile kuwo iqokobhe emva malunga 115-165 kwemizuzu, yaye emva kwemizuzu 170-230 tablets ukunyibilika.

Ngenxa film isiyobisi ingqalelo kugalelwe ngomhla 60-80% ngesi emathunjini enkulu, yaye 15-30% - apha emathunjini amancinci. Kulo mzekelo into esebenzayo ufikelela kwegazi kuphela isixa-10% ye idosi. Mesalazine ingqalelo plasma iphantsi kakhulu.

Unxibelelwano lwe isithako esebenzayo kwiiproteni plasma yi 43%. Ingqalelo ichiza kunye metabolites zayo ubisi lwebele.

Nethe mesalazine eyenziwa emathunjini wesibindi. Oku kuveza N-acetyl-5-aminosalicylic acid.

Isiqingatha-ubomi imizuzu 60-120 (ngokuxhomekeke idosi). Wabonisa kidney amayeza kwaye amathumbu.

Ubungqina obubonakalayo buxela ukuba bafumane amayeza

Lokunyanga izifo ichiza "Mesakol"? Izimvo oogqirha ingxelo ukuba esi sixhobo kakhulu kakuhle esizibonakalisa izifo Crohn kunye okwenziwa sisilonda sikabhobhosi.

Kufuneka kuqatshelwe ukuba medicament ingqalelo lisetyenziswa kuphela ukunyanga izifo ngasentla kodwa ngenxa yokuthintela exacerbations.

Izimo ukuba amayeza

Prescribers "Mesakol" akunconywa:

• e isilonda Peptic kwenkqubo wokugaya;
• izifo igazi;
• insufficiency sezintso yayinzima;
• sophele diathesis;
• ebuntwaneni;
• lomonakalo hepatic yayinzima;
• hypersensitivity ukuba izithako ichiza;
• ukungabikho glucose-6-phosphate dehydrogenase.

Ngononophelo olukhulu ichiza esetyenziswa kwi ngobulali ukumodareyitha ubuzaza ukusilela kwezintso, kwakunye aphakathi kunye nowobulali insufficiency hepatic.

Tablets "Mesakol": imiyalelo yokusebenzisa

Kwezi mali ezithathwe ngomlomo nje emva kwesidlo.

Ngexesha exacerbation izifo oko ibhalwa isixa ka 400-800 mg (ngamanye amazwi, 1-2 iipilisi) kathathu ngemini. Uthomalaliso ikhutshwa phandle iiveki 9-12.

Kuba ekuthinteleni exacerbations lokusetyenziswa kweziyobisi 400 mg kathathu ngemini. Amacwecwe jikelele ngohlobo, amanzi eziqhelekileyo okusela.

Indlela ukunika abantwana iziyobisi "Mesakol"? Amakhandlela, microclysters nokumiswa - kule fomu iyaboniswa eli chiza ukuze abantwana.

ukusabela ezingalunganga

Ngelishwa, iyeza ukuthatha ingqalelo kaninzi ibanga iziphumo ebezingalindelekanga. Ezi ziquka oku kulandelayo:

• pericarditis, tachycardia, ukuphazamiseka kwentliziyo Uhanjiso, lwegazi, iintlungu esifubeni, hypotension, iyangongoza, ukuphelelwa ngumphefumlo;
• isicaphucaphu, sinciphise ukutya, ukugabha, ukwanda transaminases zesibindi, heartburn, stomatitis, urhudo, hepatitis, iintlungu esiswini, pancreatitis, umlomo owomileyo;
• oliguria, proteinuria, crystalluria, hematuria, nephrotic syndrome, anuria;
• isiyezi, intloko ebuhlungu, ukuba nemibono, ukuduma, sokulibala, polyneuropathy, unditsho, lafa, ukudandatheka;
• eosinophilia, thrombocytopenia, ianemia (haemolytic, aplastic, okanye megaloblastic), agranulocytosis, ianemia, hypoprothrombinemia;
• oligospermia, namandla;
• ubuthathaka, photosensitivity, uqilikwane, ukunciphisa imveliso ulwelo iinyembezi, lupus-ezifana syndrome, alopecia;
• irhashalala, dermatitis, pruritus, bronchospasm, erythema.

Iimpawu libanda

Iimpawu libanda, iindlela ingqalelo ezivelileyo iimeko ezifana isicaphucaphu, gastralgia, ukugabha, nobuthongo kunye buthathaka. Nya emiselweyo lavage esiswini, laxatives kunye nonyango nomqondiso.

Ayahambisana nezinye iimveliso

Drug "Mesakol" kunciphisa nefuthe "spironolactone" "Furosemide", "rifampicin" kunye sulfonamides. Kwakhona kwandisa iziphumo hypoglycemic avela sulfonylurea, ubuthi methotrexate kunye corticosteroids ulzerogennosti.

Kufuneka kuqatshelwe kwakhona ukuba ichiza ukucola kukufakwa cyanocobalamin kunye kwandisa nefuthe arhente uricosuric (oko kukuthi, secretion blocker tubular) kwaye uphucula ifuthe anticoagulants.

izincomo ezithile

• Urhudo ezenzeka ngexesha unyango "Mesakolom" akasoloko ukukhetha isiphumo ebezingalindelekanga zeyeza. Loo imeko kube ngumqondiso lwesifo ngxabano.
• Ngexesha reception, esi sixhobo kufuneka rhoqo iimvavanyo zegazi nomchamo eqhelekileyo yenziwe.
• Ukuba ithamo entweni, ezi zinto zilandelayo kufuneka athathwe nangeliphi na elinye ixesha.
• Ngexesha unyango kunye nale amayeza kunye nomchamo iinyembezi fluid yomguli ukuze ezinemibala ngombala otyheli-orenji.

Drug "Mesakol": nabalingani kunye neendleko

Buyisela amayeza wathi kungenziwa ngeendlela ezifana "salazopiridazina", "5-ASA", "Tidokol" "Asacol", "Samezil", "salofalk", "Mesalazine", "Salozinal", "pentasil".

Ingaba yimalini "Mesakol" icwecwe? Ixabiso le ichiza engange 600-680 (tablets 50).

ukubuyekeza yabathengi

Izigulane ashiye ukulungiswa "Mesakol" yi-ncomo mixed kakhulu. Abanye babo ingxelo ukuba ichiza ngempumelelo ubaphatha isifo emathunjini. Abanye bathi ukuba ezi pilisi ngamampunge. Ngenxa yoko, nathi singatsho ukuba "Mesakol" lineziphumo ezahlukeneyo kwizigulane ezahlukeneyo.

Eyona ethile iphambili yale iyeza linani elikhulu Izimo kunye nezenzo ezibi.