Iimveliso Lipid peroxidation. Peroxidation of lipids kunye nesifo sentliziyo

Lipid peroxidation (LPO) yi ikhonkco ebalulekileyo exchange metabolic. Lo msebenzi usisiseko ngayo ukuhlaziya lipids of inwebu cell.

Abaphile umntu lipid peroxidation ilawulwa ekuthiwa inkqubo antioxidant elawula umsebenzi isantya kwaye phosphorylation ngokubopha zizinto Ngokuqunjiswa okanye yokungenelela izixa elaneleyo peroxides ukuthintela ngokugqithiseleyo iimveliso ekupheleni ukutya. inkqubo igcwala yokukhulisa isenokuba isiqalo kwiinkqubo pathophysiological kwezifo mali. Le nkqubo iquka linyathelo enzymatic kunye autoxidation non-enzymatic.

iintlobo

Ukuze shintsha bilayer phospholipid yeseli inwebu ithanda igcwala enzymatic. Ukongeza, oko ebandakanyekileyo ukuyilwa kwezinto eziphilayo esebenzayo, detoxification, ukusabela yokucolwa. igcwala Non-enzymatic wenza esizibonakalisa njengomba etshabalalisayo kubomi kwiseli. Ngenxa ukuyilwa oluninzi radicals simahla kunye peroxides Ukhuliso antioxidant uyancipha umsebenzi nkqubo kwaye ngenxa yoko, kukho na imbubhiso kweeseli ephilayo.

UPAWULOS umjikelezo

Ukuqalisa lipid peroxidation kuyimfuneko kukho ioksijini radicals simahla, ukuba amandla kwinqanaba kwi ngokugqithileyo omnye electron unpaired. Emva kwakhona mpilo wavelisa superoxide leyo idityaniswe athom hydrogen, ajike hydrogen peroxide. Nokulawula imali superoxide ngaphakathi kukho iiseli dismutase superoxide, ukwakha iperoksayidi yehidrojeni kunye catalase, peroxidase yokungenelela emanzini. Ukuba ephilayo ndazi ionizing imitha, inani radicals ezamahala hydroxyl ziya kwandisa kakhulu. Koko ioksijini hayidroksayidi kunye nezinye iindlela zayo esebenzayo ungaqala inkqubo diski peroxidation lipid.

Products of lipid peroxidation okanye ephilayo ilahlwe, okanye ezisetyenziselwa Yindibanisela prostaglandins (izinto ezibandakanyekayo reactions ukudumba), thromboxanes (kuquka ndachithelwa thrombogenic of reactions), iihomoni adrenal.

inkqubo yolawulo

Kuxhomekeka cell inwebu isantya isakhiwo esisiseko, kwaye inani umsebenzi onesiphumo iimveliso igcwala ungahluka. Umzekelo, umsebenzi lipids peroxidation ngasentla apho kukho inxalenye udonga yeseli ilawulwa asidi ezihluthiyo okunamafutha, yaye bazekelele, ukuba sisiseko COP cholesterol. Ukongezelela, into ukulawula imali kunye nezinga ukuyilwa radicals mpilo, kwakunye nokusetyenziswa peroxides, ezi enzyme yokucolwa. Nkqu indlela lipids peroxidation inxaxheba izinto ezichaphazela iseli inwebu lipid Ukwakhiwa notshintsho olungenazo ngokungqinelana neemfuno eziphilayo. Ezi ziquka vitamin E kunye K, thyroxine (ihomoni), hydrocortisone, cortisone kunye aldosterone (ingxelo). Ezenza cell udonga ion yesinyithi, iivithamini C no-D

ephula inkqubo

Iimveliso umzimba ka lipid peroxidation bangaqokelela kwi ancedisana ulwelo lomzimba ngaphandle kokuba inkqubo antioxidant akafuni ukulahla kubo kunye Velocity kuyimfuneko. Ekugqibeleni uphazanyiswe zothutho ion ngapha inwebu yeseli, leyo ngqo zinganefuthe ukwakhiwa ionic wesahlulo engamanzi igazi, izinga nokwehlukana kunye depolarization yeseli izihlunu inwebu (phula Uhanjiso neemvakalelo-luvo, contractility zabo, ayolule ixesha elinjubaqa), ukulungiselela ukungena kolwelo kwi isithuba extracellular (nokudumba, egazi, electrolyte ukungalingani). Ukongeza, iimveliso eziphambili peroxidation lipid, emva kokuba uthotho reactions kwemichiza, eziguqulelwe kwi aldehydes, ketones, asidi kwaye njalo njalo. Ezi izinto zibe nefuthe zinetyhefu kakhulu emzimbeni, esizibonakalisa kwireyithi ukuncitshiswa DNA yokuqaphela, ukwandisa capillary permeability, ukunyusa uxinzelelo oncotic, njengoko ngenxa yoko, udaka-syndrome.

Ezibonisa kwikliniki

Ekubeni ukwanda ioksijini ivideo radicals lineziphumo yonakalisa phezu kodonga yeseli, kwaye imveliso pathways ziphazamise ukutya kunye kuyondelelaniswe nucleic nesisi umzimba, ukuba into pathophysiologic kuphuhliso eziliqela iimeko zonyango. Indima peroxidation lipid kwi esibindini sisifo ebalulekileyo namalungu, izifo olwaye lwamfimfitha ezosulelayo, ukuphazamiseka hemodynamic, izifo oncological, unxinzelelo kunye nokutsha. POL ngomnye wemiba ngenxa yegazi. Free radicals oxidize cholesterol kunye eliphantsi iqhezu yayo ubunzima molekyuli ukwenza iimveliso esonzakalisa udonga nemithambo. Oku iqala ukuxubana reactions zophendlo lwezifo enohlobo ukujongana umonakalo. Oku Uxhokonxwa egazi igazi, ukuqokelelana egazi igazi le mithambo iinqanawa ezincinane okanye uncamathiselo kweendonga zawo. Ngenxa ukuhamba kwegazi kule ndawo lingancipha, njengoko sele kuba sayo isitya. Oku kunegalelo nokwanda ngakumbi egazi. Eyona basengozini kakhulu utshintsho ezinjalo imithambo yenhliziyo, i aorta, wabonakaliswa iimpawu ekliniki sifo coronary intliziyo.

amanyathelo othintelo

Iingcali kufuneka sikhumbule ukuba ukuziphatha iinkqubo zokuxilonga nezinyangayo ungenza kusebenze indlela lipid peroxidation. Oku kufuneka ukulumkisa isigulane. Ibangela zinto ziquka unyango radiation (umhlaza), ukukhanya yelanga (kunye yamathambo, izifo yokukrala sinuses, amagumbi unyango antibacterial), amasimi owahluke (MRI, CT, unyango emzimbeni) Iiseshoni ukwigumbi hyperbaric (e sepoliyo, kwendawo).

Prevention and Therapy

Abasebenzi abasebenza rentgenkabinetom, orderlies kunye nabongikazi, abaziingcali ukuyifundisa mountaineers, abantu umzimba kufuneka ukuba ukutya eziqulathe antioxidants zendalo: intlanzi, ujongilanga okanye amafutha omnquma, imifuno, amaqanda, iti eluhlaza. Ukongezelela ukutshintsha kwizidlo, iziyobisi ingasetyenziswa ebopha kumaqela athile okanye radicals ezamahala esinokudibanisa isinyithi of valency bume. Ngaloo ndlela zime mahala mpilo esebenzayo, babavalela njengesibophelelo kwi yokukhulisa peroxidation lipid.

ekuxilongweni

Ngelo xesha langoku zophuhliso yophando kwilebhu uzokwazi ukubona peroxide kuhlanganiselo ulwelo zebhayoloji omzimba womntu thina. Ukuze wenze oku, yisa fluorescence microscopy. Ngamafutshane, ukuchonga peroxidation lipid. Ixabiso le vavanyo lokuqonda kufuneka akukho ingcaciso. Enyanisweni, xa kukho isifo isixa esikhulu esekelwe umsebenzi ngokugqithisileyo peroxidation lipid. Efumanise meko limisela unyango.

Ngokwembono ukuba amalungu eqhelekileyo peroxidation lipid kuyimfuneko ukuze kwakhiwe iihomoni steroid, mediators ukudumba, cytokines kunye thromboxanes. Kodwa xa inani iimveliso exchange data ekudibaneni kwemichiza idlula avumelekile ixabiso nomonakalo pheroksayidi cell organelles, DNA kunye ukuphazamisa Yindibanisela iiprothini, ngokungathi ingena kwinkqubo antioxidant ukuba kunciphisa isixa radicals mpilo kunye ion zesinyithi kunye valency bume. Ukongeza, kwenyusa Yindibanisela catalase kunye peroxidase yokulahla peroxides abangaphezu kwemfuneko kunye nemveliso emzimbeni ngakumbi.