Ichiza "Ofloxacin": angqina nomonde. Imiyalelo zokusetyenziswa olwa "Ofloxacin"

Ukulungiselela "Ofloxacin" izigulane ratings ikakhulu HIV, imela arhente elwa ukusuka kwiqela fluoroquinolones spectrum ezibanzi umsebenzi. Ichiza ichaphazela gyrase DNA - Isiqwengana ziibhakteriya, ukubonelela supercoiling ngoko ke uzinzo iintsholongwane DNA (ngenxa destabilization le DNA umcu kufa).

pharmacodynamics

Lithetha "Ofloxacin" - i-zintsholongwane eyiyo ngokuphathelele microorganisms ukuvelisa beta-lactamase, kwakunye mycobacteria ngokukhawuleza olukhula Nedlac. Amayeza abaqaphela, gciwane ezimbi-Igram, kuquka microorganisms abanganyangekiyo methicillin kunye nezinye antibiotics. Streptococci, enterococci, kunye Mycobacterium tuberculosis luphawulwa susceptibility ezingazinzanga ukuba ichiza "Ofloxacin". Izimvo kumagqirha zibonisa ukuba unyango lwezifo anaerobic ezibangelwa peptostreptokokki, peptokokki kunye nezinye anaerobes, ichiza ayisasebenzi.

Pharmacokinetics

Emva kokufumana le medicament ibe kukufakwa lugqityiwe (95 pesenti) kunye fast. Bioavailability - ngaphezulu kwe-96 ekhulwini. Ulwalamano kwiiproteni plasma - 25 ekhulwini. Emva kweyure enye okanye ezimbini emva kulawulo yomlomo xi liphezulu lifikelelweyo. Kuyinto ulapha-ixhomekeka: ukusetyenziswa elinye ezimakhulu mabini, amane okanye amathandathu, anamakhulu milligrams ukuzikisa ingqondo iziyobisi waye ngokulandelelana 2.5, 5 okanye 6.9 ug / ml.

ukusetyenziswa ukutya kuchaphazela kukufakwa ecaleni nokwehla, kodwa akukho nomthelela obonakalayo bioavailability. Ukulungiselela "Ofloxacin" - i-zintsholongwane ukuba umthamo omkhulu zokusasaza (ikhulu iilitha), ukwenzela ukuba amalungiselelo elawulwa yi phantse imali epheleleyo ungena ngokukhululekileyo phakathi kwiiseli. Ezi lamanani aphezulu kakhulu emzimbeni, umzimba ulwelo kunye nemibutho: iiseli (macrophage alveolar, leukocytes), izihlunu ethambileyo, ulusu, ithambo, isixokelelwano sokuphefumla, kwisisu zangasese kunye esiswini, ematheni, netuwa prostatic, umchamo, inyongo. Iqula medicament ingena placental kunye negazi-nobuchopho isithintelo, kuba secreted ukusuka ubisi lwebele, kunye ulwelo fluid engena kwi inwebu yobuchopho non-asha kunye asha (14 to 60).

Malunga-5 ekhulwini ichiza umzimba esibindini ukwenza dimetilofloksatsina kunye N-oxide of ofloxacin. Kungakhathaliseki ithamo isiqingatha ubomi phakathi emine enesiqingatha ukuya kwiiyure ezisixhenxe. Isiphumo iziyobisi zingatshintshi mali ka-75-90 ekhulwini nezintso, kwi-mali ka-4 ekhulwini - in enyongweni. Ngaphantsi kwe-20 ekhulwini yokususwa extrarenal. Emva nedosi enye ye-ezimakhulu mabini neemiligram arhente ukuba ubonwe kwi umchamo iiyure 20-24. Kwimeko zinomgutyulo hepatic okanye sezintso ukuze behlisa. Xa dialysis isuswe-10 ukuya kuma-30 ekhulwini amayeza.

Ubungqina obubonakalayo buxela ukuba

Xa izifo ezosulelayo kunye ukudumba ezibangelwa iintsholongwane ezahlukeneyo, bavezwa isicelo medicament "Ofloxacin". Ukuphonononga baxele ukuba mhle kakhulu lwezifo ngokuphefumla iphecana (inyumoniya, iphika), iphecana zangentla ezihlasela zosulele ngokuphefumla (media otitis, sinusitis, laryngitis, pharyngitis). Yabela iziyobisi athambileyo izitshanguba zeethishu, amalunga, amathambo, ulusu, iphecana biliary, womchamo (urethritis, Ngokuzimela), zezintso (pyelonephritis), esiswini, esini (orchitis, colpitis, epididymitis), amalungu zangasese (salpingitis, prostatitis, cervicitis, endometritis, oophoritis, parameters).

Kwakhona iziyobisi olusebenzayo ureaplasmosis, chlamydia, ukuvuza ngaphantsi. Yisebenzise ngenxa nokuthintela izifo kwizigulane kunye ukuphazamiseka ze ngobume omzimba (kuquka neutropenia).

Ifomu balawule. isakhiwo

Ukukhutshwa kwe medicament yimilo amacwecwe bhanya-camera biconvex imilo camera ezimhlophe okanye phantse emhlophe ngeenxa zonke. Umnqamlezo somhlathi buqapheleke iileya ezimbini, enye yazo kufuneka ibe ithinti elityheli. Icandelo Active oba ofloxacin. Elinye icwecwe equlethwe ubunzima 200 okanye 400 mg. izithako ezincinane primelloza (croscarmellose sodium), microcrystalline kwincindi, Aerosil (colloidal lesilicon dioxide), dust titania, povidone, methylcellulose hydroxypropyl (hypromellose), talc, nemagnesium stearate, polyethylene ethers 4000 (macrogol). A inzuzo enkulu ichiza "Ofloxacin" - ixabiso. Amacwecwe aqulethe 200 mg ngeempahla sikhuthele umlinganiselo engange 16-20 nganye iziqwenga ezili-10, yaye abo eziqulathe milligrams 400 ofloxacin, iya kuxabisa malunga 50-55 engange ngamnye iziqwenga ezili-10.

"Ofloxacin" amayeza. Imiyalelo yokusebenzisa

Iipilisi kufuneka asele ngaphambi okanye emva kwesidlo. Kufuneka kuginywa wonke, ngaphandle ukuhlafuna, usele amanzi hi mpimo lowutsongo. Idosi kufuneka zikhethwe ngabanye ngokuxhomekeke ubungqongqo esi sifo, kwasendaweni na usuleleko, imeko jikelele yesigulane, umsebenzi kidney, isibindi, neentsholongwane ubuzaza.

Njengoko umthetho, unyango "ofloxacin" yenziwe iintsuku ezisixhenxe ukuya ezilishumi. Omdala emiselweyo imihla kwe ezimakhulu mabini, anamanci amathandathu milligrams kabini ngemini. Ithamo kufuneka kwandiswe ukuze milligrams ezisibhozo kwimeko usuleleko kakhulu, okanye xa isigulane ukuba utyebile. A ithamo milligrams ezine ingasiwa kwangoko, ekukhethwa ukuba kusasa.

Izigulane umsebenzi othile sezintso kanye asikwazi ukuthatha ngaphezulu kwamakhulu amabini neemiligram kweziyobisi, idosi iphezulu yonke imihla lomonakalo hepatic - milligrams engamakhulu amane. Emva yokuduka iimpawu kuqheleke obushushu, nokuba iintsuku ezimbini okanye ezintathu kufuneka uqhubeke unyango.

imiphumela emibi. baqinisekiswa

Ayizizo zonke izigulane ichiza "Ofloxacin 'Wanyamezela kakuhle. Izimvo abanye abantu ziqulathe ulwazi ichiza ebangela intloko, isicaphucaphu, ukugabha, urhudo, iingcangcazela, antsi of kweqondo. Ngomhla inxalenye yenkqubo okucola ekhula njengokuba iintlungu esiswini, gastralgia, ukuqumba, senyongo cholestatic, ukudla, hyperbilirubinemia, enterocolitis pseudomembranous, kwaye luvo - ukunqongophala intshukumo, amahlaba, amaphupha olukhulu, reactions zengqondo, ukuphazamiseka, ixhala, ukudideka, ukucalulwa, nemibono, ukudandatheka.

Ukongeza, kukho umngcipheko ukunyhashwa inkqubo kweemoto (arthralgia, tendonitis, myalgias), ingqondo (ukuphazamiseka incasa, umbono umbala, nokuva, ukulungelelana, ivumba), olujikeleza nentliziyo (ukuncipha uxinzelelo lwegazi, tachycardia), isikhumba (dermatitis, indawo ukopha, amaqhakuvana papular), ka hematopoiesis (thrombocytopenia, ianemia, leukopenia). Emva kokufumana "Ofloxacin" iziyobisi (reviews ukuqinisekisa oku), kwezinye iimeko kubonakala isikhumba sakho silume, bronchospasm, urticaria.

Izimo

Ukufumana medicament zobandlululo esalelweyo ofloxacin kunye nezinye nezakhi fluoroquinolone, kwimeko ukuswela glucose-6-phosphate dehydrogenase, sokuwa, izitshanguba le imisipha, kuncitshiswe kwaye athimbe zisembundwini wawo. Ukongeza, awukwazi ukuthatha amachiza "Ofloxacin" abasetyhini abakhulelweyo kunye phindeke, abantwana abangaphantsi kweminyaka elishumi elinesibhozo. Ulungiselele ngenyameko imiselwe zezigulo yokujikeleza zengqondo, yamafutha ebuchotsheni semithambo, ukusilela kwezintso in engapheliyo CNS izitshanguba indalo ephilayo.

Medicament "Ofloxacin" kwindawo ureaplasma. reviews

Eyona nto ibalulekileyo kukuba abantu bathi, sebenzisa imveliso - ukuba ukusebenza kwakhe ngokukhawuleza. Izigulane ingxelo ukuba isiphumo oqaphelekayo sele ngomhla wesithathu okanye lwesine. Kodwa kuyimfuneko ukuba alumkise ukuba oku akuthethi ukuba ukuqala unyango. Abo izigulane baye bayeka ukuba ukusela iipilisi, ngaphandle kokudlula kwi ikhosi epheleleyo, ngoko kwakhona abanamava mpawu ureaplasmosis, kuba iintsholongwane azikhange lupheliswe ngokupheleleyo.

oyi

Xa pneumonia okubangelwa pneumococcus, siyobisi angasebenzi. Kwakhona, oko makubhalwe ukuba unyango tonsils ahlekise. Kuyimfuneko ukuba ayeke ichiza ukuba kwisiqalo yokwamkelwa lakhe balufumana i uxabane nawo, i-CNS sifo, wenze pseudomembranous. Abafazi nokusebenzisa lithetha "Ofloxacin", oko ke kucetyiswa ukuba usebenzise tampons, kuba kulo mzekelo kukho ingozi enkulu yokuba thrush.