Ichiza "Baraklyud": imiyalelo ukusetyenziswa, inkcazo, ukwakhiwa kunye nohlolo

"Baraklyud" libhekisela amachiza anti-retroviral, inxalenye iqela nucleoside analogue. Ezimiselweyo yonyango engapheliyo HBV-HIV. Eyona nto elikhutheleyo entecavir kweziyobisi ngokukhawuleza ofihla phindana wentsholongwane egazini kwesibindi.

Kufuneka kubeka kufundwa Lungiselela phambi kokuba uthathe iziyobisi. Njengoko kubonisiwe imiyalelo ukusetyenziswa? "Baraklyud" (Baraclud) - ichiza nejonge ukuqalisa sokuphuma kweenkqubo fibrotic kwizigulane kunye zesibindi ukuqina.

ichiza

Ichiza ifumaneka iinketho ezimbini idosi - 0.5 no-1 mg icandelo entecavir esebenzayo abangaboniyo ezahlukeneyo kwi ngedayi umbala (omhlophe okanye pink, ngokulandelelana).

Amalungiselelo nayo iquka:

• polysorbate;
• wemagniziyam stearate;
• monohydrate lactose;
• Valium;
• povidone;
• colorant Opadry.

imiphumela kwemithi

Le esisebenza yi entecavir yinto kwiwotshi le guanosine analogue, uthethe umsebenzi uyakhetha kwesibindi B.

Entecavir ke phosphorylated ukuya triphosphate esebenzayo kunye nesiqingatha-ubomi-15 iiyure, isiqulatho intracellular leyo enxulumene uyondelelwano lwee- entecavir iiseli ngaphandle. Xa oku anayenza olwenzeka wamanzi into esebenzayo emzimbeni. Medicine "Baraklyud" imiyalelo zokusetyenziswa ebonisa ukusebenza kwayo phezulu, ayisayicinezeli umsebenzi polymerase wentsholongwane egazini, ezichaphazela kwangaxeshanye zinto zintathu:

• Yindibanisela mngxilo ezintle DNA HBV;
• umva Ukuloba msonto ezimbi mRNA pregenomic;
• HBV priming enzyme.

Triphosphate ayilo retarders enamandla enzyme DNA zeselula, nokuba ezinomthamo enkulu nafuthe ayo DNA yokuqaphela.

ukusebenza beziyobisi

I engekho mthethweni esebenzayo iyakwazi ixesha elifutshane wendele kwinkqubo yokucola yaye ifikelela kwelona ngezinto ezilapho kuyo kwimizuzu 30-90 ezingengaphi emva kokuthatha iipilisi.

ukwanda yendebe yamazwe e Cmax kunye indices AUC kwenzeka ukusetyenziswa elandelayo 0.1-1 mg medicament "Baraklyud". Imiyalelo yokusebenzisa ethetha ekuphumezeni ukulingana ngemini 6-10-th ka nedosi enye ye-ichiza ngamnye ngosuku. Sebenzisa ukutya okunamafutha nzima kakhulu inkqubo Ukutsalwa entecavir, nokuthabatha codes Cmax kunye AUC yi-45% ne-20% ngokulandelelana.

Ichiza ako ngokukhawuleza kwi inyama kunye yi-13% yento kwiiproteni plasma. Icandelo isiyobisi esebenzayo akukho kusebenza substrates, enzyme inhibitors okanye inducers benkqubo P450. Oku uyakwazi yande emzimbeni kunye neziphumo ngokusebenzisa inkqubo sezintso yi ukuhluza glomerular kunye nokukhutshwa tubular.

Ubungqina obubonakalayo buxela

Medicament "Baraklyud" ekucetyiswa ukuba ungenisa unyango entsonkothileyo sohlobo B:

• Ezineempawu ezikhoyo phindana wentsholongwane egazini kunye nongeniselo iqondo umsebenzi transaminases kwi serum, phambi ekubonakalisweni histological na ukudumba oqhubekekayo esibindini.
• izilonda isibindi Unrecovered.

isiqabu ebalulekileyo iimpawu zesifo sesibindi kwenzeka emva ulawulo iziyobisi "Baraklyud". Amacwecwe yemiyalezo lithethelela ukuba izigulane ezinochaso ezondeleyo hepatitis B, isifo zesibindi nzima kulandelayo:

• ibekwe decompensated;
• imeko isibindi yezifo kwi linyathelo imbuyekezo xa efakiweyo obubonakala phindana wentsholongwane egazini kwafunyaniswa of zesibindi abanesigulo nokonyuka AST kunye ALT.

Izimo

Ichiza "Baraklyud" liye Izimo zilandelayo:

• anda susceptibility ku entecavir kunye nezinye izinto ifakiwe ekwakhiweni iziyobisi;
• nobandlululo lactose ilifa, iswekile-galactose malabsorption, ukunqongophala okanye ukungabikho kumzimba lo yelactose ;
• yobudala engaphantsi kwe-18.

Abantu abane kwezintso kufuneka uthathe nesiyobisi amayeza kwaye phantsi kweliso unyango rhoqo.

Reception "Baraklyuda" ngexesha lokukhulelwa akukhuthazwa ngexesha unyango kufuneka uyeke ukuluncancisa.

imiphumela emibi

Kusenokubakho iintlobo ukuphazamiseka kwenkqubo zokwetyisa ngexesha unyango ngamachiza "Baraklyud". Imiyalelo yokusebenzisa zichazwe ngokucacileyo effects:

• esiswini;
• sorhudo;
• isicaphucaphu nokugabha;
• ukuqunjelwa.

Usenokuba kwakhona ikhanda, efuna okanye ukozela, ukungabi namdla, kunye negazi.

Ukusebenzisa amayeza njenge arhente kuphela kwezonyango okanye zidityaniswe namanye amachiza ee-antiretroviral kunokubangela hepatomegaly kakhulu kunye steatosis, nto leyo enokukhokelela ekufeni yesigulane.

Xa izigulane izitshanguba nembono decompensated laktatsiadoz Inokwenzeka kwesibindi, nto leyo zibandakanya:

• buthathaka kwezihlunu jikelele;
• uphefumla ngokukhawuleza kunye ukubonakala nephika;
• isicaphucaphu;
• Ukucutha ngokubonakalayo ubunzima bomzimba;
• intlungu peritoneum, epigastric.

Kwakhona, ichiza kunokubangela basabela ezahlukeneyo umzimba:

• ukwanda amazinga transaminases hepatic;
• ufunga kwesikhumba;
• basabela anaphylactoid.

Izigulane nabandezeleka isifo sesibindi decompensated, ukongeza, ngayo ezinjalo kokuphilayo abonisa:

• ukusilela kwezintso (kwiimeko ezinqabileyo);
• isiqulatho yibilirubin ukwanda egazini;
• . Ukuthotywa zegazi ubale ku-50 amawaka / mm ³ okanye ngaphantsi;
• ukuncitshiswa yesoda egazini;
• nokwanda ALT;
• ngaphezu ulwando oluphindwe-ntathu umsebenzi lipase;
• Amanqanaba yehlise albumin.

Medicament "Baraklyud": Izikali kunye nolawulo

Ichiza kufuneka kuthathwe ungatyanga, nexesha ukusuka isidlo yokugqibela phambi umthamo kufuneka ibe ngaphezulu kweeyure ezimbini.

Xa ingahlawulwa umonakalo kwesibindi lolwamkelo ekucetyiswa "Baraklyuda" 0.5 mg yonke imihla. Ekuchongeni ukumelana lamivudine idosi kufuneka liphindwe.

Izigulane kunye nezilonda zesibindi lingalungiswa emiselweyo inani imihla ngemihla 1 mg. Kuba abadala kunye izigulane insufficiency kwezintso, ithamo kufuneka zilungiswe ngokuxhomekeke kwinqanaba CK (creatinine xiyimiso) egazini.

libanda

Ulwazi amatyala libanda, isiyobisi akwanelanga.

Amavolontiya, leyo kuvavanywa ngokwezonyango, wafumana idosi yemihla ngemihla ye-20 mg iiveki ezimbini baye banikwa idosi enye aphezulu - 40 mg iziyobisi "Baraklyud". Imiyalelo Sebenzisa ithi neziphumo ezingalunganga zabonwa.

unyango posindromnoe okunikezelwe phantsi kweliso ukwenza izinto zonyango.

Intsebenziswano kunye namanye amachiza

Ngenxa yokuba icandelo entecavir esebenzayo salawo kakhulu ngenkqubo kwezintso, unyango ezintsonkothileyo xa zidityaniswe kunye namanye amachiza ezibonelela neziphumo ngqo okanye ezingathanga ngqo kwi umsebenzi wezintso kwaye kuchaphazela secretion tubular, kungabangela ukwanda umzimba entecavir kunye izinto obunentshukumo iziyobisi.

Intsebenziswano "Baraklyuda" kunye adenovirom, tenofovir, lamivudine azizange zibhalwe.

amanyathelo okhuseleko

Ukwamkela lezigulana enganyangekiyo ngamachiza ukuba lamivudine kukhokelela ingozi yokuvela uxhathiso.

Kwakhona, kukho ubungqina kukuvela exacerbations sohlobo B emva ukupheliswa ichiza "Baraklyud". Imiyalelo yokusebenzisa ichaza Umfanekiso exacerbations ngaphandle unyango olongezelelweyo.

oyi

Reception "Baraklyuda" kwi sikhokelo monotherapy kunye nonyango zidibene nezinye izinto antiretroviral, kunokubangela lactic acidosis, hepatomegaly kunye steatosis. Kulo mzekelo, kukho ingozi yokuba afe.

Emngciphekweni izigulane iquka la macandelo alandelayo:

• abaphethwe hepatomegaly;
• ukuphathwa kunye nokusetyenziswa nucleoside;
• ukuba luphele;
• izigulane ababhinqileyo.

Imiyalelo zokusetyenziswa ichiza "Baraklyud" ithi ithuba ukuyilwa ezimelene nemithi wentsholongwane egazini. Active ichiza eziletha entecavir akukhuthazwa ukuba unyango lwe immunodeficiency kwabantu yintsholongwane ngenxa ukusebenza kwayo kweli cala abangakhange bafunda ngokupheleleyo.

Xa unyango kwezigulane ngezifo inkqubo kwezintso, efunekayo ukuze kulungiswe idosi.

Ukhuseleko kunye nokusebenza usebenzisa 'Baraklyuda' ukuba unyango izigulane emva zesibindi abohlukeneyo abantu abangabaziyo kufuna amanyathelo awodwa ononophelo ukuthotyelwa.

iimeko Ukugcinwa kunye neendleko

Ukugcinwa nokuthuthwa zithutha kufuneka yenziwe lobushushu kuluhlu 15-25 ° C. Amalungiselelo ubulungeleyo azakusetyenziswa kwiminyaka emibini ukusukela kumhla wokwenziwa.

Ichiza iqukiwe kwiqela olwahlukileyo lwamayeza ayimfuneko, nangenxa iindidi ezithile yabemi echazwe unikezelo simahla ichiza "Baraklyud". Imiyalelo yokusebenzisa sitsala le nyaniso.

Ixabiso kuthetha ezikhemisti eMoscow iqala ukususela amawaka 12. Engange.

Views ezigulane

Oku kubonisa ukusebenza eliphezulu ichiza "Baraklyud" umyalelo manual. Price, reviews apho wabonisa ukuba yedemokhrasi xa kuthelekiswa analogue beziyobisi, uyahluka 12-17 amawaka package ngamnye, apho zithutha-30. Oku kwenza ichiza a ethandwa kakhulu kwaye kwemfuneko phakathi izigulane ukuba unyango sohlobo B.

Yengxelo embi ekubhekiselwe becala proitvopokazaniya kunye imiphumela beziyobisi, ezifana ubuthongo, kanye isicaphucaphu.