Ichiza "Avastin": angqina nomonde, imiyalelo ukusetyenziswa, imiphumela emibi

I 'Avastin "ichiza kugqalwa arhente antitumor, elibhekisela omzimba monoclonal. Ngexesha isicelo ichiza uchatha ukuhla lwesifo kuwenza kunye microvascular permeability xa yamathumba amabi ezahlukahlukeneyo, ingakumbi ezo zijongene webele ababhinqileyo, ikholoni, kunye injeke kunye wendlala.

ichiza

Ifumaneka iziyobisi "Avastin" ngohlobo a mxube nejonge ukulungiselela isisombululo ibe nokubandakanywa inokuba ezingenambala okanye sinombala kancinane perceptible.

I engekho mthethweni esingundoqo bevacizumab. Isixhobo iyafumaneka upakisho-100 mg, nge-4 ml into esebenzayo 400 mg / 16 ml.

imiphumela kwemithi

"Avastin" - yokulwisana ithumba ukuba abangaphangeliyo ukuyilwa iimpahla ezintsha yegazi kubonelela ioksijini kunye nezakhi ukuba kwizihlunu neoplasms yaye ngaloo ndlela ivumela nokudluliswa umhlaza wokulwa kwinqanaba ezigulo ezondeleyo. "Avastin" (iimpendulo ezigulane kunye amagqirha - proof) enza luyoyisa Ukudlulela yamathumba ezahlukeneyo amabi.

Ukuze esi sixhobo lubonakala ngokuba amancinane ze sisasazeke emzimbeni, ukongeza, ukuba lide ngokwaneleyo isuswe emzimbeni, nto leyo evumela ukugcina anenani elifunekayo ikhomponenti ephambili ichiza injecting ngayo uyifaka ngokwemiyalelo - kanye ngeentsuku 14-20. Lithathelwe imveliso amayeza ayikho esibindini okanye zezintso, nakuzo zonke iiseli zomzimba iintsuku 18 amadoda kunye nabafazi - 20.

Kodwa kulungile "Avastin"? Baqinisekiswa bathi eli chiza kakuhle kakhulu, ukuba udibanisa kunye ichemotherapy kwiintlobo ezahlukeneyo zomhlaza. Oku kuthetha kakhulu kwandisa ixesha ukusinda lwezigulana onke amaqela, kunye ukuqhubela phambili kwesifo kwenzeka.

"Avastin": zikhombisa ukuba ukusetyenziswa

Eli chiza sisetyenziswa ngokubanzi kunyango lomhlaza. Oogqirha uyakukumisela lona:

1. In kuwenza umhlaza colorectal. Ichiza akukhuthazwa ukuba zisetyenziswe ngaphakathi kunye ichemotherapy ngokusekelwe 'fluoropyrimidine'.
2. Xa umhlaza webele kuwenza. Oku kusetyenziswa njenge umgca wokuqala unyango ngokudibene "paclitaxel".
3. Xa esingasebenziyo, kunye inani elikhulu metastases okanye neplosko-, zomhlaza ezingezo-amancinci iseli lung - njengoko kwanonyango umgca wokuqala nodibaniso ichemotherapy platinum amalungiselelo ezisekelwe amayeza.
4. Xa umhlaza eliphezulu okanye kuwenza, echaphazela iiseli kidney - njenge-arhente unyango lokuqala ngokudibene ne "Interferon Alpha-2a '.
5. Xa glioblastoma ngokusebenzisana kunyango kwimitha kunye 'temozolomide' kwizigulane ezisandula ngoxilongo, xa monotherapy okanye ngokusebenzisana 'irinotecan "kwizigulane kunye glioblastoma nezolo okanye progression umhlaza.
6. Izigulane uxilongwe "ithumba ukonakala zangasese", kwaye umhlaza zaseprayimari peritoneal. Kule meko kucetyiswa ukuba abele ichiza "Avastin" njengoko unyango lokuqala zonyango ngokudibene ne "carboplatin" yaye "paclitaxel".

Ukongezelela, iyeza elawulwa with "carboplatin" yaye "Gemcitabine" inikezwe isifo phambili okanye ezibuthathaka kwiiarhente platinum-based ukuba izigulane ngumhlaza amalungu zangasese okanye peritoneum, lungakhutshwanga waphathwa ngumoya isixhobo, okanye uhlobo olunye ngumqobo of VEGF.

Indlela bangene "Avastin"?

"Avastin" (iimpendulo ezigulane kunye noogqirha ukuliqinisekisa) - ichiza elungileyo, kodwa kakuhle kufuneka ufakwe, kwaye kuphela phantsi kweliso logqirha. Akuvunyelwe ngokungqongqo ukuba bangene jet - butofelwe kuphela, koko nje kancinci kangangoko kunokwenzeka. Olubalo yi mg 5 1 kg ubunzima bomzimba 1 ixesha kwiiveki ezimbini.

Imali efunekayo mxube leyo exutywe 100 ml 0.9% sodium chloride. Kwedosi yokuqala Kucetyiswa ukuba ukungena iiyure enye enesiqingatha emva ichemotherapy, inaliti ngakumbi "Avastin" kwenziwa ngaphambi okanye emva kokuba inkqubo. Ukuba ulawulo lokuqala ichiza isigulane ukuba akukho zingxaki, kokukhona nga ufakwe ngaphakathi ilixa, yaye zonke kwizitofu ezilandelayo - kangangesiqingatha seyure, kodwa kuphela xa yesibini sele zidluliselwe kakuhle emnweni abagulayo.

Nokuba umthamo ayikhuthazwa ukunciphisa ubukho neziphumo ezingathandekiyo, ukuba kuyimfuneko, ukuxhoma okanye ayiyeke unyango.

Ukuba isigulane ibonakele umhlaza kuwenza colorectal, i ekucetyiswa ithamo yokuqala ka-5 mg nganye ubunzima bomzimba kg kanye emva kweentsuku eziyi 14 okanye 7.5 mg / kg, kodwa emva kweentsuku ezingama-21. Ukuba unyango lomgca wesibini, idosi linyuke amaxesha-2.

Ukuba umfazi kwafunyaniswa zomhlaza zamabele, kulo mzekelo, inaliti yokuqala kucetyiswa ukuba kuqulunqo 10 mg / kg kwanawokuqhuba ngenaliti rhoqo kwiiveki ezimbini. Okanye abathathu, kodwa kule meko lisiwe 15 mg nganye ubunzima bomzimba kg.

Ukuba kukho iimpawu ukuqhubela phambili kwesifo, unyango kufuneka imiswe.

Kunye ngokubanzi esingasebenziyo, nezolo, okanye kuwenza imihlaza iseli lung neplosko- okanye non-ezincinane unyango oluqhutywa kunye namachiza ichemotherapy Pt (akukho ngaphezu kwe-6 imijikelo), yaye emva koko ichiza asetyenziswa monotherapy.

kufuneka uyeke ukuba angene "Avastin" Xa ubona zimpawu zokuqhubeka zomhlaza. Imiyalelo yokusebenzisa ithi ukuba akukho ukuqhubela phambili, ukubala yi 7.5 mg / kg zonke iintsuku ezili-14 okanye idosi inyuswe ngesiqingatha kwaye ilawulwa kanye qho emva kweeveki ezintathu ukongeza kwi "cisplatin" yaye "carboplatin".

Xa zomhlaza iseli sezintso ulapha mayingabi ngaphezu 10 mg / kg iintsuku 15 kanye. Ukuba kukho iimpawu ukuqhubeka kwesifo, unyango kufuneka imiswe.

Abantu abadala akukho mfuneko yokuba ukunyenyisa idosi.

"Avastin": libanda

Drug libanda, kwenzeka kakhulu xa kuthe ukuba isigulane okhethwe ithamo eliphezulu - 20 mg kg ubunzima bomzimba nomonde zonke iintsuku ezili-14.

Kulo mzekelo, kungenzeka uhlaselo migraine ngendlela ngokwanelisayo ezintsonkothileyo, ukongeza, kuye kwakho ukwanda iziphumo ezibi ezichazwe ngezantsi. iyeza Special ayisekho, lisetyenziswa kuphela unyango nomqondiso.

"Avastin": ziziphumo ebezingalindelekanga

"Avastin" - ichiza elungileyo kakhulu, kwiimeko ezininzi kuyanceda ukwehlisa ukuqhubela yokugula, kodwa izigulane waphawula iziphumo ezingafunekiyo. Kwiimeko ezinqabe kakhulu, ukuba kubi kakhulu:

1. Perforation esiswini kunye amathumbu.
2. ukopha yangaphakathi.
3. thromboembolism wegazi.
4. uxinzelelo yegazi eyonyukileyo kunye proteinuria luphuhla. Kungenzeka, esi sisiphumo impendulo idosi nomonde.

Ukongeza, izigulane obemiswe iziyobisi "Avastin", iziphumo ebezingalindelekanga kunye nezinye iimpawu zivela:

• thrombosis umthambo ngokunzulu, uhlobo oluntsonkothileyo yokusilela kwentliziyo, tachycardia supraventricular, ukopha;
• leukopenia, neutropenia, libya umthamo thrombocytopenia;
• kabi kwi peritoneum, ukuphazamiseka isisu, igazi isitulo, nerhashalala esisulelayo emlonyeni, iintsini ukopha, kwamathumbu kokuphazanyiswa;
• wopha impumlo, yokunqongophala kwe-oksijini, thromboembolism pulmonary;
• isikhumba owomileyo, dermatitis, ibala;
• ukulahlekelwa ukungcamla, ngokukhawuleza ukwehla kobunzima, syncope, migraine, stroke, ukozela;
• ukungaboni;
• intlungu kwindawo apho medicament ilawulwa;
• ukopha evela isibeleko, usuleleko wokuchama iphecana, imvo ukudinwa, emzimbeni.

Izimo

Nokuba bonke "Avastin" ifanelekile? Baqinisekiswa bathi oku ichiza kakhulu, kodwa ke oko ke kufuneka Izimo ukuba ukusetyenziswa, kwaye phambi kokuba uqale unyango, ugqirha kufuneka akuxelele ngayo. Ichiza kufuneka ingamiselwa kwezi meko zilandelayo:

• ukuba kukho izinto ezizodwa nto engundoqo esebenzayo;
• Kukho izifo ezosulelayo iso kunye indawo periocular;
• kwenzeka ukudumba Intraocular;
• kweminyaka eli-18;
• Ukukhulelwa ne zisanyisa.

Ukongeza, ukuba isigulane indenzele ithuba kokubetha, ngoko ahlabe 'Avastin "wabeka kuphela emva kokuba isigulane sihlolisisa ngenyameko baze bafikelele kwisigqibo sokuba inzuzo iziyobisi.

oyi

iziyobisi uphathe ukuba ugqirha kuphela onamava ekwenzeni izitofu intraocular.

Emva kokuba isixhobo yaqaliswa, ukanti Kucetyiswa ukuba emva ivili le imoto kwaye wenze umsebenzi enxulumene kunye neendlela zonke ngenxa oko ukuphuhlisa ukuphazamiseka ezibonwayo idlule.

"Avastin" (umenzi iboniswe kule imiyalelo) kufuneka igcinwe kuphela kwisibandisi, ngoxa kunjalo akufuneki emkhenkceni. It okunikelwa kagqirha kuphela.

Indlela ukusebenzisana "Avastin" kunye nezinye iziyobisi?

Drug "Avastin" aluhambisani kunye nezisombululo dextrose. Kwakhona, ichiza kunokwandisa umngcipheko reactions ezibi xa zithathwe kubanjiswene ndlela:

• "Sunitinib malate" - Inokwenzeka ukuphuhlisa anemia microangiopathic hemolytic;
• platinum kunye taxanes - iingxaki ezimbi ezasulelayo, neutropenia kakhulu, basengozini enkulu yokufa;
• "Panitumumab" yaye "Cetuximab" - kwandisa iziphumo enetyhefu kweziyobisi ekhokelela ekufeni.

"Avastin" zamehlo

Kutsha nje, ulwazi ivele eendaba ukuba ichiza "Avastin" asetyenziswa ophthalmologists ukunyanga izifo iliso aze anike nemiphumo emihle kakhulu. Kodwa ngaba kunjalo? Yintoni le ikuthethayo umenzi? Ingaba esi sixhobo ikuvumela ukuba uyeke nje ukukhula yamathumba, kodwa nokuphilisa izifo le mbono?

Ewe, enyanisweni kukho inkcazelo ukuba ezinye izigulane sivile malunga iingenelo ichiza ukuya iliso, uze ube nesibindi ukuze wenze shot "Avastin" kwi vitreous, kodwa iziphumo woko. Ichiza abazange azise nayiphi na ukuphilisa, phezu koko, kukhokelele kwinto yokuba abantu abaziimfama nje. "Roche" inkampani ngokuphindaphindiweyo wagxininisa ukuba "Avastin" ayikwazi ingasetyenziswa zamehlo, injongo yalo eyahlukileyo.

Ichiza yenzelwe ukunciphisa izinga lokukhula kwemithambo yegazi kunkcenkceshela umhlaza, ngaloo ukuncitshiswa ngamandla kuphuhliso ithumba. Kungenxa yoko le nto phambi kokuqala unyango kwaye umamele iingcebiso unsubstantiated ngcono ukuba udibane nogqirha.

"Avastin": nabalingani

Ke ukuba kukho indawo, apho wayeza kumafa yayo akuphela kwento enye ezingundoqo, oko akuthethi ukuba babe "Avastin". Analogs womatshini amanyathelo, kwaye kwakhona ukunika iziphumo ezilungileyo ekunqandeni phantsi ekukhuleni imithambo yegazi kunye nophuhliso yamathumba ngumhlaza. Ezi ziquka:

• "Arzerru".
• "Campath".
• "Rituximab".
• "MabThera" et al.

Kodwa ke kufuneka kukhunjulwe ukuba ugqirha kufuneka ukhethe analogu.

"Avastin": Iimpendulo ezigulane kunye amagqirha

"Avastin" (umyalelo manual kuqinisekisiwe) sesona siyobisi kuphela equlathe xa bevacizumab layo ekwakhiweni, kuyanceda ukwehlisa ukukhula kwemithambo yegazi yokondla ithumba, ngaloo ndlela behlise phantsi ukuqhubela phambili kwesifo. Uninzi amagqirha ababona Dynamics esi sifo isigulana ethile, bathi ukuba isibini lwezitofu ngokuphawulekayo behlise ukukhula ithumba, eyona nto ibalulekileyo - unelungelo lokuthabatha ichiza kwaye musa ukuhlanganisa kunye namachiza ukuba zidityaniswe inokubangela umonakalo omkhulu isigulane.

Ukushwankathela, sinokuthi ngokuqinisekileyo ukuba "Avastin" (umvelisi - F. Hoffmann-La Roche) - elihle, nto leyo inceda kuyolula ubomi izigulane ngamathumba ngumhlaza. Kodwa oko kuyimfuneko kuphela isicelo phantsi kweliso elibukhali likagqirha, kungenjalo kungaba nemiphumela vuhlayiseki ize iphele kalusizi.