I-bacteriophage coli: imiyalelo yokusetyenziswa, imizekelo kunye nokuphononongwa

Kwindlela yokwelapha kunye ne-microflora ye-pathogenic yamkelekile ukulwa kunye noncedo lwe-antibacterial agents, ezonakalisa ingozi kuphela, kodwa ezinokusetyenziswa ezincinci. Akunabo bonke oogqirha abakhumbulayo malunga neziyobisi ezikhuselekileyo - ii-bacteriophages. Omnye wabameli balo mgca yi-bacteriophage coli. Makhe siqwalasele ngokungakumbi iinkcukacha, indlela yokusebenza, izibonakaliso zesicelo kunye nempendulo.

I-Bacteriophages - yintoni na?

Iibhaktheriya ezibangelwa zizifo zingathatyathwa yiintsholongwane ngendlela efanayo nabantu abavela kwi-ARVI okanye i-influenza. Ezi zintsholongwane ziyi-bacteriophages - uhlobo olungenalo lweselula lobomi, oluqukethe isambatho seprotini kunye ne-nucleic acid (i-RNA ne-DNA). Ngokungafani nama-antibiotics, i-bacteriophages iyonakalisa uhlobo oluthile lweebhaktheriya. Ngoko ke, baqeshwe kuphela emva kokumisela uhlobo lwe-agent engumnxeba wesi sifo.

Inzuzo ebalulekileyo kukuba iibhaktheriya azivelisi ukumelana ne-bacteriophages. Oku, kwindlela, kuthathwa njengesizathu esona sizathu sokuba kutheni umdla kwiintsholongwane zebhaktheriya uye wavuselela kutshanje. Nangona kunjalo, kufuneka kukhunjulwe engqondweni ukuba amayeza atshanje ahlukanisa ama-bacteriophages njengamayeza omzimba.

Inkcazo ye "Bacteriophage coli"

Isisombululo sesisombululo, ngesimo sokuthi singakwazi ukuthenga iyeza, siqukethe i-phagolysate filtrate ye-pathogenic Escherichia coli strains.

Isilwanyana sinomphumo othile kwaye sibangele i-lysis (intshabalalo) yeeseli ze-bacteria ze- Escherichia coli. I-nucleic acid ingena kwi-genome ye-bacteria kwaye iqala ukuzivelisa. Iiphakheji, apho igumbi lizele, likhawule ngaphakathi kwaye liqhubele phambili "kwixhoba" elilandelayo. Ngoko ke, kunye nenani elincinci le-bacteriophages, kunokwenzeka ukuphumeza umphumo omuhle weyeza.

I-bacteriophage coli ikhiqizwa yinkampani yasekhaya yezobisi. "I-NPO Mikrogen". Isisombululo singathengwa kwiibhotile ezingama-20 ml okanye 100 ml. Njengezinto ezongezelelweyo kwizinto ezisetyenzisiweyo zisetyenziswe kwi-quinazole.

Iimpawu zokusetyenziswa

Izidakamizwa ze-antibacterial zivame ukumiselwa ngaphandle kokuhlwayelwa kokuqala kwezityalo ukuchonga uhlobo lwe-pathogen, enethemba lokuba iziphumo ezahlukeneyo zeziyobisi. Akunakwenzeka ngokupheleleyo ukusebenzisa i-bacteriophage kwiimeko ezifanayo. U-Escherichia coli luhlobo oluphambili lweebhaktheriya ze-pathogenic, ezinokuchaphazeleka yiziyobisi. Ngoko ke, isilwanyana kufuneka sisetyenziswe kuphela kwizifo ezithathelwanayo ezibangelwa yi-arhente.

Ukunikezela isilwanyana sokuthintela nokunyangwa kwezi zifo ezilandelayo:

• I-Pathology ye-ENT amalungu e-bacesia genesis (otitis, angina, pharyngitis, sinusitis, sinusitis);
• Izifo zendlela yokuphefumula (i-bronchitis, i-pneumonia, i-laryngitis, i-tracheitis);
• Ukutshatyalaliswa kwebhereji yamathumbu emathunjini (i-dysbacteriosis, cholecystitis, gastroenterocolitis);
• Iinkqubo ezivuthayo zesikhumba kunye nokusuleleka kwezifo (ukutshisa, i-bursitis, ukuxhaswa kwamanxeba, i-paraproctitis, i-mastitis, i-abscess);
• Usulelo lwe-Urinary tract (pyelonephritis ngendlela ephosakeleyo neyingozi, i-cystitis, urethritis);
• Izifo zesigaba somzimba (endometritis, colpitis, salpingo-oophoritis).

Ukuthintela usulelo, isisombululo se "Bacteriophage coli" sinconywa ukuba sisebenzise kunyango lwesikhumba emva kokuhlinzwa. Ngaphambi kokusebenzisa isilwanyana, kubalulekile ukucacisa ukuphakanyiswa kwe-pathogen.

Imiyalelo yokusetyenziswa

I-arhente yelwelo ingasetyenziselwa umlomo, i-topic, ulawulo lwe-rectal. Kwakhona, isisombululo esifanelekileyo sokuhambisa amanzi, ukunkcenkceshela kunye nezicelo. Kwezinye iimeko, isilwanyana kufuneka sisetyenziswe kunye nangaphakathi, kunye nonyango lwengingqi yeendawo ezivuthayo. Ngokungafani namayeza, i-bacteriophage yonyango ihlala kwiintsuku ezi-7 ukuya kwi-20.

Ukulawulwa komlomo kwesisombululo kuboniswe i-cystitis, i-pyelonephritis kunye ne-urethritis. Xa ukhenkceza i-bladder okanye i-pelal pelvis, ichiza lilawulwa ngetyhuthi yokuhambisa amanzi. Ngaphakathi kukho kuboniswa ukuthatha i-20-30 ml yesisombululo kwizigulane ezingaphezulu kweminyaka eyi-8. Kwisithambiso sesinxibe singangena ngaphezu kwe-30 ml, kwaye kwi-pelvis - 6-7 ml yesisombululo ngosuku.

Ukunyanga izifo ze-ENT amalungu kunye ne-bacteriophage xa kunokwenzeka ngokuhlamba, ukumba nokuhlanza. Isilwanyana sisebenza ngokugqithiseleyo xa ujoba ugaqambisa ugalelwe kwisisombululo kwisigxina somlomo okanye se-auric.

I-bacteriophage coli ene-dysbacteriosis kunye nezinye izifo zendlela yokugaya kufuneka zithathwe ngomlomo 20-30 ml kathathu ngosuku, ubuncinane iyure ngaphambi kokutya. Ubungakanani bonyango olunjalo iiveki ezi-3.

Izifo ze-gynecological of the infectious nature ziphathwa ngokusombulula isisombululo kwisisu okanye ngesisu. Ukuthatha enye, i-5-10 ml yesisombululo iyadingeka. I-colpitis ifanele isetyenziswe kabini ngosuku.

Emva kokugqithisa isigxina se-abscess, ichiza lilawulwa kwincinci elincinci kunomthamo we-pus. I-bacteriophage iphinda ithululelwe kwilonda ngenxa ye-10-20 ml nge-osteomyelitis emva kokunyanga okufanelekileyo kwilonda.

Ukusetyenziswa kwezilwanyana

Isixhobo esisebenzayo siya kuba kunye nokunyangwa kwezigulana ezincinci. I-bacteriophage coli ifanele isetyenziselwe i-dysbacteriosis, i-enterocolitis ebangelwa ukusulelwa ngu-Escherichia coli. Isisombululo esifanelekileyo kunyango lwanabantwana abasengaphambili. Ngokuqhelekileyo, isilwanyana sisetyenziswe ngendlela ephakamileyo, ukuzisa isisombululo ngethubhu yegesi okanye i-catheter. Inqubo iphinda iphindwe kathathu ngosuku, isebenzise nganye idosi engaphezulu kwe-10 ml ye-liquid.

Ukulawulwa komlomo kunokwenzeka kuphela xa umntwana engabandezeleka ngokuphindaphindiweyo. Isisombululo siyaxutywa kunye nesincinci sobisi lwebele. Ubungakanani bonyango lunemihla engama-5-15. Ukuba kuyimfuneko, ii-bacteriophages zidibaniswe namanye amayeza ngexesha lonyango. Iintsholongwane zebhaktheriya ziyakwazi ukuphucula umphumo wokwelapha iziyobisi kunye nokwandisa uvelwano lwamayeza.

Imiyalelo ekhethekileyo

Kufuneka kuthathelwe ingqalelo ukuba i-vial kunye neziyobisi emva kokuvulwa akuxhomekanga kwisigxina sexesha elide. Ngaphambi kokuba nganye isebenze kufuneka idibanise kwaye ihlolwe ingqalelo kwizinto ezidityanisiweyo. Ukuba oku kufikeleleka, isilwanyana akufanele isetyenziswe.

Kubalulekile ukuvula i-vial entsha ngokwemigaqo ethile:

• Ngaphambi kokuqala ukuphathwa, kufuneka uhlambulule izandla zakho;
• Isikhuselo sokukhusela kwisibambiso siphathwa ngesisombululo esinesiphuzo;
• Susa eso sikhombisi ngaphandle kokuchukumisa i-stopper;
• Xa kususwa ngephutha iplagi, akuvunyelwe ukuyibeka etafileni ngaphakathi;
• Musa ukushiya ikhonkco evulekile;
• Gcina iyeza kuphela efrijini.

Ukunyuka kwamanzi okufunekayo kufuneka kuqhutywe nge-syringe oyinyumba ngeplagi. Kwinkqubo nganye, isirinji entsha kufuneka isetyenziswe. Awukwazi ukushiya inaliti kwindawo yokuhamba.

Analogues

Impembelelo kwi-E. coli inokwenzeka ngencedo lenye ibhetriophage. I-coli-protein ibteriophage iqulethe iintlobo ezininzi zeeprotas (mirabilis, vulgaris) kunye ne-escherichia coli. Isilwanyana sifumaneka ngesimo sesisombululo samanzi, sifakwe kwiibhotile ezingama-20 kunye ne-100 ml, kwakunye neefomethe.

Ungasebenzisa iyeza ngezifo ezahlukileyo, i-agent causative apho ibhakteria ibhalwe ngasentla. Iibhulile azisebenzisi ukuphatha abantwana abangaphantsi kwe-1. Umyinge weliza lichongiwe kuye kuxhomekeke kwi-diagnostic kunye nobudala bomguli.

I-bacteriophage coli: ukuphononongwa

Nangona i-bacteriophages ayinakudla ngokusetyenziswa kwiinkqubo ezahlukeneyo ezithathelwanayo, umntu akufanele akhuphe lolu hlobo lwamachiza kwaye akhethe okokulwa namayeza. Ngokutsho kokuphononongwa kwezigulane, i-bacteriophages iyakwazi ukujamelana nezifo ezingapheliyo ezibangelwa zizibhakteria. Ukuba kuyimfuneko, zinokumiselwa ngokudibanisa ne-antibacterial agents ukuze kuphuculwe umphumo weli xesha.