"Esomeprazole": imiyalelo ukusetyenziswa, nabalingani real

"Esomeprazole" - ichiza elisetyenziswa i Organotropona iziyobisi zesisu. Eli chiza antiulcer nyathelo kwaye inhibitor pump Proton.

Ekwakhiweni, ifomu ukukhululwa "esomeprazole" iziyobisi

Ichiza ifumaneka ngohlobo iipilisi kunye umthamo 20 no-40 mg lwe zithako esomeprazole esebenzayo, ngokunjalo uhlobo ngumgubo elungiselelwe isisombululo ukuba isitofu (40 mg igutyana). tablets camera, ngamanyala leyo ethatha indawo emathunjini.

isenzo amayeza "esomeprazole" iziyobisi

Yintoni na ichiza 'esomeprazole "? Imiyalelo yokusebenzisa ibonisa ukuba le arhente antiulcer, leyo, ukuba isiseko obuthathaka, ufumana uhlobo esebenzayo emva kokungenisa. "Esomeprazole" abangaphangeliyo i-enzayim ye H ⁺ -K ⁺ -ATPase umsebenzi, kunye secretion of zehydrochloric acid (zisebenze, Basal). amanyathelo ayimfuneko kwenzeka kwisithuba seyure emva kokungenisa beziyobisi. Xa benikwa "esomeprazole" nsuku, iintsuku ezintlanu, idosi avumelekile yemihla ngemihla - 20 mg emva inkanuko ngokuthi pentagastrin inqanaba eliphezulu zehydrochloric acid yehliswe kakhulu (malunga 90%).

Pharmacokinetics

"Esomeprazole" imiyalelo zokusetyenziswa nje ichiza, leyo ezendeleyo ngaphakathi emzimbeni, ngokukhawuleza kwaye kakuhle wendele, sibopha kwiiproteni phantse-100% (97%). Le bioavailability zinyuke nge ukusetyenziswa Ukuphindaphindwa beziyobisi ukusuka 64 ukuya 89%. Le medicament kuthatha uhlobo metabolites kunye kwazona kakhulu umchamo, inxalenye encinane yawo langoku endleni.

Iimpawu "esomeprazole" ukulungiselela

"Esomeprazole" analogue ezisetyenziswa izigulane kunye nesifo reflux gastroesophageal ngonyango kunye nothintelo likakade. Isixhobo esetyenziswa ukunyanga izilonda esiswini okanye duodenum, lokuthintela isifo ezivela ngenxa NSAIDs.

Eli chiza esetyenziswa isilonda Peptic xa ochaphazelekayo duodenum okanye isisu. Singasebenza kwizigulana abaye uphilisiweyo esophagitis, ngexesha nothintelo ukubuyela ixesha elide. Kuvumelekile isicelo ezimanyene indlela "esomeprazole" iziyobisi antibacterial. Iipilisi kunye inaliti kwi kunyango entsonkothileyo kulo mzekelo ukuvumela kutshabalalisa Helicobacter pylori.

Izimo ekufumaneni "esomeprazole" iziyobisi

Izimo ziquka yobudala ngaphantsi kweminyaka elishumi, hypersensitivity ukuba esomeprazole, ithuba lokuncancisa. Imiphumo unyango ngamachiza akukasekwa ngexesha lokukhulelwa.

Ukusetyenziswa kweziyobisi

Ichiza lisetyenziswa idosi yemihla ngemihla 20-40 mg. Ubude uthomalaliso uzimisele ezibonisa rejimeni kwaye reception ngendlela medicament "esomeprazole". Iipilisi kunye nesisombululo nzima esikhukulayo kwi insufficiency sezintso usebenzisa idosi ubuninzi-20 mg.

Ilunga reflux esophagitis zanyangwa iiveki ezine kunye idosi yemihla ngemihla ye-40 mg. Ngexesha Uthintelo elide ukuphinda ngokusekelwe yokwamkela ithetha isigulana apho esophagitis wayephilisiwe, idosi yemihla ngemihla bunikwa kwi uluhlu mg-20.

Xa yonyango reflux oesophagitis, ezijolise ekujonganeni iimpawu sifo ingxaki, ukuthatha 20 mg of "esomeprazole" iziyobisi. Amalungiselelo ngohlobo iipilisi kunye powder isetyenziselwa ukubulala H. Pylori, xa kukho unxibelelwano kunye isilonda duodenal, kwi kwanonyango zidityaniswe - "esomeprazole" (20 mg), "Clarithromycin (500 mg)," amoxicillin "(1 g). Onke amayeza esithathwe kabini ngemini.

nezilonda esiswini okubangelwa NSAIDs, kucetyiswa ukuba aphathe 20 mg "esomeprazole" ngosuku. Ithamo olifunayo lusoloko wabelwa ukuya kugqirha kuthathelwa ingqalelo impilo kwisigulana, esi sifo, ubungqongqo zawo, kunye neminye imiba ebalulekileyo.

Effects ezingalindelekanga "esomeprazole" iziyobisi

Izigulane zithatha la machiza ixesha elide, ezisengozini ukuyilwa cysts glandular esiswini ngaphezu kwezinye izigulane. Wabonakala kakhulu rhoqo ebuhlungu emzimbeni ngexesha unyango lithetha "esomeprazole" umyalelo kwi isicelo sokunikela intloko ebuhlungu kwaye ezinye abasabela embi evela iphecana zesisu, ezifana: ukuqhina, flatulence, urhudo, isicaphucaphu, ukugabha, phambi iintlungu esiswini. Ngu iziphumo ebezingalindelekanga anqabe ziquka omiswe of the isifo emlonyeni, isiyezi, urticaria, ukurhawuzelela, dermatitis. Ezinye ukusabela zinokwenzeka, ngoko ke unyango kufuneka wenziwe ngokungqongqo phantsi kweliso yincutshe.

Libanda, ihamba ubuthathaka jikelele, ukwanda kweziganeko ziziphumo ebezingalindelekanga, ukuquka inxalenye lokugaya. Kwiimeko ezinjalo, unyango lwenziwa ngokususa iimpawu libanda, kunye nonyango yesondlo. Dialysis inamalunga akukho ziphumo zinqwenelekayo, akukho iyeza.

oyi

abafazi abakhulelweyo "esomeprazole" analogs ezilawulwa ngokuqaphela okukhulu. Unyango ngexesha lokukhulelwa kumele kwenziwe phantsi kweliso likagqirha. ichiza emiselweyo ukuba abasetyhini abakhulelweyo kuphela kwiimeko apho impembelelo ezintle imizimba yazo lidlula kakhulu ngomonakalo ezingayingozi usana olungekazalwa. iinkcukacha ezithembekileyo kwi isiphumo ichiza kwi umbungu kodwa hayi, kangangoko kunokwenzeka kufuneka bakuphephe unyango kunye nale amayeza. Ukusetyenziswa ichiza "esomeprazole" xa lwebele-lokutyisa akuvumelekanga.

Xa ukunyhashwa kwesibindi elingaphezu ithamo iseti enobungozi empilweni (ukuba ezi iintshukumo zokwaphulwa kwemithetho zinkulu).

Xa iimpawu yomguli na umqondiso, ezifana hematemesis, dysphagia, isicaphucaphu, ukuncitshiswa ebalulekileyo ubunzima emzimbeni ngexesha unyango "esomeprazole" ziphawulwe ukuze kupheliswe okanye isilonda ngenxa ezithatha ichiza phambi kwesi sifo kukrokrelwa, yobubi kumele isuswe. Ukuchonga uhlobo amabi yamathumba kuyimfuneko ukuqhuba isifundo.

Izigulane kufuneka ukungabikho sucrase-isomaltase, ilifa fructose ukunyamezelana umlinganiswa uvunyelwe ukuba ubeke "esomeprazole" ntonye.

Intsebenziswano "esomeprazole" kunye namanye amachiza

Ukusetyenziswa ngaxeshanye ichiza with "citalopram", "clomipramine", "imipramine" potentiation ezi izinto kunokwenzeka, ukuphuculwa iziyobisi esebenzayo egazini. Xa ukusetyenziswa kudibaniso nge "esomeprazole" kwanciphisa ukusebenza "ketoconazole" "Itraconazole" mandundu ukufunxeka zabo.

Xa yokudibanisa i "esomeprazole" ne "ATV" liye ukuncitshiswa ukubhentsiswa eli chiza. "Esomeprazole" umyalelo yokusebenza ayikhuthazwa ukusebenzisa ngaxeshanye "phenytoin", "clomipramine", "imipramine" kunye iziyobisi ezifana "citalopram", "Diazepam", "Nelfinavir" yaye "Atazanavir". Inqanaba kula machiza ke azaba nakuvuka egazini, ngoko kusenokuba enqwenelekayo ukunciphisa ngeedosi zabo. ukusetyenziswa ehamba «esomeprazole" yaye lithetha "clarithromycin" kubangela ukuba utshintsho olukhulu sesichengeni "esomeprazole" kwenzeka waso ezinxulumene inhibition emzimbeni beziyobisi. Ekufuneka ziqwalaselwe ngononophelo instrukiyu ukuba ichiza aze adibane specialist.

Iindleko ichiza, ukubuyekeza ichiza "esomeprazole"

Ichiza kakhulu ezifunyenwe azipilisi. Pharmacy "esomeprazole" anokufunyanwa phantsi amagama zorhwebo "Nexium" yaye "Emanera". Xa uthenga ixabiso "esomeprazole" ichiza kuxhomekeke idosi enye into esebenzayo kumafa yayo. Iindleko amachiza umthamo 20 mg ( "Emanera") lumalunga 500 engange. tablet-28 kwaye uzimisele ngumvelisi. Amayeza kunye ne nedosi ye-40 mg isithako esebenzayo ( "Nexium" macwecwe 28) unako kuthengelwa 3000 engange.

"Esomeprazole" uye ncomo becala HIV. Baphawule impahla iziyobisi ukuze kuthintelwe secretion acid, zombini carcinomas kwavusa. Eli chiza liye eboniswe ngempumelelo eziphakamileyo unyango iimeko ezifana ezibonisa echazwe umyalelo. Ngexesha unyango, oku kuthetha kukho amathuba kancinane yeziphumo ebezingalindelekanga. Asingabo bonke lula nako ukufumana ichiza ezikhemisti, ezinye izigulane wamkela "esomeprazole", ixabiso ikhangeleka ngathi inkulu.

Abo wathabatha namayeza amiselwe ngugqirha emva kokuba inkcazelo ngqo kwesifo kunye idosi ekucetyiswa, phawula ukuphucuka okukhulu kwezempilo. Njengoko ncomo, "Nexium" ixhaphake phakathi izigulane ngaphezu "Emanera". Xa "Nexium" esiswini inika imbonakalo result efunekayo emva malunga nenyanga emva kokuqaliswa unyango. Ukuphucula imeko kwenzeka emva kweeveki 1.5 zonyango. Iziphumo ebezingalindelekanga ezinqabileyo kakhulu. Drug "Nexium" olusebenzayo, inceda ekupheliseni iimeko ekuthethwa ngayo imiyalelo. Ukuba iziphumo ezakhayo, kuyimfuneko ukuba kugqibezela ikhosi lonke yaye zilandele ngqo ngokupheleleyo kwiingcebiso kagqirha.

Analogs "esomeprazole"

Ezi ndlela zilandelayo zingahlukaniswa analogue beziyobisi:

• "Omeprazole" - ekwabizwa ngokuba "Losek", "Omez", "Ultop";
• "Rabeprazole" - isilungiselela eyaziwa phantsi amagama "Ontaym", "Zulbeks", "Noflyuks" "Pariet", "Hayrabezol";
• "Pantoprazole" ( "Sanpraz", "Kontrolok", "Nolpaza");
• "Lansoprazole" ( "Lanza", "Lanzoptol").

Onke la machiza kufuneka neziphumo ezifanayo, kodwa zahlukile enye kwenye ixabiso labo.

Efana "esomeprazole" yaye "Omeprazole". Somahluko wala machiza zisekuhleni kanye. "Esomeprazole" i isomer "omeprazole". Le yokulungiselela, ukuqala i data iincwadi lonyango, kukho inzuzo enkulu, kodwa inyathelo efanayo imithi. "Omeprazole" lixabiso lokwandlalela kweziyobisi kwinani elikhulu yeziphumo ebezingalindelekanga. Xa siqwalasela iimpawu "esomeprazole", ichiza lunikelwa oluphuculiweyo inguqulelo "omeprazole", ixabiso apho utsale izigulane ezininzi. Noko ke, "esomeprazole" okuba baxabane ezingafunekiyo, ngoko ethengiswa kucingwa nenzuzo ngaphezu bathenga "Omeprazole".

"Rabeprazole" yaye "esomeprazole 'abe imichiza kuqamba efanayo, babaphatha seso sifo. Kodwa iingcali zikholelwa ukuba ezinye izifo, ezifana nesifo gastroesophageal reflux, "Rabeprazole" ishenxisa ngempumelelo ngakumbi, isusa bhetele iimpawu, oko kunegalelo ibuyambo ekhawulezileyo imisebenzi umphimbo. Ukungabikho nempembelelo eyakhayo unyango 'esomeprazole "esinxulunyaniswa ne iimpawu ngabanye eziphilayo.

Ukuba kuyimfuneko, khetha analogu kufuneka udibane nogqirha. Phatha sinyamekele impilo yabo, niwele uhlolo ngexesha, ngoko ukumimitheka iya kuba ngokukhawuleza kwaye uya uphephe iingxaki ezininzi.